The economic development of the State depends on the work of the able-bodied population. The cardiovascular system is highly reactive and reacts to many harmful production factors: noise, vibration, ionizing radiation, etc. Spastic vascular changes are the precursors of peripheral angiodistonic syndrome, which is part of the symptom complex of vibration disease, and accompanies polyneuropathy from physical overstrain. Detection of the disease at the initial stage of development for the appointment of timely prevention and treatment is the main task of modern medicine. Ultrasound examination, as one of the imaging methods in radiation diagnostics, successfully copes with this problem. The study aims to develop criteria for early diagnosis of occupational pathology of the vessels of the upper extremities in workers of machine-building production. We have examined 126 workers of the machine-building plant using standard clinical and laboratory methods, ultrasound examination of the vessels of the upper extremities and X-ray examination of the hands. The main harmful production factors in the workplace were local and general vibration, the severity of the labor process, noise. The severity of the labor process of at least class 3.1 with a work experience of 21 years contributed to the development of spastic changes in the vessels of the upper extremities in power engineering workers. Patients complained in 25% of cases, although an objective examination by a neurologist revealed no pathological changes characteristic of the pathology of the vascular bed. There were radiological changes in the hands in 83% of the examined workers and manifested as a violation of local circulation: cyst-like rearrangement in the bones of the wrists were in 40% of cases, in the form of periarticular osteopenia - in 70% of cases. The most informative method of early diagnosis of vascular changes in the main arteries of the upper extremities is ultrasound. At the same time, the characteristic signs are an increase in the resistance index with the preservation of speed indicators (recorded in 100% of cases), a violation of venous outflow in 82%, pathological vascular tortuosity in 76%. Ethics. The Local Ethics Committee of the North-Western Scientific Center of Hygiene and Public Health has approved the study, Protocol No. 23.1 of 10/28/2020.