In this paper, we study the spectral properties of a class of degenerate third-order partial differential operators with variable coefficients presented in a rectangle. Conditions are found to ensure the existence and compactness of the inverse operator. A theorem on estimates of approximation numbers is proven. Here, we note that finding estimates of approximation numbers, as well as extremal subspaces, for a set of solutions to the equation is a task that is certainly important from both a theoretical and a practical point of view. The paper also obtained an upper bound for the eigenvalues. Note that, in this paper, estimates of eigenvalues and approximation numbers for the degenerate third-order partial differential operators are obtained for the first time.