Eye Pattern Research Articles

Acromegaly in Speckle Tracking Echocardiography-A New Cardiac Hypertrophy Phenotype? Case Report and Review.

This study aims to provide a comprehensive overview of speckle tracking echocardiography (STE) findings in patients diagnosed with acromegaly, exploring a potential application for the differential diagnosis of cardiac hypertrophy and guiding clinicians in patient management. To our knowledge, this is the first review showcasing changes in the bull's-eye pattern in myocardial function after acromegaly treatment, suggesting a possible pattern in this aetiology of left ventricular hypertrophy. A review of PubMed articles using the search term "speckle tracking echocardiography acromegaly" yielded 11 relevant papers published between 2017 and 2023. The final analysis evaluated each paper's substantial value and summarised pertinent information. A clinical case of myocardial strain changes before and after pharmacological and neurosurgical treatment is also described. The 11 analysed papers, with patient groups ranging from 19 to 50 individuals, revealed varying results in STE parameters between acromegalic and control groups. Left ventricular strain parameters were commonly assessed, showing discrepancies in different studies. Notably, the MAGYAR-Path Study emphasised left ventricular twist and radial strain abnormalities in acromegaly patients. Furthermore, the interplay between acromegaly and diabetes influenced myocardial function. Drug treatment with somatostatin receptor ligands demonstrated a favourable impact on left ventricular systolic function. The case study we describe in this manuscript showed changes in the posterior basal LV segment, which may be a specific pattern of acromegaly remodelling. Somatostatin therapy and neurosurgery led to the normalisation of global longitudinal strain (GLS) and improvement in myocardial work, as well as improved diastolic function, including enhanced left atrial strain (LAS) as well as a visible elastic recoil sign (ERS). While the available literature on STE in acromegaly is limited, our analysis suggests potential applications in differentiating hypertrophy aetiologies and monitoring cardiac function post-treatment. The results underscore the need for more interdisciplinary research to optimise patient management. The bull's-eye pattern with posterior basal segment strain impairment we describe may be used to differentiate this entity.

Map3k1 suppresses terminal differentiation of migratory eye progenitors in planarian regeneration.

Proper stem cell targeting and differentiation is necessary for regeneration to succeed. In organisms capable of whole body regeneration, considerable progress has been made identifying wound signals initiating this process, but the mechanisms that control the differentiation of progenitors into mature organs are not fully understood. Using the planarian as a model system, we identify a novel function for map3k1, a MAP3K family member possessing both kinase and ubiquitin ligase domains, to negatively regulate terminal differentiation of stem cells during eye regeneration. Inhibition of map3k1 caused the formation of multiple ectopic eyes within the head, but without controlling overall head, brain, or body patterning. By contrast, other known regulators of planarian eye patterning like WntA and notum also regulate head regionalization, suggesting map3k1 acts distinctly. Eye resection and regeneration experiments suggest that unlike Wnt signaling perturbation, map3k1 inhibition did not shift the target destination of eye formation in the animal. Instead, map3k1(RNAi) ectopic eyes emerge in the regions normally occupied by migratory eye progenitors, and the onset of ectopic eyes after map3k1 inhibition coincides with a reduction to eye progenitor numbers. Furthermore, RNAi dosing experiments indicate that progenitors closer to their normal target are relatively more sensitive to the effects of map3k1, implicating this factors in controlling the site of terminal differentiation. Eye phenotypes were also observed after inhibition of map2k4, map2k7, jnk, and p38, identifying a putative pathway through which map3k1 prevents differentiation. Together, these results suggest that map3k1 regulates a novel control point in the eye regeneration pathway which suppresses the terminal differentiation of progenitors during their migration to target destinations.

Regional/ethnic differences in ocular axial elongation and refractive error progression in myopic and non-myopic children.

To determine the regional and ethnic differences in ocular axial elongation and refractive error progression in myopic and non-myopic children. A retrospective analysis of 15 longitudinal clinical and population-based studies was conducted in the UK, Sweden, Australia (classified as European), China, and Vietnam (classified as East Asian) between 2005 and 2021. A total of 14,593 data points from 6208 participants aged 6-16 years with spherical equivalent from +6 to -6 D were analysed. Progression was annualised from longitudinal axial length and cycloplegic spherical equivalent (SE) refraction. Generalised estimating equation models including main effects and interactions were used for model building. Age and region-specific estimates for myopes and non-myopes and confidence intervals are reported. Factors affecting axial elongation and SE progression in children included being myopic, followed by age, region/ethnicity and sex. The magnitude of regional/ethnic differences was dependent on myopia and age. Axial elongation and SE progression were lower in European compared with East Asian children, but differences were reduced with increasing age and differences in axial elongation were larger in myopes than non-myopes. Age-specific regional/ethnic differences indicated that axial elongation for a 6-year-old East Asian myopic child was greater than a European child by 0.15 mm/year (0.58 vs. 0.43 mm/year) and by 0.09 mm/year (0.35 vs. 0.26 mm/year) for a 10-year-old myope. SE progression was lower in a 6-year-old European myope by 0.48 D/year and at 10 years of age by 0.34 D/year compared with an East Asian myope. There are regional/ethnic differences in age-specific refractive and axial growth patterns in both myopic and non-myopic eyes, with more marked differences in younger East Asian children who demonstrated a higher axial growth and greater negative SE shift than their non-Asian peers. Regional/ethnic differences in progression reflect environmental and ethnic variations. Age and region/ethnicity-specific estimates could contribute as a reference for future comparisons.

The Eye and Nose Identification Chip Controller-Based on Robot Vision Using Weightless Neural Network Method

Increasingly advanced image analysis in computer vision, allowing computers to interpret, identify, and analyze pictures with accuracy comparable to humans. The availability of data sources in decimal, hexadecimal, or binary forms enables researchers to take the initiative in applying their study findings. Decimal formats are typically used on traditional computers like desktops and minicomputers, whereas hexadecimal and binary formats were utilized on single-chip controllers. Weightless Neural Network is a method that can be implemented in a single chip controller. The aim of this research is to develop a facial recognition system, for eye and mouth identification, that works in a single chip controller or also called a microcontroller. The suggested method is a Weightless Neural Network with Immediate Scan approach for processing and identifying eye and nose patterns. The data will be handled in many memory locations that are specifically designed to handle massive volumes of data. The data is made up of primary face data sheets and face input data. The data sets utilized are (x,y) pixels, and frame sizes range from 90x90 pixels to 110x110 pixels. Each face shot will be processed by selecting the region of the eyes and nose and saving it as an image file. The eye and nose will identify the face frame. Next, the photos will be converted to binary format. A magazine matrix will be used to transmit binary data from a minicomputer to a microcontroller via serial connection. Based on a known pattern, the resultant similarity accuracy is 83,08% for the eye and 84,09% for the sternum. In contrast, the similarity percentage for an eye ranges from 70% to 85% for an undefined pattern.

Design and performance of WDM system for high-speed optical communication on different modulation formats

Abstract In this paper, the performance analysis of the WDM (wavelength division multiplexing) system on the optical fiber transmission link is proposed. High data transmission is possible by implementing a WDM optical communication system using different modulation formats. Firstly, the WDM optical communication system is designed on an Optiwave simulation tool and distortion in the optical fiber by “eye pattern analysis” is analyzed. Secondly, the optical SNR of the proposed WDM optical communication system is studied. Further, the bit-error rate (BER) plot is studied and optimization techniques are applied to enhance the proposed system for long-haul communication. Furthermore, the BER plots are analyzed by varying the length of the fiber and applying different coding techniques like NRZ (non-return zero), RZ (return to zero), QAM (quadrature amplitude modulation) etc. using the Optiwave simulation tool. The results obtained in the Optiwave simulation tool are validated by theoretical implementation in the MATLAB tool.

Evaluating fingerprint-like patterns in the healthy Henle fiber layer using enface OCT imaging

PurposeEnface OCT may disclose a distinct “fingerprint-like' pattern within the HFL in various macular disorders. This study aims to investigate the frequency and characteristics of this pattern in healthy eyes and identify potential factors influencing its visibility. MethodsTwo, independent masked reading center graders evaluated for the presence and prominence of a fingerprint pattern in the Henle fiber layer (HFL) on enface OCT images from 33 healthy subjects (66 eyes). The prominence of the pattern was rated qualitatively using a 0–3 scale, with 3 indicating the strongest prominence. Tilt angles (relative to the normal/perpendicular at the center) of the retina were measured on horizontal and vertical B-scans, and the retinal curvature was assessed using ImageJ, in order to determine the impact of the incident light angle on the visibility and prominence of the fingerprint pattern. Inter-grader agreement using Cohen's kappa and the frequency and percentage of patterns in the entire enface image and in each quadrant were calculated and compared using the Friedman test with Dunn's post-test. A generalized estimating equation (GEE) was used to analyze the association between these metrics and fingerprint prominence. ResultsSubstantial inter-grader agreement was observed (Cohen's kappa = 0.71) for assessing the prominence of the fingerprint pattern. Over 70% of eyes exhibited some evidence of the pattern (score ≥1). Significant difference in pattern prominence across quadrants was detected (p < 0.05), with lowest prominence in the temporal quadrant (p < 0.001 for pairwise comparisons against all other quadrants). The GEE analysis to account for the extent of the effect of scan tilt angle and RPE curvature was not able to predict the prominence of the fingerprint pattern, highlighting that angle of incidence (of the scanning laser light) alone could not explain the pattern. ConclusionsThis study confirms that a fingerprint-like pattern within the HFL can also be observed in healthy eyes, challenging the notion that this finding is only manifest in the setting of disease. In addition, the lack of correlation with angle of incident light suggests that the pattern may be related to other intrinsic characteristics of the HFL.

Analysis of two glass eye (Jatim) beads unearthed from the Northern Wei tomb complex in Dongxin, Datong

This study analyzed two glass eye beads discovered in an ancient tomb complex at Dongxin Furniture Square in Datong, Shanxi Province in China. The tomb complex was dated to the Northern Wei Dynasty (398–494 AD), when Datong was known as Pingcheng. We used scanning electron microscopy (SEM) and energy dispersive spectrometry (EDS) as well as a 3D microscope system with ultra-depth of field to conduct non-destructive tests on the beads. We examined the beads’ manufacturing techniques, including matrices, eye patterns, and bead holes. The composition analysis revealed that both beads belonged to the mix of v-Na-Ca and m-Na-Al glass system, which is a key indicator of local production in Java. The bases were colored using Co2+, whereas the white, red, and yellow colors of the eye patterns were achieved using SnO2, Cu2O, or Cu0, and PbSnO3, respectively. These findings indicated that both objects were Jatim beads originating in the Kingdom of Java in Southeast Asia. This study provides valuable insights into ancient trade routes between different regions and offers reliable scientific evidence of the glass trade and technical exchanges in ancient times.

The nature gaze: Eye‐tracking experiment reveals well‐being benefits derived from directing visual attention towards elements of nature

Abstract The urban lifestyle has a profound effect on mental health, contributing significantly to the challenges faced by people who reside in urban areas. Growing empirical evidence underscores the potential of nature to alleviate these mental health burdens. However, we still lack understanding of which specific natural elements provide these benefits. Using eye‐tracking technology, we experimentally explored the relationships between intentional visual attention to natural (green) and human‐made (grey) elements in urban areas and their association with well‐being measures. Participants took a 45‐min outdoor walk that simulates a walk to and from work, in which we examined pre‐ and post‐measures of cognition, affect, anxiety and perceived restorativeness. Participants were prompted to direct their attention to green, grey or a mixture of both elements. By analysing participants' eye movements and patterns, we determined adherence to experimental conditions and related visual attention to natural elements. The experimental groups instructed to direct their visual attention to green, grey or a mix of both infrastructures exhibited differences in negative and positive affect, anxiety and perceived restorativeness, but not in cognition after a walk in an urban environment. The percentage of time spent viewing natural elements showed that people who focused more on green features reported a decrease in anxiety and higher perceived restorativeness. In contrast, those who spent more time viewing grey elements reported increased anxiety and lowered perceived restorativeness. The percentage of time viewing natural elements was not linked to affect or cognition. Viewing trees showed the strongest association with well‐being measures compared to other natural elements. Together, our results indicate that a simple behaviour change (directing visual attention to elements of nature instead of grey elements) can produce mental health benefits in the form of reducing anxiety and perceived restoration for people in urban areas. Thus, efforts to integrate nature, especially trees, in urban areas and promote city dwellers to visually interact with it during their daily routine can improve mental issues associated with urban lifestyle. Read the free Plain Language Summary for this article on the Journal blog.

Design and Fabrication of a novel wideband common mode noise suppression filter using fuzzy interpolation method

This article proposes two new wideband common-mode noise suppression filters based on a defected ground structure. The first design uses the Butterworth equivalent circuit achieving a fractional bandwidth of 117 %. At first, the resonators are arranged next to each other and the equivalent circuit is extracted. Also, samples with different dimensions of resonators are prepared by electromagnetic simulation analysis, and the fuzzy interpolation method is used for estimating the circuit behavior. The ADS software is used to optimize the values of the variables to achieve the desired bandwidth in the schematic environment. This paper utilizes the Taguchi method to strike a balance between various parameters in the filter design, aiming to minimize errors during the fabrication process. Then, the new values estimated with the fuzzy interpolation method are verified by electromagnetic simulation. The fractional bandwidth of the filter increases to 124 %, and noise can be suppressed by more than 10 dB at the center frequency of 21.45 GHz in the range from 8.1 to 34.8 GHz, with a loss of less than 3 dB in the differential lines. A new equivalent circuit is proposed using the first-order Chebyshev model. It is observed that the electromagnetic simulations and circuit modeling have good agreement with the measurements. Moreover, the eye pattern with a speed rate of 21.45 Gb/s is proposed for USB 3.2 and HDMI 2.0 applications.

Eye development influences horn size but not patterning in horned beetles.

Understanding the origin of novel morphological traits is a long-standing objective in evolutionary developmental biology. We explored the developmental genetic mechanisms that underpin the formation of a textbook example of evolutionary novelties, the cephalic horns of beetles. Previous work has implicated the gene regulatory networks associated with compound eye and ocellar development in horn formation and suggested that horns and compound eyes may influence each other's sizes. Therefore, we investigated the functional significance of genes central to visual system formation in the initiation, patterning, and size determination of head horns across three horned beetle species. We find that while the downregulation of canonical eye patterning genes reliably reduces or eliminates compound eye formation, it does not alter the position or shape of head horns yet does result in an increase in relative horn length. We discuss the implications of our results for our understanding of the genesis of cephalic horns in particular and evolutionary novelties in general.

Demonstration of THz frequency hopping in the 300 GHz band based on UTC-PD and tunable DFB laser array

We explored the potential of an optoelectronic frequency hopping system within the 300 GHz band, leveraging a tunable distributed feedback laser array and uni-traveling carrier photodiode. Our experiments successfully achieved a 10-channel terahertz (THz) frequency hopping, marking a significant advancement in THz secure communication technologies. Notably, the system exhibited a rapid frequency-hopping capability with a short transition time of 0.8 ms between channels, ranging from 288 to 331 GHz. Further, we conducted data transmission tests at a rate of 5 Gbit s−1 across several channels. The results were promising, showing each channel maintained a clear eye pattern and a low bit error rate, crucial factors for reliable and secure data transmission. These findings not only demonstrate the efficacy of our system but also open new avenues for high-speed, secure THz communication.

Nanoantenna Effect at the Center of the Bull’s Eye Pattern by Controlling the Refractive Indices and Layer Thicknesses of Dielectric Media on a Silver Surface

Nanoantenna Effect at the Center of the Bull’s Eye Pattern by Controlling the Refractive Indices and Layer Thicknesses of Dielectric Media on a Silver Surface

Theoretical Demonstration of Improved Performance in Multi-Channel Photonic RF Signals Based on Optical Injection Locking of Optical Comb and Array Lasers

Multi-channel radio frequency (RF) signal generation, facilitated by photonic technology, offers significant potential for generating coherent signals with a high frequency and low phase noise, providing multifunctional capabilities across diverse platforms, including RF and photonic systems. Traditional methods for multi-channel photonic RF signal generation typically entail the integration of diverse optical components, such as filters and amplifiers. However, this integration often results in compromises related to power efficiency, cost-effectiveness, and implementation simplicity. To address these challenges, we propose a novel method for generating multi-channel photonic RF signals based on optical injection locking technology. This approach eliminates the necessity for traditional optical components, leading to a substantial enhancement in the performance of photonic RF signals. We present the design of an optical injection locking-based multi-channel photonic RF signal generation schematic and theoretically evaluate its Signal-to-Noise Ratio (SNR) and eye pattern performance for data modulation using the Lumerical INTERCONNECT simulator. Our results reveal a significant 1.3-dB and 3.6-dB enhancement in SNR for 30-GHz and 60-GHz signals, respectively. Furthermore, we observed an improved communication performance, as evidenced by enhanced eye patterns in 3-Gbps data transmission compared to passive photonic RF signal generation methods.

Seeing through a robot's eyes: A cross-sectional exploratory study in developing a robotic screening technology for autism.

The present exploratory cross-sectional case-control study sought to develop a reliable and scalable screening tool for autism using a social robot. The robot HUMANE, installed with computer vision and linked with recognition technology, detected the direction of eye gaze of children. Children aged 3-8 (M = 5.52; N = 199) participated, 87 of whom had been confirmed with autism, 55 of whom were suspected to have autism, and 57 of whom were not considered to cause any concern for having autism. Before a session, a human experimenter instructed HUMANE to narrate a story to a child. HUMANE prompted the child to return his/her eye gaze to the robot if the child looked away, and praised the child when it re-established its eye gaze quickly after a prompt. The reliability of eye gaze detection was checked across all pairs of human raters and HUMANE and reached 0.90, indicating excellent interrater agreement. Using the pre-specified reference standard (Autism Spectrum Quotient), the sensitivity and specificity of the index tests (i.e., the number of robot prompts and duration of inattentiveness) reached 0.88 or above and the Diagnostic Odds Ratios were beyond 190. These results show that social robots may detect atypical eye patterns, suggesting a potential future for screening autism using social robots.

The role of electrophysiology tests and multimodal imaging in evaluation of nystagmus

Purpose This work aimed to highlight the role of electrophysiology testing and multimodal imaging in evaluation of nystagmus. Patients and methods This is a retrospective multi-centered analytic study that recruited patients with nystagmus from the outpatient clinics referred to the electrophysiology units of the hospitals of the University of Minia, Ain Shams, Banha, and Cairo, Egypt. The study included 60 (120 eyes) patients. The performed investigations included full-field electroretinography (ffERG), pattern electroretinography, flash visual evoked potential (FVEP), pattern visual evoked potential, optical coherence tomography (OCT), OCT-angiography (OCT-A), and fundus autofluorescence (FAF), whenever possible. Results There were no or minimal detectable fundus changes in 78 (65%) eyes, of which 40 (33.3%) eyes showed severe loss of photopic responses on ffERG, with Bull’s eye pattern observed on FAF and loss of foveal photoreceptors in OCT, while 18 (12.5%) eyes showed reduced photopic and scotopic responses in ffERG with loss of foveal photoreceptors and thinned parafovea in OCT, 14 (11.7%) eyes showed average photopic and scotopic responses with different stages of foveal hypoplasia in OCT and OCT-A, and six (5%) eyes showed normal results in tests assessing the function and structure of the macula and optic nerve, including ERG, FVEP, and OCT. On the other hand, macular or optic nerve abnormalities were observed in 42 (35%) eyes, of which 20 (16.7%) eyes showed significant loss of photopic responses in ffERG and abnormal fovea in OCT and FAF tests, 10 (8.3%) eyes showed loss of photopic and scotopic responses in ffERG and abnormal results in the OCT and FAF, four (3.3%) eyes had normal results in ERG and FVEP, but showed fovea hypoplasia in OCT, and eight (6.7%) eyes had normal photopic and scotopic responses by ffERG, but with abnormal visual evoked potential responses and thinning of the nerve fiber layer in the OCT. Conclusion Electrophysiological tests and multimodal imaging are crucial to diagnosing the underlying causes of nystagmus, especially in patients with normal fundus.

Performance Analysis of New 2D Spatial OCDMA Encoding based on HG Modes in Multicore Fiber

This paper presents a pioneering 2D spatial Optical Code-Division Multiple Access (OCDMA) encoding system that exploits Mode Division Multiplexing (MDM) and Multicore Fiber (MCF) technologies. This innovative approach utilizes two spatial dimensions to enhance the performance and security of OCDMA systems. In the first dimension, we employ Hermite-Gaussian modes (HG00, HG01, HG11) to modulate each user's signal individually. This unique approach offers a robust means of data transmission while ensuring minimal interference among users. The second-dimension leverages MCF encoding, introducing two incoherent OCDMA codes: the Zero Cross Correlation (ZCC) code (λc=0) and the ZFD code (λc=1). These codes are thoughtfully designed and simulated, taking into account their cross-correlation properties to guarantee minimal interference and heightened data security. To assess the efficiency of this novel OCDMA encoding system, we implemented simulations with three active users using the Opti system software. At the transmitter end, each user's signal is modulated individually by their designated HG mode (HG00, HG01, HG11), resulting in separate channels. Subsequently, at the multicore fiber, each user's data is encoded with a unique code-word, and they are directed through specific core groups, ensuring data isolation and integrity. In this paper, the BER and eye pattern are examined with respect to different parameters such as data rate and distance. At a distance of 5 km and data rate of 10 Gbit/s, a BER value around 10-70 is achieved.

Performance Analysis of New 2D Spatial OCDMA Encoding based on HG Modes in Multicore Fiber

This paper presents a pioneering 2D spatial Optical Code-Division Multiple Access (OCDMA) encoding system that exploits Mode Division Multiplexing (MDM) and Multicore Fiber (MCF) technologies. This innovative approach utilizes two spatial dimensions to enhance the performance and security of OCDMA systems. In the first dimension, we employ Hermite-Gaussian modes (HG00, HG01, HG11) to modulate each user's signal individually. This unique approach offers a robust means of data transmission while ensuring minimal interference among users. The second-dimension leverages MCF encoding, introducing two incoherent OCDMA codes: the Zero Cross Correlation (ZCC) code (λc=0) and the ZFD code (λc=1). These codes are thoughtfully designed and simulated, taking into account their cross-correlation properties to guarantee minimal interference and heightened data security. To assess the efficiency of this novel OCDMA encoding system, we implemented simulations with three active users using the Opti system software. At the transmitter end, each user's signal is modulated individually by their designated HG mode (HG00, HG01, HG11), resulting in separate channels. Subsequently, at the multicore fiber, each user's data is encoded with a unique code-word, and they are directed through specific core groups, ensuring data isolation and integrity. In this paper, the BER and eye pattern are examined with respect to different parameters such as data rate and distance. At a distance of 5 km and data rate of 10 Gbit/s, a BER value around 10-70 is achieved.

Characterization of postoperative LASIK ectasia features on higher-order aberration excimer ablation maps

BackgroundTo characterize anterior corneal higher-order aberration (HOA) excimer ablation map patterns in postoperative LASIK ectasia (POE) and to examine correlations between newly identified corneal HOA ablation map features of POE and known topographic indices.MethodsProspective multicenter non-interventional descriptive study. A total of 28 eyes from 22 POE patients were enrolled. The postoperative HOA ablation map was derived from Topolyzer Vario corneal imaging at the time of POE diagnosis. Features that recurred were identified and then analyzed. Correlations to Orbscan indices were studied.ResultsAn arrangement of two elliptical paracentral ablation islands, deep inferior and shallow superior, in direct mirror-like opposition to each other, were identified on all HOA maps. The paracentral islands were accompanied by peripheral ablation crescents. The deep paracentral inferior island ‘hot spot’ coincided with the topographical apical POE cone and was highly reproducible in angular position (249.3 ± 17.3°). There was significant variation in ablation depth (shallow superior island: 11.5 ± 6.9 μm and deep inferior island: 32.5 ± 18.8 μm). The superior crescents had high variability in depth (34.8 ± 18.9 μm). Strong correlations were found between the corneal irregularity index and the ablation depth difference between the deep and shallow paracentral islands (R = 0.96; P < 0.0001).ConclusionThe corneal HOA excimer ablation map revealed a recurring, distinct, easily recognizable pattern in POE eyes. Validated Orbscan POE indices and HOA ablation map islands showed a strong correlation. It is possible to extract useful information from the corneal HOA ablation map, potentially making it suitable for diagnosing and monitoring POE although more studies are needed.

Phenotypic and Genetic Alterations in Adult-Onset Cone and Cone-Rod Dystrophy

Introduction: The objective of this study was to investigate the clinical characteristics and genetic spectrum of adult-onset cone/cone-rod dystrophy (AOCD/AOCRD) in Korean individuals. Methods: This is a single-center, retrospective cross-sectional study. We analyzed 22 individuals with genetically confirmed cone dystrophy, with symptoms beginning after 30 years of age. All patients underwent comprehensive ophthalmic and electrophysiological examinations. Exome sequencing of 296 genes associated with inherited retinal disease was performed. The clinical features of patients with AOCD/AOCRD and the causative genes and variants detected by exome sequencing were analyzed. Results: The median age at the first visit was 52 years (range, 31–76 years), and the most common initial symptom was reduced visual acuity. In most cases, fundus photography showed a bull’s eye pattern with foveal sparing, consistent with perifoveal photoreceptor loss on optical coherence tomography. We identified disease-causing variants in six genes: RP1, CRX, CDHR1, PROM1, CRB1, and GUCY2D. Pathogenic variants in RP1, CRX, and CDHR1 were identified in 77% of the AOCD/AOCRD cases, including p.Cys1399LeufsTer5, p.Arg1933Ter, and p.Ile2061SerfsTer12 in RP1; p.Ter300GlnextTer118 in CRX; and p.Glu201Lys in CDHR1. No characteristic imaging differences were observed for any of the causative genes. Most of the RP1-related AOCD/AOCRD cases showed a decreased amplitude only in the photopic electroretinogram (ERG), whereas CRX-related AOCD/AOCRD cases showed a slightly decreased amplitude in both the scotopic and photopic ERGs. Conclusion: In case of visual impairment with bull’s eye pattern of RPE atrophy recognized after the middle age, a comprehensive ophthalmic examination and genetic test should be considered, with the possibility of AOCD/AOCRD in East Asians.

Enhancing high-speed networks using RGB-based WLAN through Ro-FSO integration in the 5 GHz band

Abstract The limited bandwidth constraints imposed by conventional wireless carriers pose a significant hurdle when it comes to the delivery of high-speed broadband services. In response to this challenge, Radio over Free Space Optics (Ro-FSO) has emerged as a viable and innovative solution, seamlessly amalgamating wireless and optical systems. This integration proves particularly invaluable in sensitive environments, such as hospitals, where the risk of electromagnetic interference disrupting critical medical equipment is a real concern. Ro-FSO offers a disruption-free avenue for high-speed data transmission, positioning it as the ideal choice for broadband services, including Wireless Local Area Networks (WLANs). Within the scope of this study, we introduce a high-speed Ro-FSO link, showcasing the capability to concurrently transmit three independent channels with Red, Green and Blue (RGB) laser respectively, each supporting a robust 1 Gbps data rate. These data streams are skilfully up-converted to the 5 GHz RF bands, encompassing transmission distances of 650 m across the FSO channel. Our numerical simulation findings underscore the successful transmission of all the channels using wavelength division multiplexing (WDM), seamlessly meeting the prescribed Bit Error Rate (BER) and eye pattern criteria, solidifying the Ro-FSO’s standing as a promising solution for high-speed broadband delivery.