Representing and reasoning uncertain causalities have diverse applications in fault diagnosis for industrial systems. Owing to the complicated dynamics and a multitude of uncertain factors in such systems, it is hard to implement efficient diagnostic inference when a process fault occurs. The cubic dynamic uncertain causal graph was proposed for graphically modeling and reasoning about the fault spreading behaviors in the form of causal dependencies across multivariate time series. However, in certain large-scale scenarios with multiconnected and time-varying causalities, the existing inference algorithm is incapable of dealing with the logical reasoning process in an efficient manner. We, therefore, explore the solutions to enhanced computational efficiency. Causality graph decomposition and simplification, and graphical transformation, are proposed to reduce model complexity and form a minimal causality graph. An algorithm, event-oriented early logical absorption, is also presented for logical reasoning. It is mainly intended to minimize the computational costs for compulsory absorption operations in the early stage of reasoning process. The effectiveness of the proposed algorithm is verified on the secondary loop model of nuclear power plant by utilizing the fault data derived from a nuclear power plant simulator. The results show the anticipated capability of efficient fault diagnosis of the proposed algorithm for large-scale dynamic systems.