Measurement of the thickness of oxide scales that develop over high-temperature components has found an innovative application in life assessment of steam generation and handling systems. The present study is an investigation of the high-temperature corrosion and scale thickness across the weldments of a “chromium-molybdenum” steel, and reviews its possible relevance to the life assessment of the welded high-temperature components by scale thickness measurement. Results are presented of the recent investigations on the combined roles of the oxidizing environment and secondary carbide precipitation on the extent of void formation in the microstructurally different regions of weldments of the chromium-molybdenum steel. Specimens of the weld metal, heat-affected zone (HAZ), and base metal of a 2.25Cr-1Mo steel weldment were oxidized in steam. Extensive internal oxidation and oxidation-induced void formation (with a much greater intensity in the case of the HAZ) is discussed. The greater intensity of oxidation-induced void formation in the HAZ may facilitate preferential cracking in this region of the weldments and, hence, is proposed to be an important parameter in the context of the recently developed codes for life assessment of aging high-temperature components.