Single-pilot operations (SPO), i.e., one pilot on board the flight in charge of all the operations, has received extensive attention in recent years. SPO involves several participants including the pilot, the autopilot, and the ground operator, and it is of great significance to determine the roles of these participants under the SPO mechanism. However, the evaluation of SPO mechanism has received little attention. Aiming at providing a reliable approach for SPO mechanism evaluation under uncertainty, this paper proposes a novel hesitant 2-tuple linguistic Pythagorean fuzzy decision-making method based on hesitant fuzzy linguistic term sets (HFLTS), 2-tuple linguistic information, Pythagorean fuzzy sets (PFS), and VIKOR method to handle the SPO mechanism evaluation problem. Firstly, based on the analysis of SPO, the evaluation criteria system for SPO mechanism is established. Then, considering the uncertain information in the SPO mechanism evaluation process, the HFLTS is used to represent the linguistic judgments of experts under uncertainty. Next, the HFLTSs of different experts are converted into 2-tuple linguistic information and PFSs to model the overall judgments of different criteria. Finally, the extended VIKOR method is adopted to evaluate and rank different SPO mechanisms. A case study of SPO mechanism evaluation for the ground proximity warning system (GPWS) is used to demonstrate the effectiveness and feasibility of the proposed method, and the SPO mechanism that the autopilot being responsible for GPWS is evaluated by the proposed method to be optimal. Sensitivity and comparison analyses further confirm that the proposed method could provide reliable and reasonable SPO mechanism evaluation results. In conclusion, the proposed method presents a novel and effective way to evaluate and select appropriate SPO mechanisms.