The article is aimed at defining and disclosing the scientific and methodological foundations for implementing the concept of ensuring socio-economic security of enterprises in the context of innovative development. The subject of the research in the article is the scientific and methodological principles of ensuring socio-economic security of enterprises in the context of innovative development. To achieve this goal, the following theoretical methods were used: analysis of the source base, comparison, systematisation and generalisation. The category of innovative enterprise development and socio-economic security has been identified. A number of indicators may be employed to evaluate the extent of social and economic security enjoyed by an enterprise. These may be classified according to their financial, social, innovative, operational or environmental impact. This paper considers the distinctive characteristics and principal consequences of the impact of innovative development on the social and economic security of enterprises. It has been established that the scientific and methodological principles of social and economic security comprise a set of theoretical and practical tools, methods and approaches that facilitate the identification, assessment and management of risks associated with innovative activities. In the context of outlining the scientific and methodological foundations, a number of principles for developing a system of socio-economic security for the enterprise were identified and expanded upon, and a list of scientific approaches for studying and providing socio-economic security for the enterprise was provided. The importance of a systemic approach in ensuring the socio-economic security of the enterprise in the context of its innovative development is demonstrated. It is determined that the methodological principles include the development and implementation of a system of indicators for assessing the level of socio-economic security, analysis of risks associated with innovation activities. The components of methodological support for the system of socio-economic security are proposed: monitoring, evaluation, risk management. The conclusions of the study are that the innovative development of enterprises determines the competitiveness and long-term sustainability of business. The socio-economic security of an enterprise can be defined as a dynamic state of stable functioning and development in the presence of external and internal threats. This encompasses the protection of the enterprise's economic interests, the assurance of financial stability, risk management, the optimisation of resource utilisation and the enhancement of production efficiency. The concept of the relevant scientific and methodological principles can be developed on the basis of the principal approaches to the study of the socio-economic security of the enterprise, as well as the principal principles of its development, which are presented in the article.