Excited-state Intramolecular Proton Transfer Process Research Articles

Exploring and Regulating Heteroatom-Electronegativity-Associated with Ring Aromaticity and Excited State Intramolecular Proton Transfer Mechanism for Benzothiazole-Based Fluorophore.

A novel fluorophore 2-(2'-hydroxy-5'-benzaldehyde phenyl) benzothiazole (HBBT) with excited state intramolecular proton transfer (ESIPT) characteristics, showing good selectivity for Cu+/Cu2+ ions had been synthesized experimentally (Molecules 2022, 27, 7678). However, its ESIPT mechanism and fluorescent performance related to atomic substituents have not been investigated systematically. In this work, two HBBT derivatives, 2-(2'-hydroxy-5'-benzaldehyde phenyl)benzoimidazole (HBBI) and 2-(2'-hydroxy-5'-benzaldehyde phenyl)benzopyrrole (HBBP), were obtained by respectively using -NH and -CH2 groups in place of the sulfur atom in the thiazole ring. The absorption/emission spectra and ring aromaticity as well as ESIPT processes of HBBT and its derivatives were studied using density functional theory (DFT) and time-dependent DFT (TD-DFT). The simulated absorption and fluorescence wavelengths of HBBT agreed well with the corresponding values obtained in the experiment. According to the analyses of geometry structures, electron densities, and infrared vibration frequencies, the intramolecular hydrogen bond becomes stronger upon light excitation. The frontier molecular orbitals were analyzed via establishing potential energy curves, and the ESIPT behavior was described deeply. Obviously, the NH-substitution makes ring 4 more aromatic, while the CH2-substitution changes ring 4 from aromatic to antiaromatic. The ESIPT process helps to alleviate the excited state antiaromaticity. The greater the antiaromaticity of the S1 state normal form, the higher the barrier of ESIPT.

Photoconductance Induced by Excited-State Intramolecular Proton Transfer (ESIPT) in Single-Molecule Junctions.

Excited-state intramolecular Proton Transfer (ESIPT) molecules have been drawing considerable attention due to their unique photophysical properties and potential applications in optoelectronic devices. Although ground and excited-state tautomerism in various proton transfer systems associated with ESIPT has been extensively studied both experimentally and theoretically, the charge-transport characteristics of ESIPT molecules at the single-molecule level has been little investigated. In this work, scanning tunneling microscope-based fixed junction technique (STM-FJ) is employed with theoretical calculations to explore the electronic properties of SMe-PhOH (with ESIPT properties), together with its photoconductance induced by ESIPT photocycle processes under continuous light illumination (254/275/295/310nm). The conductance variation of SMe-PhOH with different UV wavelengths exhibits a continuous photoconductance distribution, which is highly consistent with the results of its UV-vis absorption spectrum. Theoretical calculations indicate that the interaction between localized HOMO and delocalized LUMO of SMe-PhOH K*-state gives rise to Fano resonance, thereby leading to enhanced conductance compared with its E-state. It reveals the microscopic mechanism of ESIPT process at the nanoscale and provides a constructive perspective for optimizing the photoresponsive properties of ESIPT-type molecules, as well as designing high-performance single-molecule devices.

Relationship between antioxidant activity and ESIPT process based on flavonoid derivatives: A comprehensive analysis

Antioxidant activity, as a topic of current interest, is discussed together with the excited state intramolecular proton transfer (ESIPT) process for three flavonoid derivatives, based on density functional theory (DFT)and time-dependent DFT (TD-DFT) methods, as well as DPPH free radical scavenging assay. The potential energy curves and transition states demonstrate that the three molecules can undergo only single proton transfer in the excited state, and all of them are ultrafast ESIPT processes. The absorption spectra of all the molecules show effective protection against UV radiation with low fluorescence intensity, especially Baicalein (Bai), which demonstrates their great potential for sunscreen applications. The density of states, HOMO energy values, global and local indices reveal that the antioxidant activity of the molecules after ESIPT process is enhanced, with Bai having the highest antioxidant activity, which is significantly attributed to the number and position of phenolic hydroxyl groups. Moreover, by comparing the DPPH free radical scavenging activity under the dark and UV radiation conditions, the radical scavenging activity (RSA) value in the UV radiation is remarkably higher than that in the dark condition, in which Bai achieves RSA value of 93.4%. Overall, the antioxidant activity of all three ESIPT-based flavonoid derivatives, especially Bai, is significantly elevated in the keto* form, which reinforces the significant relationship between antioxidant activity and ESIPT process, and provides new application prospects for molecules with ESIPT properties.

Tactfully regulating the ESIPT mechanism of novel benzazolyl-4-quinolones fluorophore by atomic electronegativity

The effects of atomic electronegativity (O, S and Se) on the excited state intramolecular proton transfer (ESIPT) behavior of fluorescent benzazolyl-4-quinolones derivatives have been investigated theoretically. Analysis of structure parameters and infrared vibrational spectra indicate that the intramolecular hydrogen bonds (O1H1⋯N1) are gradually strengthened in the first (S1) excited state as the atomic electronegativity diminishes (O → S → Se). The topological parameters, reduced density gradient (RDG) scatter plots and interaction region indicator (IRI) isosurface further confirm our results. The energy gap of molecular orbitals reflect that the less atomic electronegativity prompt greater excited state reactivity. In addition, the constructed potential energy curves (PECs) reveal that Se substituent has lower potential barrier (0.42 kcal/mol), which is more likely to accelerate the occurrence of ESIPT process. These results show that the atomic electronegativity helps to regulate the ESIPT process, which will pave the way for the design and synthesis of ESIPT-based fluorophores in future.

ESIPT-induced intersystem crossing leads to tautomer fluorescence quenching for 3-mercapto-2-(4-(trifluoromethyl)phenyl)-4H-chromen-4-one molecule

The excited-state intramolecular proton-transfer (ESIPT) dynamics of 2-(4-(diethylamino)phenyl)-3-mercapto-4H-chromen-4-one (3NTF) and 3-mercapto-2-(4-(trifluoromethyl)phenyl)-4H-chromen-4-one (3FTF) have been investigated using time-dependent density functional theory (TDDFT). Upon photoexcitation, 3NTF exhibits a single fluorescence emission while 3FTF is fluorescence quenched when dissolved in cyclohexane solution. The present study reveals that both species undergo barrierless ESIPT process, and the underlying reason for fluorescence quenching in 3FTF has been elucidated. Specifically, it is concluded that intersystem crossing (ISC) is responsible for the fluorescence quenching in the 3FTF molecule due to the energy gap between the S1 and T2 states is only 0.12 eV plus large S1 → T2 spin–orbit coupling resulting in a strong interaction between the singlet and triplet states. The present study provides a reference for the fluorescence quenching associated with thiol-hydrogen bond molecules, and it is helpful for further research on ESIPT reactions of sulfur-containing molecules.

When a Twist Makes a Difference: Exploring PCET and ESIPT on a Nonplanar Hydrogen-Bonded Donor-Acceptor System.

Bioinspired benzimidazole-phenol constructs with an intramolecular hydrogen bond connecting the phenol and the benzimidazole have been synthesized to study both proton-coupled electron transfer (PCET) and excited-state intramolecular proton transfer (ESIPT) processes. Strategic incorporation of a methyl group disrupts the coplanarity between the aromatic units, causing a pronounced twist, weakening the intramolecular hydrogen bond, decreasing the phenol redox potential, reducing the chemical reversibility, and quenching the fluorescence emission. Infrared spectroelectrochemistry and transient absorption spectroscopy confirm the formation of the oxidized product upon PCET and probe excited-state relaxation mechanisms, respectively. Density functional theory calculations of redox potentials corroborate the experimental findings. Additionally, time-dependent density functional theory calculations uncover the fluorescence quenching mechanism, showing that the nonradiative twisted intramolecular charge transfer state responsible for fluorescence quenching is more energetically favorable in the methyl-substituted system. Incorporating groups causing steric hindrance expands the design of biomimetic systems capable of performing both PCET and ESIPT.

Effects of functional groups on ESIPT and antioxidant activity of apigenin: A non-existent enol* state fluorescein

The development and enhancement of antioxidant drugs, which are aimed at mitigating DNA damage, mutations, and cancer, are of paramount significance in the biomedical sphere. In recent years, antioxidant drug molecules with photoluminescence have sprung up like mushrooms. Apigenin (AP), characterized by its distinctive property of excited state intramolecular proton transfer (ESIPT), plays a pivotal role in mediating antioxidant and anticancer activities. Despite being a representative molecule of the non-existent enol form (E*) state with ESIPT nature, there is a notable lack of theoretical investigations into its antioxidant properties. Herein, density functional theory (DFT) and time-dependent DFT methodologies were utilized to explore the effects of various functional groups on AP molecules in a methanol solvent. Studies have demonstrated that for the non-existent E* state fluorescence molecule AP, the ESIPT process can significantly enhance the antioxidant potency of AP and its derivatives. However, the introduction of electron-withdrawing groups significantly accelerated the ESIPT process while simultaneously suppressing the antioxidant activity of AP-CN. Conversely, the incorporation of electron-donating groups effectively inhibited the ESIPT process, yet markedly enhanced the antioxidant activity of AP-NH2. This investigation furnishes vital perspectives and sources of reference for the conception and advancement of groundbreaking antioxidant medications that aim to tackle non-existent E* state molecules.

Roles of ESIPT and TICT in the Photophysical Process of a Ratiometric Fluorescence Sensor for Al3.

Precise detection of Al3+ with the aid of a fluorescence sensor is of fundamental importance in the fields of water pollution control and food safety. A comprehensive understanding of the photophysical process of the sensor as well as its underlying detection mechanism is a precondition for the design of highly efficient sensors. This contribution performs a thorough investigation of the ratiometric fluorescence sensing mechanism of an Al3+ sensor with the aid of density functional theory and time-dependent density functional theory. Two excited-state intramolecular proton transfer (ESIPT) processes are observed on the S1 state potential energy surface, which leads to emission around 565 nm. A twisted intramolecular charge transfer state is observed after one of the ESIPT processes via cis-trans isomerization of the C═N bond. However, the large energy barrier hinders its occurrence, which is quite unusual. Al3+ is found to form three strong coordination bonds with the sensor, which eliminates ESIPT processes and induces a significant blue shift of the emission spectrum to 480 nm. The origination of the sensor's selectivity is also uncovered by investigating the interaction between the sensor and interfering metal ions.

Excited-State Decay and Photolysis of O-Nitrophenol after Proton Transfer. II: A Theoretical Investigation in the Microsolvated Atmospheric Environment.

Changes in atmospheric humidity affect the number of water molecules surrounding o-nitrophenol (ONP), creating an anisotropic chemical environment. It, in turn, influences the photodynamic behaviors of ONP, differing from those observed in the gas phase and in solution. Recently, we explored the excited-state decay and the generation of the hydroxyl (OH) radical before proton transfer of ONP in the microsolvated environment using the MS-CASPT2//CASSCF approach. As is well known, ONP is capable of converting to its aci-nitro isomer (aciONP) via an excited-state intramolecular proton transfer (ESIPT) process. In the present work, the photoinduced dynamics of aciONP, which can lead to an OH radical and nitrous acid (HONO), was studied using the same computational model. Our calculations demonstrated that increasing the number of water molecules affects the molecular geometries, particularly the key bond lengths and dihedral angles of the HONO group, while also reducing the relative energies of minima and intersections. Moreover, we identified two distinct types of minimum structures: one that retains the intramolecular hydrogen bond and the other that breaks the hydrogen bond with the H atom flipping outward. The latter structure, compared with the former, has a different electronic-state character and facilitates intersystem crossing processes. Subsequently, two major excited-state decay paths were proposed: (PATH I) ESIPT → S1 → S1S0 → S0; (PATH II) ESIPT → S1 → S1-2 → S1T1 → T1 → S0T1 → S0. Furthermore, the T1 state has a relatively long lifetime, allowing for the formation of the OH radical and HONO, and the corresponding energy barriers decrease as the number of water molecules increases. These theoretical findings provide valuable insights into the photodynamics of aciONP in the microsolvated atmospheric environment.

A dual-response fluorescent hemicyanine probe for the detection of mitochondrial hypochlorite and viscosity based on ESIPT/AIE and TICT

Viscosity and hypochlorite (ClO−) are two important factors affecting the physiological activity and function of mitochondria. Hypochlorite (ClO−) is a vital reactive oxygen species, and endogenous ClO− acts as an important germicidal oxidant in the immune system at low concentrations. While, fluctuations in viscosity can cause mitochondrial dysfunction that is linked to several diseases. We herein report on a hemicyanine-based probe (BDTB-PA) for the detection of hypochlorite (ClO−) and viscosity. The probe exhibits a very low fluorescence background in an aqueous solution due to twisted intramolecular charge transfer (TICT) and blocked excited-state intramolecular proton transfer (ESIPT). In a viscous solution, the TICT of the probe was inhibited, generating a strong emission at 580 nm. In contrast, upon treatment with ClO−, the phenylboronic acid pinacol ester group of probe BDTB-PA was removed, and the hydroxyl group was released, activating the ESIPT process. Coupled with its aggregation-induced emission (AIE) characteristics, the product of BDTB-PA with ClO− exhibited a distinct emission at 540 nm. As such a solution of the probe BDTB-PA exhibited a distinct fluorescent color change from colourless to green under UV light with the addition of ClO−. More importantly, probe BDTB-PA was used for monitoring ClO− and viscosity in the mitochondria of living cells, plants and zebrafish.

Theoretical Investigation on Proton Transfer Directionality and Dynamics Behavior of 3-(Benzo[d]thiazol-2-yl)-2-hydroxy-5-methoxybenzaldehyde with Two Asymmetric Proton Acceptors.

A detailed theoretical investigation on the excited state intramolecular proton transfer (ESIPT) directionality and dynamics behavior of 3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methoxybenzaldehyde (BTHMB) with two unsymmetric proton acceptors (N and O2) has been performed. The hydrogen bond O1-H···N in BTHMB-a formed by the O1-H group with the N atom or O1-H···O2 in BTHMB-b formed by the O1-H group with the O2 atom is enhanced upon photoexcitation, and the strength of the O1-H···N bond is stronger, which will drive the O1-H proton to the N atom. Potential energy curves further confirm that ESIPT occurs in the N atom because of the smaller energy barrier (0.39 kcal/mol). Results of dynamics simulations manifest that no surface hopping exists between the S0 and S1 states within 300 fs, and ESIPT time constants of BTHMB-a and BTHMB-b are 48 and 151 fs, respectively. While the reverse ESIPT is observed in BTHMB-b at 294 fs, implying that the O1-H proton is transferred to the N atom instead of the O2 atom. The consistency of the calculated absorption (390 nm) and fluorescence spectra (443 and 602 nm) of BTHMB-a with the experimental values (390, 410, and 605 nm) confirms this conclusion again. The charge distribution analysis shows that the charge on the proton acceptors increases, and the O2 atom has higher electronegativity because it has more negative charges. The minimum surface electrostatic potential on the N atom in BTHMB-b correlating with the pKb value is -47.38 kcal/mol, indicating that the N atom has strong basicity. Therefore, the basicity of the N atom dominates the ESIPT process rather than the electronegativity of the O2 atom.

Tunable Emission and Structural Insights of 6-Arylvinyl-2,4-bis(2'-hydroxyphenyl)pyrimidines and Their O∧N∧O-Chelated Boron Complexes.

In this study, we present the synthesis and photophysical characteristics of a novel series of 6-arylvinyl-2,4-bis(2'-hydroxyphenyl)pyrimidines. These compounds exhibit nonemissive properties attributed to the potential occurrence of a excited-state intramolecular proton transfer process from the OH groups to the nitrogen atoms of the pyrimidine ring. The introduction of an acid for protonation of the pyrimidine ring results in a significant enhancement of the fluorescence response, easily perceptible to the naked eye. Notably, these molecules serve as intriguing rigid O∧N∧O ligands for boron chelation. The incorporation of boron atoms promotes structural planarity, increases rigidity, and successfully restores fluorescence in both solution and the solid state. Moreover, the photoluminescence was found to be strongly influenced by the nature of the end groups on the arylvinylene fragment, allowing for the modulation of the emission color and covering the optical spectrum from blue to red. Strong emission solvatochromism was observed in various solvents, a finding that supports the formation of intramolecular charge-separated emitting states, particularly when terminal electron-donating groups are present in the structure. X-ray diffraction analysis enables the determination of inter- and intramolecular interactions, as well as molecular packing structures, aiding in the rationalization of distinct luminescent behaviors in the solid state. All experimental findings are elucidated through extensive density functional theory (DFT) and time-dependent DFT calculations.

AI-Powered Mining of Highly Customized and Superior ESIPT-Based Fluorescent Probes.

Excited-state intramolecular proton transfer (ESIPT) has attracted great attention in fluorescent sensors and luminescent materials due to its unique photobiological and photochemical features. However, the current structures are far from meeting the specific demands for ESIPT molecules in different scenarios; the try-and-error development method is labor-intensive and costly. Therefore, it is imperative to devise novel approaches for the exploration of promising ESIPT fluorophores. This research proposes an artificial intelligence approach aiming at exploring ESIPT molecules efficiently. The first high-quality ESIPT dataset and a multi-level prediction system are constructed that realized accurate identification of ESIPT molecules from a large number of compounds under a stepwise distinguishing from conventional molecules to fluorescent molecules and then to ESIPT molecules. Furthermore, key structural features that contributed to ESIPT are revealed by using the SHapley Additive exPlanations (SHAP) method. Then three strategies are proposed to ensure the ESIPT process while keeping good safety, pharmacokinetic properties, and novel structures. With these strategies, >700 previously unreported ESIPT molecules are screened from a large pool of 570000 compounds. The ESIPT process and biosafety of optimal molecules are successfully validated by quantitative calculation and experiment. This novel approach is expected to bring a new paradigm for exploring ideal ESIPT molecules.

Emissively enhanced novel azo compounds featuring with ESIPT core

This study presents the synthesis and detailed characterization of novel azo compounds featuring Excited State Intramolecular Proton Transfer (ESIPT) cores derived from orcinol, resorcinol, and 2-naphthol. Using a comprehensive suite of spectroscopic techniques, including Nuclear Magnetic Resonance (NMR), Liquid Chromatography-Mass Spectrometry (LC-MS), Ultraviolet-Visible (UV–Vis) spectroscopy, and fluorescence spectroscopy, we explored the unique photophysical properties of these compounds. Notably, the synthesized compounds exhibited exceptionally large Stokes shifts, with values recorded at 204 nm, 251 nm, and 168 nm for compounds 1A, 2A, and 3A, respectively. These shifts indicate significant potential for applications in areas such as optical sensing and fluorescent imaging. Furthermore, Density Functional Theory (DFT) calculations were employed to investigate the nonlinear optical (NLO) properties of the enol and keto tautomeric forms of these compounds. The findings revealed that compound 2A, in particular, demonstrated impressive first-order hyperpolarizability, especially in chloroform, underscoring its suitability for advanced nonlinear optical applications. The study highlights the pivotal role of the ESIPT mechanism, where efficient intramolecular hydrogen bonding facilitates proton transfer upon excitation, leading to enhanced fluorescence properties. This phenomenon is particularly pronounced in compound 2A, where dual O—H interactions contribute to its remarkable fluorescence behavior, making it a standout candidate for use in high-performance optical materials. These findings not only advance our understanding of azo compounds and their versatile photophysical characteristics but also open new avenues for their application in cutting-edge technologies such as optical sensors, imaging agents, laser materials, and other fluorescence-based devices. By strategically leveraging the ESIPT process and the unique structural features of these compounds, this research paves the way for future innovations in the field of advanced optical materials and photonic devices.

Theoretical Study on the Effect of Cyano- and Dimethylamine-Group on ESIPT Behavior and Luminescent Properties of Novel Flavone-Based Fluorophore.

Recently, a new fluorescent senor based on 3-hydroxy-2-(naphthalen-2-yl)-4H-chromen-4-one (HFN) for selective detection of H2Sn was obtained in the experiment (Spectrochim. Acta Part A 271(2022)120962). Based on HFN, three new compounds (HFN1, HFN2 and HFN3) are designed to explore the influences of dimethylamine (-N(CH3)2) and cyano (-CN) groups on the excited-state intramolecular proton transfer (ESIPT) process and luminescent features of HFN. After analyzing the mainly geometrical parameters, electron densities and infrared spectra, we discovered that the intramolecular hydrogen bonds (IHBs) in the target molecules become stronger upon photo-excitation. Introducing -CN or/and -N(CH3)2 groups into HFN indeed influences its ESIPT behavior and luminescent properties. The -N(CH3)2 group enhances IHB, reduces ESIPT barrier and caused absorption/ fluorescence (at T form) peak blue-shift, while the -CN group shows a counterproductive effect. The coincidence of -N(CH3)2 and -CN made the absorption/fluorescent wavelength of HFN red-shift more than single -N(CH3)2 or -CN group does.

Theoretical study on the cascaded double proton transfer mechanism involving two adjacent hydrogen bonds in conjugated organic molecules

The cascaded double proton transfer reaction has attracted the interest of many researchers due to its effective six-level system cycle. Herein, the double proton transfer mechanism of naphthalene-based analog NDH and anthracene-based analog ADH in different solvents is investigated using density functional theory (DFT) and time-dependent density functional theory (TDDFT). The results indicate that the first occurrence of excited-state intramolecular proton transfer (ESIPT) in NDH and ADH is an ultrafast, barrierless process. Additionally, ADH undergoes a second ESIPT reaction, radiating a wider range of fluorescence spectrum. Theoretical studies reveal that this is due to the significantly increased hydrogen bond strength of ADH compared to NDH in the first excited (S1) state, creating favorable conditions for the second ESIPT. Analysis of electronic properties indicates that ADH exhibits enhanced chemical and kinetic activity, with a more pronounced intramolecular charge transfer (ICT), leading to increased stability of the keto structure (KB2*) after the second ESIPT. Finally, we identify the factors influencing the cascaded double proton transfer reaction. The second ESIPT process is promoted by extending the π-conjugated skeleton of the core molecule horizontally and leveraging the driving force provided by the H3 atom near the proton donor O3–H2. It is expected that these studies will provide theoretical guidance and new insights for the design and synthesis of near infrared (NIR) organic materials.

Fine-tuning the photophysical properties of Imidazo[1,2-a]pyridine-based dyes by the change in substituent and solvent media: DFT and TD-DFT studies

In the present work, photophysical properties of the nine excited-state intramolecular proton transfer (ESIPT) active 2-(2 -hydroxyphenyl)imidazo[1,2-a]pyridine (HPIP)-based dyes A1-A9 (X= H, Me, F, Cl, OMe, OH, CN, NO2 and CF3) were investigated at PBE0/6-31++G(d,p) and M06-2X/6-31++G(d,p) levels of theory in the gas phase and solvent media. The structural parameters, relative energies, vibrational spectra, photophysical properties, potential energy curves, natural bond orbital (NBO) charges, hole and electron isosurfaces, electron density properties and reduced density gradient (RDG) spikes were computed. The H-bonding is strengthened at the S1 state by comparing infrared vibrational spectra, the relevant bond length and bond angle, electron density properties and RDG analysis. The results revealed that ESIPT in the A1-A7 and A9 in the gas phase is a barrier-less process, while there is an energy barrier for the A8 (X=NO2). In polar solvents, it is predicted that the ESIPT process only in A5 and A6 is a barrier-less process. The A2, A4 and A5 exhibited the greatest redshift in the keto fluorescence emission in tetrahydrofuran solvents. The significant Stokes shift observed in the S1-K emission of certain dyes makes these molecules highly appealing for various applications such as chemosensors, fluorescent probes, laser dyes and optoelectronic devices.

Theoretical study on the effect of different positions of -CN group on photophysical properties and forward-reverse ESIPT behaviours of 2,5-bis(benzo[d]thiazol-2-yl)phenol derivatives

Excited state intramolecular proton transfer (ESIPT) compounds have been widely used in many fields due to its unique photophysical properties, but they are strongly affected by substituents. There are many studies on the effect of substituents at the same position on the ESIPT process, but there are few studies on the effects of substituents at different positions on the proton transfer process. In this work, a strong electron-withdrawing cyano group ( – CN) was introduced into different positions of 2,5-bis(benzo[d]thiazol-2-yl)phenol. The effect of different substituted positions on intramolecular hydrogen bond (IHB), photophysical properties and forward-reverse energy barrier of ESIPT reaction have been systematically investigated adopting density functional theory (DFT) and time-dependent DFT. The result showed that the introduction of – CN group at different positions led to a slight red-shift of absorption, and intramolecular charger transfer is the intrinsic reason for this photophysical phenomenon. The position of – CN group obviously influenced the excited state IHB, and then had an effect on ESIPT process. The substitution positions in the left benzo[d]thiazole ring and phenol ring respectively hinder and promote the ESIPT process, while the substitution in the right benzo[d]thiazole ring not only impetus the ESIPT process, but also increase the tautomer fluorescence.

Effects of atomic electronegativity on the ESIPT process and photophysical properties of naphthalene derivatives

The effect of atomic electronegativity on the excited state intramolecular proton transfer (ESIPT) and photophysical properties of naphthalene derivatives containing DNHP, DPHP and DAHP have been researched through the density functional theory (DFT) and time-dependent DFT (TD-DFT) methods. The potential energy curve (PEC) calculated shows that DNHP, DPHP and DAHP can generate ESIPT process and the ESIPT rate increases with the decrease of atomic electronegativity. Subsequently, we further explain the influence of atomic electronegativity on the ESIPT mechanism and photophysical properties of these molecules by electron-hole analysis. Eventually, we sincerely hope that these studies can be helpful in their application.

A multi-stimuli-responsive fluorescence material based on 1,8-naphthalimide.

A pair of 1,8-naphthalimides (NPIs) were designed and successfully synthesized through embellishing amino-containing NPI with 4-diethylaminosalicyladehyde and 4-diethylaminobenzaldehyde, respectively. Their structures were fully confirmed by 1H/13C NMR, HR-MS and FT-IR spectroscopic studies. Their photophysical properties were systematically investigated in different solvents of varied polarity, in THF/water mixtures with varying water fractions (fw), and in THF solvent with varying concentrations of NPIs. It inferred that the distinct differences in emission between two NPIs during self-assembled process could be ascribed that the hydroxyl-containing NPI allowed the excited-state intramolecular proton transfer process between -OH and CH=N units in the aggregation state. Interestingly, the solid of 4-diethylaminosalicyladehyde-functionalized NPI exhibited multi-stimuli-responsive fluorescence changes involving mechanofluorochromism and HCl/NH3 vapor stimulus-induced conversion. However, no remarkable change was observed in the photoluminescence (PL) spectra for the solid of 4-diethylaminobenzaldehyde-functionalized NPI under the stimuli of mechanical force and organic solvent.