The aim of this paper is to establish some results about the existence of multiple solutions for the following singular semipositone boundary value problem of fourth-order differential systems with parameters: {u(4)(t)+β1u″(t)−α1u(t)=f1(t,u(t),v(t)),0<t<1;v(4)(t)+β2v″(t)−α2v(t)=f2(t,u(t),v(t)),0<t<1;u(0)=u(1)=u″(0)=u″(1)=0;v(0)=v(1)=v″(0)=v″(1)=0,\\documentclass[12pt]{minimal}\t\t\t\t\\usepackage{amsmath}\t\t\t\t\\usepackage{wasysym}\t\t\t\t\\usepackage{amsfonts}\t\t\t\t\\usepackage{amssymb}\t\t\t\t\\usepackage{amsbsy}\t\t\t\t\\usepackage{mathrsfs}\t\t\t\t\\usepackage{upgreek}\t\t\t\t\\setlength{\\oddsidemargin}{-69pt}\t\t\t\t\\begin{document}$$ \\textstyle\\begin{cases} u^{(4)}(t)+\\beta _{1}u''(t)-\\alpha _{1}u(t)=f_{1}(t,u(t),v(t)),\\quad 0< t< 1; \\\\ v^{(4)}(t)+\\beta _{2}v''(t)-\\alpha _{2}v(t)=f_{2}(t,u(t),v(t)),\\quad 0< t< 1; \\\\ u(0)=u(1)=u''(0)=u''(1)=0; \\\\ v(0)=v(1)=v''(0)=v''(1)=0, \\end{cases} $$\\end{document} where f_{1},f_{2}in C[(0,1)times mathbb{R}^{+}_{0}times mathbb{R}, mathbb{R}], mathbb{R}_{0}^{+}=(0,+infty ). By constructing a special cone and applying fixed point index theory, some new existence results of multiple solutions for the considered system are obtained under some suitable assumptions. Finally, an example is worked out to illustrate the main results.