The global transition to renewables in response to climate change has largely been supported by the expansion of wind power capacity and improvements in turbine technology. This is being made possible mainly due to improvements in the design of highly efficient turbines exceeding a 10 MW rated power. Apart from power efficiency, wind turbines must withstand the mechanical stress caused by wind–hydro conditions. Such comprehensive structural analysis has rarely been performed previously, especially for large-scale wind turbines under real environmental conditions. The present work analyzes the energy production and structural performance of an NREL-IEA 15 MW wind turbine using measured wind and hydro data. First of all, an optimum operating range is determined in terms of the wind speed and blade pitch angle to maximize the power coefficient. Then, at this optimum range, a detailed breakdown of the forces and moments acting on different components of the wind turbine is presented. It was found that wind speeds of 9 to 12 m/s are best suited for this wind turbine, as the power coefficient is at its maximum and the mechanical loads on all components are at a minimum. The loads are at a minimum due to the optimized blade pitch angle. The bending force on a monopile foundation (fixed on the seabed) is found to be at a maximum and corresponds to nearly 2000 kN. The maximum blade force is nearly 700 kN, whereas on the tower it is almost 250 kN. The maximum force on the tower occurs at a point which is found to be undersea, whereas above-sea, the maximum force on the tower is nearly 20% less than the undersea maximum force. Finally, seasonal and annual energy production is also estimated using locally measured wind conditions.