The geologic history of the Western Tianshan region is important for understanding the evolution of the Central Asian Orogenic Belt and accretionary orogenesis. Paleozoic and Mesozoic igneous rocks are present along the northern margin of the Yili Block; however, studies of Paleozoic subduction and collisional events have been relatively limited. Published geochronologies of Middle Devonian magmatic rocks in this region are also lacking. Therefore, this study analyzed the zircon U–Pb ages and major and trace elemental compositions of three granite types collected from Biezhentao Mountain (Wenquan County, Western Tianshan). The medium-grained diorite (384.1 ± 3.6 Ma) and diorite–porphyrite (382 ± 3.2 Ma) are silica-rich, weakly peraluminous, alkali-rich, enriched in large-ion lithophile elements, depleted in high field strength elements, and belong to the calc–alkaline series, with A-type granite characteristics. The monzogranite (423.3 ± 9.4 Ma) exhibits A-type granite characteristics and belongs to the peraluminous calc–alkaline series. The findings suggest that the granitoids recorded two stages of tectonomagmatism during the Middle Devonian–Late Silurian. The Middle Devonian medium-grained diorite and diorite–porphyrite formed in a back-arc extensional setting, whereas the Late Silurian monzogranite formed in an active continental margin setting during the subduction of the North Tianshan Ocean. These results provide insights into the tectonic and magmatic processes that occurred during the evolution of the Western Tianshan region and the formation and evolution of the Central Asian Orogenic Belt.