When is it explanatorily better to adopt a conjunction of explanatory hypotheses as opposed to committing to only some of them? Although conjunctive explanations are inevitably less probable than less committed alternatives, we argue that the answer is not ‘never’. This paper provides an account of the conditions under which explanatory considerations warrant a preference for less probable, conjunctive explanations. After setting out four formal conditions that must be met by such an account, we consider the shortcomings of several approaches. We develop an account that avoids these shortcomings and then defend it by applying it to a well-known example of explanatory reasoning in contemporary science.