The release of fissile material into the coolant caused by fretting of the fuel rods at the interface with spacer grids is a significant safety issue and cause of financial losses in the operation of Pressurized Water Reactors (PWRs). Each fuel rod is kept in position inside spacer grids through friction from the preload exerted by retaining elements (springs and dimples). Fretting of the fuel rods occurs at the contact with the springs and dimples. In severe fretting cases the integrity of the fuel rod cladding is compromised and fission byproducts enter the primary coolant circuit. The reciprocating motion at the contact interface of the fuel rods and spacer grids resulting in material fretting is due to the Flow-Induced Vibrations (FIV) of fuel rods, caused by the unstable surrounding coolant flow, which in PWRs is predominantly parallel to the length of fuel rods (axial flow). Under specific flow conditions, fretting develops rapidly. The vibrations of fuel rods, as well as the relationship of fretting wear mechanisms with several factors associated with the fission process and coolant flow dynamics and stability (vibration amplitude, preload, oscillating loads, irradiation, axial slip, spring relaxation, temperature, oxidation, material of spacer grids and fuel rods), have been considered in the literature. However, direct experimental measurements of the contact force and axial slip during FIV have not been treated in the literature, likely because of the absence of suitable measurement methods. This gap in experimental measurement techniques is addressed in this work, specifically for the analysis of PWR fuel assemblies, by installing a piezoelectric stack and aiming laser Doppler vibrometers on a one-meter-long fuel rod, supported by two full-scale spacer grids, in-air or immersed in quiescent water. In the presence of small- and large- amplitude forced vibrations, the signal of the piezoelectric force transducer increases with the amplitude of vibration, but it is also affected by vibrations perpendicular to the excitation, which appear for large-amplitude excitations. The axial motion of the fuel rod at the spacer grid has a complex evolution and is significant for large-amplitude vibrations only. At any rate, the time histories of contact force and axial motion display the effects of impacts and slips, particularly during the tests in water. The measurement system shows that the severity of the interaction at the spacer grid interfaces is influenced strongly by the amplitude of the forced fuel rod vibrations. Since fuel rods and fuel assemblies are prone to several nonlinear phenomena, as demonstrated by recent studies, it follows that the usage of nonlinear models will be essential to numerically estimating the severity of fretting.