Objective: To introduce the Kessler-CBS Process, a detailed item-by-item instruction for reliably administering a validated functional neglect assessment to stroke survivors. Background Spatial neglect is a debilitating post-stroke neurocognitive disorder, associated with longer hospitalization and worse rehabilitation outcomes. However, clinicians have difficulty reliably identifying affected survivors, even when using validated neglect assessment procedures. CBS is the only published tool assessing performance in personal, peri-personal (within arm9s reach) and extra-personal spaces, as well as in both perceptual and motor domains. Our team at the Kessler Foundation Research Center has used the CBS in our rehabilitation research on spatial neglect since 2008. However, we encountered implementation obstacles in reliably administering and scoring this instrument, and thus developed the K-CBS Process to standardize spatial neglect diagnosis and enhance stroke care. Design/Methods: Rehabilitation researchers, physiatrists, and occupational therapists (OTs) drafted a detailed manual for using and scoring the CBS, reviewed videos of the actual CBS administration by OTs, and refined the manual in four iterative cycles over three years. The K-CBS Process constrained key features of examiners9 structured observations. Results: The K-CBS Process uses two forms: Form A contains the table of the scale and instructions for calculating the final score and assigning the severity of spatial neglect; Form B provides item by item instructions for how to make observations. Conclusions: Research confirms the validity and value of the CBS as an outcome measure, and it has the unique attribute of potentially separating function in different brain-behavior networks supporting different spatial processing stages. The Kessler-CBS Process may improve the CBS, making it more reliable for detecting spatial neglect and its functional consequences, and may help clinicians to assign neglect treatments. Routinely identifying post-stroke spatial neglect fulfills national post-stroke rehabilitation guidelines and may enhance the quality of care and improve rehabilitation outcomes for these patients. Supported by: The Kessler Foundation and the NIH/NINDS (K02 NS 047099-05, R01 NS 055808-02, PI: Barrett). Disclosure: Dr. Chen has nothing to disclose. Dr. Hreha has nothing to disclose. Dr. Fortis has nothing to disclose. Dr. Goedert has nothing to disclose. Dr. Barrett has received personal compensation for activities with WebMD. Dr. Barrett has received research support from the Kessler Foundation, NIH, O9Brien Technologies, Pfizer/Eisai, and the Wallerstein Foundation for Geriatric Improvement.