Eyes Test Research Articles

Social isolation and social cognition: A cross-sectional analysis.

The impact of social isolation on social cognition is not entirely clear. The aim of the study is to investigate the association between social isolation and social cognition. In a population-based sample of 83 individuals aged 50+ years without dementia, we assessed the relationship between social isolation (measured by the Lubben Social Network Scale - LSNS-6) and performance on emotional recognition (measured by the Emotion Recognition Task (ERT)) and on Theory of Mind (ToM) abilities (measured by the Reading the Mind in the Eyes Test (RMET)), two core aspects of social cognition. No significant association was found between social isolation and ToM abilities for both the unadjusted and adjusted models. Similarly, no significant association was observed between social isolation and emotion recognition. Further research is needed to understand the complex correlation between social relationships and cognitive health, particularly in different cognitive domains, adopting a life course perspective.

Pre and postoperative comparative evaluation of tear film stability and conjunctival impression cytology after phacoemulsification using clear corneal temporal incision

Abstract Introduction: Development of significant dry eye symptoms and visual disturbances after successful cataract surgery remains the common and unsatisfying experience for ophthalmologists. Corneal incision site and surgical technique contribute in ocular surface damage after cataract surgery. To assess the pre and post-operative conjunctival impression cytology and tear film stability after phacoemulsification by clear corneal temporal incision. Methodology: This prospective interventional study was conducted in department of ophthalmology at tertiary care teaching hospital. 72 patients were enrolled and the dry eye assessment was done considering the Schirmer’s test, tear meniscus height, tear breakup time and conjunctival impression cytology; preoperatively and then at 1 week and 4 weeks postoperatively. ANOVA and Post Hoc test were used for statistical analysis and p value of <0.05 was considered significant. Results: Mean age of the patients was 59.86±9.56 years and most of the males were employed while females were mostly homemakers. The overall trend for dry eye tests showed significant (P<0.0001 on ANOVA) increase at 1st week postoperatively, while the significant recovery was achieved by 4th week postoperatively. There was a significant decline (p<0.0001) in goblet cell density (GCD) at 1st week, which was reversed by the 4th week postoperatively. Conclusion: The transient dry eye was seen in the patient’s undergoing phacoemulsification by 1st week postoperatively, which resolved spontaneously but partially with routine postoperative care by the 4th week follow up.

Parental Ability to Detect Visual or Ocular Anomalies in Their Children

INTRODUCTION: Children typically depend on their parents to seek eyecare. Visual and ocular disorders can be challenging for parents to identify with the absence of apparent symptoms. This may hinder timely clinical diagnosis for children who need treatment. Parental awareness regarding common paediatric eye and vision anomalies along with eye care seeking behaviour has been reported, but there is a lack of studies that demonstrate parental ability to identify a presenting eye or vision disorder in their own children. AIM: This study aimed to determine parental ability to recognise a significant eye problem in their children. METHODS: The study population consisted of beneficiaries of Jaber Al Ahmad Armed Forces Hospital in Kuwait. Structured history and symptoms were taken from parents and comprehensive eye examinations were conducted for their children. Parental responses were compared to the eye test results to attain the study purpose. RESULTS: A total of 188 parental interviews and 188 eye test results data were collected from 137 parents and their children. Only a few parents (18.1%) were able to detect significant visual or ocular anomalies in their children. One-third of the parents (33%) were under the assumption that the visual or ocular status of their children was within the norm, while the eye test results showed that the children had clinically significant issues. Overall, 41.5% of the entire group of parents were wrong in their assumption about the children’s visual or ocular status. CONCLUSION: The findings suggest that a large proportion of parents may not be able to identify a presenting eye disorder in their children. This emphasises the significance of routine eye examinations at an early age.

Uncertain reflective functioning, anxious attachment, and cumulative impact of early relational trauma as predictors of severity in borderline personality disorder

ABSTRACT Background: The mentalization model of borderline personality disorder (BPD) utilizes a developmental psychopathology lens, emphasizing an unstable or reduced capacity to mentalize—stemming from early attachment disruptions and relational trauma—as the core feature of BPD. While the empirical evidence for the proposed intersections between mentalizing, attachment, and trauma and the development and manifestations of borderline personality is still limited, this knowledge is essential for developing effective assessments and interventions. Aim: To examine mentalizing, attachment, and early relational trauma as predictors of the severity of symptoms in BPD. Materials and Methods: The sample included 60 individuals diagnosed with BPD, aged 18–45 years, recruited from inpatient and outpatient services in a tertiary care mental health center. Participants completed measures of mentalizing (Reflective Functioning Questionnaire, Interpersonal Reactivity Index, and Reading the Mind in the Eyes test), attachment (Attachment Style Questionnaire), early relational trauma (Complex Trauma Questionnaire), and symptom severity (Borderline Symptom List). Results: The majority of the participants reported experiences of polyvictimization (93.3%) with the most common traumas being psychological abuse (93.3%), neglect (91.7%), and rejection (90.0%). Regression analyses revealed that uncertain reflective functioning, anxious attachment style, and the cumulative impact of trauma together predicted 53.1% of the variance in BPD symptom severity. Conclusion: Impaired mentalizing, characterized by inflexible understanding of mental states, is a critical target for therapeutic interventions in BPD. The significant role of anxious attachment and the necessity of assessing the perceived impact of traumatic experiences highlight the importance of trauma-informed and mentalization-based interventions for this vulnerable group.

Dissecting neural correlates of theory of mind and executive functions in behavioral variant frontotemporal dementia

Behavioral variant frontotemporal dementia (bvFTD) is characterized by profound and early deficits in social cognition (SC) and executive functions (EF). To date it remains unclear whether deficits of the respective cognitive domains are based on the degeneration of distinct brain regions. In 103 patients with a diagnosis of bvFTD (possible/probable/definite: N = 40/58/5) from the frontotemporal lobar degeneration (FTLD) consortium Germany cohort (age 62.5±9.4 years, gender 38 female/65 male) we applied multimodal structural imaging, i.e. voxel-based morphometry, cortical thickness (CTH) and networks of structural covariance via source based morphometry. We cross-sectionally investigated associations with performance in a modified Reading the Mind in the Eyes Test (RMET; reflective of theory of mind - ToM) and five different tests reflective of EF (i.e. Hamasch-Five-Point Test, semantic and phonemic Fluency, Trail Making Test, Stroop interference). Finally, we investigated the conjunction of RMET correlates with functional networks commonly associated with SC respectively ToM and EF as extracted meta-analytically within the Neurosynth database. RMET performance was mainly associated with gray matter volume (GMV) and CTH within temporal and insular cortical regions and less within the prefrontal cortex (PFC), whereas EF performance was mainly associated with prefrontal regions (GMV and CTH). Overlap of RMET and EF associations was primarily located within the insula, adjacent subcortical structures (i.e. putamen) and the dorsolateral PFC (dlPFC). These patterns were more pronounced after adjustment for the respective other cognitive domain. Corroborative results were obtained in analyses of structural covariance networks. Overlap of RMET with meta-analytically extracted functional networks commonly associated with SC, ToM and EF was again primarily located within the temporal and insular region and the dlPFC. In addition, on a meta-analytical level, strong associations were found for temporal cortical RMET correlates with SC and ToM in particular. These data indicate a temporo-frontal dissociation of bvFTD related disturbances of ToM and EF, with atrophy of the anterior temporal lobe being critically involved in ToM deficits. The consistent overlap within the insular cortex may be attributable to the multimodal and integrative role of this region in socioemotional and cognitive processing.

Visual Attention and Cardiac Response to Faces in Relation to Emotion Recognition

Abstract: Rapid and accurate emotion recognition is a crucial skill for social interactions, and visual attention to informative social cues in the environment can facilitate emotion recognition. Studies have found that emotion recognition is also associated with underlying cardiac autonomic responses. The current study examined (1) visual attention and cardiac response (change in heart rate) to emotionally-expressive faces and houses (as a nonsocial control image), and (2) associations between these responses and emotion recognition on the Reading the Mind in the Eyes Test (RMET) in college students. Results showed increased overall attention, but shorter first fixation durations, to faces as compared to houses. Across faces, attention was greater to eyes than mouth, but the magnitude of this difference was dependent on emotion. Analysis of cardiac responses revealed greater heart rate deceleration to happy and fearful faces as compared to neutral faces and houses. Better emotion recognition accuracy on the RMET was related to greater attention to faces, and eyes specifically, as well as greater heart rate deceleration to faces relative to houses. No relations between visual attention and cardiac response were found. The current work points to variations in visual attention and cardiac responses while viewing emotional faces that can be markers of emotion processing ability.

Effects of Smart Glasses on the Visual Acuity and Eye Strain of Employees in Logistics and Picking: A Six-Month Observational Study.

The usage of smart glasses in goods logistics and order picking has mainly been studied through cross-sectional experimental studies. Our longitudinal field study investigated the effects of smart glasses on the eyesight of 43 employees at two German companies. We combined ophthalmological examinations and questionnaire surveys at two points in time, six months apart. The vision of the employees was examined before and after each work shift. Mixed effects logistic regression was conducted to determine the associations between smart glasses use and effects on visual acuity. In the baseline examination, differences in eyesight before and after shifts were small and not statistically significant. However, some individuals experienced deteriorations, especially in visual acuity at near distances (n = 7 for the right eye, n = 6 for the left). Participants over 40 years of age had 16.1 times higher odds of deterioration compared to those under 40 years (95% CI: 2.7-95.9, p = 0.002). The most commonly reported eye strains were eye fatigue (n = 32), rubbing (n = 25), and burning (n = 24). If smart glasses are to be implemented in logistics companies, it is recommended to offer employees eye tests with an industrial physician in advance.

Reliability of Theory of Mind Tasks in Schizophrenia, ASD, and Nonclinical Populations: A Systematic Review and Reliability Generalization Meta-analysis.

Though theory of mind (ToM) is an important area of study for different disciplines, however, the psychometric evaluations of ToM tasks have yielded inconsistent results across studies and populations, raising the concerns about the accuracy, consistency, and generalizability of these tasks. This systematic review and meta-analysis examined the psychometric reliability of 27 distinct ToM tasks across 90 studies involving 2771 schizophrenia (SZ), 690 autism spectrum disorder (ASD), and 15,599 nonclinical populations (NC). Findings revealed that while all ToM tasks exhibited satisfactory internal consistency in ASD and SZ, about half of them were not satisfactory in NC, including the commonly used Reading the Mind in the Eye Test and Hinting Task. Other than that, Reading the Mind in the Eye Test showed acceptable reliability across populations, whereas Hinting Task had poor test-retest reliability. Notably, only Faux Pas Test and Movie for the Assessment of Social Cognition had satisfactory reliability across populations albeit limited numbers of studies. However, only ten studies examined the psychometric properties of ToM tasks in ASD adults, warranting additional evaluations. The study offered practical implications for selecting ToM tasks in research and clinical settings, and underscored the importance of having a robust psychometric reliability in ToM tasks across populations.

An initial exploration of factors that may impact radiographer performance in reporting mammograms

ObjectivesIn the United Kingdom, radiographers with a qualification in image interpretation have interpreted mammograms since 1995. These radiographers work under the title of radiography advanced practitioners (RAP) or Consultant Radiographer. This study extends upon what has been very recently published by exploring further clinical, non-clinical and experiential factors that may impact the reporting performance of RAPs. MethodsFifteen RAPs interpreted an image test set of 60 2D mammograms of known truth using the Detected-X software platform. Unknown to the reader, twenty cases contained a malignancy. Sensitivity, specificity, lesion sensitivity, receiver operating characteristic (ROC) and jack-knife free response operating characteristic (AFROC) values were established for each RAP. Specific features that had significant impact on accuracy were identified using Student's-T and Mann Whitney tests. ResultsRAPs with more than 10 years' experience in image interpretation, compared to those with less than 10 years’ experience, demonstrated lower specificity (51.3% vs 84.8%, p = 0.0264), ROC (0.83 vs 0.91, p = 0.0264) and AFROC (0.75 vs 0.87, p = 0.0037) values. Further, higher sensitivity values of 90.7% were seen in those RAPs who had an eye test in the last year compared to those who had not, 82% (p = 0.021). Other changes are presented in the paper. ConclusionThese data reveal previously unidentified factors that impact the diagnostic efficacy of RAPs when interpreting mammographic images. Highlighting such findings will empower screening authorities to better examine ways of standardising performance and offer a baseline for performance benchmarks. Implications for practiceThis study for the first time performs an initial exploration of the factors that may be associated with RAP performance when interpreting screening mammograms.

Dermal toxicity studies of 1,2-benzisothiazolin-3-one (CAS number: 2634-33-5) in Sprague-Dawley rats

Biocides are used as preservatives in various household products, and 1,2-benzisothiazolin-3-one (BIT) is one of the popular chemicals. Therefore, BIT is highly likely to be exposed to human skin, necessitating dermal toxicity evaluation. In this study, we aimed to investigate dermal toxicity, eyes and skin irritation, and skin sensitization of BIT. All studies were conducted according to the Organisation for Economic Co-operation and Development testing guidelines. In acute dermal toxicity using rats, no treatment-related responses were observed at the highest dose (2000 mg/kg). A 28-day repeated dermal toxicity study at 1, 4, and 12 mg/kg/day showed transient local skin irritation lesions, including erythema, exfoliation, and crust formation. Based on no systemic effects, the no observed adverse effect level (NOAEL) of BIT of the 28-day repeated dermal toxicity study was determined to be 12 mg/kg/day. Eye and skin irritation tests showed that BIT is a strong irritant and corrosive to the eyes and a mild irritant to the skin. However, BIT showed no skin sensitization reactions in a local lymph node assay. These dermal toxicity studies can provide valuable information for the risk assessment of BIT.

A chart-based test of contrast sensitivity in noise: reference ranges, effects of age and optical abnormality

ABSTRACT Clinical relevance Contrast sensitivity plays an important role in the comprehensive assessment of visual function; however, measurement with standard eye charts can be affected by age and optical abnormality. Background This study describes a novel chart-based test of letter contrast sensitivity (CS) in luminance noise (the Illinois Eye and Ear Noise CS test), defines normal reference ranges, estimates test-retest repeatability, and assesses the effects of age and simulated optical abnormalities. Methods Seventy-five individuals with normal visual function (age 18–85 years) participated. Subjects identified letter optotypes that spanned a broad contrast range (0.9% to 59.6%) printed in a book-based test. Letters were presented against a grey background (no-noise condition) and in luminance noise that consisted of light and dark checks (noise condition). A subset of 10 subjects repeated the test to define short-term variability and performed the test under three additional conditions: simulated cataract, +2.00D defocus, and low room illuminance. Results In the no-noise condition, CS was independent of age (mean log CS of 1.74) until approximately 54 years, and declined for older subjects (CS loss of 0.1 log unit/decade). CS measured in noise was independent of age across the range of ages tested (mean log CS of 0.91). The 95% limits of agreement for test-retest repeatability was 0.19 log units. Simulated cataract, +2.00D defocus, and reduced illumination significantly reduced CS in the no-noise condition (F = 102.6, p < 0.001), whereas these optical manipulations did not significantly affect CS in noise (F = 2.58, p = 0.074). Conclusions Measurements of CS in luminance noise may be valuable, as these measures are largely independent of age and certain forms of optical degradation. CS measurements in noise may provide useful insight into visual function in patients who have combined neural and optical abnormality, as noise minimises CS loss from optical defects.

Resting-state EEG microstates predict mentalizing ability as assessed by the Reading the Mind in the Eyes test

Microstates analysis of electroencephalography (EEG) has gained increasing attention among researchers and clinicians as a valid tool for investigating temporal dynamics of large-scale brain networks with a millisecond time resolution. Although microstates analysis has been widely applied to elucidate the neurophysiological basis of various cognitive functions in both clinical and non-clinical samples, its application in relation to socio-affective processing has been relatively under-researched. Therefore, the main aim of the current study was to investigate the relationship between EEG microstates and mentalizing (i.e., the ability to understand the mental states of others). Eighty-two participants (thirty-six men; mean age: 24.28 ± 7.35 years; mean years of education: 15.82 ± 1.77) underwent a resting-state EEG recording and performed the Reading the Mind in the Eyes Test (RMET). The parameters of the microstates were then calculated using Cartool v. 4.09 software. Our results showed that the occurrence of microstate map C was independently and positively associated with the RMET total score and contributed to the prediction of mentalizing performance, even when controlling for potential confounding variables (i.e., age, sex, education level, tobacco and alcohol use). Since microstate C is involved in self-related processes, our findings may reflect the link between self-awareness of one's own thoughts/feelings and the enhanced ability to recognize the mental states of others at the neurophysiological level. This finding extends the functions traditionally attributed to microstate C, i.e. mind-wandering, self-related thoughts, prosociality, and emotional and interoceptive processing, to include mentalizing ability.

One-year developmental changes in motor coordination and tennis skills in 10–12-year-old male and female tennis players

BackgroundTo date, no longitudinal studies of quarterly changes have been conducted on the differences in the development of motor coordination between boys and girls in relation to changes in their tennis skills level. Therefore, the aim of the study was to assess the development of motor coordination of 10–12-year-old tennis players over the course of 1 year, in the light of changes in tennis skills preparation.MethodsOne-hundred eighty male and female tennis players aged 10, 11, or 12 years old participated in the study. Each age group comprised 30 boys and 30 girls. To investigate their motor coordination development, a battery of general tests (simple reaction, complex reaction, Spalding test, spider test, hexagon jumping, Starosta’s test, hand–eye test, balance, plate tapping, jump rope) and specific tennis skills tests (wall game and 100-tennis ball tests) were performed 4 times quarterly over 1 year. Differences between sexes and the time points were assessed. The rate of development evaluation was based on beta coefficient of linear regression.ResultsBoys generally performed better in tennis skills tests than girls. The boys performed better also in one motor coordination test (Spalding test) among 10-year-olds, in two additional tests (spider and plate tapping tests) among 11-year-olds, and another three more tests (simple reaction, complex reaction and Starosta’s tests) among 12-year-olds. Jump rope test among 10-year-olds and hexagon jump test among 12-year-olds were the only tests where girls performed better than boys. On the other hand, girls showed higher rate of development in balance and complex reaction tests than boys.ConclusionsWe conclude that motor coordination and tennis skills development over 1 year is age-, sex-, and task-dependent, with the 10–12-year-old male tennis players performing better in tennis skills and overall motor coordination than females.

Impact of alexithymia, speech problems and parental emotion recognition on internalizing and externalizing problems in preschoolers.

Alexithymia, characterized by difficulty identifying and describing emotions and an externally oriented thinking style, is a personality trait linked to various mental health issues. Despite its recognized importance, research on alexithymia in early childhood is sparse. This study addresses this gap by investigating alexithymia in preschool-aged children and its correlation with psychopathology, along with parental alexithymia. Data were analyzed from 174 parents of preschoolers aged 3 to 6, including 27 children in an interdisciplinary intervention program, all of whom attended regular preschools. Parents filled out online questionnaires assessing their children's alexithymia (Perth Alexithymia Questionnaire-Parent Report) and psychopathology (Strengths and Difficulties Questionnaire), as well as their own alexithymia (Perth Alexithymia Questionnaire) and emotion recognition (Reading Mind in the Eyes Test). Linear multivariable regressions were computed to predict child psychopathology based on both child and parental alexithymia. Preschool children's alexithymia could be predicted by their parents' alexithymia and parents' emotion recognition skills. Internalizing symptomatology could be predicted by overall child alexithymia, whereas externalizing symptomatology was predicted by difficulties describing negative feelings only. Parental alexithymia was linked to both child alexithymia and psychopathology. The findings provide first evidence of the importance of alexithymia as a possible risk factor in early childhood and contribute to understanding the presentation and role of alexithymia. This could inform future research aimed at investigating the causes, prevention, and intervention strategies for psychopathology in children.

Interim safety and efficacy of gene therapy for RLBP1-associated retinal dystrophy: a phase 1/2 trial

Gene therapy holds promise for treatment of inherited retinal dystrophies, a group of rare genetic disorders characterized by severe loss of vision. Here, we report up to 3-year pre-specified interim safety and efficacy results of an open-label first-in-human dose-escalation phase 1/2 gene therapy clinical trial in 12 patients with retinal dystrophy caused by biallelic mutations in the retinaldehyde-binding protein 1 (RLBP1) gene of the visual cycle. The primary endpoints were systemic and ocular safety and recovery of dark adaptation. Secondary endpoints included microperimetry, visual field sensitivity, dominant eye test and patient-reported outcomes. Subretinal delivery of an adeno-associated viral vector (AAV8-RLBP1) was well tolerated with dose-dependent intraocular inflammation which responded to corticosteroid treatment, and focal atrophy of the retinal pigment epithelium as the dose limiting toxicity. Dark adaptation kinetics, the primary efficacy endpoint, improved significantly in all dose-cohorts. Treatment with AAV8-RLBP1 resulted in the resolution of disease-related retinal deposits, suggestive of successful restoration of the visual cycle. In conclusion, to date, AAV8-RLBP1 has shown preliminary safety and efficacy in patients with RLBP1-associated retinal dystrophy. Trial number: NCT03374657.

An fMRI study on alexithymia and affective state recognition in the Reading the Mind in the Eyes Test.

Recognizing others' affective states is essential for successful social interactions. Alexithymia, characterized by difficulties in identifying and describing one's own emotions, has been linked to deficits in recognizing emotions and mental states in others. To investigate how neural correlates of affective state recognition are affected by different facets of alexithymia, we conducted a functional magnetic resonance imaging study with 53 healthy participants (aged 19-36 years, 51% female) using the Reading the Mind in the Eyes Test (RMET) and three different measures of alexithymia [Toronto Structured Interview for Alexithymia (TSIA), Toronto Alexithymia Scale (TAS-20), and Bermond-Vorst Alexithymia Questionnaire]. In addition, we examined brain activity during the RMET and replicated previous findings with task-related brain activation in the inferior frontal and temporal gyri, as well as the insula. No association was found between alexithymia and behavioral performance in the RMET, possibly due to the low number of participants with high alexithymia levels. Region of interest based analyses revealed no associations between alexithymia and amygdala or insula activity during the RMET. At the whole-brain level, both a composite alexithymia score and the unique variance of the alexithymia interview (TSIA) were associated with greater activity in visual processing areas during the RMET. This may indicate that affective state recognition performance in alexithymia relies on a higher compensatory activation in visual areas.

Social Cognition in Parkinson's Disease after Focused Ultrasound Subthalamotomy: A Controlled Study.

Social cognition (SC) encompasses a set of cognitive functions that enable individuals to understand and respond appropriately to social interactions. Although focused ultrasound subthalamotomy (FUS-STN) effectively treats Parkinson's disease (PD) clinical motor features, its impact and safety on cognitive-behavioral interactions/interpersonal awareness are unknown. This study investigated the effects of unilateral FUS-STN on facial emotion recognition (FER) and affective and cognitive theory of mind (ToM) in PD patients from a randomized sham-controlled trial (NCT03454425). Subjects performed SC evaluation before and 4 months after the procedure while still under blind assessment conditions. The SC assessment included the Karolinska Directed Emotional Faces task for FER, the Reading the Mind in the Eyes (RME) test for affective ToM, and The Theory of Mind Picture Stories Task (ToM PST) (order, questions, and total score) for cognitive ToM. The active treatment group showed anecdotal-to-moderate evidence of no worsening in SC after FUS-STN. Anecdotal evidence for an improvement was recognized in the SC score changes, from baseline to post-treatment, for the active treatment group compared with sham for the RME, ToM PST order, ToM PST total, FER total, and recognition of fear, disgust, and anger. This study provides the first evidence that unilateral FUS-STN does not impair social cognitive abilities, indicating that it can be considered a safe treatment approach for this domain in PD patients. Furthermore, the results suggest FUS-STN may even lead to some improvement in social cognitive outcomes, which should be considered as a preliminary finding requiring further investigation with larger samples sizes. © 2024 International Parkinson and Movement Disorder Society.

Assessing metarepresentational abilities in adolescence: an exploratory study on relationships between definitional competence and theory of mind.

Several developmental changes occur in adolescence, particularly in the metarepresentational domain, which allows and promotes adaptive sociality. We explored the possible relationships between theory of mind (ToM) and definitional competence, both metarepresentational, beyond age and gender effects. To reach our goals, we involved 75 adolescents (age range 14-19 years, M = 15.7, and SD = 1.36). ToM was measured through "The Reading the Mind in the Eyes Test" (RMET), and definitional competence was assessed through a new instrument, namely, the "Co.De. Scale". Attention was paid to check whether results were different when considering mental states vs. non-mental states of the scale and emotional words vs. non-emotional words. T-tests showed that older adolescents (third grade of high school) performed better than younger ones (first grade of high school) in both tasks. Only in the male group, there were no school grade differences in the ToM task. Regression analyses showed that RMET performance predicted the score of non-emotional mental states definitions and, even if marginally, of ToM word definitions. However, RMET was not a predictor of the general performance of the definitional task or emotion definitions. Connections with global adolescents' development and possible educational implications are discussed.

Pupillary response during social emotion tasks in autism spectrum disorder.

Autistic individuals encounter challenges in recognizing emotional expressions of others. Pupillary response has been proposed as an indicator of arousal dysregulation or cognitive load. The pupillary response of autistic individuals during socio-affective tasks remains unclear. This study investigated pupillary response in autistic adults when viewing emotional faces/eyes and recognizing emotions during the Reading the Mind in the Eyes Test (RMET) and watching interpersonal touch scenes in the social touch task. The study included 98 participants diagnosed with autism spectrum disorder and 37 typically developing controls (TD). Pupil size was measured using the Tobii X2-30 Eye Tracker. The results showed that autistic adults had larger maximal pupil sizes, smaller minimal pupil sizes, and greater change rates of pupil size, particularly during the RMET Eyes task. Clinical correlations revealed that attention switching difficulty positively correlated with mean pupil size in TD participants, while social communication deficitspositively correlated with mean pupil size in autistic participants. In conclusion, our findings suggest atypical pupillary responses in autistic adults during socio-affective tasks, indicating heightened cognitive demand. Further investigation is necessary to understand the underlying mechanisms and their association with autistic traits.

Differential Social Cognitive Performance in Older Adults With Mild Cognitive Impairment and Dementia

To study general and subdomain performance in measures of social cognition in individuals with mild cognitive impairment (MCI), and dementia, and to explore associations between social cognitive and neuropsychological subdomains. Cross-sectional study of participants from the Sydney Memory and Ageing Study (MAS). Current data was collected in 2016-2018. Community-dwelling older adults (n=321) aged 80 years and above, with no history of neurological or psychiatric conditions. Participants had dementia, MCI, or no cognitive impairment (NCI). Social cognition was indexed using the Reading the Mind in the Eyes Test (RMET), the Interpersonal Reactivity Index - Perspective Taking (IRI-PT) and Empathic Concern (IRI-EC) subscales, and the Emotion Recognition Task (ERT). These subdomain scores were used to make a composite social cognition score. Apathy was measured via the Apathy Evaluation Scale (AES). Neurocognitive function was indexed using the Addenbrooke Cognitive Examination v3 (ACE-3). Dementia was associated with poorer overall social cognitive composite performance. MCI and dementia participants performed poorer on RMET and recognition of anger, disgust and happiness on ERT. RMET and ERT disgust remained significant after controlling for relevant covariates. Dementia participants performed poorer than MCI and NCI on the IRI-PT, IRI-EC, and AES. AES remained significant after regression. RMET was correlated with ACE-3 Fluency and/or Language in all study groups. MCI is associated with poorer scores in specific social cognitive assessments. Dementia is somewhat associated with poorer scores in informant-rated social cognition scales, though this is no longer significant after accounting for apathy.