BackgroundGray-to-white matter ratio (GWR), measured by computed tomography (CT), is commonly used to predict poor neurological outcomes after out-of-hospital cardiac arrest (OHCA). The prognostic performance of GWR in OHCA patients receiving extracorporeal cardiopulmonary resuscitation (ECPR) is not known. MethodsThis study is a secondary analysis of data from the SAVE-J II registry, a retrospective, multicenter study. Participants were divided into four groups according to average GWR (aGWR) values ranging from 1.00 to 1.39, separated by 0.1 intervals. The aGWR values were calculated for bilateral basal ganglia, centrum semiovale, and high convexity obtained by head CT within 24 h after ECPR. Primary outcome was poor neurological outcomes at 30-day. ResultsIn total, 1,146 OHCA patients treated with ECPR were included in our analysis. Overall, participants with lower aGWR more likely had poor neurological outcomes, aGWR 1.00–1.09 (94.6%), aGWR 1.10–1-19 (87.8%), aGWR 1.20–1.29 (78.5%), and aGWR 1.30–1.39 (70.3%). Multivariable logistic regression showed that lower aGWR was associated with poor neurological outcome at 30-day, aGWR 1.30–1.39: reference, aGWR 1.00–1.09: adjusted odds ratio (aOR) 10.01 (95% confidence interval (CI) [3.58–27.99]), aGWR 1.10–1.19: aOR 4.83 (95% CI [2.31–10.12]), aGWR 1.20–1.29: aOR 2.16 (95% CI [1.02–4.55]). Receiver operating characteristic curve analysis revealed that the prognostic performance of aGWR had an area under the curve of 0.628, 95% CI [0.59–0.66]). The aGWR threshold of 1.005 for predicting poor neurological outcome reached 100% specificity with 0.1% sensitivity. ConclusionEarly neuro-prognostication depending on GWR may not be sufficient after ECPR and requires a multimodal approach.