Ground-based ionospheric, CHAMP/STAR, and GOCE satellite neutral density ρ observations under deep solar minimum conditions were used to find whether there is a dependence of longitudinal variations on polar vortex strength. Ionospheric stations at fixed-dipole geomagnetic Φ ≈ 38° and geographic φ ≈ 40°N latitudes located in ‘near-pole’ and ‘far-from-pole’ longitudinal sectors were used in the analysis. No significant longitudinal NmF2 (electron concentration in the F2-layer maximum) dependence on the polar vortex strength was revealed. Geomagnetic control was shown to be responsible for the observed longitudinal NmF2 variations. Satellite-observed longitudinal variations in neutral density did not show any visible reaction to the polar vortex strength. However, the impact of sudden stratospheric warming (SSW) on the upper atmosphere is strong enough to change the neutral density longitudinal distribution. The impact of SSW shows a global occurrence and ‘works’ within 3–5 days in geographic coordinates in the vicinity of the SSW peak. Atomic oxygen values retrieved under ‘strong’ and ‘weak’ polar vortex strengths confirm the results obtained on longitudinal variations in NmF2 and ρ. In conclusion, no visible effects related to ‘strong’ or ‘weak’ polar vortex strengths have been revealed in either NmF2 or satellite neutral density longitudinal variations. Alternatively, such effects may be very small and therefore cannot be confirmed experimentally.