The present experiment was conducted to analysis mean performance and inbreeding depression in six F2 hybrids. The F2 populations of wheat along with their parents differed significantly (P≤0.01) for all yield and its components, suggesting that abundant genetic diversity is available in these genotypes. For mean performance, among the parents, the variety TD-1 demonstrated better performance for early maturity, plant height, tillers plant -1 , spikelets spike -1 , grains spike -1 , seed index and grain yield plant -1 ; however, among the F2 progenies, the F2 progeny TD-1 x Imdad exhibited better performance for various traits such as days to 50% heading, plant height, grains spike -1 , seed index and grain yield plant -1 , indicating that these genetic resources can further be utilized in various breeding programs to improve bread wheat. With regards to inbreeding depression, the F2 progeny TJ-83 x Moomal expressed low amount of inbreeding depression for various traits including spike length (-9.88%), spikelets spike -1 (-0.82%), seed index (-5.98%), grain yield plant -1 (-3.62%) while same F2 progeny also showed maximum (3.72%) inbreeding depression for the trait days to 50% heading, and indeed is desirable for that trait. Consequently, the F2 progeny TJ-83 x Moomal would be useful F2 hybrid to be utilized for commercial cultivation since this progeny showed minimum inbreeding depression for variety of