Extraorbital Sebaceous Carcinoma Research Articles

Sebaceous carcinoma of scalp with parietal bone destruction: A rare case presentation

Sebaceous carcinoma is a rare malignant tumor of the skin appendages, which occurs in the elderly. The most commonly involved site is the orbital region and it is rarely seen in the extra-orbital sites. We report a rare case of extra-orbital sebaceous carcinoma of the scalp with parietal bone destruction in a 45-year-old male. He was treated with wide local excision of the tumor with no regional or distant metastases. The patient received adjuvant chemo-radiation therapy, with no evidence of any local recurrence after one year of follow-up period. It is imperative to diagnose sebaceous carcinoma at an early stage to execute the primary treatment i.e., wide local excision and prevent recurrence of the tumor.

Metastatic sebaceous cell carcinoma, review of the literature and use of electrochemotherapy as possible new treatment modality.

BackgroundMetastatic extraorbital sebaceous carcinoma is a rare event that could involve the head and neck. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.Material and methodsExtensive literature search was done, and the treatment options are discussed.ResultsResults. The literature search found several treatment modalities in use for the treatment of metastatic extraorbital sebaceous carcinoma. Electrochemotherapy was not included in the reported treatments. We used this technique for a man of 85 years old with a recurrent and locally metastatic extraorbital sebaceous carcinoma of the scalp. During the period of 8 months, two sessions of electrochemotherapy were employed, which resulted in an objective response of the tumour and good quality of life.ConclusionsElectrochemotherapy has shown to be a interesting tools for treatment of metastatic extraorbital sebaceous carcinoma when other radical options are not available or convenient.

Lomber Deriden Köken Alan ve Yaygın Lenfadenopatilerle Seyreden Agresif Ekstra-Oküler Sebase Karsinoma: PET-BT Değerlendirmesi

Sebaceous carcinoma (SC) is a malignant adnexal tumor, usually originating from eyelids. Extra-orbital sebaceous carcinoma is a rare carcinoma localized commonly in head and neck region. Although extra-orbital SC has an indolent course, it may have highly invasive properties and may cause distant metastases rapidly. We report a 46 year-old-woman with extra-orbital SC originating from lumbar skin. Just after two months from the excision of primary lesion, patient readmitted with axillary lymphadenopathies. positron emission tomography (PET-CT) was used for evaluation of both extent of disease and treatment response. Partial remission was observed with docetaxel treatment. This case illustrates how extra-ocular SC can behave aggressively despite the traditional belief. PET-CT can help to evaluate the extent of disease and response to therapy.

DIAGNOSIS AND MANAGEMENT OF SEBACEOUS CARCINOMA: AN AUSTRALIAN EXPERIENCE

Cutaneous sebaceous carcinoma (SC) is a rare malignancy derived from adnexal epithelium of sebaceous glands. Periorbital SC is approximately three times more common than extraorbital SC. To date, there are few data from an Australian source to document the prevalence or clinical outcome of this tumour. A retrospective review was undertaken of the cases from the Institute of Clinical Pathology and Medical Research using their histopathology database for patients with a diagnosis of SC. Patients were identified over a period of 34 years from 1971-2005 and their management and follow up are reported. There were 25 patients in all. Seventeen were men and eight were women. Of the 25 cases, 12 were extraorbital and 13 were periorbital. Three metastases and one tumour showed extensive local invasion. There were nine cases of incomplete excisions and 13 patients were reoperated on for either incomplete excisions, to obtain a wider margin or for local recurrences. Adjuvant radiotherapy was used on five patients, three of whom had lymph node deposits. Sebaceous carcinoma is a rare tumour. Extraorbital SC is an aggressive and invasive malignancy. Excision margins may need to be wider than previously thought. Exposure to ultraviolet radiation (sunlight) may play a role in the aetiology. Wide excision and selective use of radiotherapy remain the treatment of choice.

Undifferentiated Sebaceous Carcinoma: an Unusual Childhood Cancer

Sebaceous carcinoma is an aggressive, adnexal, rare malignant tumor that may arise in ocular or extra-ocular sites. Extraorbital sebaceous carcinoma is exceptional in childhood. We report a 12-year-old boy with an ocular sebaceous carcinoma who was first seen with an asymptomatic firm, cutaneous nodule on the right eyebrow. The tumor developed slowly within 1 year. Histologically, it was an undifferentiated sebaceous carcinoma. The patient had surgery with wide surgical margins. He was alive and free from disease at a follow-up of 34 months. Close follow-up of this tumor is recommended because of the risk of aggressive behavior.

Extraorbital Sebaceous Carcinoma With Rapidly Developing Visceral Metastases

Extraorbital Sebaceous Carcinoma With Rapidly Developing Visceral Metastases

Combined therapeutic approach for extraorbital sebaceous carcinoma in a Torre's syndrome

Extraocular sebaceous carcinomas are extremely uncommon neoplasms. More exceptional is their association with an internal malignancy as first described separately by Torre and Muir in 1967. We report the first use of combined adjuvant radio- and chemotherapy in a sebaceous carcinoma of the anal margin in a Torre's syndrome. An interesting partial response was attained before the patient died from general debility. The therapeutic approach is discussed.

Sebaceous carcinoma of the periorbital and extraorbital regions

Sebaceous carcinomas are uncommon amongst cutaneous malignancies. These lesions can broadly be classified into 2 groups; (i) periorbital, which behave aggressively, and (ii) extraorbital, which are reported to metastasize rarely. A retrospective review has identified 12 cases of primary sebaceous carcinoma treated at Canniesburn Hospital over the decade from mid-1983 to mid-1993. Out of 7 cases with periorbital primary lesions, one patient died from metastatic disease and another developed local recurrence which was successfully excised. The series included an unusual case of metastasizing primary extraorbital sebaceous carcinoma.