Extrinsic Influences Research Articles

The lives of cells, recorded.

A paradigm for biology is emerging in which cells can be genetically programmed to write their histories into their own genomes. These records can subsequently be read, and the cellular histories reconstructed, which for each cell could include a record of its lineage relationships, extrinsic influences, internal states and physical locations, over time. DNA recording has the potential to transform the way that we study developmental and disease processes. Recent advances in genome engineering are driving the development of systems for DNA recording, and meanwhile single-cell and spatial omics technologies increasingly enable the recovery of the recorded information. Combined with advances in computational and phylogenetic inference algorithms, the DNA recording paradigm is beginning to bear fruit. In this Perspective, we explore the rationale and technical basis of DNA recording, what aspects of cellular biology might be recorded and how, and the types of discovery that we anticipate this paradigm will enable.

From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression.

This review explores the progression of pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma through a dual lens of intrinsic molecular alterations and extrinsic microenvironmental influences. PanIN development begins with Kirsten rat sarcoma viral oncogene (KRAS) mutations driving PanIN initiation. Key additional mutations in cyclin-dependent kinase inhibitor 2A (CDKN2A), tumor protein p53 (TP53), and mothers against decapentaplegic homolog 4 (SMAD4) disrupt cell cycle control and genomic stability, crucial for PanIN progression from low-grade to high-grade dysplasia. Additional molecular alterations in neoplastic cells, including epigenetic modifications and chromosomal alterations, can further contribute to neoplastic progression. In parallel with these alterations in neoplastic cells, the microenvironment, including fibroblast activation, extracellular matrix remodeling, and immune modulation, plays a pivotal role in PanIN initiation and progression. Crosstalk between neoplastic and stromal cells influences nutrient support and immune evasion, contributing to tumor development, growth, and survival. This review underscores the intricate interplay between cell-intrinsic molecular drivers and cell-extrinsic microenvironmental factors, shaping PanIN predisposition, initiation, and progression. Future research aims to unravel these interactions to develop targeted therapeutic strategies and early detection techniques, aiming to alleviate the severe impact of pancreatic cancer by addressing both genetic predispositions and environmental influences.

Harmony in Progress: Exploring Motivation’s Role in My Piano Learning and Practice Journey

This autoethnography explores the role of motivation in the piano learning and practice journey of the first author. The study is underpinned by understandings of how motivation evolves from extrinsic influences, such as parental support, teachers’ guidance, and peer influence, to intrinsic motivation that drives personal growth. Using a reflective and collaborative approach incorporating narratives, we examine key moments and emotional landscapes as the first author reveals the transformative power of motivation in shaping her piano learning experience. Our findings highlight the critical role of self-determination in fostering sustained engagement and success on the path of piano learning and practice. More broadly, this exploration enhances comprehension of the intricate connection between motivation and personal growth in the field of music instruction, informing both learner and educator.

Leisure and cultural identity: an empirical study based on root-seeking summer camp for ethnic Chinese new generation.

This study examines the role of root-seeking summer camps in enhancing Chinese cultural identity among the new ethnic Chinese generation (ECNG) amidst the challenges of globalization. Semi-structured interviews with thirty campers revealed that ECNG often lack clear ethnic consciousness, experience conflict in community relationships, and have limited opportunities for traditional cultural experiences. The study found that summer camps exert both intrinsic and extrinsic influences on campers. Intrinsically, they facilitate the internalization of leisure motivation, foster a deepened leisure experience, and promote strengthened leisure interactions. Extrinsically, they provide opportunities for leisure education and cultural immersion. Through this synergy, summer camps enhance the cultural identification of ECNG. However, the study also noted that course enjoyment and teaching staff behavior could influence perceptions of the camp. This study contributes to understanding the relationship between leisure and identity, explaining how summer camp activities enhance ECNG's cultural identity, and offering insights for governments and agencies.

Why Law? Examining the Factors that Influence the Decision to Undertake a Law Degree

Existing research is largely silent on determining what factors influence individuals to undertake a law degree. Are they deeply intrinsic drivers like ‘self-efficacy’ or ‘self-confidence’, and how might extrinsic influences, such as family, teachers, or friends’ impact on those drivers? To address these questions, data were attained from 378 commencing students enrolled across three Australian law schools. Results indicate students with higher levels of self-efficacy and self-confidence are more likely to be satisfied with their decision to study law and pursue a law career. The influence of ‘teachers’ on a student’s ‘satisfaction with their choice’ was only significant for students who were also influenced by their ‘family’ – the more support from teachers and family members increased a student’s level of satisfaction. Friends only influenced a students’ intention to pursue a career in law, but not their satisfaction with their choice to pursue a law degree. This is the first study to determine the intrinsic motivations that impact a student’s choice to undertake a law degree and what extrinsic factors influence that choice.

The influence of context on diagnostic reasoning: A narrative synthesis of experimental findings.

Contextual information which is implicitly available to physicians during clinical encounters has been shown to influence diagnostic reasoning. To better understand the psychological mechanisms underlying the influence of context on diagnostic accuracy, we conducted a review of experimental research on this topic. We searched Web of Science, PubMed, and Scopus for relevant articles and looked for additional records by reading the references and approaching experts. We limited the review to true experiments involving physicians in which the outcome variable was the accuracy of the diagnosis. The 43 studies reviewed examined two categories of contextual variables: (a) case-intrinsic contextual information and (b) case-extrinsic contextual information. Case-intrinsic information includes implicit misleading diagnostic suggestions in the disease history of the patient, or emotional volatility of the patient. Case-extrinsic or situational information includes a similar (but different) case seen previously, perceived case difficulty, or external digital diagnostic support. Time pressure and interruptions are other extrinsic influences that may affect the accuracy of a diagnosis but have produced conflicting findings. We propose two tentative hypotheses explaining the role of context in diagnostic accuracy. According to the negative-affect hypothesis, diagnostic errors emerge when the physician's attention shifts from the relevant clinical findings to the (irrelevant) source of negative affect (for instance patient aggression) raised in a clinical encounter. The early-diagnosis-primacy hypothesis attributes errors to the extraordinary influence of the initial hypothesis that comes to the physician's mind on the subsequent collecting and interpretation of case information. Future research should test these mechanisms explicitly. Possible alternative mechanisms such as premature closure or increased production of (irrelevant) rival diagnoses in response to context deserve further scrutiny. Implications for medical education and practice are discussed.

Exploring mixed-reality approaches for inclusive blended learning in higher education

Purpose This paper aims to investigate how mixed-reality (MR) can be used to enhance inclusivity in synchronous working activities where groups of people may be present either face-to-face or online – focusing on blended learning in the higher education (HE) context. Design/methodology/approach In a research methods module, 140 university master’s-level students were given the option to attend and engage in seminars/practical sessions either in a real lecture room or online through a virtual version of an equivalent environment, accessible on everyday devices. The MR platform provided two-way video “windows” enabling all students on the module to freely interact with staff and their peers. Attendance was recorded throughout the semester and survey data was captured after all sessions (33% response rate). In addition, student activity was video recorded within both the real and virtual spaces. Findings Attendance was high throughout the semester and students were very positive about this novel approach to their education. Students chose to either engage purely in-person, online or as a mixture of the two; performance on the module was not impacted by this decision. The survey highlighted several factors that impacted on students’ choice of learning space, including those related to intrinsic characteristics of individual students (e.g. desire for traditional/novel social interactions) and those related to extrinsic influences (e.g. weather and travel demands). Video analysis revealed numerous differences in the behaviours exhibited across the virtual and real spaces, related to individual versus team mentalities. Practical implications Conclusions are drawn regarding how MR can be used in HE and potentially other work-related contexts to enhance engagement, a sense of community and ultimately learning/productivity outcomes. Originality/value This study investigated how a large (>100) cohort of students responded to an MR blended learning experience across a whole semester. In this respect, to the best of the author’s knowledge, this is the first study to consider such issues at this scale in a university education setting.

Nonlinearity in affect dynamics persists after accounting for the valence of daily-life events.

In recent years, increased attention has gone to studying nonlinear characteristics of affective time series. An example of such nonlinear features is multimodality-the presence of more than one mode in an affective time series-which might mark the presence of discrete-like transitions between one and another affective state. In an attempt to capture these nonlinear features, Loossens et al. (2020) proposed the Affective Ising Model (AIM) as a model of affect dynamics. This model was validated on daily-life data, but these data did not contain any information on potential environmental factors that might have influenced a participant's affective state. Unfortunately, this omission may have led to erroneously concluding that nonlinearity is a defining characteristic of the affective system, even when it is solely driven by extrinsic influences. To accommodate this limitation, we applied the AIM on daily-life data in which the valence of such external events was measured. Overall, we found that nonlinearity persisted after accounting for the valence of daily-life events, suggesting that nonlinearity is a defining characteristic of affect and should thus be accounted for. Interestingly, this effect was more pronounced for composite compared to single-item measures of affect. While in line with previous research, these results should be replicated in a larger, more representative sample. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

국외 한국어 학습자의 동기 및 탈동기 연구 -베트남 대학의 한국어 학습자를 중심으로-

This study investigates the motivations, demotivating factors, and strategies for overcoming demotivation among Vietnamese university students majoring in Korean. The results indicate that motivations for learning Korean include interest in Korean culture and language, future prospects, and career aspirations, reflecting a mix of intrinsic and extrinsic influences. Demotivating factors primarily include the difficulty of learning Korean, comparisons with others, excessive study load, and low grades. To overcome these demotivations, the most effective strategy was recognizing the necessity and importance of learning Korean, followed by engaging in hobby activities, counseling, and taking breaks. These findings highlight the need for effective teaching methods and learning support, as well as the provision of cultural education and practical training opportunities to encourage student participation.

Cultural differences in wine conceptualization among consumers in France, Portugal and South Africa

Consumers’ mental pictures of wine are multifaceted and are shaped by their sensory (taste, smell, visual, sensation) perceptions, in addition to emotional, cultural and extrinsic (brand, price, and awards) influences. This study explores whether consumers from three different wine cultures share mental representations of three wine concepts. Through an online survey, French, Portuguese, and South African wine consumers described their conceptualizations of Wine, Red wine and White wine aroma. Given these nations’ rich winemaking traditions and diverse wine styles, differences in consumer perspectives were likely to emerge. The findings demonstrate that, regardless of cultural background, the broad concept of Wine aligns with the more specific Red and White wine conceptualizations, although the latter concepts diverge from each other. Notably, cultural contexts significantly influence participants’ representations of Red Wine, with particularly marked contrasts between the South African and French respondents. This suggests that like experts, wine consumers have also built representations of wine through semantic memory. This cross-cultural analysis of consumer interpretations of wine concepts holds the potential for refining marketing strategies to overcome cultural barriers in wine purchasing behaviour.

The Influence of Intrinsic Halal Awareness and Extrinsic Halal Awareness on Purchasing Decisions

This research aims to determine and analyze the influence of intrinsic halal awareness and extrinsic halal awareness variables on purchasing decisions among Muslim students in the Department of Business Administration, Malang State Polytechnic. Do the variables of intrinsic halal awareness and extrinsic halal awareness influence purchasing decisions, either partially or simultaneously. The location of this research in the Department of Business Administration, Malang State Polytechnic. This research was analyzed using multiple linear regression. This research found the results as following: intrinsic halal awareness variables and extrinsic halal awareness variables influence purchasing decision variables both partially and simultaneously. Extrinsic halal awareness variables are the dominant variables in influencing purchasing decision variables.

A study on the effect of the geometric properties and surface defects on silicon chip flexibility for wearable electronics

A study on the effect of the geometric properties and surface defects on silicon chip flexibility for wearable electronics

A Critical Review on Recent Advancements in Aluminium-Based Metal Matrix Composites

Aluminum matrix composites (AMCs) have garnered significant attention across various industrial sectors owing to their remarkable properties compared to conventional engineering materials. These include low density, high strength-to-weight ratio, excellent corrosion resistance, enhanced wear resistance, and favorable high-temperature properties. These materials find extensive applications in the military, automotive, and aerospace industries. AMCs are manufactured using diverse processing techniques, tailored to their specific classifications. Over three decades of intensive research have yielded numerous scientific revelations regarding the internal and extrinsic influences of ceramic reinforcement on the mechanical, thermomechanical, tribological, and physical characteristics of AMCs. In recent times, AMCs have witnessed a surge in usage across high-tech structural and functional domains, encompassing sports and recreation, automotive, aerospace, defense, and thermal management applications. Notably, studies on particle-reinforced cast AMCs originated in India during the 1970s, attained industrial maturity in developed nations, and are now progressively penetrating the mainstream materials arena. This study provides a comprehensive understanding of AMC material systems, encompassing processing, microstructure, characteristics, and applications, with the latest advancements in the field.

A novel approach to the detection of facial wrinkles: Database, detection algorithm, and evaluation metrics

Skin wrinkles result from intrinsic aging processes and extrinsic influences, including prolonged exposure to ultraviolet radiation and tobacco smoking. Hence, the identification of wrinkles holds significant importance in skin aging and medical aesthetic investigation. Nevertheless, current methods lack the comprehensiveness to identify facial wrinkles, particularly those that may appear insignificant. Furthermore, the current assessment techniques neglect to consider the blurred boundary of wrinkles and cannot differentiate images with varying resolutions. This research introduces a novel wrinkle detection algorithm and a distance-based loss function to identify full-face wrinkles. Furthermore, we develop a wrinkle detection evaluation metric that assesses outcomes based on curve, location, and gradient similarity. We collected and annotated a dataset for wrinkle detection consisting of 1021 images of Chinese faces. The dataset will be made publicly available to further promote wrinkle detection research. The research demonstrates a substantial enhancement in detecting subtle wrinkles through implementing the proposed method. Furthermore, the suggested evaluation procedure effectively considers the indistinct boundaries of wrinkles and is applicable to images with various resolutions.

Origin of the near-room temperature resistance transition in lutetium with H2/N2 gas mixture under high pressure.

The recent report of room-temperature superconductivity at near-ambient pressure in nitrogen-doped lutetium hydride (Lu-H-N) by Dasenbrock-Gammon etal. [Nature 615, 244-250 (2023)] has attracted tremendous attention due to its anticipated great impact on technology. However, the results could not be independently reproduced by other groups worldwide in follow-up studies, which elicited intense controversy. Here, we develop a reliable experimental protocol to minimize the extensively concerned extrinsic influences on the sample by starting the reaction from pure lutetium loaded with an H2/N2 gas mixture in a diamond anvil cell under different pressures and temperatures and simultaneously monitoring the entire chemical reaction process using in situ four-probe resistance measurements. Therefore, we could repeatedly reproduce the near-room temperature upsurge of electrical resistance at a relatively early stage of the chemical reaction. However, the mechanism is suggested to be a metal-to-semiconductor/insulator transition associated with the structural modulation in the non-stoichiometric Lu-H-N, rather than superconductivity.

Barriers and facilitators to the formation of professional identity among nursing students: A four-year longitudinal qualitative study

BackgroundNursing professional identity (NPI) is essential for nurses to develop their nursing profession. It reflects the competencies consistent with the professional practices of nurses and contributes to them providing better healthcare and public health. The formation process of NPI started with undergraduate nursing education and continued throughout the nursing career. ObjectiveTo explore nursing students' perceptions of facilitators and barriers to the formation of NPI during their study. MethodsA 4-year longitudinal, qualitative research design with yearly semi-structured interviews undertaken from 2019 to 2022. The reflexive thematic analysis methodology was applied for the data analysis. ResultsNinety-three nursing students were recruited, joining a group or individual interview. The four-year nursing baccalaureate program revealed a dynamic formation process of NPI: “Outsider of nursing”, “Entering the nursing courses”, “Building nursing competence”, and “Thinking and acting like a nurse”. A total of 12 themes were identified to present the barriers and facilitators to the NPI formation at different stages. Specifically, the six barriers include conflict between their ideals and reality, sociocultural stereotypes about nursing, the negative impact of COVID-19, the pre-internship concerns, struggling to meet expectations, and potential danger and discrimination in the healthcare settings. The enablers were: self-motivation and inner belief towards the nursing profession, the power of role models, the improvement of nursing capacity, well integration into the healthcare professional teams, understanding of the clinical environment, and recognition and encouragement from others. ConclusionsThe formation of nursing students' NPI is an ever-changing process, with various intrinsic and extrinsic influences during their four-year study. Nursing educators are suggested to prepare and develop students' professional comportment in their theoretical and clinical practice to develop their professional identity as a nurse.

Psychosocial and auditory factors that influence successful music-based auditory training in pediatric cochlear implant recipients.

Cochlear implants (CIs), which are designed to support spoken communication of persons with severe to profound hearing loss, can provide improved hearing capability through passive exposure. However, auditory training may optimize perception of spectrally complex sounds such as music or speech. Reviews of music-based training for pediatric CI users have reported modest though variable benefits, as well as problems with attrition. It is presumed that more substantial changes may result from longer, more intensive training; however, the development of protocols sufficiently motivating for sustained intensity is challenging. This article examined the experiences of star pediatric CI users, whose years of music training have yielded exceptional auditory benefits. Greater understanding of their experiences and attitudes may suggest best practices for music-based training. Research aims included: (a) characterizing the musical behaviors and perceptual learning processes of music-centric (Music-centric, for purposes of this paper, refers to CI users who engage in sustained and successful music making such as music lessons and ensembles and focused music listening over a period of years, and who derive deep satisfaction from those experiences.) pediatric CI users, and (b) identifying psychosocial and auditory factors that motivated persistence in auditory training. We used qualitative and patient-engaged research methodologies, gathering data through questionnaires with open-ended questions. The participants, six music-centric CI users and five parents, described their experiences and attitudes regarding music training, and factors that supported or undermined those experiences. Data were analyzed using reflexive thematic analysis. The codes were consolidated into five themes and organized into a Model of Music-Based Learning for Pediatric Cochlear Implant Recipients. Sustained participation in music training was perceived as a dynamic process including varied musical stimuli, and moderated by intrinsic (attitude, perceived behavioral control) and extrinsic (parents, teachers, peers) influences, hearing status, sound access and background factors. These themes highlighted motivational factors that pediatric CI users and parents considered important to sustained, intensive and successful music learning throughout childhood and adolescence. These factors should be considered in the development of music-based training for pediatric CI recipients.

Topological circular dichroism for asymmetric converging light beams

Light beams possess three types of angular momentum. They are the spin angular momentum, the extrinsic orbital angular momentum, and the intrinsic orbital angular momentum. Interaction of these momenta due to translational or cylindrical symmetry breaking leads to effects of the spin-orbit interaction of light, including topological effects. Topological optical activity or topological circular phase anisotropy, known as Rytov-Vladimirsky-Berry-Chao-Tomita plane polarization rotation, is the result of the extrinsic orbital angular momentum influence on the spin angular momentum. The effect manifests under linear polarized light propagation along a curved trajectory when the translational symmetry is breaking. We predict a new topological effect under the cylindrical symmetry breaking. This effect is the result of the extrinsic orbital angular momentum influence on the spin angular momentum in the converging asymmetrical light beam. It manifests as the transformation of linear polarized light into elliptically polarized one when an asymmetrical in the vertical direction beam passes through the left or right half of the focal plane. We have estimated the value of the ellipticity and proposed an experimental setup. We successfully observed the ellipticity change of 10(−3) using our method of small ellipticity determination. We have considered this transformation as the topological circular dichroism (topological circular amplitude anisotropy). We have demonstrated the connection of the ellipticity change with the value of the topological circular amplitude anisotropy R. The measured value of the topological circular amplitude anisotropy R turned out to be R=±(0.60±0.08)×10−3. This new effect of the spin-orbit interaction of light contributes to our understanding of the nature of light. It can be used to develop new sensors in optics, including nano and quantum optics.

The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)-phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation.

Coordinated cell movement is a fundamental process in organ formation. During heart development, bilateral myocardial precursors collectively move toward the midline (cardiac fusion) to form the primitive heart tube. Extrinsic influences such as the adjacent anterior endoderm are known to be required for cardiac fusion. We previously showed however, that the platelet-derived growth factor receptor alpha (Pdgfra) is also required for cardiac fusion (Bloomekatz et al., 2017). Nevertheless, an intrinsic mechanism that regulates myocardial movement has not been elucidated. Here, we show that the phosphoinositide 3-kinase (PI3K) intracellular signaling pathway has an essential intrinsic role in the myocardium directing movement toward the midline. In vivo imaging further reveals midline-oriented dynamic myocardial membrane protrusions that become unpolarized in PI3K-inhibited zebrafish embryos where myocardial movements are misdirected and slower. Moreover, we find that PI3K activity is dependent on and interacts with Pdgfra to regulate myocardial movement. Together our findings reveal an intrinsic myocardial steering mechanism that responds to extrinsic cues during the initiation of cardiac development.

Morphological effect of retained austenite microstructure on hydrogen diffusion under contact loading of bearings

Hydrogen diffusion within bearings presents a significant risk for the development of white etching cracks. This study investigates the impact of the morphological effect of austenite on hydrogen diffusion behavior under contact loading using the finite element method. Our findings reveal that horizontal lamellar austenite exhibits a superior capacity for trapping hydrogen. The presence of horizontal lamellar austenite leads to a more pronounced reduction of stress within martensite. The stress states of various austenite morphologies potentially influence hydrogen diffusion properties. Moreover, hydrogen diffusivity is significantly reduced by horizontal lamellar austenite. This reduction is related to the effective area of austenite, which is defined as the area perpendicular to the direction of hydrogen diffusion. Austenite with various morphologies intrinsically serves as a hydrogen trap and directly affects hydrogen diffusivity. These results highlight the effects of austenite morphology on hydrogen diffusion, encompassing both intrinsic and extrinsic influences.