We present a search for electron-recoil signatures from the charged-current absorption of fermionic dark matter using the EXO-200 detector. We report an average electron-recoil background rate of 6.8×104 cts kg−1 yr−1 keV−1 above 4 MeV and find no statistically significant excess over our background projection. Using a total Xe136 exposure of 234.1 kg yr, we exclude new parameter space for the charged-current absorption cross section for dark matter masses between mχ=2.6–11.6 MeV with a minimum of 6×10−51 cm2 at 8.3 MeV at the 90% confidence level.Received 6 July 2022Accepted 8 December 2022Corrected 9 February 2023DOI:https://doi.org/10.1103/PhysRevD.107.012007Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Funded by SCOAP3.Published by the American Physical SocietyPhysics Subject Headings (PhySH)Research AreasDark matterNeutrinoless double beta decayParticles & FieldsNuclear Physics