Extraordinary Benefits Research Articles

Books: Magic Pill: The Extraordinary Benefits and Disturbing Risks of the New Weight Loss Drugs: The rise of semaglutide.

Books: Magic Pill: The Extraordinary Benefits and Disturbing Risks of the New Weight Loss Drugs: The rise of semaglutide.

Hollow gold nanoparticles coated with ZnS with distance-dependent plasma coupling and surface enhanced Raman spectroscopy for applications

Metal@semiconductor core-shell heterostructure with strong exciton-plasmon coupling can integrate multiple functions of each component and exhibit extraordinary benefits in the optical, catalytic, electrical, and magnetic properties due to its excellent synergistic properties at the heterointerfaces. In our work, hollow gold nanoparticles (HGNs)- 4-mercaptobenzoic acid (MBA) @ZnS core-shell heterostructure with the adjustable shell thickness (tshell) of ZnS varied from 1 to 19 nm were successfully prepared for the first time by low temperature and simple two-step method. Here, we report our findings that the surface enhanced Raman scattering (SERS) spectral intensity of HGNs-MBA@ZnS under the 633 nm excitation correlates with the tshell of ZnS, and the experimental results are consistent with theoretical studies. Furthermore, we also investigated the excitation wavelength-dependent SERS enhancement mechanism of HGNs-MBA@ZnS (tshell = 2 nm) and the result showed that the near-field enhancement and plasmon-induced interfacial charge transfer transition (PICTT) synergistically increase the SERS intensity under the excitation line at 633 nm. Our work not only provides guidance for the design and synthesis of other important metal@semiconductor core-shell heterostructure, but presents significant insights into their SERS enhancement mechanism.

Linking of digital supply chains and digital transformation on the competitiveness of government companies in the supply chain 4.0 era

In the ever-growing digital era, technology has changed various aspects of human life, including the way governments manage supply chains in procuring goods and services. Digital transformation has opened new opportunities to increase efficiency, transparency, and accountability in procurement in government companies. This research aims to investigate the relationship between digital supply chains and competitiveness and the relationship between digital transformation and the competitiveness of government companies. This type of research is quantitative through survey methods. The population of this research is employees of government logistics companies who are responsible for supply chain processes, have digital activities and implement Enterprise Resource Planning (ERP). The research questionnaire was designed using a Likert scale of 1 to 9, a scale of 1 indicating strongly disagree and a scale of 9 indicating strongly agree. Questionnaires were distributed via social media to 780 employees of government logistics companies related to supply chain processes, respondents were determined using a simple random sampling method. Of the 780 questionnaires that were returned, 570 were returned for analysis. Data analysis uses the partial least square-structural equation modelling (PLS-SEM) method with data analysis tools, namely SmartPLS 3.0. The data analysis stages are reliability, validity and hypothesis testing. The independent variables of this research are digital supply chain and digital transformation. The dependent variable is the company's competitiveness. The results of this research show that digital supply chains have a positive and significant relationship to competitiveness and digital transformation has a positive and significant relationship to competitiveness. By utilizing digital technology optimally, companies can obtain several extraordinary benefits. Among other things, companies will be able to expand markets and increase revenue more effectively. Apart from that, digital technology also makes it easier to monitor business activities, create structured financial reports, and reduce costs, especially in terms of marketing, logistics and shipping.

The Effect of Fermented Honey on Seminiferous Tubule Cells While being Induced by Cisplatin and Islamic Perspective Review

Background: Cisplatin is the most effective cancer treatment used in chemotherapy. Cisplatin works by inducing oxidative stress, but it also has toxic side effects on healthy cells in the male reproductive organs. Therefore, there is a need for a solution to reduce the side effects of cisplatin. Honey fermentation is a natural substance that can reduce the toxicity of cisplatin. Honey is known as “The food of God” which is a gift of sustenance from Allah SWT due to its extraordinary benefits. Methodology: This study utilized primary data with an experimental posttest-only control group design conducted in vivo. The research involved four experimental groups of rats: a control group without any treatment, a cisplatin group, a 5% honey fermentation group exposed to cisplatin, and a 10% honey fermentation group exposed to cisplatin. All rats were weighed before, during, and after the treatment. Subsequently, HE staining was performed for both descriptive and quantitative observations. Results: Honey fermentation can provide a protective effect on primary spermatocytes and Leydig interstitial cells, almost reaching normal levels. The highest improvement was observed in the 5% honey fermentation group for primary spermatocytes and the 10% group for Leydig interstitial cells. Conclusion: Honey fermentation administration can be protective for testicular organ cells against the side effects of cisplatin. From an Islamic perspective, Allah has created honey for consumption, as mentioned in Surah An-Nahl.

Community Empowerment Through Optimizing Local Wisdom as a Support for The Value of Economic Life

Community Service (PKM) is an annual program carried out by each university which is an application of the Higher Education Chess Dharma. While the Real Work Lecture (KKN) is an annual program carried out by each university which is an application of the Higher Education Chess Dharma. With the implementation of PKM and KKN, it provides extraordinary benefits for students and the community because the results obtained from the implementation of PKM and KKN are enormous, such as an experience gained by students in the form of how to live with the community properly and much more. The implementation of PKM and KKN with "Building Competitive Villages Based on Local Potential, Technology & Green Economy" is oriented towards community empowerment, aiming for students to be able to think critically, analyze problems carefully, and find the best solutions in dealing with various problems related to the scientific field theoretically and practically. From PKM and KKN activities, students are able to develop science, technology, and art in community life.

Marine Nearshore Biodiversity: Introduction to the Special Issue

Millions are nourished, economies are fueled, and culture is inspired—these are just a few of the extraordinary benefits stemming from the coastal waters adjoining the shorelines of the world [...]

GLUT1 transporter-facilitated solid lipid nanoparticles loaded with anti-cancer therapeutics for ovarian cancer targeting

The therapeutics available for cancer treatment have the major hurdle of site-specific delivery of anti-cancer drugs to the tumor site and non-target specific side effects. The standard therapy for ovarian cancer still poses numerous pitfalls due to the irrational use of drugs affecting healthy cells. As an appealing approach, nanomedicine could revamp the therapeutic profile of anti-cancer agents. Owing to the low manufacturing cost, increased biocompatibility, and modifiable surface properties, lipid-based nanocarriers, particularly solid lipid nanoparticles (SLN), have remarkable drug delivery properties in cancer treatment. Given the extra-ordinary benefits, we developed anti-neoplastic (paclitaxel) drug-loaded SLN (PTX-SLN) and functionalized with N-acetyl-d-glucosamine (GLcNAc) (GLcNAc-PTX-SLN) to reduce the rate of proliferation, growth, and metastasis of ovarian cancer cells over-expressing GLUT1 transporters. The particles presented considerable size and distribution while demonstrating haemocompatibility. Using GLcNAc modified form of SLNs, confocal microscopy, MTT assay, and flow cytometry study demonstrated higher cellular uptake and significant cytotoxic effect. Also, molecular docking results established excellent binding affinity between GLcNAc and GLUT1, complimenting the feasibility of the therapeutic approach in targeted cancer therapy. Following the compendium of target-specific drug delivery by SLN, our results demonstrated a significant response for ovarian cancer therapy.

Educational Values in Seloko Traditional Marriage of the Mersam Community, Batanghari Regency

Purpose of the study: This study aims to examine the value of education because the value of education provides extraordinary benefits for creating a living environment, and can provide the most valuable information regarding outlook on life, the future, and assist humans in preparing their essential needs to deal with change.
 Methodology: This research is included in the qualitative descriptive research. The instruments used in this study are based on the characteristics found in the literature review. These characteristics are grouped based on educational values: having faith in and fearing God Almighty, having a noble character, being healthy, knowledgeable, democratic, and being responsible. The data analysis technique used in this study uses the mark reading technique, namely looking directly at the markers being studied.
 Main Findings: In the customary marriage verses of the Mersam Community, Batanghari Regency, there are six educational values, namely the first is the value of education of faith and piety to God Almighty contained in the verses (1) Apply, (2) Order to Pick Up the Bride, (3) Open Lanse. The value of education of faith and piety to God Almighty is manifested by orders to carry out and obey His prohibitions, be grateful and pray.
 Novelty/Originality of this study: Assessment of wisdom values in the environment is very important to do, because by knowing the wisdom values that are around, this can be an innovation for teachers in implementing learning.

A user-generated content analysis of tourists at wildlife tourism attractions

IntroductionCaptive wildlife tourism is an increasingly complex subsector of ecotourism due to the varying degrees of care given to the animals, interpretation or education provided, and tourist expectations of potential interaction with the animals. Two recent tourism trends are the growing wildlife tourism sphere of ecotourism and the increased use of social media in both marketing and for tourists to share their experiences. In scientific literature, the connection between social media and tourism was largely under-studied, and tourist behavior on Instagram after visiting wildlife tourism attractions (WTAs) has not been studied. Some researchers call for more tourism research using social media data created by tourists, called user-generated content (UGC), to understand tourist behaviors.MethodsThis netnographic study examines tourists who visited a WTAs by analyzing their post-visit photos and captions on Instagram through the lens of involvement theory to evaluate the strength of their connection to wildlife and conservation. Previous research indicated wildlife tourism can have extraordinary benefits to conservation and communities, but some WTAs, some of which are photo-prop tourism attractions where animals are handed over to tourists for close-contact selfies, produce negative impacts on individual animals and entire species due to illegal sourcing, improper care, human interaction, and habituation.ResultsFindings from this study suggest WTAs with good or excellent conservation and welfare practices were found to lead to more highly involved tourists, ultimately benefitting community investment, animal welfare, and conservation efforts via the flow of tourist dollars and spread of information on social media, the tourist changing their behavior, or all the aforementioned. Conversely, WTAs with negative conservation and welfare practices were found not to foster the same level of tourist involvement as their counterparts, often leading to more anthropocentric Instagram posts that do not spread conservation messaging or imply appropriate tourist-animal interactions.DiscussionThe implications from this research suggest that WTA management practices should move toward a model focusing on conservation-themed interpretation, education, and positive animal welfare for the improvement of conservation efforts within wildlife and eco-tourism. Such models should keep up with evolving sustainability, responsible, and regenerative practices adopted by the tourism and outdoor recreation industry.

Program Konservasi Mangrove di Pantai Glagah Wangi Demak Ditinjau dari Upaya Mencapai Sustainable Development Goals (SDGs)

On the north coast of Central Java, the abrasion area has reached 5,500 hectares spread over 10 regencies/cities. Abrasion is the erosion or reduction of land (beach) due to wave activity, currents and tides. In Tambakbulusan Village, Karangtengah Subdistrict, Demak Regency, there is a Glagahwangi beach which is affected by abrasion. This study uses an interview approach, observation, and documentation techniques, which then support data obtained from research journals, online media, and others. Based on these problems, a mangrove conservation program was carried out on the Glagahwangi beach in an effort to achieve the SDGs in the pillars of environmental development which is a national program launched by the government. With this program, it is hoped that the preservation of the surrounding environment will improve, the welfare and economy of the surrounding community will increase. The results show that the mangrove conservation program has a tremendous positive impact on the environment, society, and the economy around the coast. In terms of the environment, mangrove conservation can protect biodiversity, namely aquatic semi-terrestrial and terrestrial, the life of future generations, clean water salinity, absorb pollutants, reduce the greenhouse effect with the "sequestration" mechanism, reduce CO2 in the atmosphere, and as the lungs of the world. . From an economic point of view, mangrove trees provide high economic value because parts of the mangrove tree can be processed and consumed, thus providing extraordinary benefits to the surrounding community in improving welfare. In addition, mangrove conservation can be used as an ecotourism area that aims to educate and preserve the environment and improve the economy of the community around the coast.

Curcumin-loaded hydroxyapatite nanocomposite as a novel biocompatible shield for male Wistar rats from γ-irradiation hazard

Curcumin (CUR) is well known for its extraordinary benefits as an anti-cancer, anti-inflammatory, and wound healing agent. However, nano-formulation could maintain and regulate its pharmacological effect. Herein, we report the preparation of CUR/hydroxyapatite nanocomposite (CUR/HA NC) and its application in the protection of male Wistar rats from γ-irradiation carcinogenic consequences. TEM images of the nanocrystalline HA nanoparticles (NPs) had a rod-like form with average dimensions of 40±5 nm in length and 10 ± 5 nm in width. XRD analysis illustrated the formation of a single phase of hexagonal crystalline HA NPs. The presence of the CUR fingerprint is visible in its FTIR spectra of the CUR/HA NC. Biochemical analysis and histological examinations revealed that CUR/HA NC injection does not significantly affect non-irradiation rats compared to the control. However, when injected pre-irradiation, it controls the pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6) GSH level, kidney, and liver functions as proved by biochemical histopathological and immunohistochemical findings. This research introduces a novel effective protection modality for the γ-irradiation hazard via biocompatible CUR/HA NC injection.

Gastronomic Travel Exploration Based on Healthy Traditional Beverage

One beverage with a unique presentation from Yogyakarta is Wedang Uwuh. Besides the presentation and health benefits also interesting to become a gastronomy tourist attraction that is unknown by the tourist who comes to this city. This paper aims to reveal how and why the concoction of the sacred and highly respected Sultan became the drink of ordinary people and develop a gastronomic sightseeing tour, adopting a phenomenological hermeneutic of study of literature methods approach to enable the bracketing of literature phenomena, combined with informant interview to gain a blended analysis that brings a different perspective of wedang uwuh historical interpretation. To ensure attractiveness in developing the Wedang Uwuh Gastronomic sightseeing tour and present the uncovered narration behind Wedang Uwuh, we are adopting the gastronomic tourism component method. The result finding that this beverage is part of ordinary people's tradition and since the reign of Mataram Kingdom. Wedang uwuh has at least 14 medical benefits for health. It is a unique blend made by the courtiers of Sultan Agung when accompanying the great Sultan meditating in order to determine the location currently known as Imogiri. However, the other perspective there was a "pagebluk" or pandemic in the form of typhoid and plague, where such a concoction was an immune booster to fight the pandemic. With such an interesting historical background and the extraordinary benefits of this wedang uwuh, it deserves to be the main object of a gastronomic tour package

Alluvial Island Herbal Plant Landscape And The Ethno-Medico Malay Tradition Of Binamulia (Study Of The Bomoh Tradition-Based Medicine System In Malay Villages, Meranti Islands Regency, Riau)

This study aims to identify and analyze various types of herbal plants around the Sago forest ecosystem which are often used as traditional medicine by the people of the Meranti Islands. This study uses qualitative methods, withdata collection techniques through interviews and direct observation in the field. The result was found a lot of herbal plants around the sago ecosystem that have many benefits and extraordinary benefits. However, nowadaystraditional medicine with herbal ingredients has started to disappear dueto the development of chemical drugs andthe decreasing number of peoplewho understand and understand traditional medicine. Therefore, this is where the importance of this research is to explore and examine and introduce efficacious herbal plants so that they can be preservedThis study aims to identify and analyze various types of herbal plants around the Sagoforest ecosystem which are often used as traditional medicine by the people of the Meranti Islands. This study uses qualitative methods, with data collection techniquesthrough interviews and direct observation in the field. The result was found a lot of herbal plants around the sago ecosystem that have many benefits and extraordinary benefits. However, nowadaystraditional medicine with herbal ingredients has started to disappear due to the development of chemical drugs and the decreasing number of people who understand and understand traditional medicine. Therefore, this is where the importance of this research is to explore and examine and introduceefficacious herbal plants so that they can be preserved

CFD Investigation for Structural Analysis of a Leaf Spring

Numerical and computer modelling have been playing a significant role in the Computer Aided Engineering (CAE) process of many products over the most recent 60 years. Simulation offers extraordinary benefits in the turn of events and examination period of items and offers a quicker, better and more practical way than utilizing actual models alone. A leaf spring is the simplest type of suspension framework, widely used in heavy commercial vehicles. commercial simulation software and experimental analysis was carried out for the model of electric auto rickshaw leaf spring. Considering electric auto rickshaw’s own weight and seven passenger’s weight with factor of safety, the material selection for leaf spring was 50Cr1V23 which have good mechanical and chemical properties for using as leaf spring. Leaf spring was fabricated by using this alloy 50Cr1V23 for designed dimensions. Deflection and stress has been calculated theoretically for same load as commercial simulation software analysis. The computational analysis was carried out on commercial simulation software 18.2. In this research work leaf spring has been analysed using commercial simulation software static analysis considering inter-leaf contact, the stress distribution, strain and deflection obtained. The results highlight theoretical deflection, stress and strain compare with commercial simulation software results. The comparison results showed that results varied 8.9 % deflection and 7.33% stress in commercial simulation software results from theoretical results. Deflection vs. force, stress vs. strain graph plotted from commercial simulation software analysis results and graph showed that they were proportional to each other’s.

POSSIBLE REVOLUTIONARY SUBSTITUTE TO WHEAT: A REVIEW ON NUTRIENT RICH AND HEALTHY DIET DEVELOPMENT BY PSEUDO CEREALS

People of modern age are very health and diet conscious. Various plants have been used as source of nutrition by human beings. Cereals have been one of them. But due to health problems (Celiac disease, WDEIA and baker’s asthma) and allergens present in cereals such as by wheat gluten, people are looking for alternative diet. Population is increasing day by day and to provide them a healthy nutritious diet free of allergens is uphill task. Researchers are looking to exploit various alternative plant sources. Recent findings suggest that pseudo cereals are best alternative to wheat. Buckwheat, Amaranth and Quinoa (pseudo cereals) were underutilized crops. Now, people are gaining more interest in Pseudo cereals for their excellent nutrition profile and gluten free products. They contain essential amino acids, carbohydrates, dietary fibers, minerals, vitamins and other important biological compounds in their nutrition profile. Important biological compounds present in pseudo cereals like phenolics impart beneficial health impacts on human beings. Keeping in view the extra ordinary benefits of consuming pseudo cereals, they must be grown at commercial level. It will make sure availability of diet full of nutrition and free from health risks.

NAGAN RAYA DISTRICT ATTORNEY'S OFFICE COMMUNICATION STRATEGY IN BUILDING A COMMUNITY IMAGE THROUGH SOCIAL MEDIA

The existence of social media cannot be separated from everyday life because it has become part of human life, both personal and agency, both private and government. They are competing to make information technology using various types of social media because social media has extraordinary benefits. is a great opportunity for the Nagan Raya District Attorney who presents the people. The Nagan Raya District Attorney can get closer to the people through social media, both to socialize activities, absorb information and aspirations, as well as communicate exclusively to find out the people's wishes. Related to that, conduct a study with the title of the Nagan Raya Public Prosecutor's Communication Strategy in Building the Image of the Community Through Social Media. The purpose of this study is to find out how the strategies and steps have been taken by the Nagan Raya District Attorney in building an image of the community through social media. So far public perception of the prosecutor's office well. This study uses a qualitative descriptive method of in-depth data collection from interviews with several informants, field observations and studies of documents related to objects that are used as references for the Nagan Raya District Attorney as part of the Regional Government in the use of social media to build a positive image of society. The results showed that the use of social media as a tool to increase the positive image of the Nagan Raya District Attorney was quite good.

Brain Cancer Chemotherapy through a Delivery System across the Blood-Brain Barrier into the Brain Based on Receptor-Mediated Transcytosis Using Monoclonal Antibody Conjugates.

Advances in pharmacotherapy have brought extraordinary benefits to humanity. However, unmet medical needs in patients remain, particularly in the treatment of central nervous system (CNS) diseases and cancers. CNS drug delivery into the brain across the endothelium is difficult due to the blood-brain barrier (BBB), which is composed mainly of tight junctions and efflux transporters, such as multiple drug resistance 1 (MDR1) (P-glycoprotein). On the other hand, the development of anti-cancer drugs is a challenging task due to their frequent off-target side effects and the complicated mechanisms of cancer pathogenesis and progression. Brain cancer treatment options are surgery, radiation therapy, and chemotherapy. It is difficult to remove all tumor cells, even by surgical removal after a craniotomy. Accordingly, innovative brain cancer drugs are needed. Currently, antibody (Ab) drugs that show high therapeutic effects are often used clinically. Furthermore, antibody-drug conjugates (ADCs), such as trastuzumab deruxtecan, an anti-HER2 (human epidermal receptor 2) ADC with low-molecular cancer drugs through the suitable linker, have been developed. In the case of trastuzumab deruxtecan, it is internalized into cancer cells across the membrane via receptor-mediated endocytosis. Moreover, it is reported that drug delivery into the brain across the BBB was carried out via receptor-mediated transcytosis (RMT), using anti-receptor Abs as a vector against the transferrin receptor (TfR) or insulin receptor (InsR). Thus, anti-TfR ADCs with cancer drugs are promising brain cancer agents due to their precise distribution and low side effects. In this review, I introduce the implementations and potential of brain cancer drug delivery into the brain across the BBB, based on RMT using ADCs.

PERAN BANK SYARIAH DALAM PEREKONOMIAN MASYARAKAT (Studi Kasus Masyarakat Kota Binjai)

Abstract
 This study is intended to find out what work has been done by Islamic banks in the city of Binjai, and the extent to which people in the city of Binjai feel the impact of Islamic banks, especially in the monetary sector. The problem Islamic banks see is that people are used to ordinary financial foundations that have served the financial needs of the local area. The issue that is often discussed is the difference in the understanding of premiums in ordinary banks and benefits in Islamic banking. The results of this study can be concluded that Islamic banks are still classified as having less role in the economy of the special community in the city of Binjai, this is caused by the lack of effectiveness in maximizing the programs that have been designed so that people are still not familiar with the products and benefits of Islamic banks.
 As for this research using a quantitative methodology. This methodology withdraws from mathematical information, which is remembered for logical types, into a special examination that looks to clarify the state of each factor under study and the relationship between these factors. The consequence of the review shows that in its use, it is very noticeable that the types of goods that connect money with clients are very diverse and fluctuate. From these important items it is still possible to develop a variety of different items. Islamic banks have various kinds of income from profit sharing, rent, administrative costs, benefits, and profit sharing such as Shadaka, Infaq and Zakat. Through these halal products, Islamic banks provide extraordinary benefits to their customers. The relationship between Islamic banks and the benefits felt by clients through the use of sharia agreements can be seen that financial instruments and the progress of monetary business practice using contract standards that rely on Islamic sharia.

Marriage Preparation Courses in Indonesia: Comparative Study of Muslims and Christians

This paper aims to prove that after attending the Marriage Preparation Course, the prospective wives and husbands of the course participants feel the extraordinary benefits of attending the Marriage Preparation Course. Because the material presented is very relevant and vital as a provision in living household life. This paper reports the research results on implementing Marriage Preparation Courses among Muslims in Pekanbaru, Riau and Christians in Yogyakarta. These two objects result from selecting the best performance in carrying out the Marriage Preparation Course. This research includes qualitative research with a juridical approach and uses the theory of the legal system. The result of the study is that the implementation of a good Marriage Preparation Course can give a positive impression and knowledge to the course participants. The participants stated the importance of prospective wives and husbands taking Marriage Preparation Courses. This course assists candidates in dealing with the romance of domestic life in the future, especially if the material also provides testimonials of the couples. One problem to solve by working couples is not being able to get permission from the workplace to take courses. Hopefully, there will be a policy from the government that requires workplaces to permit workers to take courses in the future.

Budidaya Tanaman Kelor (Moringa Oleifera. Lam) dan Pelatihan Pembuatan Masker Daun Kelor pada Kelompok Ibu-Ibu PKK di Desa Muaro Pijoan

The Moringa plant (moringa olifera lam), is famous because all parts of the Moringa plant have extraordinary benefits and are easy to cultivate and do not require intensive care, Moringa plants can be consumed directly or processed into various traditional medicines and products for skin care, namely Moringa leaf herbal masks. Muaro Pijoan Village is a village located on the border and its residents have a fairly large yard, some residents already plant Moringa plants, but they do not know about the benefits and how to process Moringa plants into high-value products. This service activity aims to educate 50 Family Welfare Program (FWP) women in Muaro Pijoan village, about cultivating Moringa plants and improving the skills of mothers to make herbal masks from Moringa leaves, which will be carried out in July-September 2021 with activity methods including counseling, direct practice in cultivating Moringa plants for making Moringa leaf herbal masks and packaging them into attractive products with high economic value, as well as how to market them. The results of the service activities showed an increase in the knowledge of mothers about the cultivation and utilization of Moringa plants by 38% based on the results of the pre-post test, as well as the formation of 5 groups of FWP women to cultivate Moringa plants and an increase in the skills of FWP mothers in Muaro Pijoan village by 64.0% on how to make Moringa leaf spice mask herbal products. This activity is expected to motivate mothers to cultivate Moringa plants and process them into various products for health and beauty, which have high economic value as a means of entrepreneurship, as well as the need for assistance from village officials, health workers and related agencies so that Moringa plant cultivation and manufacture This product is sustainable.