Extranodal Histiocytic Sarcoma Research Articles

Enhanced Computed Tomography and 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Uncommon Histiocytic Sarcoma of Small Intestine Arising after Gastric Large B-Cell Lymphoma.

Histiocytic sarcoma (HS) is an extremely rare and aggressive malignant neoplasm of hematopoietic origin that shows morphologic and immunophenotypic evidence of histiocytic differentiation. In approximately 25% of the cases, presumed transdifferentiation of a preexisting hematolymphoid disorder can be demonstrated. Various extranodal sites, particularly the gastrointestinal tract, soft tissue, skin, and spleen, can be involved. Enhanced CT and FDG PET/CT findings of extranodal histiocytic sarcoma have been barely reported. We present a case with extranodal HS originating in the small intestine after gastric large B-cell lymphoma, mistaken for prostate cancer metastasis in a 76-year-old man.

A rare primary localized extranodal histiocytic sarcoma of oral mucosa: a case report

<h3>Background</h3> Histiocytic sarcoma is a rare hematopoietic malignancy which typically involves extranodal sites, mainly of the gastrointestinal tract. Of the small number of reported cases in the head and neck region, only one case was localized to the oral cavity. The disease may present as a solitary lesion or disseminated process secondary to other hematopoietic malignancies. Histopathologically, the tumors can be mistaken for other lymphoprolifera- tive disorders. Immunohistochemistry shows tumor cells expressing one or more of the histiocytic markers CD163, CD68, or lysozyme. Surgery with or without chemotherapy or radiotherapy are the mainstays of treatment. Even though histiocytic sarcoma has clinically aggressive behavior with poor response to therapy, studies show that a subset of the patients with localized disease and small tumor size have more favorable outcome with surgery alone. We present a case with localized extranodal histiocytic sarcoma of oral mucosa. <h3>Case Description</h3> A 31-year-old, fe- male with onemonth duration of a 10 × 8 × 2 mm smooth-surfaced, well circumscribed, firm soft tissue enlargement at buccal vestibule of #11/12. Biopsy shows a diffuse population of pleomorphic cells with atypical mitoses and fine granular cytoplasm within fibrocollagenous connective tissue. Immunohistochemical studies demonstrated tumor cells positive to CD163, CD68, CD45, CD43, CD4, muramidase, SOX10, S100, NSE and vimentin with a diagnosis of his- tiocytic sarcoma. Surgical excision with uninvolved margins was performed. The diagnosis of histiocytic sarcoma was confirmed with hematopathology consultation. There was no evidence of tumor recurrence after 3 months fol- low up. <h3>Conclusion</h3> To the best of our knowledge, this is the second case of primary localized extranodal histiocytic sarcoma of oral cavity. Surgery alone was the treatment modality for our case. However, due to the rarity/limited number of reported cases, treatment outcomes of a localized disease is limited. The treatment protocol may become more evident as newer studies emerge.

HISTIOCYTIC SARCOMA OF THE SMALL INTESTINE: A CASE REPORT WITH REVIEW OF THE LITERATURE

Histiocytic sarcoma is very rare malignant neoplasm showing morphological and immunophenotypic characteristics of histiocyte. Morphologic diagnosis is challenging due to overlapping histologic features with diverse mimics. Histologic diagnosis is confirmed by expression of one or more histiocytic markers, including CD163, CD68, and lysozyme. We present a bona fida case of extranodal histiocytic sarcoma involving the small intestine in a 67-year-old male. The diagnosis is confirmed by diffuse immunoreactivity of CD163, which is believed to be more specific histiocytic marker than CD68.

HISTIOCYTIC SARCOMA OF THE SMALL INTESTINE: A CASE REPORT WITH REVIEW OF THE LITERATURE.

Histiocytic sarcoma is very rare malignant neoplasm showing morphological and immunophenotypic characteristics of histiocyte. Morphologic diagnosis is challenging due to overlapping histologic features with diverse mimics. Histologic diagnosis is confirmed by expression of one or more histiocytic markers, including CD163, CD68, and lysozyme. We present a bona fida case of extranodal histiocytic sarcoma involving the small intestine in a 67-year-old male. The diagnosis is confirmed by diffuse immunoreactivity of CD163, which is believed to be more specific histiocytic marker than CD68.

Imaging features of primary extranodal histiocytic sarcoma: report of two cases and a review of the literature

Histiocytic sarcoma is an extremely rare and aggressive malignancy of bone marrow origin that occurs in lymph nodes, skin, and the gastrointestinal tract. We report on the imaging features of two cases of primary histiocytic sarcoma, one in the retroperitoneum causing a tumor–bowel fistula and another with primary bone involvement.

Multifocal histiocytic sarcoma of the gastrointestinal tract

We report a rare case of extranodal histiocytic sarcoma with multifocal gastrointestinal tract involvement, which has not been documented in the literature so far. A diagnosis of interdigitating dendritic cell/ histiocytic sarcoma was made on the preoperative gastric biopsy. Computed tomography scan revealed multifocal, circumferential gastrointestinal wall thickening involving the stomach and jejunal loops. Patient underwent distal gastrectomy with extended D1 dissection and proximal jejunal resection with gastrojejunostomy. Immunohistochemistry profile of both the gastric and jejunal tumors was similar to the preoperative gastric biopsy. The histiocytic origin of the tumor was confirmed by positive reaction of the tumor cells for CD 163. She received four cycles of CHOP chemotherapy, and is free of disease three years, following surgery.

Primary extranodal histiocytic sarcoma of lumbar spine

A 17-year-old male patient presented with lower back pain and weakness of lower limbs. On radiological investigation, a destructive bony lesion involving the third lumbar vertebra was seen associated with soft tissue extension and an extradural component. The lesion was surgically excised in view of the rapidly progressing symptoms. The histologic diagnosis was histiocytic sarcoma. Further investigations did not reveal any other lesion elsewhere. The case is being presented in view of the uncommon occurrence of a primary extranodal histiocytic sarcoma of the lumbar spine, which simulated a primary bone tumor.

A Case Report of an Extranodal Histiocytic Sarcoma Presenting in the Oral Cavity

A Case Report of an Extranodal Histiocytic Sarcoma Presenting in the Oral Cavity

A Case Report of an Extranodal Histiocytic Sarcoma Presenting in the Oral Cavity

A Case Report of an Extranodal Histiocytic Sarcoma Presenting in the Oral Cavity

A Case of Extranodal Histiocytic Sarcoma of Stomach Mimicking Gastric Adenocarcinoma

Histiocytic sarcoma is a rare malignant neoplasm that originates from a histiocytic hematopoietic lineage characterized by histiocytic differentiation and its corresponding immunophenotypic features. Patients with histiocytic sarcoma usually have a poor prognosis due to its aggressive clinical behavior. Here we report a rare case of extranodal histiocytic sarcoma of the stomach which was confirmed through immunohistochemical staining. A 71-year- old man was presented with epigastric pain. Gastroscopy, abdominal CT, and EUS revealed a mass located on the posterior wall of upper body and fundus of the stomach. Grossly, grayish white solid masses were seen extending down to the submucosal layer. Microscopically, the tumor cells had eosinophilic cytoplasm, abundant vacuole, and mitosis. Immunohistochemical staining revealed that the tumor cells were positive for LCA, CD68, and lysozyme. Early detection and accurate diagnosis of this rare neoplasm is important because it can make a great difference in prognostic outcomes. To make an accurate and definitive diagnosis, immunohistochemical staining is essential in the confirmation of histiocytic origin.