Many decision problems in modern industries involve the performance optimization of discrete-event dynamic systems. Because of the stochasticity of these systems, performance usually is evaluated through simulation. Finding the optimal designs of these systems can be modeled as a ranking and selection problem. This research considers the problem of selecting the best design from among numerous designs. We minimized the expected opportunity cost (EOC) of incorrect selection with a limited computing budget. The entire domain of designs could be divided into several adjacent partitions, and the performances of designs in each partition were estimated using a regression metamodel. We assumed the underlying function in each partition to be quadratic. Using large deviations theory, we then derived an asymptotically optimal budget allocation rule and developed a sequential allocation algorithm to implement the allocation rule. The EOC measure was compared with the probability of correct selection measure in a set of large-scale simulation optimization problems. Numerical experiments verified the effectiveness of our proposed simulation procedure.