Extra Shift Research Articles

Searching for new fundamental interactions via isotopic shifts in molecular lattice clocks

Precision measurements with ultracold atoms and molecules are primed to probe beyond-the-standard model physics. Isotopologues of homonuclear molecules are a natural testbed for new Yukawa-type mass-dependent forces at nanometer scales, complementing existing mesoscopic-body and neutron scattering experiments. Here, we propose using isotopic shift measurements in molecular lattice clocks to constrain these new interactions from new massive scalar particles in the keV/c2 range: The new interaction would impart an extra isotopic shift to molecular levels on top of one predicted by the standard model. For the strontium dimer, a Hz-level agreement between experiment and theory could constrain the coupling of the new particles to hadrons by up to an order of magnitude over the most stringent existing experiments. Published by the American Physical Society 2024

Monophonic rubbling number of some standard graphs

Let G be a connected graph with vertices V and edges E. Rubbling is a recent development in graph theory and combinatorics. In graph rubbling an extra shift is allowed that adds a pebble at a node after the deletion of one pebble each at two neighbouring vertices. For the first time, we introduce the concept of monophonic rubbling numbers into the literature. A monophonic rubbling number, μr(G), is the least number m required to ensure that any vertex is reachable from any pebble placement of m pebbles using a monophonic path by a sequence of rubbling shifts. We calculate the upper bound and lower bound using the monophonic rubbling number of some standard graphs and derived graphs.

A ratiometric fluorescent probe with dual-targeting capability for heat shock imaging

HSO3− is an important reactive sulfur species that maintains the normal physiological activities of living organisms and participates in a variety of redox homeostatic processes. It has been found that changes in HSO3− levels is closely related to the heat stroke phenomenon of the organism. Heat stroke causes damage to normal cells, which in turn causes damage to the body and even death. It is crucial to accurately monitor and track the physiological behavior of HSO3− during heat stroke. Herein, a ratiometric multifunctional fluorescent probe DRM-SO2 with dual-targeting ability to rapidly and precisely recognize HSO3− being constructed based on the FRET mechanism. DRM-SO2 has extra Large Stokes shift (216 nm), very high sensitivity (DL = 12.2 nM), fast response time and good specificity. When DRM-SO2 undergoes Michael addition with HSO3−, the fluorescence emission peak was blue-shifted from 616 nm to 472 nm, and a clear ratiometric signal appeared. The interaction between lysosomes and mitochondria in maintaining cellular homeostasis was investigated by the dual-targeting ability of the probe using HSO3− as a mediator. DRM-SO2 achieved successful targeting and real-time monitoring of exogenous and endogenous HSO3− in the cells. More importantly, imaging experiments in heat stroke mice revealed high HSO3− expression in intestinal tissues. This provides new ideas and research tools for early prevention of heat stroke-induced diseases such as intestinal injuries. In addition, the semi-quantitative monitoring experiments for paper-based visualization of HSO3− make the probe promising for the design of portable detectors.

Wellness 911

Wellness 911

Nonzero Phase Shifts of Acoustic Waves in the Lower Solar Atmosphere Measured from Realistic Simulations and Their Role in Local Helioseismology* *Current Version: 0.00.

Previous studies analyzing the evanescent nature of acoustic waves in the lower solar atmosphere, up to 300 km above the photosphere, have shown an unexpected phase shift of an order of 1 s between different heights. Those studies investigated the spectral line Fe i λ6173.3, commonly used for helioseismic measurements. Such phase shifts can contribute to a misinterpretation of the measured travel times in local helioseismology, complicating inferences of, e.g., the deep meridional flow. In this study, we carry out phase shift computations using a simulated, fully radiative, and convective atmosphere from which the Fe i λ6173.3 line is synthesized. The resulting phase shifts as functions of frequency across multiple heights show nonzero values in evanescent waves, similar to what was found in observational data. Comparing the Doppler velocities estimated from the synthesized absorption line with the true velocities directly obtained from the simulated plasma motions, we find substantial differences in phase shifts between the two. This leads us to hypothesize that the nonadiabaticity of the solar atmosphere yields extra phase shift contributions to Doppler velocities. Finally, computing phase differences for different viewing angles reveals a systematic center-to-limb variation, similar to what is present in observations. Overall, this study helps to improve our understanding of the physical cause of the helioseismic center-to-limb effect.

Improved Triple-Phase-Shift Modulation for Bidirectional CLLC Converters

CLLC resonant converters are an attractive option for battery charging applications due to their bidirectional power flow and high efficiency. Pulse frequency modulation (PFM) is the simple method to drive CLLC converters. However, PFM cannot regulate the output voltage under the light-load condition properly, which leads to high switching and core losses. Phase shift modulation techniques like dual-phase shift (DPS) modulation can overcome this challenge. However, more improvements are demanded due to high circulating currents in phase shift modulations. In this paper, an improved modulation technique based on triple-phase shift (TPS) has been applied in CLLC converters to improve the light-load efficiency. TPS modulation like any other phase-shift modulation, keeps the switching frequency of CLLC converters fixed at the resonant frequency under the light-load condition and regulates the output voltage by its three phase shift parameters. The improved TPS modulation has lower circulating current at the same average output current compared to DPS modulation. Therefore, higher efficiency, smaller peak, and RMS current values can be achieved under the light-load condition. In addition, the proposed TPS modulation has a better flexibility in regulating the output voltage under the light-load condition due to an extra phase shift parameter compared to DPS modulation. The proposed TPS modulation has been analyzed thoroughly in this paper and a proper selection of phase shift values has been explained to improve the efficiency of the converter. Finally, advantages of the improved TPS modulation have been validated by simulation and a 1 kW experimental setup.

Impacts of Liquid Level on Microwave Resonance Sensing with a Flexible Microfluidic Channel

AbstractPermittivity sensing based on resonance tracking lays the fundamental principle for a variety of biochemical sensors, which has found vast applications in cancer biomarker detection, antigen‐antibody analysis, and so on. Driven by continuous promotion of the detection limit, precise environmental control highlights its critical importance. Here, the impacts of liquid level on microwave resonance sensing are investigated, in which a flexible polydimethylsiloxane microfluidic channel and soft tubing are employed to control the liquid under test. The hydraulic pressure affects the effective permittivity of the liquid and the channel material, hence causing extra resonance shift signals. Both contactless and contacting sensing scenarios are studied in numerical simulations and experiments. It is demonstrated that the resonance frequency varies sensitively with the liquid level, and a sensitivity of 343 kHz mm−1 is measured. Meanwhile, a spoof localized surface plasmon resonator and its optimized excitation structure are employed and analyzed for a good figure of merit, addressing the detectability difficulties for high‐permittivity and high‐loss aqueous solutions. These results provide general guidelines for understanding and controlling the resonance sensors in aqueous environments and help to realize further lower detection limits.

Automated phase plate cryo-EM imaging using serialEM

Volta phase plate has shown great promise in single particle cryo-EM and cryo-Electron tomography due to the enhanced contrast introduced by the extra phase shift. It can resolve protein complexes less than 100KD to near-atomic resolution. But the lack of automation has hindered its wider adoption. Here we report a serialEM workflow that can automatically 1) change phase plate location, 2) condition the phase plate, and 3) perform astigmatism correction and coma-free alignment. We have used this workflow to collect a test dataset and achieve high-resolution structure determination.

SG-APSIC1182: Sequential time workforce management

Objectives: Since 2018, the workload in the central sterilization services department (CSSD) has intensified as surgeries have increased. The extended operative time among complicated surgical cases has also led to shortages of resterilized surgical instruments. One factor influencing these shortages was inadequate CSSD staff during high workload periods. We developed a strategy to improve the availability of resterilized instruments. We sought to reduce wasted time and improve effectiveness of surgical instrument preparation by adopting a shift-work arrangement. We additionally sought to minimize unorganized instrumentation and surgical equipment loss. Methods: Team members investigated workload disproportion shift by shift. We devised a practical arrangement of staff for each work shift by dividing manpower in ratios based on workload. Results: The period from 10:00 a.m. to 7:00 p.m. was the period of most intense workload in the CSSD. However, 3 staff worked the morning shift and 2 staff worked the evening shift (4:00 p.m.– 2.00 a.m.). We reassigned 1 person to work from 8.00 a.m. to 4.00 p.m. and 2 persons for an extra shift from 10:30 a.m. to 6:30 p.m. After the manpower readjustment, surgical equipment damage and loss decreased from 57 to 26 losses per year from 2018 to 2021. In addition, work productivity increased from 85% to 115%. Worker satisfaction improved >70%. Conclusions: Internal inconsistency concerning instrumental preparation and improper instrument arrangement can affect surgery time. By addressing workload and shift distribution of labor, productivity notably improved, with higher satisfaction and a dramatic decrease in surgical equipment loss.

Bandgap prediction for a beam containing membrane-arch-mass resonators

This work aims to propose a promising locally resonating system consisting of a tensioned elastic membrane and two-arch masses attached on the membrane surface. Traditional membrane-type resonators, which usually create one obvious attenuation zone at low frequencies, might not be efficient in multi-frequency vibration suppression. The proposed structure can produce an extra clear flexural attenuation region and shift bandgap frequencies below 300 Hz. By adjusting geometric parameters (thickness, width, and location) of the arch mass, the bandgap region can be tuned. Introducing a feasible analytical model for accurately predicting the first and second initial frequencies of the bandgaps for a beam structure containing membrane-arch-mass resonators is another focus of this study. The proposed theoretical framework can be used to tune the bandgap to different target frequency ranges without knowing the actual width of the bandgap. Finite-element analysis and experiments are conducted to verify the theoretical predictions. A good agreement is seen among the theoretical, finite-element analysis, and experimental results. In addition, adjacent cells with different arch-mass distributions can generate two pairs of flexural bandgaps, increasing the practicality in engineering applications. The proposed structure might be used in low-frequency vibration isolation and filters.

Beyond the linear tide: impact of the non-linear tidal response of neutron stars on gravitational waveforms from binary inspirals

ABSTRACT Tidal interactions in coalescing binary neutron stars modify the dynamics of the inspiral and hence imprint a signature on their gravitational wave (GW) signals in the form of an extra phase shift. We need accurate models for the tidal phase shift in order to constrain the supranuclear equation of state from observations. In previous studies, GW waveform models were typically constructed by treating the tide as a linear response to a perturbing tidal field. In this work, we incorporate non-linear corrections due to hydrodynamic three- and four-mode interactions and show how they can improve the accuracy and explanatory power of waveform models. We set up and numerically solve the coupled differential equations for the orbit and the modes and analytically derive solutions of the system’s equilibrium configuration. Our analytical solutions agree well with the numerical ones up to the merger and involve only algebraic relations, allowing for fast phase shift and waveform evaluations for different equations of state over a large parameter space. We find that, at Newtonian order, non-linear fluid effects can enhance the tidal phase shift by $\gtrsim 1\, {\rm radian}$ at a GW frequency of 1000 Hz, corresponding to a $10{{\%}}-20{{\%}}$ correction to the linear theory. The scale of the additional phase shift near the merger is consistent with the difference between numerical relativity and theoretical predictions that account only for the linear tide. Non-linear fluid effects are thus important when interpreting the results of numerical relativity and in the construction of waveform models for current and future GW detectors.

Untwining multiple parameters at the exclusive zero-coincidence points with quantum control

In this paper we address a special case of ‘sloppy’ quantum estimation procedures which happens in the presence of intertwined parameters. A collection of parameters are said to be intertwined when their imprinting on the quantum probe that mediates the estimation procedure, is performed by a set of linearly dependent generators. Under this circumstance the individual values of the parameters can not be recovered unless one tampers with the encoding process itself. An example is presented by studying the estimation of the relative time-delays that accumulate along two parallel optical transmission lines. In this case we show that the parameters can be effectively untwined by inserting a sequence of balanced beam splitters (and eventually adding an extra phase shift on one of the lines) that couples the two lines at regular intervals in a setup that remind us a generalized Hong-Ou-Mandel interferometer. For the case of two time delays we prove that, when the employed probe is the frequency-correlated biphoton state, the untwining occurs in correspondence of exclusive zero-coincidence (EZC) point. Furthermore we show the statistical independence of two time delays and the optimality of the quantum Fisher information at the EZC point. Finally we prove the compatibility of this scheme by checking the weak commutativity condition associated with the symmetric logarithmic derivative operators.

Nurse staffing and inpatient mortality in the English National Health Service: a retrospective longitudinal study

ObjectiveTo examine the impact of nursing team size and composition on inpatient hospital mortality.DesignA retrospective longitudinal study using linked nursing staff rostering and patient data. Multilevel conditional logistic regression models...

Intermediate mass-ratio inspirals with dark matter minispikes

The dark matter (DM) distributed around an intermediate massive black hole (IMBH) forms an overdensity region called DM minispike. We consider the binary system which consists of an IMBH with DM minispike and a small black hole inspiralling around the IMBH in eccentric orbits. The factors which affect the evolution of the orbit include the gravity of the system, the dynamical friction and accretion of the small black hole caused by the DM minispike, and the radiation reaction of gravitational waves (GWs). Using the method of osculating orbit, we find that when the semi-latus rectum $p\ensuremath{\ll}{10}^{5}{R}_{s}$ (${R}_{s}$ is the Schwarzschild radius of the IMBH) the dominated factors are the dynamical friction and accretion from the DM minispike, and the radiation reaction. When $p\ensuremath{\gg}{10}^{5}{R}_{s}$, the gravity from the DM minispike dominates the orbital evolution. The existence of DM minispike leads to the deviation from the Keplerian orbit, such as extra orbital precession, henceforth extra phase shift in the GW waveform. By calculating the signal-to-noise ratio for GWs with and without DM minispikes and the mismatch between them, we show that the effect of the DM minispike in GW waveforms can potentially be detected by future space-based GW detectors such as LISA, Taiji, and Tianqin.

A Planar Bidirectional Circularly Polarized Antenna Using Orthogonal Magnetic Dipoles Without Extra Phase Shift Line

A planar bidirectional circularly polarized (CP) antenna using orthogonal magnetic dipoles (OMDs) without an extra phase shift line is proposed in this work. It consists of a rectangular microstrip magnetic dipole antenna (MMDA) and a loop radiator with two arms directly connected to the open edge of MMDA. The working principle is revealed by the equivalent sources model to provide a clear physical insight at first. The theoretical investigations imply that by controlling the width and the feed locations of the loop antenna on the aperture, the phase and magnitude for CP radiation can be realized in both endfire and backfire directions without introducing an additional phase shift line structure. For demonstration, one antenna prototype is designed and fabricated. The experimental results indicate that an overlapping bandwidth of 5.91% from 2.30 to 2.44 GHz is attained. Compared with the counterpart using OMDs, the proposed antenna exhibits a low design complexity and improved gains of 3.56/1.83 dBic in the endfire/backfire directions.

Unusual behaviour of the spin-phonon coupling in the quasi-one-dimensional antiferromagnet RbCoCl3

We present an experimental and theoretical study for the lattice vibrational (phonon) modes in the quasi-one-dimensional (or chain-like) antiferromagnet RbCoCl3 at low temperatures both above and below the two different magnetic phase transitions. Clear evidence is found for the role of spin-phonon interactions in providing a temperature-dependent contribution for the frequencies of the E1g and E2g symmetry phonons that occur with frequencies comparable to those of the spin wave excitations (magnons) in this compound. The behaviour in RbCoCl3, as studied here by Raman scattering experiments, is quite different from that typically observed in rutile-structure antiferromagnets where the spin-phonon coupling has been well characterized. The theory is modified to take account of the strong Ising-like component in the spin Hamiltonian. This enables the spin-phonon coupling parameters to be deduced, with the analysis also revealing the onset of an extra frequency shift for the phonons below the transition temperature TN1 = 28 K associated with magnetic ordering along the Co chains.

Reinforcing DNA Supramolecular Hydrogel with Polymeric Multiple-Unit Linker

Reinforcing DNA Supramolecular Hydrogel with Polymeric Multiple-Unit Linker

Computational Design of Rhenium(I) Carbonyl Complexes for Anticancer Photodynamic Therapy.

New Re(I) carbonyl complexes are proposed as candidates for photodynamic therapy after investigating the effects of the pyridocarbazole-type ligand conjugation, addition of substituents to this ligand, and replacement of one CO by phosphines in [Re(pyridocarbazole)(CO)3(pyridine)] complexes by means of the density functional theory (DFT) and time-dependent DFT. We have found, first, that increasing the conjugation in the bidentate ligand reduces the highest occupied molecular orbital (HOMO)–lowest unoccupied molecular orbital (LUMO) energy gap of the complex, so its absorption wavelength red-shifts. When the enlargement of this ligand is carried out by merging the electron-withdrawing 1H-pyrrole-2,5-dione heterocycle, it enhances even more the stabilization of the LUMO due to its electron-acceptor character. Second, the analysis of the shape and composition of the orbitals involved in the band of interest indicates which substituents of the bidentate ligand and which positions are optimal for reducing the HOMO–LUMO energy gap. The introduction of electron-withdrawing substituents into the pyridine ring of the pyridocarbazole ligand mainly stabilizes the LUMO, whereas the HOMO energy increases primarily when electron-donating substituents are introduced into its indole moiety. Each type of substituents results in a bathochromic shift of the lowest-lying absorption band, which is even larger if they are combined in the same complex. Finally, the removal of the π-backbonding interaction between Re and the CO trans to the monodentate pyridine when it is replaced by phosphines PMe3, 1,4-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA), and 1,4,7-triaza-9-phosphatricyclo[5.3.2.1]tridecane (CAP) causes another extra bathochromic shift due to the destabilization of the HOMO, which is low with DAPTA, moderate with PMe3, but especially large with CAP. Through the combination of the PMe3 or CAP ligands with adequate electron-withdrawing and/or electron-donating substituents at the pyridocarbazole ligand, we have found several complexes with significant absorption at the therapeutic window. In addition, according to our results on the singlet–triplet energy gap, all of them should be able to produce cytotoxic singlet oxygen.

Passband-Flattened Frequency-Tunable Optical Fiber Multiwavelength Filter with Composite Combination of Waveplates.

We propose a passband-flattened frequency-tunable optical multiwavelength filter with a composite combination of waveplates, which is realized by harnessing a polarization-diversified loop structure. The proposed filter comprises a polarization beam splitter (PBS), two polarization-maintaining fiber (PMF) segments of equal length, an ordered waveplate combination (OWC) of a half-wave plate (HWP) and a quarter-wave plate (QWP) before the first PMF segment, and an OWC of a QWP and an HWP before the second PMF segment. The second PMF segment is butt-coupled to one port of the PBS so that its slow axis is oriented at 22.5° for the horizontal axis of the PBS. Based on the filter transmittance derived through the Jones calculus, we found the orientation angle (OA) sets of the four waveplates, which could induce an extra phase shift Φ from 0° to 360° in the passband-flattened transmittance function. From the transmission spectra calculated at the eight selected OA sets, which caused Φ to increase from 0° to 315° by steps of 45°, it was confirmed that the passband-flattened multiwavelength spectrum can be continuously tuned by properly controlling the OAs. This indicates continuous wavelength tunability based on composite OWCs. Then, this theoretical prediction was verified by experimental demonstration.

Doppler effect in rotating systems and Mössbauer rotor experiments

We address once more the problem of the physical interpretation of the Mössbauer effect in a rotating system in the view of the recently discovered extra energy shift (EES) between emitted and absorbed resonant radiation, which emerges in addition to the usual second order Doppler shift for an orbiting absorber. We highlight that both fractional components of the total energy shift have the same sign and correspond to the blueshift of the resonant radiation propagating from the rotational axis to the rotor rim. We indicate a possible way of understanding the origin of the EES in terms of combining metric effects in rotating systems with the quantum mechanical description of resonant nuclei confined in crystal cells by taking into account the recoil-free essence of the Mössbauer effect, where no energy is transmitted to the source (absorber) during the emission (absorption) of resonant radiation.