External Control Scheme Research Articles

External control of qubit-photon interaction and multi-qubit reset in a dissipative quantum network

A quantum network is a promising quantum many-body system because of its tailored geometry and controllable interaction. Here, we propose an external control scheme for the qubit-photon interaction and multiqubit reset in a dissipative quantum network, which comprises superconducting circuit chains with microwave drives and filter-filter couplings. The traditional multiqubit reset of the quantum network requires physically disconnected qubits to prevent their entanglement. However, we use an original effect of dissipation, i.e., consuming the entanglement generated by qubits’ interaction, to achieve an external control of the multiqubit reset in an always-connected superconducting circuit. The reset time is independent of the number of qubits in the quantum network. Our proposal can tolerate considerable fluctuations in the system parameters and can be applicable to higher-dimensional quantum networks.

Accurate force control and co-manipulation control using hybrid external command

The control of the interaction between a robot and the environment is very important in the medical area. The control of this interaction can be realized with either a force control, which does not need human intervention, or co-manipulation, where the human operator moves the robot himself. This paper focuses on a simple hybrid external control scheme allowing these two applications by modelling the robot as a rigid structure interacting with the environment thanks to a spring representing the force sensor. Simulations were used to test the control system. Several experiments prove the accuracy of the control, for a one degree of freedom robot.

Enzymatic Pyruvate Measurement by Cobas®6000 Open Channel Assay

Blood pyruvate measurement in conjunction with lactic acid is useful for differentiating pyruvate dehydrogenase deficiencies from primary or secondary disorders of mitochondrial electron transport. We evaluated the analytical performance of pyruvate measurement by an enzymatic open channel assay on a Roche Cobas 6000. The assay was linear from 0.07 to 0.50 mmol/L pyruvate. Total imprecision ranged from 15.7% to 7.1% at pyruvate levels of 0.08 to 0.31 mmol/L, respectively. Functional sensitivity was 0.07 mmol/L. The assay showed no interference by lipids or bilirubin, whereas haemolysis influenced pyruvate concentrations in a hemoglobin concentration-independent manner. Method comparison with patient samples (n = 41) showed that the Cobas 6000 enzymatic method correlated well (r2 = 0.930) with a similar enzymatic assay on a Cobas Mira platform and showed better accuracy in external control schemes. Enzymatic pyruvate measurement by a Cobas 6000 open channel shows satisfactory analytical performance. The assay can be integrated in the automated laboratory workflow and is always ready for use thanks to its on-board reagents.

Robust synchronization control scheme of a population of nonlinear stochastic synthetic genetic oscillators under intrinsic and extrinsic molecular noise via quorum sensing

BackgroundCollective rhythms of gene regulatory networks have been a subject of considerable interest for biologists and theoreticians, in particular the synchronization of dynamic cells mediated by intercellular communication. Synchronization of a population of synthetic genetic oscillators is an important design in practical applications, because such a population distributed over different host cells needs to exploit molecular phenomena simultaneously in order to emerge a biological phenomenon. However, this synchronization may be corrupted by intrinsic kinetic parameter fluctuations and extrinsic environmental molecular noise. Therefore, robust synchronization is an important design topic in nonlinear stochastic coupled synthetic genetic oscillators with intrinsic kinetic parameter fluctuations and extrinsic molecular noise.ResultsInitially, the condition for robust synchronization of synthetic genetic oscillators was derived based on Hamilton Jacobi inequality (HJI). We found that if the synchronization robustness can confer enough intrinsic robustness to tolerate intrinsic parameter fluctuation and extrinsic robustness to filter the environmental noise, then robust synchronization of coupled synthetic genetic oscillators is guaranteed. If the synchronization robustness of a population of nonlinear stochastic coupled synthetic genetic oscillators distributed over different host cells could not be maintained, then robust synchronization could be enhanced by external control input through quorum sensing molecules. In order to simplify the analysis and design of robust synchronization of nonlinear stochastic synthetic genetic oscillators, the fuzzy interpolation method was employed to interpolate several local linear stochastic coupled systems to approximate the nonlinear stochastic coupled system so that the HJI-based synchronization design problem could be replaced by a simple linear matrix inequality (LMI)-based design problem, which could be solved with the help of LMI toolbox in MATLAB easily.ConclusionIf the synchronization robustness criterion, i.e. the synchronization robustness ≥ intrinsic robustness + extrinsic robustness, then the stochastic coupled synthetic oscillators can be robustly synchronized in spite of intrinsic parameter fluctuation and extrinsic noise. If the synchronization robustness criterion is violated, external control scheme by adding inducer can be designed to improve synchronization robustness of coupled synthetic genetic oscillators. The investigated robust synchronization criteria and proposed external control method are useful for a population of coupled synthetic networks with emergent synchronization behavior, especially for multi-cellular, engineered networks.

High-throughput liquid–liquid extraction and LCMSMS assay for determination of circulating 25(OH) vitamin D3 and D2 in the routine clinical laboratory

Background Increasing focus on vitamin D as essential to health has underscored the need for accurate and precise high-throughput measurement of serum 25(OH)D. Methods Serum was denatured in acetonitrile containing hexadeuterated 25(OH)D3 as internal standard (IS) and automatically applied to filter plates packed with inert diatomous earth material for subsequent heptane extraction. Extracts were chromatographed on a C12 HPLC column, and detected on a triple quadropole mass spectrometer. Results The inter-assay precision was 9.4% and 8.8% respectively at 32.0 and 59.7 nmol/l for 25(OH)D3 and 8.6% and 8.0% at 23.4 and 64.4 nmol/l for 25(OH)D2. The detection limit was 10 nmol/l for both metabolites. Three percent of samples contained > 50 nmol/l 25(OH)D2. Total run time was 4 min. We have performed more than 200,000 routine samples and the method performs well in external control schemes. Conclusion We describe a robust, high-throughput, LLE-LCMSMS method for accurate and precise quantitation of 25(OH)D3 and 25(OH)D2 in serum. The use of diatomaceous earth material for extraction of vitamin D in 96-well format enables fast, simple and efficient sample preparation. The method offers a cost-effective alternative to immunological methods for use in the routine clinical biochemical laboratory.

Bias correction and yield optimization of MMICs with external digital control

AbstractA new methodology for yield optimization of integrated circuits is presented. We propose a dc external control scheme which performs on‐line estimation of the active device model parameters and proper correction of the bias point. Design of a 2.5 Gbit/s front‐end amplifier has been performed, and a strong yield improvement has been found. © 2001 John Wiley & Sons, Inc. Microwave Opt Technol Lett 31: 134–137, 2001.

External force control of an industrial puma 560 robot

AbstractDeformations occurring in a robot working in contact with a rigid environment is a real problem in the industrial world. This problem can be solved by taking into account forces undergone by the robot at the end‐effector level. The first part of this article is aimed at determining a force control scheme that satisfies this constraint and that can be implemented on a non‐modified industrial robot controller. Various existing force control schemes are investigated and the reasons for discarding them are given. Then, the emphasis is put on a so‐called external force control scheme, which seems to be a solution to our problem. The control law appearing in such a scheme is determined by means of a realistic robot simulator developed on a SUN workstation. A simple integral term on the force error gives acceptable results in various robot configurations. This is illustrated in the form of graphs. In a second part, the implementation of this external control scheme in a real PUMA 560 robot's UNIMATE controller is presented. Certain software issues and implementation solutions are pointed out. Several experiments are described. Once again, graphs are used to show the experimental results. © 1994 John Wiley & Sons, Inc.

5.1 External Analytical Quality Assurance for Proteins

In the Nordic Protein Project an external control scheme (external quality assessment) was combined with the two other indispensable aspects of analytical quality, i.e. standardization (with a common high quality calibrator) and specification of needed analytical quality for sharing common reference intervals for nine serum proteins in the Nordic countries. The quality specifications are reliable for the purpose and given in clinical chemical terms--ready for application to the control systems. Further, a control design for disclosing external and internal errors, separately, is designed with respect to calibration and robustness towards analytical interference from turbid patient samples.