To boost medication bioavailability, target the stomach mucosa, and lengthen gastric residence time, a multi-unit oral floating drug delivery system was created. Due to their potential to enhance drug delivery, floating tablets have become more significant in pharmaceutical formulation. In the upper GIT, where the environment is acidic, tablets absorbs poorly. The bioavailability shows 50% when administer orally. An H2-receptor antagonist called tablets is frequently prescribed to treat gastrointestinal issues brought on by excess stomach acid. With the right excipients and polymers, floating tablets are meant to float on the contents of stomach Over an extended length of time, extending medication release and bioavailability. This review examines the advantages, disadvantages, and in vitro or in-vivo evaluation of famotidine floating tablets with an emphasis on their potential to improve treatment outcomes and patient compliance.