Nano calcium silicate modified by copper oxide (CSC) has been prepared as a new sorbent material. The prepared nano sorbent was characterized by applied different analytical techniques as FTIR and SEM as well as thermal analysis (TG/DSC). The Adsorption process for cesium and cobalt ions was executed considering notable parameters such as effect of initial pH, impact of shaking time as well as initial concentration of each ion, and finally the effect of temperature. The obtained results have been revealing that the adsorption process of the studied ions was remarkably get better using CSC. The monolayer capacities of CSC for Cs(I) and Co(II) in binary system were 83.67 and 103.18 mg/g respectively. The kinetic studies exposed that the adsorption process followed nonlinear pseudo-first-order model. The isothermal studies show that the extended Langmuir model is more applicable than Freundlich model for binary system adsorption process. The maximum value of desorption for the Co (II) and Cs(I) is 97.5% and 73.5 utilized 0.1 M of nitric acid. This indicated that CSC can be regenerated and reused for further adsorption of Co (II) and Cs(I) from wastewater.