Extraction Of Mandibular Molars Research Articles

Mandibular second molar extraction: A retrospective cohort study of spontaneous occlusal changes in adolescent patients.

Evaluate long-term spontaneous occlusal changes following L7 extraction in adolescent patients. Study models of 144 participants (63 males, 81 females) retrospectively assessed prior to L7 extraction (9-16 years old; T1) and following L8 eruption (14-25 years old; T2). All received upper fixed appliances. A sub-group (n = 86) received no lower fixed appliances and acted as controls. Occlusal changes were compared between treatment (lower fixed appliance) and control (no lower fixed appliance) groups using PAR index. At T2, L8 occlusal outcome was assessed using ABO grading system. Mean follow-up period 6 (SD 2) years. At T1, lower scores observed in control group for Lower Anterior (P < .001), Midline (P = .033) and Lateral Segments (P = .040) components. At T2, lower scores continued being observed in control group for Midline (P < .001) and Lateral segment (P = .019) components. Higher decrease in Lower Anterior PAR scores observed in treatment group (<.001) with comparable scores between groups at T2 (P = .057). Similar PAR score changes between groups for Lateral Segments, Overjet and Overbite components. At T2, no significant difference observed in Total PAR score reduction between control (83%) and treatment (82%) groups. Good-to-acceptable occlusal outcome of the L8 observed in 81.55% of cases at T2 with no difference between groups. In growing patients with mild mandibular crowding, extraction of L7 followed by upper fixed appliance therapy, leads to favourable occlusal changes over a 6-year follow-up period, with or without lower fixed appliance therapy, being an alternative extraction protocol where lower fixed appliance therapy is not recommended.

Dexamethasone and concentrated growth factors on peripheral nerve injury: A clinic-relevant animal study

BackgroundMandibular nerve injury is a common clinical condition that affects clinicians’ management and patients’ quality of life. In the literature, there are various effective treatments available. The primary purpose of this study was to determine and compare the effects of dexamethasone and concentrated growth factor (CGF) on regeneration in patients with nerve trauma that mimics clinical situations. MethodsIn this study, 36 rats were divided into 3 groups: the control, dexamethasone and CGF groups. The inferior alveolar nerve was traumatized through the extraction socket after mandibular molar tooth extraction in each group. ResultsThe data showed a decrease in the control (4.5–4), dexamethasone (3–2), and CGF (4–3) groups according to the histological injury severity score (HISS) results. Compared with those in the other groups, the number of degenerative axons and edematous areas observed via histological examination were significantly lower in the CGF groups. Similarly, compared with those in the control group, the nNOS and Neurofilament-H positivity in the dexamethasone group on the 30th day (2,2 to 1,1 respectively) was significantly lower. The positivity of all the primary antibodies in the 3rd and 30th day CGF groups was significant compared than that in the dexamethasone 30th day group. ConclusionAccording to the results of the analysis of the immunohistopathological and HISS data, the CGF groups exhibited greater regeneration than did the dexamethasone groups.

Effectiveness of Resorbable Surgical Gelatin Sponge Following Impacted Mandibular Tooth Extraction: A Prospective Split Mouth Comparative Investigation

Background: Post-operative pain is common complication following surgical extraction of impacted mandibular teeth. Absorbable Surgical Gelatin sponge is a hemostatic Agent commonly used in controlling bleeding in oral surgery. The specific aim of this study is to understand the efficacy and efficiency of absorbable surgical gelatin sponge in reducing post-operative complication after surgical extraction of impacted mandibular molars.

Prevalence of Extraction of Primary Mandibular Second Molar in 3 to 5 Year Old Children

Introduction: Tooth extraction is done based on a variety of reasons, the most common reason being the tooth becoming unrestorable as a result of dental caries, trauma to the tooth or periodontal disorder. The tooth indicated for extraction is usually associated with pain except in some cases where the tooth is removed for orthodontic treatment. Dental caries is a chronic disease of the tooth which is represented by demineralisation and destruction of the organic matter of the tooth. It is the most common cause of dental extraction. The aim of this study is to analyze the prevalence of extraction of primary mandibular second molars in children treated under general anesthesia from a private dental hospital.&#x0D; Materials and method: This study is a single centered retrospective study in which the data was collected from a private dental college and hospital in Chennai, India. Patient details were collected from the hospital management system and a total of 47 samples were collected. The data was tabulated using Excel and then statistically analyzed using the latest version of SPSS software.&#x0D; Results and discussion: Prevalence of extraction of primary mandibular second molar in 3 to 5 year old children wasstudied. The primary mandibular right second molar was found to be extracted the most. Also, primary mandibular second molar was extracted more in males and in the age group of 5.&#x0D; Conclusion: In the study conducted, the primary mandibular right second molar was the most extracted tooth.

The Effects of Intraoperative Placement of Tetracycline, Tetracycline + Gelatin Sponge, and Placebo on Postoperative Dry Socket Incidence After Mandibular Molar Extraction: (A Comparative Prospective Study)

Background: The aim of the study evaluation 0f tetracycline, tetracycline plus gelatin sponge efficacy in lowering dry socket incidence among patients experienced extraction procedure for mandibular molars compared to control group.. Material and Methods: The sample was divided into three groups each group have 30 patients (34 male and 56 female) :  Group A (patients dealt without intra-socket tetracycline) in which only applying figure of 8 suturing and dressing adhesive material for sockets.  Group B (patients managed with intra-socket tetracycline alone) in which patients managed after extraction with tetracycline solution, figure of 8 suturing and dressing adhesive material.  Group C (patients managed with intra-socket tetracycline plus gelatin sponge complex) in which patients managed after extraction with tetracycline-gelatin sponge vehicle, figure of 8 suturing and adhesive dressing material. Results: Dry socket following extraction was encountered in 4 female patients, with an incidence of 4.4%. Group A reported the highest number. Conclusions: In spite of the limits of this clinical trial, the placement of tetracycline as intra-socket medicament serve in a good choice for treating extracted socket, by reducing bacterial load that will result in lowering the possible chances of infection thus relieving pain, on the other hand the Ora-aid dressing material serve a good way accompanied with suturing in avoiding dry socket occurrence.

Evaluation of Recombinant Human Platelet Derived Growth Factor (rhPDGF-BB) Along with Tricalcium Phosphate (β-TCP) in Impacted Mandibular 3rd Molar Sockets

Aim: The aim of this study was to evaluate efficacy of Recombinant Human Platelet derived Growth Factor (rhPDGF-BB) mixed with Tricalcium Phosphate (β-TCP) particles in mandibular 3rd molar extraction socket for bone regeneration. Setting And Design: A comparative clinical trial consisting of 10 patients who wanted to undergo the surgical extraction of mandibular 3rd molar bilaterally, were undertaken in the institutional settings, where in each patient one side of lower third molar extraction site was kept as control and in the other side graft material was used, after the approval from the institutional ethical committee. Materials And Methods: In this study 10 patients were included with mean age of 28.3 years (Ranging from (20-35 years). These were 4 male and 6 female patients. In each patient one side of lower third molar extraction site was kept as control site and in the other side graft material was used kept as study site. Hence 10 control sites were compared with 10 study sites. Selection of site for placement of graft was done randomly. In 6 patients study site was on right side and in 4 patients study site was on left side. Clinical parameters like pain, facial swelling, total number of analgesic tablets required evaluated at 48hrs and at 7th day. While, radiographically bone density was evaluated after 1st and 3rd month postoperatively. Other parameters like infection, sinus discharge, wound dehiscence, dry socket or graft leakage were also observed. Results: rh PDGF with β – TCP when used in mandibular third molar extraction socket results in rapid bone regeneration seen via increased bone density. It also results in less post-operative discomfort to the patient like pain and swelling. Complications like infection, sinus discharge, wound dehiscence, dry socket or graft leakage were not encountered and the tissue showed good acceptance with no graft rejection. Conclusions: The rh PDGF/β – TCP combination is a novel bone grafting material with excellent results and should be included in the armamentarium when bone defect is encountered.

Evaluation of Socket Preservation Using Collagen Plug and Injectable Platelet Rich Fibrin in Extracted Sockets of Mandibular Molars: A Split Mouth Study

Aim and Objectives: Evaluation of socket preservation using collagen plug and injectable platelet rich fibrin in extracted sockets of mandibular molars. To evaluate wound healing and bone density using collagen plug and I-PRF and to compare wound healing and bone density between collagen plug and I-PRF. Methodology: This experimental study involves 13 healthy patients at the Sibar Institute of Dental Sciences and Hospital in Guntur, Andhra Pradesh, India, who underwent mandibular molar extraction under local anesthesia. Patients underwent clinical and radio-graphic examinations and received periodontal treatment. The study involved extraction of right and left mandibular molar teeth, AbGel placement, collagen plug placement, and sockets secured with sutures and pressure packs. Postoperative pain, swelling, and wound healing were assessed using Wong-Baker faces pain rating scale, VAS scale, and LANDRY healing index. CBCT was obtained after 1 month and 3 months after extraction for bone quality assessment. Results: In the study, there were 69.2% men and 30.8% women. According to the study, 14.3% of individuals in the collagen plug group and 85.7% of those who received injectable platelet-rich fibrin experienced very good wound healing. On the first and seventh days, the mean pain intensity was lower in the injectable group, but there was not a noticeable distinction between the groups. The injectable group had the lowest swelling score, but by day seven, it had dramatically decreased. At the third month, the collagen plug group had the highest bone density readings, with no discernible difference between the groups. Conclusion: It can be concluded that I-PRF can be utilized as an alternative to collagen plug.

Gas Plasma Treatment Improves Titanium Dental Implant Osseointegration-A Preclinical In Vivo Experimental Study.

Recent technological advancements led to the development of various plasma-based technologies for post-packaging modifications. The purpose of the present preclinical in vivo study was to assess the safety and efficacy of a novel chairside nonthermal gas plasma treatment for enhancing osseointegration of titanium implants. Six male mixed foxhounds underwent extraction of mandibular premolars and first molars, and the sockets healed for 42 days. Canine mandibles were randomized to receive either plasma-treated (test) or non-plasma-treated (control) dental implants. A total of 36 implants were placed in six animals, and they were sacrificed at 2 weeks (two animals), 4 weeks (two animals), and 6 weeks (two animals) after the implant surgery. When the radiographic analysis was performed, the changes in bone level were not statistically significant between the two groups at 2 weeks and 4 weeks. The difference became significant at 6 weeks (p = 0.016), indicating more bone loss from baseline to 6 weeks for the control group. The bone-to-implant contact (BIC) appeared to be higher for the test groups at all time points, and the BIC was significantly higher for the test group at 4 weeks (p = 0.046). In conclusion, this study underscored the potential of nonthermal plasma treatment in enhancing implant osseointegration.

Effectiveness of buccal infiltration anaesthesia compared to inferior alveolar nerve block anaesthesia in primary mandibular molar extractions: a randomised controlled study.

Aim The current study assessed the efficiency of buccal infiltration (BI) and inferior alveolar nerve block (IANB) during the extraction of deciduous mandibular molars.Subjects and method A total of 112 children aged between 5-8 years with mandibular molar indicated for extraction were divided into two groups at random. The BI group was injected with 4% articaine using BI, while the IANB group was injected with 2% lidocaine using IANB. The effectiveness of both techniques was examined using the Wong-Baker FACES Pain Rating Scale (W-BFPRS); Faces, Legs, Activity, Cry, and Consolability (FLACC) scale; and pulse oximetry.Results Using the W-BFPRS scale, success rates were 83.9% and 75.0% for the BI group and 82.1% and 71.4% for the IANB group during the injection and extraction, respectively, while using the FLACC scale, success rates were 83.9% and 92.9% for the BI group and 78.6% and 89.3% for the IANB group. In terms of pulse rate and oxygen saturation, there was no significant difference between the two groups.Conclusions BI with articaine is as efficient as IANB with lidocaine in the extraction of deciduous mandibular molars.

Story of a Displaced Tooth – A Case Report

Various iatrogenic complication may be seen during extraction of mandibular 3rd molar. Displacement of mandibular 3rd molar into pterygomandibular space is usual but displacement into an unusual space like submandibular space or sublingual space is very rare. This can cause significant physical and psychological problems for the patient. The treatment for this kind of complications may vary from a conservative treatment to surgical procedure, what will depend on clinical features, symptoms, the location of the tooth, and its relation to adjacent structures. The present case report illustrates a rare complication of extraction of impacted mandibular third molar that was displaced into the sublingual region. Upon locating the tooth, successful removal of tooth was performed. Healing was uneventful after a 3 month of follow up.

Use of Physics Forcep Versus Conventional Forcep in Extraction of Mandibular First Molar

Dental extractions are common. Atraumatic extractions utilizing various technologies are said to protect paradental structures. The new physics forceps can extract the teeth without stress. Objective: To compare the efficacy of physics versus conventional forcep in extraction of mandibular first molar. Methods: Patients aged 18 t0 40 requiring extraction of mandibular first molar were included in the study. The efficacy of extraction was evaluated based on bone loss, soft tissue tear, time required for extraction, postoperative pains, and root fracture. The participants were divided into two groups (Physics forcep and conventional forcep) using block randomization technique, and the pain and time between both groups were compared using independent samples t-test. Results: The two groups had a mean age of 2.85 ± 0.355 years. Physics Forceps (n=1, 6.7%) caused less soft tissue tears than Conventional Forceps (n=14, 93.3%) (p=0.01). 55.5% of the Physics Forceps group and 44.5% of the Conventional Forceps group took more than 10 minutes to extract (p=0.045). Physics Forceps had a greater rate of complete success (p=0.043) than Conventional forceps (p=0.043). In terms of overall instrument utility, physics forceps scored better than Conventional forces in both good and average scores (p=0.021). The difference in mean pain score in the two groups was statistically significant (p=0.0018) at day 3 and day 7 (p=0.0001) being lower in physic forcep. Conclusions: Physics forceps are a more favorable substitute to traditional forceps for atraumatic tooth extraction.

Alveolar bone loss and root resorption in mesialized second molars in mandibular first molar extraction cases as compared to contralateral non-extraction side in young adults: A retrospective cross-sectional study

The alveolar bone loss (ABL) and external apical root resorption (EARR) depict the safety of mesialization of mandibular second molars into the extraction space of mandibular first molars. The aim of this study was to evaluate the ABL and EARR after closure of mandibular first molar extraction space by mesialization of second molar on extraction side (ES) as compared to the contralateral non-extraction side (NES). A retrospective cross-sectional study was carried out using the pre and posttreatment orthodontic records of young adults with complete set of permanent dentitions treated with extraction of unilateral mandibular first molar and non-extraction treatment on the contralateral side. All patients underwent mini-implant supported mesialization of second molar on ES. The ABL and EARR of second molar on ES and contralateral NES were measured on digital orthopantomograms. The ABL and EARR of second molars on ES and contralateral NES were compared using independent sample t-test. A total of 36 subjects (14 males and 22 females) were included in the study. The mean treatment duration for molar mesialization was 28.75±8.05months. The mean crown and root movements of mandibular second molar on ES were 10.94±1.25mm and 9.04mm±1.14mm, as compared to 0.91±1.01mm and 0.77±0.83mm on contralateral NES, respectively. The mean ABL and EARR at mandibular second molar were found to be significantly greater on the ES than the contralateral NES (P<0.001 and<0.05, respectively). A total of seven patients (19.4%) experienced ABL≥1mm on ES as compared to none in the contralateral NES. EARR of>2mm of at least one root was found in seven patients (19.4%) in ES as compared to four (11%) in contralateral NES. There was small but statistically significant difference in the ABL and EARR of mesialized mandibular second molar at first molar ES as compared to the contralateral NES. For majority of patients this difference was small but few isolated cases experienced severe ABL and EARR.

Patients’ perception of gustatory changes after lower molar extractions

Introduction and Aim: Gustatory changes in the form of loss of taste or alteration of taste or lingual paresthesia are often encountered post-extraction of molar teeth. The aim of this study was to assess patients' perception of gustatory changes/taste alterations following lower molar extractions in female patients attending the OPD (dentistry-clinics) at College of Dentistry, King Khalid University, Abha, Saudi Arabia. Materials and Methods: Thirty consecutive new female adult patients indicated for extraction due to grossly decayed mandibular molars between the age of 19-45 were included in the study. These patients were evaluated using a self-administered interview to assess the lingual tactile and gustatory function impairments immediately after surgical procedures/extraction involving the lower molar region. They were re-evaluated seven days and one month after the surgical procedure. ANOVA for repeated measures was used to assess the statistical difference between patient responses at baseline (before the procedure), seven days, and one month after the surgical procedure. Tukey HSD post hoc multiple comparisons were made to find the group that is significantly different from others. Results: There were no statistically significant differences between the responses at baseline, seven days, and one month after the surgical procedure concerning all the questions asked except Q2 and Q7 that dealt with the presence of tingling sensation on the tongue and ability to continue with their usual diet after the dental procedure, respectively. Conclusion: There was only a transient change in a small proportion of patients in the lingual tactile and gustatory function after surgical extraction of mandibular molars, which was self-limiting and resolved by one month postoperatively.

Efficacy of inferior alveolar nerve block and intraligamentary anesthesia in the extraction of primary mandibular molars: A randomized controlled clinical trial

ObjectiveThe study aims to compare the effectiveness and quality of intraligamentary anesthesia (ILA) and inferior alveolar nerve block (IANB) for primary mandibular molar extraction. MethodsThis prospective, randomized clinical study included patients aged 5 to 13 years scheduled for primary mandibular molar extraction. A total of 208 participants were randomly allocated into two groups (n = 104 each group), IANB and ILA, who were administered 2% lignocaine with epinephrine 1:100,000. Patients rated their pain during injection and extraction (VAS pain score). Frankl’s behavior rating score, quality of anesthesia as perceived by clinician, and duration of procedure were recorded. Demographic and other variables were analysed using Pearson x2 test, Pearson correlation coefficient, Fisher exact test, or an analysis of variance, as appropriate. ResultsIn patients who received IANB, the clinician reported a slightly better quality of anesthesia (p = 0.19) than those who received ILA (VAS score 1.3 ± 0.7 Vs 1.6 ± 0.4). Mean (±SD) score for pain during extraction were found be 1.7 (±0.6) for the IANB group and 1.8 (±0.5) for the ILA group. The clinician observed 46.2% of patients in the IANB group and 39.4% of patients in the ILA group had no discomfort during extraction. Frankl’s behavior score was negatively correlated with the quality of anesthesia and the time taken to complete the extraction (p = 0.017 and p = 0.053, respectively). ConclusionThe efficacy of conventional ILA was similar to IANB, and thus ILA might be a good alternative to the IANB while extracting primary mandibular molars.

Clinical evaluation of feasibility and effectiveness using a virtual reality device during local anesthesia and extractions in pediatric patients.

Pediatric dentistry requires more than routine dental knowledge and skills in executing quality dental care. The quality of dental treatment is indirectly proportional to a child's anxiety and fear. The recent distraction technique, the use of virtual reality (VR) devices has intrigued many researcher's minds. Therefore, this study was conducted to assess the clinical feasibility and effectiveness of the VR device in reducing pain and anxiety in pediatric patients during mandibular primary molar extraction. This research trial had 30 healthy children between the ages of 6 and 12 who required mandibular primary molar extraction. The subjects were divided into two groups using a simple randomization method. In the study group (n = 15), extraction was carried out using a VR device, whereas, in the control group (n = 15), extraction was carried out without the use of a VR device. Pre- and post-extraction anxiety levels were measured by Venham's picture test (VPT) and the heart rate. After the procedure, pain and behavior were evaluated by the Wong-Bakers Faces pain rating scale (WBS) and FLACC Scale respectively. The pre-extraction values of the VPT and heart rate showed no statistically significant difference. This indicates that participants of both groups had a similar level of anxiety at baseline. There was a statistically significant increase (p = 0.028) between pre- and post-heart rates in the control group, with no significant change in the study group. The use of a virtual reality device in children can reduce anxiety during primary molar extractions as evaluated by heart rate. Virtual reality devices might be an adjunct to high-quality dental care and to other behavior managementmethods. Definitive outcomes can be attained by encouraging studies overcoming the present limitations, and considering salivary biochemical indicators for the assessment of these devices.

Do Antimicrobial Photodynamic Therapy and Low-Level Laser Therapy Influence Oral Health-Related Quality of Life After Molar Extraction?

Most individuals experience significant deterioration in their oral health-related quality of life (OHRQoL) in the first few days after tooth extraction. Thus, this study aimed to evaluate the impact of antimicrobial photodynamic therapy (aPDT) and low-level laser therapy (LLLT) protocols on OHRQoL after extraction of lower molars. The investigators designed a double-blind, randomized controlled clinical trial study. Patients with indications for lower molar extraction were included in the study and randomized into four groups: control group, antimicrobial photodynamic therapy group, LLLT group (LLLT.G), and aPDT and LLLT group (aPDT+LLLT.G).The Oral Health Impact Profile (OHIP-14) questionnaire was used through an interview with the participants before the extraction (T0 - baseline) and on the 7th (T1) and 30th (T2) days after extraction. Other variables were age, sex, ethnicity, decayed-missing-filled teeth (DMFT) and tooth types. Appropriate univariate and bivariate statistics were computed, and statistical significance was set at a value P<.05. The sample was composed of 40 patients with a mean age of 41.25±13.97 and 25 (62.5%) were women. The mean OHIP-14 scores were significantly different in the intervals at T0 versus T1 and T0 versus T2 for all domains (P<.001), demonstrating a positive impact on the OHRQoL. The total scores indicated a significant improvement in the OHRQoL in the aPDT (7.10, standard deviation 4.18, P=.043), LLLT (6.40, SD 5.87, P=.025), and aPDT+LLLT (5.30, SD 3.59, P=.012) groups compared to that in the control group (12.90, SD 6.64) at T1. Patients undergoing extraction of lower mandibular molars with aPDT+LLLT had the lowest mean OHIP-14 total score at T1 (5.30) and T2 (0.70). The aPDT and LLLT protocols had a positive impact on the participants' OHRQoL. These procedures can be applied in everyday surgical practice.

Influence of L-PRF Topical Application on Bone Tissue Healing after Surgical Extraction of Impacted Mandibular Third Molars: Randomized Split-Mouth Clinical Study

The beneficial effect of autologous blood products in the post-extraction period has been proven regarding acceleration of soft tissue healing, pain reduction, swelling and trismus, but data concerning bone healing are contradictory. The objective of this study was to evaluate the effect of L-PRF on bone tissue healing after third mandibular molar extraction. Extractions of bilateral, symmetrical, impacted mandibular molars were performed in 30 patients, in a prospective split-mouth, randomized, double-blind clinical trial. L-PRF was applied to one alveolus, while the other alveolus was left to heal spontaneously. A sample of 60 extraction alveoli (the control and experimental groups, with 30 alveoli each) was analyzed. Two CBCT images were performed immediately after the surgery and eight weeks postoperatively to reconstruct the healing site and analyze the volume of the extraction defect and bone density. The depth of the periodontal pocket on the adjacent tooth was clinically measured 7 days and 8 weeks after extraction. The results show that the minimum and maximum values of the monitored parameters in the alveoli in both the control and experimental groups are within the expected range. Based on p = 0.826 (MANOVA; for I measurement) and p = 0.499 (MANOVA; for II measurement), it was concluded that no significant difference and clearly defined boundary between the groups were observed. Considering that p &gt; 0.1 (VOL, bone density, periodontal pocket) is for both I and II measurement, no significant difference was observed between the groups regarding the wound volume, bone density and periodontal pocket.

Evaluation of a Nishit-Rama Modification of a Gow-Gates Technique for Giving Mandibular Nerve Block: A Randomized Controlled Trial.

In pursuit of improving currently available anesthetic techniques for dental procedures, present study evaluated a novel mandibular nerve block technique in comparison with control group administered standard inferior alveolar nerve block (IANB) technique. A randomized, comparative, parallel design, double-blind study was conducted at Tata Main Hospital, Jamshedpur, India which enrolled 140 adult patients (70 in experimental group and 70 in control group) requiring minor surgical dental procedures involving normal forceps method extractions of mandibular molars. Tingling or numbness of the lower lip of the same side was considered suggestive of successful IANB blockage. Onset of anesthesia, aspiration of blood and failure of anesthesia were also assessed and compared between study groups. Mean age and gender distribution were statistically comparable between study groups (p > 0.05). Diagnosis of the enrolled cases was either acute or chronic apical periodontitis, which was distributed similarly in study groups (p > 0.05). Mean time to onset of the IANB blockage was found to be significantly longer in experimental group versus control (3.72 ± 0.84 versus 1.93 ± 0.62min, p < 0.05). Both, number of positive aspirations (7.14% versus 25.72%, p < 0.05) and need for additional injection were significantly lower in experimental group (18.58% versus 74.28%, p < 0.05). Incidence of pain while tooth removal was similar between study groups (p > 0.05). The novel technique for mandibular nerve block evaluated in present study has various advantages like avoidance of technical difficulties with absence of extra-oral landmark, lower chances of reinsertion reducing complication risk, and decreased systemic complications, evident by lower rates of aspirations.

Effects of Early Unilateral Mandibular First Molar Extraction on Condylar and Ramal Asymmetry

Effects of Early Unilateral Mandibular First Molar Extraction on Condylar and Ramal Asymmetry

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model.

This study introduces the development of a molar extraction model in the murine mandible to provide a practicable model for studying alveolar bone regeneration and intramembranous ossification. C57/J6 mice were used to extract the mandibular first molar to establish this model. They were executed, and the bilateral mandibles harvested, at 1 week and 4 weeks post-surgery, respectively. Subsequent serial stereoscopic harvest, histological assessment, and immunofluorescence staining were performed to demonstrate successful surgery. Immediately after surgery, the stereoscopic images displayed an empty extraction socket. The hematoxylin and eosin (H&E) at 1 week and Masson staining at 4 weeks post-surgery showed that the area of the original root was partially and fully filled with bone trabeculae, respectively. The immunofluorescence staining showed that, compared with the homeostasis side, the Sp7 expression increased at 1 week post-surgery, suggesting vigorous osteogenesis in the alveolar fossa. All these results demonstrated a practicable murine tooth extraction socket healing model. Upcoming studies revealing the mechanisms of jawbone defect healing or socket healing could adopt this method.