Industries have shown interest in the use of dissimilar metals to make corrosion-resistant materials combined with good mechanical properties in marine environments. Explosive welding can be considered a good method for joining dissimilar materials to prevent galvanic corrosion. The aim of the present study was to simulate the non-linear behaviour of a Ti6Al4V/Inconel 625 welded joint obtained by explosion welding from the values of the tensile ultimate strength and yielding strength of the parent materials. The present study compared the stress-strain curve from tensile loading obtained by the non-linear finite element analysis with the experimental stress-strain curve of a bimetallic joint. The applied method provides useful information for the development of models and the prediction of the structural behaviour of Ti6Al4V/Inconel 625 explosive welded joints.