Objective: Extreme obesity is associated with subclinical inflammation, which is important for development of several obesity-associated complications. Increased level of chemerin protein in obesity may influence on inflammatory cascades. The objective of the study was to assess changes of chemerin levels after bariatric surgery among hypertensive and normotensive subjects. Design and method: Study population consisted of patients with severe obesity who met the eligibility criteria and underwent bariatric surgery (sleeve gastrectomy and Roux-en-Y gastric bypass). Body mass index (BMI), ambulatory blood pressure (Spacelabs 90207), and laboratory investigations (glucoce, cholesterol, leptin, adiponectin, insulin, chemerin, hsCRP) were measured before and six months after bariatric surgery. Data were analyzed in two groups: I–patients with diagnosis of hypertension and II–normotensive subjects. Results: Data from 49 patients (mean age 41,0 ± 12,0 years, 40% men) were analyzed. Hypertensives (n = 30) were older (44,4 ± 11,4 vs 36,8 ± 11,8 years, p = 0,02), presented higher values of systolic blood pressure (SBP; 124,8 ± 12,2 vs 118,0 ± 8,7mmHg, p = 0,02) and insulin levels (40,7 ± 15,0 vs31,2 ± 13,9 μIU/ml, p = 0,01), but lower levels of adiponectin (3461 ± 1728 vs 4605 ± 2329pg/ml, p = 0,04) than normotensives. However, initial values of BMI, diastolic BP and other laboratory parameters were similar in both groups. BMI diminished similarly in both groups after surgery. SBP decreased in both groups but remained significantly higher in hypertensives. Chemerin levels decreased significantly in both groups, but hsCRP diminished only in the normotensive group. Adiponectin and insulin levels were similar in both groups after surgery. Conclusions: Modulation of immunity after bariatric surgery changes in different way in hypertensive and non-hypertensive obese patients.
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