Exogenous Factors Research Articles

Diagnosis and treatment of oral mucus lesions: case series of four patients

One of the pressing issues in dermatovenerological and stomatological practices pertains to diseases of the oral mucosa. This challenge is primarily attributed to the intricacies associated with diagnosing these conditions in their early stages, the resemblance of clinical presentations to various oral mucosal lesions, and the potential lack of awareness among healthcare practitioners. Diseases such as lichen planus, herpes simplex, erythema multiforme exudative with skin lesions and vulgar pemphigus are characterized by a particularly persistent long-term course, thereby reducing the patient's ability to work and the overall quality of life. A multitude of endogenous and exogenous factors can influence the state of the oral mucosa. Endogenous factors encompass genetic predisposition, endocrine disturbances, carbohydrate metabolism disorders, neurogenic disorders, autoimmune conditions and infectious diseases. Exogenous factors, as a rule, include taking medications (non-steroidal anti-inflammatory drugs, antibiotics), galvanism, excessive use of alcohol and narcotic substances, and others. It should be noted that the condition of the oral mucosa is also influenced by a wide range of different trigger factors. The narrative delves into the complexities of diagnosing these conditions early on and explores the challenges inherent in devising effective treatment strategies.

Implications of HR managers' green attitude: a study of Indian hospitality sector

PurposeThe paper examines the influence of green attitude of HR managers on the other key HRM variables in an organizational context. Specifically, the objective of the paper was to determine if HR managers’ green attitude influences the green behavior of employees in an organization, while accounting for the mediating and moderating effect of contingent variables.Design/methodology/approachData were gathered from 175 human resources managers of Indian hotels using a structured instrument and subjected to partial least squares-structural equation modeling (PLS-SEM) analysis, using SmartPLS 3.0 software.FindingsWhile the green attitude of human resource managers was found to positively influence the green behavior of employees, it was observed that the extent of green rewards played a mediating role in the relationship. Top management support was found to moderate the relationship between green attitude of human resource managers and green human resource management practices.Practical implicationsThe study identifies how green behavior of employees can be improved by focusing primarily on the green attitude of HR managers. Thus, recruiting HR managers with high green orientation, contingent on the exogenous factors mentioned in the study being considered, will result in greater pro-environment employee behavior.Originality/valueOur unique contribution was viewing greening practices in the organization through the HR managers’ lens, who are critical in implementing green practices in an organization, thus providing novel insights compared to earlier studies in the field.

'Emerging into the World' - the regulation and control of dormancy and sprouting in geophytes.

Geophytic plants synchronize growth and quiescence with the external environment to survive and thrive under changing seasons. Besides seasonal growth adaptation, dormancy and sprouting are critical factors determining crop yield and market supply as various geophytes also serve as major food, floriculture, and ornamental crops. Dormancy in such crops decides crop availability in the market, as most of such crops are consumed during the dormant stage. On the other hand, uniform/maximal sprouting is crucial for maximum yield. Thus, dormancy and sprouting regulation have great economic importance. Dormancy-sprouting cycles in geophytes are regulated by genetic, exogenous (environmental), and endogenous (genetic, metabolic and hormonal, etc.) factors. Comparatively, the temperature is more dominant in regulating dormancy and sprouting in geophytes, unlike aboveground tissues, where both photoperiod and temperature control are involved. Despite huge economic importance, studies concerning the regulation of dormancy and sprouting are scarce in the majority of geophytes. To date, only a few molecular factors involved in the process have been suggested. Recently, omics studies on molecular and metabolic factors involved in dormancy and growth regulations of underground vegetative tissues have provided more insight into the mechanism. Here, we discuss current knowledge of the environmental and molecular regulation and control of dormancy and sprouting in geophytes and discuss challenges/questions that need to be addressed in the future for crop improvement.

3D Bioprinting of Biomimetic Alginate/Gelatin/Chondroitin Sulfate Hydrogel Nanocomposites for Intrinsically Chondrogenic Differentiation of Human Mesenchymal Stem Cells.

3D-printed hydrogel scaffolds biomimicking the extracellular matrix (ECM) are key in cartilage tissue engineering as they can enhance the chondrogenic differentiation of mesenchymal stem cells (MSCs) through the presence of active nanoparticles such as graphene oxide (GO). Here, biomimetic hydrogels were developed by cross-linking alginate, gelatin, and chondroitin sulfate biopolymers in the presence of GO as a bioactive filler, with excellent processability for developing bioactive 3D printed scaffolds and for the bioprinting process. A novel bioink based on our hydrogel with embedded human MSCs presented a cell survival rate near 100% after the 3D bioprinting process. The effects of processing and filler concentration on cell differentiation were further quantitatively evaluated. The nanocomposited hydrogels render high MSC proliferation and viability, exhibiting intrinsic chondroinductive capacity without any exogenous factor when used to print scaffolds or bioprint constructs. The bioactivity depended on the GO concentration, with the best performance at 0.1 mg mL-1. These results were explained by the rational combination of the three biopolymers, with GO nanoparticles having carboxylate and sulfate groups in their structures, therefore, biomimicking the highly negatively charged ECM of cartilage. The bioactivity of this biomaterial and its good processability for 3D printing scaffolds and 3D bioprinting techniques open up a new approach to developing novel biomimetic materials for cartilage repair.

Degrees of demand: a task-based analysis of the British graduate labour market

Abstract This study investigates the evolving demand for graduate skills in the British workforce, leveraging a task-based approach with data from the Skills and Employment Survey Series. Focused on the changing importance of job tasks related to graduate skills, the research explores the mapping of these tasks to educational attainment, discerns the price employers pay for tasks requiring graduate skills, and addresses regional variation in graduate supply and demand. Despite a slowing growth of graduate skills requirements post-2006, we find a stable assignment of graduate education with job tasks and an overall flat task price related to graduate skills requirements. We present regional evidence showing education expansion rather than exogenous factors drove high-skills demand, balancing the development of supply and demand in the British graduate labour market over 1997–2017.

Inflammation-Responsive Hydrogel Accelerates Diabetic Wound Healing Through Immunoregulation and Enhanced Angiogenesis.

Angiogenesis is a prominent component during the highly regulated process of wound healing. The application of exogenous vascular endothelial growth factor (VEGF) has shown considerable potential in facilitating angiogenesis. However, its effectiveness is often curtailed due to chronic inflammation and severe oxidative stress in diabetic wounds. Herein, an inflammation-responsive hydrogel incorporating Prussian blue nanoparticles (PBNPs) is designed to augment the angiogenic efficacy of VEGF. Specifically, the rapid release of PBNPs from the hydrogel under inflammatory conditions effectively alleviates the oxidative stress of the wound, therefore reprogramming the immune microenvironment to preserve the bioactivity of VEGF for enhanced angiogenesis. In vitro and in vivo studies reveal that the PBNPs and VEGF co-loaded hydrogel is biocompatible and possesses effective anti-inflammatory properties, thereby facilitating angiogenesis to accelerate the wound healing process in a type 2 diabetic mouse model. This article is protected by copyright. All rights reserved.

Collagen and Alginate Hydrogels Support Chondrocytes Redifferentiation In Vitro without Supplementation of Exogenous Growth Factors

Collagen and Alginate Hydrogels Support Chondrocytes Redifferentiation In Vitro without Supplementation of Exogenous Growth Factors

A REVIEW ON ROLE OF TRIDOSHA IN HEALTH AND DISEASES

Healthy and unhealthy state of a human being depends on normal and abnormal functional state of Tridosha, considering the physiological importance of Dosha in maintenance of homeostasis of the body. Tridosha have been called as root (Dosha Dhatu Mala Moolam hi Shariram) of the body. All the functions of the body could be explained in terms of Dosha, Dhatu, and Mala. Panchamahabhuta are chief controllers of universe. By Loka purusha saamyavaada existence of entities in universe and living body is similar. Hence controllers in human body must also be Panchabhoutika. Since Dosha are functional representatives of Panchamahabhuta, they are controllers of body functions. They are structurally Panchabhoutika in nature. Synthesis of Dosha is brought about in two stages. Those synthesized in unicellular zygote and impress every cell after differentiation are Prakruta Dosha, which are decisive factors for body characteristics. Those synthesized from food material which control routine body metabolism are called Vaikrata Dosha, which are decisive factors for homeostasis. Both stages are observed in intra uterine as well as extra uterine life. Both these kinds of Dosha work in synergism to carry out all bodily functions. Vatadosha is divided into five types and These types are according to function, chief location etc. Similarly, Pitta as well as Kaphadosha are also divided into five types. Within limits Doshas are maintaining living body, as they maintain homeostasis. Doshas are only and direct responsible factors for genesis of diseases. Even though there are exogenous and endogenous etiological factors in pathogenesis, Ayurveda suggests that any cause leads to vitiation of Dosha in the first place and then next events start for generation of diseases. Doshas control other two entities namely Dhatu and Mala. Aim & Objectives: Observing the role of Doshas in health and disease conditions Materials and Methods: All the classical texts of Ayurveda with available commentaries, published research papers, PUB med, Google scholar, research Gate, subject related data on Internet and other sources were reviewed for the present study Results and Conclusion: The Doshas having the primary role in maintaining health and any disturbance in Doshas will causes disease KEY WORDS: Doshas, Ahara, vihara, Vikruti, vyadhi

Indirect 3D printing CDHA scaffolds with hierarchical porous structure to promote osteoinductivity and bone regeneration

Hierarchical porous structures, which include macropores, minor pores, and micropores in scaffolds, are essential in the multiple biological functions of bone repair and regeneration. In this study, patient-customized calcium-deficient hydroxyapatite (CDHA) scaffolds with the three-level hierarchical porous structure were fabricated by indirect 3D printing technology and particulate leaching method. The sacrificial template scaffolds were fabricated using a photo-curing 3D printer, which provided a prerequisite for the integral structure and interconnected macro pores of CDHA scaffolds. Additionally, the 20 wt% pore former was incorporated into the slurry to enhance the content of smaller pores within the CDHA-2 scaffolds, and then the CDHA-2 scaffolds were sintered to remove the sacrificial template scaffolds and pore former. The obtained CDHA-2 scaffolds exhibited interconnected macropores (300–400 μm), minor pores (∼10–100 μm), and micropores (< 10 μm) distributed throughout the scaffolds, which could promote bone tissue ingrowth, increase surface roughness, and enhance protein adsorption of scaffolds. In vitro studies identified that CDHA-2 scaffolds had nanocrystal grains, high specific surface area, and outstanding protein adsorption capacity, which could provide a microenvironment for cell adhesion, spreading, and proliferation. In addition, the murine intramuscular implantation experiment suggested that CDHA-2 scaffolds exhibited excellent osteoinductivity and were superior to traditional BCP ceramics under conditions without the addition of live cells and exogenous growth factors. The rabbit calvarial defect repair results indicated that CDHA-2 scaffolds could enhance in situ bone regeneration. In conclusion, these findings demonstrated that the hierarchical porous structure of CDHA scaffolds was a pivotal factor in modulating osteoinductivity and bone regeneration, and CDHA-2 scaffolds were a potential candidate for bone regeneration.

Atlantic Economy and the British Industrial Revolution : Rethinking the Debate about the Endogenous and Exogenous Factors of Industrial Revolution

Atlantic Economy and the British Industrial Revolution : Rethinking the Debate about the Endogenous and Exogenous Factors of Industrial Revolution

The Influence of Website Quality and Social Media Quality on Brand Image, with Brand Awareness and Electronic Word of Mouth Mediating (Case Study at Legend Coffee Yogyakarta)

The purpose of this study is to compare the quality of websites and social media to brand image, using brand awareness and E-WOM as mediation factors. The exogenous factors in this study are website and social media quality; the endogenous variables are brand image; and the mediating variables are brand awareness and E-WOM. The Legend Coffee coffee shop is the focus of this study, with a sample size of 200 respondents. The study's subjects were Legend Coffee consumers. The data analysis approach used in this work is Structural Equation Modeling (SEM) utilizing AMOS 24 analytic tools. Based on the results of this study, it shows that website quality has a positive and significant effect on brand awareness, social media quality has a positive and significant effect on brand awareness, website quality does not have a positive and significant effect on brand image, social media quality has a positive and significant effect on brand image, brand awareness has a positive and significant effect on E-WOM, E-WOM has a positive and significant effect on image brand, as well as brand awareness and E-WOM mediate website quality and social media quality to brand image.

Undergraduate Students' Intention to Start their Own Business in Nigeria: the Importance of Family-Support, Innovativeness and Alertness

Entrepreneurship is one of the effective solutions to address a range of social and economic issues. Therefore, the Nigerian government decided to integrate entrepreneurial subjects in tertiary institutions to promote entrepreneurship and strengthen students' entrepreneurial prowess and intentions. Entrepreneurial development requires an understanding of the factors that are intrinsic to the entrepreneurial process. The current study examines the relationship between university students' entrepreneurial intention, family-support and innovativeness alertness. Survey design was used and convenience sampling was employed in obtaining a sample of seven hundred (700) respondents across selected federal universities in southeast geopolitical zone of Nigeria. The results demonstrated a favorable correlation between students’ entrepreneurial intention and innovativeness, entrepreneurial alertness, and family-support. Furthermore, among undergraduate students, family-support mitigated the association between entrepreneurial awareness and entrepreneurial ambition, but it had no effect on innovativeness. Our research indicates that when trying to encourage college students to take entrepreneurial actions through policies or educational programs, educators and policymakers should take into account the influence of exogenous factors such as family-support. They should also reconsider the current models of entrepreneurial education that are widely used in our educational system in order to integrate inclusiveness of both exogenous and endogenous factors influencing entrepreneurship.

Disentangling the impact of climate change, human activities, vegetation dynamics and atmospheric CO2 concentration on soil water use efficiency in global karst landscapes

Soil Water Use Efficiency (SWUE), which quantifies the carbon gain against each unit of soil moisture depletion, represents an essential ecological parameter that delineates the carbon-water coupling within terrestrial ecosystems. However, the spatiotemporal dynamics of SWUE, its sensitivity to environmental variables, and the underlying driving mechanisms across various temporal scales in the global karst region are largely uncharted. This study utilized the sensitivity algorithm of partial least squares regression, partial differential equations, and elasticity coefficients to investigate the characteristics of SWUE variations across different climatic zones in the global karst region and their responsiveness to environmental variables. Moreover, the study quantified the individual contributions of climate variability, atmospheric carbon dioxide concentration, human activities, and vegetation changes to SWUE variations. The results indicated that SWUE across different climatic zones in the global karst region demonstrated an increasing trend from 2000 to 2018, with the most notable improvement observed in the humid zone. SWUE presented regular distribution and variation characteristics across different latitudinal zones at a monthly scale. The sensitivity of SWUE to precipitation was significantly higher compared to its responsiveness to other environmental factors. Additionally, the trend in SWUE's sensitivity to precipitation demonstrated the most significant change. The sensitivity of SWUE to various environmental factors and the trend of this sensitivity in the arid zone revealed significant variation compared to other climatic zones. Gross primary productivity and soil moisture were identified as the intrinsic factors influencing SWUE changes, contributing 16 % and − 84 %, respectively. Climate variability and human activities were identified as the primary exogenous factors contributing to the increase in SWUE, accounting for 76 % and 16 %, respectively. This study advances the understanding of carbon-water coupling in karst regions, providing significant insights into the ecological management of global karst environments amidst climate variations.

How Does the Spatial Structure of Urban Agglomerations Affect the Spatiotemporal Evolution of Population Aging?

China has fully become an aging society, and the scientific response to population aging has become a major task that the country must face in the future. Research on population aging in the Chengdu-Chongqing urban agglomeration (CCUA) can provide a scientific basis for future population management in the CCUA. This paper applies spatial autocorrelation, geodetection, and other methods to analyze the temporal and spatial pattern of population aging and its driving factors in the CCUA from 2000 to 2020, taking districts (counties) as the basic unit and combining them with the spatial structure of the urban agglomeration. The results show that: ① in the time dimension, the population aging in CCUA has gone through the evolution process of “mild–moderate–heavy”; in the spatial dimension, the influence of the urban agglomeration’s development planning axes on the spatial differentiation of the aging population has become more and more prominent. ② The aging level has a strong spatial correlation, and with time, the spatial correlation has changed from weak to strong, and the spatial difference has increased. The dual core city shows a typical spatial pattern of a decreasing aging level in the core area and an increasing aging level in the peripheral area, and the heavily aging area is spreading along the axis. ③ The overall aging speed is high, and the aging speeds of the core cities and node cities are lower than those of other regions. There is a clearer positive correlation between the aging level and the speed of aging, showing the characteristic of “the older the faster”. ④ Endogenous factors such as the aging level and fertility level at the beginning of the period have a significant determining power on the change in the aging level, while exogenous factors such as the in-migration rate and the out-migration rate have a persistent determining power on the urban agglomerations and key areas (core cities, central cities, main axes of development, city belts, and dense urban areas).

О формировании предпосылок стратегирования городской конкурентоспособности

Strategic urbanization needs new theoretical and methodological tools at the current stage of Russia’s territorial development. This article identifies prerequisites for a new approach to urban development based on strategizing the urban competitiveness. Using the general theory of strategy and the methodology of strategizing developed by Professor V.L. Kvint, the author studied the socio-economic phenomenon of urban competitiveness. The review of scientific publications involved a narrative bibliographic analysis, which made it possible to determine and classify the key factors of urban competitiveness. By strategizing the urban competitiveness, municipal authorities obtain scientifically based theoretical and methodological foundations for solving various issues of urban development. The review also highlighted urban competitiveness as a socio-economic phenomenon and revealed four groups of factors, i.e., social, economic, infrastructural, and institutional. The main prerequisites for strategizing the urban competitiveness should rely on a comprehensive analysis and forecast of endogenous and exogenous factors, while taking into account the dichotomy of the subject to be strategized. The main directions of strategizing should depend on the system of unique competitive advantages of the urban settlement in question. The approach and the basic strategizing principles introduced in this article do not complete urban competitiveness as a system: the matter needs further methodological research. However, the groundwork can be independently used to strategize urban development.

Financial system dynamics model for multidimensional flexibility in toll road PPPs: a life-cycle analysis

Although scholars have developed simulation models and analyzed bankability criteria in numerous papers to enhance the financial outcomes of Public-Private Partnerships (PPPs), the intersection between both fields considering alternatives to assess the financial impact of flexibility in both scope and financing, remains underdeveloped. To address this gap, this paper introduces a financial model that assesses the financial impact of suitable life-cycle flexibility alternatives while coexisting with revenue performance alterations in each project phase within toll road PPPs. This model serves as a tool to gain insight into the planning of strategic actions to implement flexibility in both scope and financing. Based on system dynamics and validated using financial data from two toll road PPPs in India and East Europe, simulation results suggest that two key drivers (capital expenditures and debt repayment period) have the greatest influence on financial performance. Findings support the implementation of flexible scopes to effectively address the most influential exogenous factor impacting the financial performance of PPPs, namely traffic shortfalls. This model provides a suitable tool for assessing the life-cycle economic sustainability of PPPs in uncertain and complex environments.

The Manufacturing Reshoring Phenomenon: A Policy-Oriented Analysis of Factors Driving the Location Decision

For several decades, multinational enterprises (MNEs) have offshored their manufacturing activities to low-cost countries to achieve significant productivity gains. However, changes in the relative competitiveness of countries, social effects of deindustrialization in advanced economies and the vulnerability of global value chains (GVCs) revealed by the COVID-19 pandemic have encouraged some firms, supported by governments, to “reshore” part, or all of their offshore industrial operations back to their home country. Reshoring decisions are motivated by a variety of endogenous and exogenous factors that are empirically analyzed in this paper to understand how reshoring policies implemented by governments can more effectively address the factors driving the firms’ location decisions. A review of the reshoring policies implemented in Europe, the UK and the US is conducted to provide general policy recommendations regarding policy instruments, SMEs, innovation and regionalization of value chains. This paper fills a gap in the literature by connecting the micro-level supply chain management analysis of firms’ reshoring drivers with the macro-level economic policy perspective on reshoring. The review of existing reshoring policies calls for an in-depth analysis by the manufacturing sector and at the local level.

Recent advances and challenges in the interaction between myofibrillar proteins and flavor substances.

Myofibrillar proteins are an important component of proteins. Flavor characteristics are the key attributes of food quality. The ability of proteins to bind flavor is one of their most fundamental functional properties. The dynamic balance of release and retention of volatile flavor compounds in protein-containing systems largely affects the sensory quality and consumer acceptability of foods. At present, research on flavor mainly focuses on the formation mechanism of flavor components, while there are few reports on the release and perception of flavor components. This review introduces the composition and structure of myofibrillar proteins, the classification of flavor substances, the physical binding and chemical adsorption of myofibrillar proteins and volatile flavor substances, as well as clarifies the regulation law of flavor substances from the viewpoint of endogenous flavor characteristics and exogenous environment factors, to provide a theoretical reference for the flavor regulation of meat products.

RBC aggregation, deformation and adhesion to endothelium: Role of nitric oxide derived from L-Arginine and sodium nitroprusside

Red blood cells (RBCs) are the most abundant human blood cells. RBC aggregation and deformation strongly determine blood viscosity which impacts hemorheology and microcirculation. In turn, RBC properties depend on different endogenous and exogenous factors. One such factor is nitric oxide (NO), which is mainly produced by endothelial cells (EC) from L-arginine amino acid in the circulatory system. Since the mechanisms of the RBC-endothelium interplay are not clear up to date and considering its possible clinical importance, the aims of this study are to investigate in vitro: (1) The effect of L-arginine induced NO on RBC aggregation and adhesion to endothelium; (2) the NO effect on RBC aggregation and deformation induced by L-arginine and sodium nitroprusside without the presence of endothelium in the samples. The RBC aggregation and adhesion to a monolayer of EC were studied using optical tweezers (OT). The RBC deformability and aggregation without endothelium in the samples were studied using the flow chamber method and Myrenne aggregometer. We confirmed that NO increases deformability and decreases aggregation of RBCs. We showed that the soluble guanylate cyclase pathway appears to be the only NO signaling pathway involved. In the samples with the endothelium, the “bell-shaped” dependence of RBC aggregation force on L-arginine concentration was observed, which improves our knowledge about the process of NO production by endothelium. Additionally, data related to L-arginine accumulation by endothelium were obtained: Necessity of the presence of extracellular L-arginine stated by other authors was put under question. In our study, NO decreased the RBC-endothelium adhesion, however, the tendency appeared to be weak and was not confirmed in another set of experiments. To our knowledge, this is the first attempt to measure the forces of RBC adhesion to endothelium monolayer with OT.

Advances in Gut Microbiota-Targeted Therapeutics for Metabolic Syndrome

Previous investigations have illuminated the significant association between the gut microbiome and a broad spectrum of health conditions, including obesity, diabetes, cardiovascular diseases, and psychiatric disorders. Evidence from certain studies suggests that dysbiosis of the gut microbiota may play a role in the etiology of obesity and diabetes. Moreover, it is acknowledged that dietary habits, pharmacological interventions, psychological stress, and other exogenous factors can substantially influence the gut microbial composition. For instance, a diet rich in fiber has been demonstrated to increase the population of beneficial bacteria, whereas the consumption of antibiotics can reduce these advantageous microbial communities. In light of the established correlation between the gut microbiome and various pathologies, strategically altering the gut microbial profile represents an emerging therapeutic approach. This can be accomplished through the administration of probiotics or prebiotics, which aim to refine the gut microbiota and, consequently, mitigate the manifestations of associated diseases. The present manuscript evaluates the recent literature on the relationship between gut microbiota and metabolic syndrome published over the past three years and anticipates future directions in this evolving field.