Indian Experience Research Articles

Haematopoietic stem-cell transplantation for sickle cell disease in low-income and middle-income countries: the experience in India.

Haematopoietic stem-cell transplantation for sickle cell disease in low-income and middle-income countries: the experience in India.

The Impact of Political Interference on the Judiciary: India Vs. Pakistan

This paper investigates the significant effects of political interference on the judiciary in India and Pakistan, two countries with a common colonial history but differing paths since gaining independence. The judiciary serves as a fundamental pillar of democratic governance, designed to function independently while protecting the rule of law and upholding constitutional rights. Nevertheless, in both nations, political influences have notably affected judicial operations, compromised judicial independence and eroding public confidence. Through a comparative examination, this study highlights important historical moments, landmark rulings, and constitutional frameworks that demonstrate the degree and nature of political interference within both judicial systems. In India, such interference has emerged through executive control over judicial appointments and crises, notably during the Emergency period from 1975 to 1977. In contrast, Pakistan's judiciary has experienced direct meddling from military governments and political authorities, frequently rationalized by the contentious Doctrine of Necessity. Additionally, the paper investigates how the judiciary has responded to these interferences, including instances of judicial activism and civil society initiatives that promote judicial independence, such as the Lawyers' Movement in Pakistan. Ultimately, this research emphasizes the urgent need for strong protections to ensure judicial independence, bolster public trust in the judiciary, and maintain democratic principles in both countries. By highlighting the comparative experiences of India and Pakistan, this study aims to enrich the broader discussion on judicial independence in South Asia.

Outcome of Childhood and Adolescents and Young Adults ALL Treated with ALL IC-BFM 2009 Protocol–A Single-Center Experience in India

Outcome of Childhood and Adolescents and Young Adults ALL Treated with ALL IC-BFM 2009 Protocol–A Single-Center Experience in India

The Evolving Role of Prosecution in Pakistan's Criminal Justice System: A Comparative Analysis with India

The purpose of this research is to investigate the function of prosecution within the framework of Pakistan's criminal justice system as seen through the lens of India. Through the use of historical and doctrinal research methodologies, the examination dives into the development of prosecutorial functions in both nations. Within the scope of this study, a comparison and contrast of the legislative frameworks that control the prosecutorial function is carried out. Particular attention is paid to important aspects such as prosecutorial discretion, pre-trial investigation, and trial advocacy. The purpose of this research is to investigate the ways in which the courts in Pakistan and India have interpreted the powers and restrictions of the prosecutor by analyzing significant cases. This comparative technique allows the investigation to identify both commonalities, which are a result of a shared colonial past, and differences, which are a result of separate legal processes. The research provides an in-depth analysis of the efficiency of the prosecution process in each nation, stressing both the positive and negative aspects of the system as well as prospective areas for improvement. The findings of this study present suggestions for enhancing the prosecutorial position within Pakistan's criminal justice system. These recommendations are derived from the Indian experience, which the research draws upon. One of the goals of this research is to make a contribution to the continuing conversations that are taking place about how to assure a more strong and efficient prosecutorial role, which would eventually result in a criminal justice system in Pakistan that is more effective and just.

Cartridge-Based Nucleic Acid Amplification Test Compared to Fine Needle Aspiration Cytology in Suspected Cases of Tubercular Lymphadenitis (the Indian Experience)

INTRODUCTION: Diagnosis of tubercular lymphadenitis is daunting as there are varied clinical presentations and no single confirmatory gold standard test. Cartridge-based nucleic acid amplification test (CBNAAT) of the lymph node is a rapid molecular diagnostic test for simultaneously detecting tuberculosis (TB) and rifampicin resistance. AIM: To evaluate the performance of the CBNAAT test for detecting M. tuberculosis in lymph node specimens compared to fine needle aspiration cytology (FNAC). MATERIALS AND METHODS: The study was conducted in a rural tertiary care hospital in central India. A total of 180 patients clinically suspected of tubercular lymphadenitis were included. The male-to-female ratio was 1:1.3. The average age was 33.3 years. The age group 21–40 years had the highest number of cases. The most common complaints among the patients were fever (29.4%), followed by loss of appetite (9.5%), weight loss (9.5%), and cough (6.6%). However, most patients presented to the hospital with only lymphadenopathy (44.4%). The most common site involved was the anterior cervical lymph node (78.8%), followed by the axillary group (10.5%), submandibular (2.8%), inguinal (2.8%), supraclavicular (2.2%), submental (1.7%) and infraclavicular (1.1%) group of lymph nodes. The patients were subjected to both FNAC and CBNAAT testing. Results were reported as positive or negative for M. tuberculosis as CBNAAT gives a semiquantitative estimate of the concentration of bacilli. Rifampicin resistance results were reported as detected or not detected. RESULTS: Cytological examination of the lymph node aspirates revealed that most were tubercular lymphadenitis cases. Cytomorphological analysis of the cases of tubercular lymphadenitis revealed Type 6 (tubercular abscess) as the predominant pattern. CBNAAT testing detected 26 cases of M. tuberculosis and three cases of rifampicin resistance. The study reported a specificity of 92.92% and low sensitivity of 26.86% of combined FNAC and CBNAAT is much higher compared to only CBNAAT. CONCLUSION: CBNAAT, along with FNAC, is a valuable addition in first-line investigations of tubercular lymphadenitis to make a timely diagnosis.

Indian Experience with Vericiguat: A Review Based upon Case Series.

Heart failure (HF) is a condition that can result in repeated hospitalizations every year and can result in worsening HF (WHF). Although current pharmacological treatment for HF is fairly effective, there is a need to lower the residual risk of cardiovascular events and hospitalizations. Vericiguat, a soluble guanylate cyclase (sGC) stimulator, a new entrant, seems to present a promising therapeutic option for HF with signs of worsening, and early initiation of this therapy may be beneficial in certain patient profiles. This article explores the potential benefits of early vericiguat initiation in four patient profiles who presented with WHF.

EP.08F.19 Dosimetric Benefits in Adaptive Intensity Modulated Radiotherapy with Sib for Lung Cancer: An Indian Regional Cancer Centers' Early Experience

EP.08F.19 Dosimetric Benefits in Adaptive Intensity Modulated Radiotherapy with Sib for Lung Cancer: An Indian Regional Cancer Centers' Early Experience

DC-CRP: Deep Cerebral Venous Thrombosis, Clinicoradiological Profile, and Treatment Outcome in Indian Population-A Tertiary Care Experience.

Deep cerebral venous thrombosis (DCVT) is an uncommon cause of stroke with diverse predisposing factors, clinical presentations, imaging findings, and functional outcomes, which makes the diagnosis of DCVT even more challenging. Retrospective observational study (December 2018 to January 2023). Cases with imaging data suggestive of DCVT were included. The neuroradiological assessment was performed using multimodality imaging to determine the location of parenchymal changes and the number of deep veins involved in isolation or with the superficial dural venous system. Clinical variables were tabulated. Of the 206 cases with CVT in the study period, 27 had DCVT (13.1%), of which four (14.8%) had isolated DCVT (male-to-female ratio 13:14; mean age = 33.4 years). Hyperhomocysteinemia (n = 11) is the most common risk factor associated with it. The most common presentations were headaches (n = 27) and focal motor deficits (n = 13). Raised intracranial tension (ICT) was present in almost half of the study population (n = 14). Mean and median modified Rankins score (mRS) at the time of discharge were 2.0 and 1, respectively. The most common deep vein involved was the straight sinus (SS) (n = 25), followed by the internal cerebral vein (n = 23). The mean and median mRS after 3 months from discharge were 0.3 and 0, respectively. A knowledge of diverse clinical presentations in DCVT, its neurovascular anatomy, and imaging characteristics with prompt diagnosis and timely interventions can assist in attenuating the risk of acute complications and long-term sequelae. Extensive deep grey matter involvement in DCVT is associated with neurological manifestations like altered sensorium and motor deficits, with increased severity of illness as measured by the mRS score.

Bargaining Freedoms: How Women in Urban India Experience a Sense of Agency

Bargaining Freedoms: How Women in Urban India Experience a Sense of Agency

The Archaeology of Absence in Kamila Shamsie’s <i>A God in Every Stone</i>

Approximately 1.4 million Indians were recruited to the First World War. Despite their role in the war and the high number of deaths, most of the literature in English on the Great War has been narrowed down to British experience. However, in recent years their stories have been emerging through fiction, in academic research and educational projects resulting in a more complete picture of the war and who was involved. A British arts education group engaged students in a project designed to teach and share the stories of forgotten soldiers from World War I. Writing about the project in The Guardian in 2018 Kamila Shamsie claimed the aim was to teach school children about the war and the involvement of non-British recruits whose narratives had up till then been unknown. In academia, respected scholars such as Santanu Das or Claire Buck have undergone thorough research on the representation of Indian recruits through an analysis of literary texts and artefacts states that war memories of the Indian sepoy whose stories were left behind and forgotten on the battle ground. According to Das, the lack of stories by Indian recruits does not mean that history cannot be rectified since it is possible to recover the experience and memory of the recruits. Recently emerging literary representation of the Indian recruit provided historical insight into their experience shedding light on new perspectives of the War. The aim of this article is to analyse the representation of Indian recruits and their experience of World War I in Kamila Shamsie’s 2014 novel <i>A God in Every Stone.</i> I argue that through fiction, it is possible to construct a broader and more inclusive understanding of this historical event as well as to uncover deeper complexities and anxieties on the Indian colonial experience.

Reforming the Judiciary: Lessons from the Indian Experience

Reforming the Judiciary: Lessons from the Indian Experience

P.426: Exploring complexities of consent in deceased organ donation - insights from a public sector institutional experience in India.

P.426: Exploring complexities of consent in deceased organ donation - insights from a public sector institutional experience in India.

A Retrospective Analysis of Short-Term Outcomes of Robotic and Laparoscopic Cholecystectomy: An Indian Tertiary Care Comparative Experience.

Background There has been a gradual adoption of general surgery robotic programs in India. However, we still do not have a single comparative study reporting the initial experience of robotic cholecystectomy (RC) compared to laparoscopic cholecystectomy (LC). This retrospective study is aimed at addressing this clinical data gap. Methods This is a retrospective medical chart review where data related to patient demographics, and intraoperative and postoperative outcomes were collected. All patients underwent either RC or LC for gallstone disease, performed by a single surgeon from January 2020 to September 2023. The surgeon had passed the learning curve for RC and this data collection reflects his post-learning curve experience. Results A total of 100 cases (RC: 50; LC: 50) were collected. Baseline parameters such as age, sex, BMI, and comorbidities were comparable. There were no conversions from the planned procedure in either of the groups (0% vs 0%). There were no intraoperative complications such as bleeding or common bile duct injury (0% vs 0%). The rates of surgical site infections (SSIs) were numerically lower in the robotic group, 2% vs 6% (p = 0.3099). There were no postoperative complications in the robotic group, whereas one patient in the laparoscopic group experienced port side bleeding (0% vs 2%, p = 0.3173). The mean length of hospital stay was one day in both groups. The mean pain score 24- hours after the surgery was 1.78 ± 0.68 in the robotic group and 3.3 ± 1.2 in the laparoscopic group (p = <0.001). None of the patients required opioid analgesics in the robotic group, whereas 20% of patients in the laparoscopic group needed at least one dose of opioid analgesics (p = 0.0009). There were no reoperations reported in the robotic group, whereas the laparoscopic group reported 1 case. The 30-day mortality was nil in both groups. Conclusion RC is feasible in Indian settings. Compared to LC, it does not increase morbidity. The improvement in acute postoperative pain can potentially allow early ambulation and recovery. A larger multicentric study, comparing RC to LC in India will validate our initial experience.

Outcomes of mitral transcatheter edge to edge repair with MitraClip™ – An Indian single center experience

ObjectiveTo evaluate the outcomes of transcatheter edge-to-edge repair (TEER) with MitraClip™ (Abbott Vascular) in symptomatic high surgical risk Indian patients with significant mitral regurgitation (MR). MethodsPatients with moderately severe or severe primary or secondary MR and deemed high surgical risk were treated with MitraClip™. The data were collected retrospectively from medical records. The primary outcome was technical success, and secondary outcomes were ≤2+ MR reduction and improvement in functional capacity at 30 days. ResultsBetween November 2018 and August 2023, 64 patients were treated with MitraClipTM. The mean age was 70.0 ± 12.1 years and 64 % were males. The mean EuroScore II and STS score predicted mortality for mitral valve repair were 5.8 ± 4.5 % and 4.0 ± 3.8 % respectively. MR etiology was primary in 56.3 %, secondary in 40.6 % and mixed in 3.1 %. The device was implanted successfully in all but one patient with technical success rate of 98.4 %. The average number of clips per patient was 1.5 ± 0.6 and 42.2 % patients received more than one clip. The mean mitral valve gradient was 3.5 ± 1.6 mmHg. The MR severity of ≤2+ was achieved in 91.8 % of the subjects and similar proportion were in New York Heart Association Functional Class I or II at 30 days. ConclusionIn high-risk Indian patients with symptomatic significant MR, TEER with MitraClip™ was achieved with a high technical success rate. It was associated with significant reduction in MR severity and improvement in functional capacity in >90 % of the subjects.

405.1: A multicenter retrospective cohort study of Indian experience with the kidney paired donation transplantation.

405.1: A multicenter retrospective cohort study of Indian experience with the kidney paired donation transplantation.

Hospital Acquired Infections, A Public Health Concern: Management Solutions from an Indian Experience

Hospital Acquired Infections, A Public Health Concern: Management Solutions from an Indian Experience

Observational Study with a New Portable Cryosurgery Device, HYDROZID®, in Superficial Epidermal Lesions: An Indian Experience

Abstract Background: Cryosurgery remains an important treatment modality in dermatology practice. HYDROZID®, a new portable cryosurgery medical device using norflurane as a cryogen, was recently introduced in the Indian market. This paper reports the findings of the phase IV study conducted in India. Aims: This is a prospective phase IV study to evaluate its safety and efficacy in the treatment of superficial epidermal and dermal lesions. Methods: The study was conducted across 4 centres in India. The cryosurgery cycles were decided based on the skin lesion considered for the treatment. Safety and efficacy parameters were assessed at day 1, day 7, day 14, day 30 (±2) (end of treatment), and day 60 (±2) after the initial cryosurgery treatment. The local skin reactions scale, pain VAS scale, and Vancouver scale for assessment of pigmentation and scarring were used for the assessment of cutaneous reactions. Assessment of efficacy was done by evaluating the total disappearance of skin lesions at the end of the study visit. Results: Ninety-seven patients completed the study. The reported post-procedural pain was mild to moderate and subsided over the period of 24 hours. There was no pain observed in 84.76% of patients at the end of 24 hours. Complete disappearance of the lesion was seen in 47.4% of patients at the end of the study, while the reduction in the diameter of skin lesions by more than 50% was observed in 79.38% of patients. Conclusion: The data from this study support good clinical tolerability and safety of the Hydrozid® portable cryo device.

Religious origins of nationalist movements: The experience of India and the Sudan

AbstractNationalism in Asia and Africa is generally understood as a modern secular movement for independence. However, this idea is contestable. Analysing nationalism in India and the Sudan, this paper argues that nationalist movements there actually had their origins in Islamic religious resistance against the British colonial rule preceding the development of secular nationalism. Depending on political development following the colonial advancement, the secular elite‐led nationalism also largely fostered religious communal nationalism in India and the Sudan. This substantiates the argument that religion never ceased to play the most central role in the nationalist movements in India and the Sudan. Following an inter‐continental approach to study nationalism, this article explores exclusively the connection between religion and the first ever generic nationalist movements in the context of colonialism in India and the Sudan.

DO DIGITAL PAYMENTS SPUR GST REVENUE: INDIAN EXPERIENCE

DO DIGITAL PAYMENTS SPUR GST REVENUE: INDIAN EXPERIENCE

‘The Food Must Reach the Hungry’: Lessons from Judicial Enforcement of Right to Food in India

Abstract Food security and securing right to food for all is one of the essential mandate for a welfare State especially for achieving aspiring targets of Sustainable Development Goals 2030. Judicialisation of right to food is a substantial way through which right to food can be protected and implemented at domestic level. The Indian experience of right to food adjudication depicts that the Supreme Court has carved out an expansive role for itself through judicial activism to secure the fundamental rights of the citizens. The PUCL case, popularly called as right to food case has set off a cascade of judicial action and made India a model showing how courts can effectively implement socio-economic rights through judicial intervention. This model of adjudicatory leadership by the constitutional courts shows a remedy-oriented approach which have overcome the normative concerns of democratic legitimacy and polycentricity. Courts have strengthened the institutional legitimacy through participatory democracy with citizens and adjudicated multifaceted policy concerns. The author put forth the emergence of ‘triad model’ of adjudication where interaction of courts, local bodies and citizens makes enforcement of the right more practicable. The article concludes that Courts can be a catalyst for transforming public policy implementation by securing basic right to the citizens through innovative remedies.