In this paper, the putative phenomenon of adsorption involved in the insect olfactory perception of four fruity odorants on Machilishrabei olfactory receptor MhOR5 was studied at a molecular scale. Thus, the experimental concentration–response curves of propyl acetate, butyl acetate, isobutyl acetate, and prenyl acetate on MhOR5 were adjusted using the monolayer model of ideal gas established using the powerful statistical physics approach, which was selected as the most appropriate model among the others. The fitted model parameters were applied to stereographic and energetic analyze the four olfactory systems. Indeed, the modeling results indicated that the tested fruity key food odorants (KFOs) were docked as 2- or 3-aggregated molecules on one MhOR5 binding site via a nonparallel position (i.e., multi-molecular adsorption mechanism). Energetic parameters were used to characterize the adsorption process involved in the studied systems via the determination of the molar adsorption energies (ranging from 12.91 to 17.52 kJ/mol). Hence, the values of the molar adsorption energies are positive and inferior to 40 kJ/mol; this means that the putative adsorption mechanism presented an exothermic character and a physical type. The docking simulation results proved that the adsorption of propyl acetate, butyl acetate, isobutyl acetate, and prenyl acetate on MhOR5 may occur via physical interactions (weak interactions) like alkyl, pi-alkyl, van der Waals, carbon hydrogen bond, and conventional hydrogen bond. The statistical physics theory may also be utilized to quantitatively characterize Machilishrabei MhOR5 activated by propyl acetate, butyl acetate, isobutyl acetate, and prenyl acetate odorants via the estimation of the different site size distributions (SSDs) and site energy distributions (SEDs).