Traditional Chinese Medicine Experience Research Articles

Research progress on mechanism of traditional Chinese medicine intervention in angiogenesis in prevention and treatment of nontraumatic avascular necrosis of femoral head

Nontraumatic avascular necrosis of the femoral head(NANFH) is a common and refractory femoral head disease that causes bone death due to interruption of blood supply. Early clinical symptoms are atypical, such as hip pain and limited joint function. In the late stage, severe pain, shortening of the affected limb, claudication, and other serious symptoms are common, which se-riously affects the quality of life of patients. Therefore, it is of great significance to actively improve the clinical symptoms of NANFH to enhance the quality of life of patients. The pathogenesis of NANFH is complex, such as traumatic vascular circulatory disorders, the use of hormones or other drugs, alcoholism, and diabetes mellitus. These factors directly or indirectly lead to femoral head vascular damage, thrombosis, and coagulation system disorders, which reduce the blood supply to the acetabulum and femoral head, thus causing ischaemic death of the femoral head or even femoral head collapse. NANFH is mainly categorized as "bone impotence" and "bone paralysis" in traditional Chinese medicine(TCM). The treatment of NANFH with TCM has the characteristics and advantages of a long history, stable and reliable therapeutic effect, fewer adverse reactions, good patient tolerance, and high acceptance. Previous studies have shown that the promotion of angiogenesis is a key initiative in the prevention and treatment of NANFH, and TCM can promote fe-moral head angiogenesis by interfering with the expression of angiogenesis-related factors, which in turn can help to restore the blood supply of the femoral head and thus improve clinical symptoms of NANFH and prevent and treat NANFH. This article described the roles of blood supply interruption and angiogenesis in NANFH and the accumulated knowledge and experience of TCM in NANFH and summarized the role of angiogenesis-related factors in NANFH and the research progress on TCM intervention, so as to provide an idea for the subsequent research and a new basis for the clinical application of TCM in the treatment of NANFH.

Quality requirements of human use experience research on traditional Chinese medicine

The human use experience of traditional Chinese medicine(TCM) is of great significance for the development of new traditional Chinese medicine. In 2023, the National Medical Products Administration(NMPA) issued the Special Regulations on Registration Management of Traditional Chinese Medicine, which explicitly encouraged the conduct of high-quality human use experience research on TCM clinical practice to obtain sufficient evidence for registration support. It also required that human use experience research should comply with relevant requirements and undergo registration verification. The quality of human use experience research on TCM directly determines the reliability of the evidence. This article discussed the quality requirements for human use experience research on TCM from the perspectives of basic requirements, organizational management, key pharmaceutical information, scientific research, risk management, ethical compliance, and study implementation and proposed differential treatment in quality requirements and registration verification focus based on different research purposes, stages, and types of studies. While ensuring the authenticity of data, retrospective studies should pay particular attention to the integrity of the data, and prospective studies should focus on the normativity of the data, which may affect the research conclusions. Human use experience research, as part of drug registration materials, falls within the scope of relevant regulatory oversight. Researchers should have a strong awareness of regulations to avoid serious quality issues. The standardized conduct of human use experience research on TCM requires joint efforts from regulatory authorities, applicants, research institutions, and researchers to establish a research quality management system based on the clinical characteristics of TCM.

Analysis of Medication Law in Treatment of Chronic Atrophic Gastritis Based on TCM Inheritance Auxiliary System

Object: The use of traditional Ghinese Medicine Inheritance assistance system (TMC) for the treatment of chronic atrophic gastritis prescription and the rule of compatibility. Methods: Computer - based Retrieval of Chinese journal full-text database (CNKI) for the treatment of chronic atrophic gastritis related literature, search time limit: 2008-2018. In order to explore the combination of high frequency drug pairs and new prescriptions, the database was established with the aid of traditional Chinese medicine inheritance system. The purpose of this paper was to demonstrate the clinical experience of traditional Chinese medicine in the past ten years, and to find a new breakthrough for the treatment of CAG in traditional Chinese medicine. Result: After screening 223 prescriptions that met the inclusion criteria, including 217 herbs of traditional Chinese medicine, the statistical results show that in the treatment of CAG, the main medicine is invigorating qi and invigorating spleen and Codonopsis and Atractylodes macrocephala are the most common. Combined rule analysis showed that Atractylodes macrocephala had the most association with other drugs. The six new formulas are summarized again. Conclusion: Through the data mining statistical analysis, the prescription of treating CAG included in the selected database is mainly invigorating spleen and stomach, regulating qi, warming and tonifying deficiency, activating blood circulation, nourishing yin and nourishing stomach, clearing heat and dispelling dampness and so on. It has developed a new way of thinking for the clinical treatment of CAG in traditional Chinese medicine.

Machine Learning-Based Technique for the Severity Classification of Sublingual Varices according to Traditional Chinese Medicine.

Tongue diagnosis, a noninvasive examination, is an essential step for syndrome differentiation and treatment in traditional Chinese medicine (TCM). Sublingual vein (SV) is examined to determine the presence of blood stasis and blood stasis syndrome. Many studies have shown that the degree of SV stasis positively correlates with disease severity. However, the diagnoses of SV examination are often subjective because they are influenced by factors such as physicians' experience and color perception, resulting in different interpretations. Therefore, objective and scientific diagnostic approaches are required to determine the severity of sublingual varices. This study aims at developing a computer-assisted system based on machine learning (ML) techniques for diagnosing the severity of sublingual varicose veins. We conducted a comparative study of the performance of several supervised ML models, including the support vendor machine, K-neighbor, decision tree, linear regression, and Ridge classifier and their variants. The main task was to differentiate sublingual varices into mild and severe by using images of patients' SVs. To improve diagnostic accuracy and to accelerate the training process, we proposed using two model reduction techniques, namely, the principal component analysis in conjunction with the slice inverse regression and the convolution neural network (CNN), to extract valuable features during the preprocessing of data. Our results showed that these two extraction methods can reduce the training time for the ML methods, and the Ridge-CNN method can achieve an accuracy rate as high as 87.5%, which is similar to that of experienced TCM physicians. This computer-aided tool can be used for reference clinical diagnosis. Furthermore, it can be employed by junior physicians to learn and to use in clinical settings.

Practical experience of Traditional Chinese Medicine nursing clinical teaching path in teaching of breast care nursing students

Practical experience of Traditional Chinese Medicine nursing clinical teaching path in teaching of breast care nursing students

Rituals in Traditional Chinese Medicine: Taking a Case of Infertility as an Example

Ritual is one of the most classic research topics in the field of Anthropology, and rituals have close connection with medial practice. However, the research on this topic from the experience of Traditional Chinese Medicine is limited. This paper presents the whole story that a patient suffering from infertility got cured got cured by a doctor of Traditional Chinese Medicine(TCM) and finally became a mother. With the detailed description of each medical practice, including pulse-taking, traditional Chinese herb therapy, and postpartum confinement, this paper analyzes the ritualized elements in the whole process, interprets how ritual play a role in the practice of TCM, and points out ritual’s essential significance in contributing to human’s well being and adjusting the relationships between individual and the world.

Progress in Traditional Chinese Medicine Syndrome Differentiation and Treatment of Premature Ovarian Failure

Premature ovarian failure has directly or indirectly caused unspeakable physical and mental suffering to many women because of its increasing incidence. People of all ethnic groups in the world are actively seeking the best method, but the results are only basically satisfactory. As far as treatment is concerned, Chinese and Western medical treatments have their own advantages and disadvantages. However, because of the variety of syndrome types in traditional Chinese medicine, there are many descriptions of a single disease syndrome, and there are few systematic generalizations and classifications. Therefore, the experience of traditional chinese medicine in the treatment of premature ovarian failure in recent 10 years is classified and summarized. Traditional chinese medicine believes that the root cause of premature ovarian failure is the disorder of viscera, and the pathological sign is phlegm dampness and blood stasis. Therefore, the treatment should be based on kidney, syndrome differentiation and treatment of multiple viscera, taking into account phlegm dampness and blood stasis, combined with periodic therapy and acupuncture treatment, striving to nourish the kidney, regulate the heart, liver, spleen and lungs, and smooth phlegm dampness and blood stasis, so as to achieve the effect of prevention and treatment.

Experience of traditional Chinese medicine nursing staff from Beijing assisting Hubei in the treatment of patients with COVID-19: a qualitative study

Background: Through in-depth interviews, to understand the treatment experience of traditional Chinese medicine (TCM) nursing staff from Beijing assisting Hubei in the fight against coronavirus disease 2019 (COVID-19) by applying TCM characteristic nursing, so as to provide basis for formulating more perfect nursing countermeasures for similar emerging infectious diseases in the future.

Application of real world study and human use experience in research and development of new traditional Chinese medicine drugs

Real world study(RWS) refers to the process of collecting real world data related to the health of research subjects in the real world environment for pre-set clinical problems and obtaining the status of drug use and potential benefits/risks through analysis. The data are derived from the hospital information system(HIS), medical insurance system, disease registration system, adverse drug reaction monitoring system, etc. Human use experience of traditional Chinese medicine(TCM) is a new concept put forward by experts after summarizing the problems existing in clinical trials of new TCM drugs. The data come partially from the real world, and more importantly, such key elements as the formulated prescriptions of new TCM drugs, principles and methods, and clinical applications should be covered. RWS is mainly used for adverse drug reaction monitoring after marketing, benefit evaluation of listed drugs, decision-making of medical treatment and medical insurance, as well as supervision and approval of special medical devices and special drugs. It is complementary to randomized controlled clinical trials. Human use experience is suitable for the research and development of Chinese medicinal compound preparations and the expansion of functions and indications. There are no special provisions for clinical indications and target population. There exists a sequential relationship between the human use experience and clinical trials. Specifi-cally, the summarization of human use experience provides good support for the design and implementation of clinical trials, which is an important segment in the research and development of new TCM drugs. The correlation between real-world data and research results and their reliability should be ensured in RWS, and the unreality should be avoided. The key to summarizing the human use experience is to identify the clinical orientation, target population, course of treatment, usage and dosage of new TCM drugs, and it should be noted that human use experience does not only mean clinical experience. Experimental clinical trial(PCT), a type of study in the real world, has been commonly employed for the summary of human use experience. RWS and human use experience are different research designs targeting different clinical questions in the research and development of new TCM drugs, which can be flexibly selected depending on the actual situation.

Typical experience of traditional Chinese medicine participating in the prevention and control of coronavirus disease 2019 in Tianjin

Typical experience of traditional Chinese medicine participating in the prevention and control of coronavirus disease 2019 in Tianjin

Professor Xiaoquan Du’s Seven Methods of Treating Stomachache

Stomachache is the main symptom of stomach duct pain near the heart. Professor Xiaoquan Du is experienced in treating spleen and stomach diseases with traditional Chinese medicine (TCM) syndrome differentiation. He has vast practical TCM experience through years of clinical diagnosis and treatment, and incorporated his own characteristic methods in treatments, thereby developing seven methods for the treatment of stomachache. Clinically, methods such as “invigorating the spleen and benefiting the stomach” and “warming the middle and dispersing cold” are mostly adopted to treat stomach duct pain.

Analysis of the hotspots and trends in traditional Chinese medicine immunomodulation research based on bibliometrics

ObjectiveTo analyze the intellectual structure, hotspots and trends of traditional Chinese medicine (TCM) in immune regulation research. MethodsThe data were extracted from the Web of Science Core Collection (WoSCC) and the China National Knowledge Infrastructure (CNKI) and verified by two experienced TCM researchers. The time of literature retrieval is up to 2020. CiteSpace 5.7.R1 and Microsoft Excel 2016 were used for the statistical analysis and bibliometric diagrams, including the co-occurrence network of authors, institutions, countries, keywords, references, dual-map overlays of journals and citation bursts, etc. ResultsA total of 12 270 publications related to TCM in immune regulation were included. The annual number of publications has increased in this field. There was close cooperation of countries and institutions, while the distribution of scholars was scattered. China was the core of the cooperation network. The dual-map overlays analysis of journals showed that core and marginal fields had increased. The keywords and references analysis showed that network pharmacology, metabolism and cancer were the most high-frequency keywords with high-intensity bursts. ConclusionTCM in immune regulation has attracted wider attention, with multi-country, multi-field, multi-disciplinary and multi-level research developing toward informatization. Network pharmacology, metabolism and cancer may be the focus of future research in this field.

A Brief Reading of the Republic of China Era Journal "Chinese Medicine Pillar Monthly"

As one of the many traditional Chinese medicine journals in the Republic of China (ROC) era, the journal "Chinese Medicine Pillar Monthly" had been published for 11 consecutive years. It has rich content and covers a wide range of topics. It has important reference value for studying the direction of cultural development, political dynamics, and development trends of Chinese and Western medicine during the ROC era, and the journal was intended to spread the classics and clinical experience of traditional Chinese medicine, making it a medical treasure house. This paper mainly introduces the current status of the journal, the date of its inception, and its main content, features and contributions.

Data collection, quality and evidence formation for human use experience of traditional Chinese medicine

Collecting and summarizing human use experience(HUE) data, forming high-quality data and evidences that can be used for evaluation are the key links of HUE research on traditional Chinese medicine(TCM). The collection, collation and summary of human experience data were discussed in this paper. It is pointed out that the collection of HUE should be focus on the source of prescription of new traditional Chinese medicines, and be summarized based on dialectical thinking, experience in medication, characte-ristics of prescription and clinical application. The collected contents include prescription, process, clinical location and applicable population, efficacy data and safety data, etc. The methods include interview, clinical data summary and data mining. When the data formed based on HUE information is used as drug registration information, it is necessary to ensure that the data source is legal and compliant, and the ownership of intellectual property is clear.Data sources should meet the requirements of medical ethics. To avoid conflict of interest, data analysis should be conducted by an independent third party. It is necessary to develop the quality control measures of HUE data to ensure the data traceability, integrity, consistency and accuracy, and avoid data bias.The data of HUE should include the key data such as accurate clinical location and applicable population, recognized clinical efficacy and safety.After the formation of HUE, the statistical analysis plan of empirical data of human use should be formulated. Through strict data processing, statistical analysis and clinical interpretation, HUE can be produced for evaluation.

Retrospective Review of Traditional Chinese Medicine Treatment of COVID-19 in China: Clinical Practice and Researches

In the fight against COVID-19 in China, traditional Chinese medicine (TCM) has played an important role in relieving symptoms, preventing deterioration, improving cure rate, reducing death rate, and promoting recovery. Since the third edition of the Diagnosis and Treatment Protocol for COVID-19 (simply referred to as the National Protocol), TCM has been included in the national guidance to tackle the epidemic. In order to make the international medical community fully understand the experience of TCM in the prevention and treatment of COVID-19, we comprehensively reviewed the history, etiology and pathogenesis, prevention and treatment, rehabilitation, and clinical and pharmacological research of TCM used in the endemic. The COVID-19 is under the category of plague or pestilence in TCM. Herbal medicine treatment for COVID-19 is mainly performed based on the syndrome differentiation of three stages and four types. The method also applies to acupuncture and moxibustion treatments. Herbal medicine granules and injections are used flexibly, and Western medicine is adopted to rescue patients in critical conditions. In rehabilitation, the integration of Chinese and Western medicine can be used to improve the respiratory and somatic function of patients. The role TCM has been playing in fighting this epidemic is a further proof of the effect of TCM in preventing and treating infectious diseases, and the relevant experience has been summarized and sublimated.

Tetrahydropalmatine triggers angiogenesis via regulation of arginine biosynthesis

Over a short span of two decades, the central role of angiogenesis in the treatment of wound healing, diverse cancers, nerve defect, vascular injury and several ophthalmic diseases has become evident. Tetrahydropalmatine, as the index component of Corydalis yanhusuo W. T. Wang, is inseparable from protecting cardiovascular system, yet its role in angiogenesis has been poorly characterized. We have demonstrated the binding potential of THP and VEGFR2 using molecular docking based on the clinical experience of traditional Chinese medicine in the pretest study. Here, we identified tetrahydropalmatine (THP) as one proangiogenic trigger via regulation of arginine biosynthesis by pharmacological assays and DESI-MSI/GC–MS based metabolomics. First, the proangiogenic effects of THP were evaluated by quail chorioallantoic membrane test in vivo and multiple models of endothelial cells in vitro. According to virtual screening, the main mechanisms of THP (2/5 of the top terms with smaller p-value) were metabolic pathways. Hence, metabolomics was applied for the main mechanisms of THP and results showed the considerable metabolite difference in arginine biosynthesis (p < 0.05) altered by THP. Finally, correlated indicators were deteced using targeted metabolomics and pharmacological assays for validation, and results suggested the efficacy of THP on citrulline to arginine flux, arginine biosynthesis, and endothelial VEGFR2 expression sequentially, leading to the promotion of angiogenesis. Overall, this manuscript identified THP as the proangiogenic trigger with the potential to develop as pharmacological agents for unmet clinical needs.

Rapid establishment of traditional Chinese medicine prevention and treatment of 2019-nCoV based on clinical experience and molecular docking

The coronavirus disease 2019(COVID-19) is raging in China and more than 20 other countries and regions since the middle of December 2019. Currently, there is no specific drug or vaccine besides symptomatic supportive therapy. Taking full advantage of the clinical experience of traditional Chinese medicine(TCM) in preventing and controlling major epidemics such as SARS, it is an important mission for TCM to propose effective formula with immediate response and solid evidence by using modern biomedical knowledge and techniques(molecular docking assisted TCM formulation for short). In view of the high homology between the gene sequences of the novel coronavirus and SARS virus, and the similarities between the two in terms of pathogenic mechanism and clinical manifestations, our team established a rapid screening and optimization model for the prevention and treatment of the novel coronavirus based on clinical experience and molecular docking technology. Firstly, the clinical team and the research team pre-developed and screened TCM formula by using &quot;back-to-back&quot; manner. Then, the formula was optimized and determined by comparing and analyzing the results of the two groups. The results showed that the research team screened out 46 active ingredients from candidate TCMs that could act on the novel coronavirus S-protein-binding site of human ACE2 protein, which were mainly attributed to 7 herbs such as Lonicerae Japonicae Flos and Mori Folium. The result was largely consistent with the formula raised by the clinical group, verifying and supporting its rationality. This provides evidence for the scientific and potential efficacy of the TCM prescription from the perspective of treatment target analysis, and also suggests that the TCM prescription has the potential to directly inhibit viral infection in addition to improving clinical symptoms or syndromes. Based on this, our team optimized and formed a new anti-coronavirus TCM prescription &quot;Keguan Yihao&quot;, immediately providing the TCM prescription with certain clinical experience and objective evidence support for the prevention and treatment of new emergent infectious diseases in our hospital. The TCM prescription was combined with modern medicine symptomatic supportive treatment for clinical treatment, preliminary results showed better effect than symptomatic supportive therapy alone. This research has innovated the method mode in clinical practice and basic research integration of traditional Chinese medicine for the prevention and control of new emerging infectious diseases. It is of great significance to further improve the rapid response mechanism of TCM in face of major epidemics, and further improve the capability level of TCM to prevent and treat new emerging infectious diseases.

Clinical Experience of Traditional Chinese Medicine in the Treatment of Chronic Renal Failure

Clinical Experience of Traditional Chinese Medicine in the Treatment of Chronic Renal Failure

Drug syndrome of ephedra based on its property and pharmacology

Ephedra is a classic herb in traditional Chinese medicine( TCM). The new effects of ephedra were gradually found,and the contraindications of the drug were broken in later ages. Because the principles of expanded application were not well elucidated,it is difficult to use in the clinical flexibility. Based on the characteristics of ephedra and its classic clinical application,the authors summarized the possible principles of clinical application of ephedra and the drug property and pharmacological characteristics of ephedra.Studies showed that ephedrine substances are an important material basis for the efficacy of ephedra,and its adrenergic action is the pharmacological basis of its efficacy. It is the key to grasp the autonomic function and the interaction between sympathetic/adrenal medulla and adrenal cortex for the clinical application of ephedra. The authors discussed the principles of clinical application of ephedra and the effects of processing of ephedra. Finally,the authors put forward the basic research process of clinical application of drugs,and provide ideas for the inheritance and further development of TCM experience.

Discussion on TCM nursing for patients with diabetic nephropathy

This manuscript aims to study the main points of Chinese medicine nursing and its precautions for patients with diabetic nephropathy, and to better guide the clinical nursing work of TCM.To summarize the experience of traditional Chinese medicine clinical nursing work for patients with diabetic nephropathy in our department, and to explore effective methods of traditional Chinese medicine nursing to standardize the traditional Chinese medicine nursing work for diabetic nephropathy. Key words: Diabetic nephropathy; Medicine, Chinese traditional; Nursing care; Benchmarking; Discussion