Existence Of Inhibitory Factor Research Articles

ANALISIS MODEL DAN IDENTIFIKASI FAKTOR PENDUKUNG DAN PENGHAMBAT DALAM PROSES REKRUTMEN BAGI TENAGA KERJA PENYANDANG DISABILITAS FISIK DI KOTA SERANG

The difficulty of people with disabilities in Serang City in getting a job both in government agencies and in private companies, even though the right to get a job has been supported by Law Regulation No. 13 of 2019. One of the causes is supporting factors and obstacles in the recruitment process that cause problems in the recruitment model of people with disabilities. The purpose of the study is to analyze recruitment models and identify supporting factors and inhibit the recruitment process of people with physical disabilities in Serang City. This research uses descriptive qualitative methods, data collection techniques using interviews, observations with relevant parties and document studies. The results of the study are that the recruitment model of people with disabilities is closely related to supporting factors in the recruitment process of prospective workers with disabilities including skills, relationships and education, while the inhibiting factors are lack of family support, self-spirit, accessibility and environment. The conclusion of this study is that there are several obstacles to the recruitment model, namely the availability of limited quality resources, low levels of education and knowledge and criteria that cannot be met by prospective employees who are closely related to supporting factors and obstacles in the recruitment process of prospective workers with physical disabilities in Serang City. The existence of inhibitory factors in the recruitment process resulted in supporting factors not running optimally, thus causing various obstacles in the existing recruitment model

Suppression of 4.1R enhances the potency of NKG2D-CAR T cells against pancreatic carcinoma via activating ERK signaling pathway

Pancreatic carcinoma (PC) is one of the most common malignancies. Chimeric antigen receptor (CAR)-modified T cells has achieved remarkable efficacy in the treatment of hematological malignancies. However, lack of tumor-specific targets and the existence of inhibitory factors limit the function of CAR T cells when treating solid tumors. 4.1R has been reported to suppress the anti-tumor activity of T cell responses. In this study, we investigated the anti-tumor activity of 4.1R deletion in natural killer group 2D (NKG2D)-CAR T cells against PC. The CAR T cells were obtained by transfecting T cells with lentiviral vector carrying NKG2D-CAR, NC-NKG2D-CAR, or KD2-NKG2D-CAR. In vitro, NKG2D-CAR T cells showed higher cytotoxicity than Mock T cells. However, compared to NKG2D-CAR T cells, furtherly higher cytotoxicity against PC cells in a dose-dependent manner was found in KD2-NKG2D-CAR T cells. In addition, the proliferation rate and cytotoxic activity of KD2-NKG2D-CAR T cells were significantly higher than those of NKG2D-CAR T cells. Besides, the inhibitory receptors PD-1 and TIM-3 were expressed in lower level on KD2-NKG2D-CAR T cells. In vivo, KD2-NKG2D-CAR T cells suppressed tumor growth more effectively in a xenograft model compared to NKG2D-CAR T cells. Mechanistically, 4.1R regulated CAR T cell function via activating ERK signaling pathway. Therefore, the study provides a new idea to enhance the anti-tumor efficiency of CAR T therapy.

Indonesian Faculty Barriers in Providing Help to College Students in Distress

Colleges are experiencing a surge of students in distress, particularly those with suicidal and self-harm tendencies. Despite numerous researchers having explored this phenomenon, very little action has been taken to address this issue at the university level, indicating the existence of inhibitory factors that have not yet been explored. The purpose of this study is to explore barriers that inhibit Indonesian faculty members from providing help to distressed college students. As many as 173 academic faculty members from 72 universities across Indonesia participated in this exploratory study by completing an online self-reported survey. Free text responses were thematically analyzed to provide information about the challenges that faculty members face. The findings were categorized into three main themes: lack of mental health information, unclear professional boundaries, and lack of institutional support. Further implications of the study will be discussed.