Excessive Physical Activity Research Articles

Race, Ethnicity, and Geography as Determinants of Excessive Weight and Low Physical Activity in Pediatric Population: Protocol for Systematic Review and Meta-Analysis.

The rationale for the current study is the sparsity of data on the combined effect of the environmental and individual risks of obesity and sedentary lifestyle in children of different races/ethnicities from different regions. An effective weight management strategy is hard to design due to insufficient evidence. This work was initiated to study race, ethnicity, and geography as determinants of excessive weight and low physical activity in the pediatric population. To achieve this aim, we systematically review publications on daily length of physical activity of light, moderate, and vigorous intensity, as well as sedentary time and BMI and its dynamics in children of different races/ethnicities and geographies. The extracted data are stratified into six major geographic regions and six races/ethnicities. Then, a random-effects meta-analysis is used to calculate the pooled mean of each outcome measure. A ridge regression is constructed to explore age-related change in BMI. A Kruskal-Wallis H test is applied to compare the pooled duration of physical activity and sedentary time in the subgroups. Finally, we calculate paired correlation coefficients between BMI and physical activity/inactivity for each group. The findings can be further used in public health surveillance to clarify the epidemiology of obesity, to guide priority setting and planning, and to develop and evaluate public health policy and strategy.

Prevalence, causes, and treatment of plantar fasciitis in young females of a medical college

BackgroundPlantar fasciitis, a common musculoskeletal disorder, is characterized by inflammation of the plantar fascia, a thick band of tissue that connects the heel bone to the toes. The plantar fascia plays a crucial role in supporting the arch of the foot and absorbing shock during movement. Factors such as excessive physical activity, improper footwear, and biomechanical abnormalities are recognized contributors to the development of plantar fasciitis. However, the prevalence and underlying causes may vary across different demographic groups, necessitating targeted investigations.ObjectiveThis study aims to investigate the prevalence, causes and treatment of plantar fasciitis in young female students (18–30) of a medical college in Pakistan and explore potential associations with high-heel footwear.MethodologyIn this study, a cross-sectional survey was carried out, engaging 100 young females from a medical college. Employing a structured questionnaire, we assessed a spectrum of parameters, including heel pain symptoms, footwear habits, and available treatment options. The diagnostic precision of the Windlass test, specific to plantar fasciitis, was incorporated. Rigorous data analysis, utilizing SPSS, centered on discerning associations between the nuances of high-heel wear (considering types and duration) and the reported symptoms. This methodological framework ensures a comprehensive and precise exploration of the prevalence, causes, and treatment of plantar fasciitis in our targeted demographic.ResultsAll the participants were female, and the total number was 100, of which 66% felt pain in the heel when they wore high heels. Out of this 66%, only 6% are diagnosed with plantar fasciitis. The rest of the 60% have pain in the heel due to different causes such as heel spurs, stress fractures, etc. 2% of people receive treatment with steroid injections, and 12% are treated with ice.ConclusionWe conclude that the prevalence of plantar fasciitis is high in females wearing high heels. This study reveals that an increase in the total duration of wearing high heels with hard soles increases the symptoms of plantar fasciitis. Plantar fasciitis can be prevented by education and applying ergonomics and could be treated by steroids and the ice method, according to medical practitioners.

Risk factors for diminished ovarian reserve in women: Current state of the problem

Ovarian reserve is the basis of female fertility. The main markers of ovarian reserve are the level of anti-Mullerian hormone and the number of antral follicles. In addition to the natural age-related loss of follicles, many women experience a premature diminished ovarian reserve associated with a number of factors. This can be caused by both various diseases and environmental factors, lifestyle, and social aspects.The aim of this review was to examine the influence of external factors on the ovarian reserve and women fertility. A systematic analysis of data from modern scientific literature, domestic and foreign sources was carried out. The search involved such resources as PubMed, MEDLINE, Science Direct, eLibrary, Scopus, Cyberleninka. A detailed analysis of the influence of environmental pollution, lifestyle (sleep, nutrition, physical activity), previous surgeries, bad habits, obesity, psychological and social factors on the ovarian reserve and reproductive function of women was carried out. Significantly diminished ovarian reserve was noted with low sleep quality, excessive physical activity, and an unbalanced diet poor with animal proteins. Regular consumption of alcohol, smoking and exposure to certain chemical environmental pollutants cause premature follicle apoptosis and the onset of menopause. Circadian dysrhythmia, chronic stress and obesity can lead to the ovarian menstrual cycle disorders and the development of infertility in women. Previous parovarium surgeries are a significant risk factor for diminished ovarian reserve. Further population-based studies are needed to determine the precise mechanisms of influence of various factors on female fertility.

Poster 327: Postoperative Physical Activity in the Setting of Delayed ACL Reconstruction is Associated with Increased Local and Systemic Immune Responses in Mice

Objectives: The local and systemic immune responses to anterior cruciate ligament (ACL) injury and ACL reconstruction likely have substantial effects on graft-to-bone healing and patient recovery; however, the immune cell profile following ACL injury and reconstruction has not been well-characterized. The primary aim of the study was to evaluate the local and systemic immune response to ACL injury and reconstruction using a murine ACL reconstruction model. The secondary aim of the study was to evaluate the impact of postoperative physical activity on the immune cell profile. Methods: Following IACUC approval (IACUC approval number: 2019-0034), fifty-five 11-week-old male C57BL/6 mice were randomized to one of 3 groups: (1) closed ACL rupture only (“closed” group, n = 15), (2) closed ACL rupture followed by immediate ACL reconstruction (“immediate” group, n = 19), or (3) closed ACL rupture followed by delayed ACL reconstruction at 7-days post-injury (“delayed” group, n = 15). Thirty-three of the mice were sacrificed at 10 days post-injury or post-surgery, 16 of the mice were sacrificed at 3 days, and 6 mice were sacrificed as uninjured controls. For the group of mice sacrificed at 10 days, half of the mice underwent 1 week of daily treadmill running for 40 minutes (n = 6 in the immediate group, n = 6 in the delayed group, and n = 6 in the closed group), with the other half remaining as a free cage activity group (n = 6 in the immediate group, n = 6 in the delayed group, and n = 3 in the closed group). Draining ipsilateral iliac lymph nodes (iLN) to assess local immune responses and spleens to assess systemic responses were harvested and processed for flow cytometry. Unpaired, two-tailed t-tests were used to evaluate for differences in total lymph node cellularity between groups. In addition, the OsteoArthritis Research Society International (OARSI) scoring system was used to evaluate the degree of articular cartilage degeneration in each mouse. Results: Compared to uninjured normal mice, mice undergoing closed ACL rupture with or without ACL reconstruction had increased total iLN cellularity. The greatest increase in cellularity (over 8-fold) was observed in the 10-day immediate ACL reconstruction group with postoperative physical activity having little effect. There was a similarly large increase in cellularity in the 10-day delayed group only observed in mice that underwent daily treadmill running (Figure 1, p < 0.001). These differences were reflected in the absolute B cell and CD4+, CD8+, and T regulatory cell counts. Monocyte, macrophage, resident dendritic cell (DC), migratory DC, and neutrophil counts also mirrored this trend. In contrast, differentiated plasma cells (PCs) were increased only in the treadmill running groups regardless of surgical timing. Compared to normal uninjured mice, total spleen cellularity was increased only in 10-day immediate, and 10-day delayed running groups. Splenic monocyte and neutrophil counts were increased in these groups as well. The B/T cell ratio was elevated in only the 3-day groups. Conclusions: Postoperative physical activity in the setting of delayed ACL reconstruction is associated with increased local and systemic immune responses, reflecting either increased inflammation to clear the site of injury or an aberrant, prolonged inflammatory response. Postoperative physical activity played a smaller role in the setting of immediate ACL reconstruction. We hypothesize that excessive physical activity may delay or prevent resolution of the post-injury inflammatory process. The greater increase in immune response in the delayed ACL reconstruction group may be due to further stimulation of inflammation secondary to knee instability following the ACL injury. While inflammation is part of the normal response to injury, unresolved or excessive inflammation may impair graft healing due to stimulation of fibrosis and may also contribute to the development of PTOA. Our ongoing histologic, gene expression, and biomechanical studies will provide further insight into the biological relevance of such immune responses.

Physical activity and the osteoarthritis of the knee: A Mendelian randomization study.

Previous studies have reported an association between physical activity and the occurrence and progression of knee osteoarthritis (KOA). However, the existing evidence remains limited and of low-quality. This study aimed to examine the causal relationship between different levels of physical activity and KOA. Instrumental variables, represented by single nucleotide polymorphisms (SNPs), were utilized to capture sedentary behavior, appropriate physical exercise, and excessive physical activity. Aggregated statistics from the UK Biobank genome-wide association study dataset were used to assess the impact of these SNPs on KOA. Causality was estimated using inverse variance weighting (IVW), MR Egger, simple model, weighted median, and weighted model approaches. The stability of the results was assessed through heterogeneity and sensitivity analyses. Mendelian randomization (MR) analysis revealed a strong association between sedentary behavior and KOA, with an odds ratio (OR) of 2.096 (95% CI: 1.506-2.917) and a P value of 1.14 × 10-5. Appropriate physical exercise behavior exhibited a strong negative association with KOA, with an OR of 0.147 (95% CI: 0.037-0.582) and a P value of 0.006. Conversely, excessive physical activity behavior showed a significant positive association with KOA, with an OR of 2.162 (95% CI: 1.327-3.521) and a P value of .002. Our findings indicate that sedentary behavior and excessive physical activity are identified as risk factors for KOA, whereas engaging in appropriate physical exercise emerges as a protective factor against the development of KOA.

Associations of excessive internet use, sleep duration and physical activity with school absences: a cross-sectional, population-based study of adolescents in years 8 and 9

BackgroundInternet use has increased and sleep and physical activity (PA) have decreased in recent years among adolescents. Besides sleep and PA, another determinant of future health for adolescents is education....

Functional movement screen score to predict injury risk of sports students: a review of foot shape and body mass index

Background and Study Aim. Excessive physical activity poses a risk of injury, particularly when coupled with high exercise intensity. Factors such as Body Mass Index (BMI) and foot morphology may contribute to this risk. This study seeks to evaluate the relationship between BMI, foot shape, and the likelihood of injury among sports students. Material and Methods. A total of 119 sports students, comprising 33 females and 86 males, participated in this study. Purposive sampling was employed to select participants. BMI was determined using height and weight measurements, while foot shape was assessed through footprint measurements. The Functional Movement Screening (FMS) instrument, encompassing 7 movements: Deep Squats, Hurdle Steps, Inline Lunges, Shoulder Mobility, Active Straight Leg Raises, Trunk Stability Push-ups, and Rotary Stability, was utilized to assess injury risk. Data analysis was conducted using Microsoft Excel and IBM SPSS v.25.0, employing descriptive statistics. Results. Based on data analysis, the FMS value in females shows a mean of 18.7 and a standard deviation of 1.21. At the same time, the FMS value in males shows 18.5 and a standard deviation of 1.41. BMI values in females showed a mean of 21.6 and a standard deviation of 3.03. At the same time, BMI values in males showed a mean of 22.9 and a standard deviation of 4.62. The results were that all FMS scores were ≥14. While of BMI measurements, some samples obtained ˂18 kg/m² and ˃30kg/m². BMI measurements according to gender were mainly in the normal weight category. However, those who fall into the obesity category are primarily males. With the results of measuring the foot's shape, the percentage of flat feet is only 0.84% in females and 7.59 in males, while the rest of the sample has a normal foot shape. Conclusions. Individuals with a BMI in the overweight to obese category are more susceptible to high-category injuries, likely due to limited motion range. However, the study did not find evidence linking flat foot shape to high-category injury risk. This inability to establish a correlation may be attributed to the predominantly normal foot shape observed in the sample, resulting in a prediction of low-category injury risk.

The Effectiveness of Discharge Planning Implementation on the Quality of Life of Post Opname Patients with Heart Failure at Hospital

Background: Heart failure is a disease with a high rehospitalization rate due to patients not fulfilling recommended therapy, for example, breaking a diet, doing excessive physical activity and lack of understanding during discharge planning. This causes a decrease in the quality of life after patient is discharged. Purpose: This research aims to determine the effectiveness of discharge planning implemention on the quality of life of post-opname patients with heart failure at Bhayangkara Hospital, Kediri City. Method: The type of research used is quantitative research with a descriptive cross-sectional study design. The number of samples in this study were 31 respondents with accidental sampling technique. Results: The results of the non-parametric Spearman rank correlation test analysis obtained a value of p = 0.022 (p <0.05) and a correlation coefficient of 0.411 which is moderate and has a positive direction. This shows that there is a positive relationship between the effectiveness of implementing Discharge Planning on the quality of life of post-hospitalized patients with heart failure at Bhayangkara Hospital, Kediri City. Conclusion: Discharge Planning given to patients with heart failure at Bhayangkara Hospital, Kediri City is not yet effective and needs to be improved. However, the majority of respondents have a good quality of life where respondents experience an increase in socialization, psychology, but still experience physical discomfort.

The association between edentulism and progress of multimorbidity over 12 years among older American adults.

To examine the relationship between edentulism and the progress of multimorbidity, and the role of nutritional intake and behaviours among older Americans. We used 7 waves (2006-2018) of the Health and Retirement Study, a longitudinal survey of older Americans (number included in analysis 2,224). Edentulism was assessed in 2006 and 2012. Multimorbidity was indicated by 5 self-reported conditions: diabetes, heart conditions, lung diseases, cancer, and stroke. Behavioural factors were smoking, excessive alcohol consumption, physical activity, and body mass index. Nutritional intake was calculated by summing 10 nutrients (Protein, Vitamins C, D, B12, E, Calcium, Zinc, Polyunsaturated fatty acids, Folate and ß- carotene). Multilevel models for analysis of longitudinal data were used to assess the association between change in repeated measures of multimorbidity (between 2006 and 2018) and edentulism (2006) adjusting for nutritional intake, behavioural and socioeconomic factors. Participants who were edentate in 2006 and 2012 had higher rate-ratios (RR) for change in multimorbidity between 2006 to 2018 (RR: 1.29 and 1.28, respectively). After adjusting for socioeconomic factors, total nutrients and behavioural factors, these RR attenuated to 1.12 (95%CI: 1.06, 1.18) and 1.10 (95%CI: 1.05, 1.16), respectively. Total nutrition was negatively associated with progress of multimorbidity, but after adjusting for socioeconomic and behavioural factors the association became insignificant. Total nutrients rates in 2013 were significantly lower among those who were edentate in 2006 and 2012. There was a longitudinal association between edentulism and progress of multimorbidity. The relationship appeared to be mediated be behaviours and nutrition.

Effectiveness of Oral Providing of Ajwa Date Fruit Extract on Malondialdehyde and Superoxide Dismutase Levels of White Rats Induced by Excessive Physical Activity

Natural food ingredients are becoming increasingly popular as a treatment. According to studies and investigations, experts increasingly turn to natural remedies to treat disease, including date fruit extract (Phoenix dactylifera). This study tested the effectiveness of oral date palm fruit extract (Phoenix dactylifera) in reducing blood malondialdehyde levels in white rats (Rattus norvegicus) induced by excessive physical activity and increasing blood levels. Intense physical exercise increases white rat blood superoxide dismutase. This research is a laboratory experimental research or an actual experiment. The research design used a pre-test and post-test with a control group design to analyze the effectiveness of oral administration of date palm (Phoenix dactylifera) extract on the MDA and SOD levels of white rat (Rattus norvegicus) samples induced by excessive physical activity. The results of date fruit extract (Phoenix dactylifera) at 5 ml were more effective at reducing MDA and increasing SOD levels in white mice induced by excessive physical activity than at 3 and 4 ml. The experimental group treated with date fruit extract (Phoenix dactylifera) had lower MDA and higher SOD levels than the group given distilled water. Date fruit extract (Phoenix dactylifera) contains flavonoids and tannins. Some bioactive substances are antioxidants. Antioxidants can assist the body fight free radicals from excessive physical exertion.

Faktor-Faktor yang Berhubungan dengan Siklus Menstruasi pada Wanita Usia Subur: Literature Review

Menstruation is associated with sexual maturity, fertility, overall health, and even changes in various parts of the body. The menstrual cycle typically remains relatively stable during the reproductive years. However, 11.7% of adolescent girls in Indonesia experience menstrual cycle disturbances. Therefore, it is essential to identify factors related to the menstrual cycle. The study was a literature review. The literature used consisted of articles from national journals published in the last five years (2018–2023). The literature sources were obtained from "Google Scholar" using the keyword "siklus menstruasi".Five articles meeting the criteria were identified. Factors influencing the menstrual cycle in women of reproductive age included fast food consumption, stress levels, overweight or obesity, sleep quality, physical activity level, and anxiety. Conclusion: Effectively managing stress, maintaining an ideal body weight, ensuring an adequate amount of sleep, avoiding excessive physical activity, and addressing anxiety could contribute to a normal menstrual cycle.

Full-Field Strain Measurements of the Muscle-Tendon Junction Using X-ray Computed Tomography and Digital Volume Correlation.

We report, for the first time, the full-field 3D strain distribution of the muscle-tendon junction (MTJ). Understanding the strain distribution at the junction is crucial for the treatment of injuries and to predict tear formation at this location. Three-dimensional full-field strain distribution of mouse MTJ was measured using X-ray computer tomography (XCT) combined with digital volume correlation (DVC) with the aim of understanding the mechanical behavior of the junction under tensile loading. The interface between the Achilles tendon and the gastrocnemius muscle was harvested from adult mice and stained using 1% phosphotungstic acid in 70% ethanol. In situ XCT combined with DVC was used to image and compute strain distribution at the MTJ under a tensile load (2.4 N). High strain measuring 120,000 µε, 160,000 µε, and 120,000 µε for the first principal stain (εp1), shear strain (γ), and von Mises strain (εVM), respectively, was measured at the MTJ and these values reduced into the body of the muscle or into the tendon. Strain is concentrated at the MTJ, which is at risk of being damaged in activities associated with excessive physical activity.

Physical therapy management for muscle tightness in a surfing athlete: a case report study

Background: Muscle tightness refers to the sensation of tension or stiffness in the muscles, often resulting from factors such as excessive physical activity, inadequate warm-up before exercise, muscle injury, or underlying medical conditions. This article describes a case of a surfer patient with muscle tightness who has had ACL reconstruction meniscectomy and physical therapy management.
 Case description: The patient was a 51-year-old male surfing athlete from New Zealand diagnosed with muscle tightness. The patient had a history of ACL and meniscus injuries, followed by ACL reconstruction and meniscectomy of the right knee. The patient was on vacation in Bali, and he was surfing every day. The patient underwent physical therapy twice a week. The intervention program included modalities (transcutaneous electrical nerve stimulation and ultrasound), manual therapy (massage and patellar mobilization), and exercise therapy (range of motion exercises, strength training, and stretching).
 Conclusion: The physical therapy intervention program designed for one week can yield positive results in reducing pain levels, improving the range of motion of the right knee, increasing the circumference of the right knee segment, and enhancing the functional activities of the right knee.

Case report on Arrhythmogenic Right Ventricular Dysplasia

Arrhythmogenic cardiomyopathy (AC) is a genetic disease characterized by fibro-fatty replacement of either ventricles in isolation or in combination. It may cause tachyarrhythmias to sudden cardiac death, especially in young adult. When ventricular tachycardia (VT) is the principal manifestation then the condition is termed as arrhythmogenic right ventricular dysplasia (ARVD). Here we present a case of ARVD in a 36 years old hypertensive male who presented with sudden onset of chest tightness, palpitations, breathing difficulty, dizziness for 20 minutes. In emergency department his electrocardiogram (ECG) showed sustained VT. After 200 joule DC cardioversion he was reverted to sinus rhythm, then resting ECG showed T-wave inversion (TWI) in V1-V3 along with epsilon wave. His echocardiogram also revealed dilated right ventricle (RV) along with hypertrabeculation, RV wall motion abnormality and low RV ejection fraction (EF), his coronaries were normal on coronary angiogram (CAG). He was discharged from the hospital after Implantable Cardioverter Defibrilator (ICD) implantation with beta-blocker and advised to restrict excessive physical activity. J Bangladesh Coll Phys Surg 2024; 42: 86-91

CORRELATION OF ACADEMIC STRESS WITH OLIGOMENORRHEA IN FEMALE MEDICAL STUDENTS

Introduction: Oligomenorrhea is defined as an irregular menstrual cycle of more than 35 days or only experiencing 4 to 9 menstrual cycles in a year. According to research involving 12,964 women of childbearing age in China, it was found that 1,579 women (12.2%) experienced oligomenorrhea. Risk factors for oligomenorrhea are poor nutritional status, namely BMI < 18.5 or ≥ 25, excessive physical activity, high levels of stress (around 20%), and late age at menarche. Various studies have found a relationship between stress and abnormal menstrual cycles. Objective: To determine the relationship between academic stress and oligomenorrhea in female students at the Faculty of Medicine, Widya Mandala Catholic University, Surabaya, Class of 2019. Method: Analytical observational research with a cross-sectional approach. The population for this research is all 7th-semester female students at the Faculty of Medicine, Widya Mandala Catholic University, Surabaya, class of 2019, with a total sample of 32 female students taken using simple random sampling. The independent variable is academic stress while the dependent variable is oligomenorrhea. The research instrument used a questionnaire. Data analysis used the Spearman Rank correlation test. Result: A total of 20 respondents (62.5%) experienced moderate levels of academic stress, 3 respondents (9.4%) experienced low levels of academic stress, and 9 respondents (28.1%) experienced high levels of academic stress. For the menstrual cycle from August to October 2022, 23 female students (71.9%) experienced normal menstrual cycles, and 9 female students (28.1%) experienced oligomenorrhea. The results of the Spearman Rank correlation test obtained a significance value of 0.023. Conclusion: There is a relationship between academic stress and oligomenorrhea in students at the Faculty of Medicine, Widya Mandala Catholic University, Surabaya, Class of 2019.

Assessing the Accident-Cost Relationship in Building Construction Projects Using Structural Equation Modeling

This study aimed to evaluate the accident-causing factors affecting the total cost of building construction projects using a structural-equation model (SEM). Through the analysis of 35 identified factors categorized into construction, natural disaster, physical and human and psychological domains, this study examined their effects on project costs. The data collected from 120 construction experts in Iraq was analyzed using the SmartPLS software. This study assessed the fit of the measurement model using the following key criteria: reliability, convergent validity and divergent validity. All latent constructs demonstrated Cronbach’s-alpha values of above 0.70 and composite-reliability (CR) values of above 0.70, indicating their reliability. The average variance extracted (AVE) values exceeded the 0.5 threshold, confirming convergent validity. The model also demonstrated acceptable discriminant validity. The results confirmed the significant impact of accident-causing factors on project costs, with "excessive physical activity," "storm," "improper ventilation," "low motivation and low efficiency of the workers," and "fire, explosion and vibration" emerging as the top five influencing factors. These findings emphasized the need for tailored safety measures to mitigate such risks. The study underscored the importance of addressing accident-causing factors to enhance both safety planning and financial outcomes in building construction projects. KEYWORDS: Accident-causing factors, Project cost, Construction-project management, Safety assessment, Structural-equation modeling

THE RELATIONSHIP BETWEEN ALLOSTATIC LOAD AND PROGRESS OF MULTIMORBIDITY AMONG OLDER AMERICANS

Abstract To examine the relationship between allostatic load and progress of multimorbidity over 10 years among older Americans and whether it mediates socioeconomic inequalities in multimorbidity. Methods Six Waves of Health and Retirement Study (HRS), a longitudinal survey of older American adults from 2006 -2016. Multimorbidity was indicated by 5 chronic conditions: diabetes, heart conditions, lung diseases, cancer, and stroke. Socioeconomic factors were education, total wealth, poverty-income ratio (income), and race/ethnicity. Behavioural factors were smoking, excessive alcohol consumption, physical activity, and body mass index (BMI). Allostatic load was used as a biomarker of stress and was indicated by a combination of total cholesterol, high-density lipoprotein, glycosylated hemoglobin, c-reactive protein, waist circumference, and high blood pressure. Two Multilevel mixed effects generalized linear models were constructed to assess the association between allostatic load and progress of multimorbidity and whether allostatic load explained socioeconomic inequalities in the progress of multimorbidity. All variables included in the analysis were time-varying except gender, race/ethnicity, and education. Results Allostatic load was significantly associated with the progress of multimorbidity even after adjusting for socioeconomic and behavioural factors with a rate ratio (RR) of 1.12 (95%CI: 1.11, 1.13). The association between socioeconomic factors and multimorbidity was slightly attenuated after adjusting for allostatic load. Socioeconomic factors were also associated with changes in allostatic load. Conclusion Biological markers of stress indicated by allostatic load were associated with the progress of multimorbidity. Allostatic load appears to be induced by adverse socioeconomic factors and mediates the relationship between socioeconomic factors and progress of multimorbidity.

Effectiveness of bay leaf extract in reducing malondialdehyde levels

Excessive physical activity can lead to oxidative stress, resulting in elevated levels of free radicals in the human body. Oxidative stress is believed to be a precursor of various degenerative and chronic disorders, including arthritis, autoimmune diseases, cardiovascular diseases, neurodegenerative disorders, inflammatory diseases, and cancer. Malondialdehyde serves as a biomarker for oxidative stress and lipid peroxidation. Hence, the use of antioxidants is imperative to restore the balance in the body. The aim of this study was to investigate the effect of bay leaf administration on malondialdehyde levels in male Wistar rats. A pre-test–post-test design with a control group was employed in this study. Bay leaf extract was prepared using a maceration method with 70% ethanol. The rats were divided into four groups, including one control group and three treatment groups based on the dosage. Technical terms were explained when first used, and concise objective language was employed throughout the report. The study adhered to the conventional structure with standard citations and was free from grammatical, spelling, and punctuation errors. Blood samples were collected from the retro orbital plexus on days 1 (pretest) and 15 (posttest). Blood MDA levels were measured using the thiobarbituric acid reactive substances (TBARs) method, which involves reacting blood plasma with 20% TCA, 1% TBA, and 50% glacial acetic acid. To determine the significance of differences between the test groups, one-way ANOVA was used at a 95% confidence level (p < 0.05). Post Hoc Test with LSD technique was conducted for additional analysis or testing. Phytochemical test results indicated the presence of flavonoids, steroids, and tannins as secondary metabolites in the bay leaf extract. Administering bay leaf extract significantly lowered the MDA levels. The group receiving a 5 ml dose demonstrated greater effectiveness in reducing MDA levels in male white Wistar rats induced with excessive physical activity, based on average MDA levels.

Providing Of Mahkota Dewa Fruit Extract (Phaleria Macrocarpa) To Reduce Malondialdehyde Levels In The Blood Of White Rats (Rattus Norvegicus) Triggered By Excessive Physical Activity

Anti-inflammatory, antioxidant, and apoptosis-modulating potential are just a few biological activities that have garnered much interest in natural food-derived components during the past two decades. Mahkota Dewa fruit (Phaleria macrocarpa) has several beneficial pharmacological activities. This study investigated whether Mahkota Dewa fruit extract (Phaleria macrocarpa) reduced malondialdehyde levels in blood samples of white rats (Rattus norvegicus) generated by excessive physical activity. The samples for this study were white rats (Rattus norvegicus) weighing 160-200 gr and 2-3 months old. The independent variable was the Mahkota Dewa fruit extract (Phaleria macrocarpa). The dependent variable was excessive physical activity-induced malondialdehyde levels in white rats (Rattus norvegicus). The average Malondialdehyde (MDA) levels show that the group given 5 ml of the Mahkota Dewa fruit extract (Phaleria macrocarpa) had tremendous success in lowering MDA levels compared to the other groups. The results of the observations and data analysis show that administration of the extract can reduce MDA levels significantly in male Wistar rats (Rattus norvegicus) because of too much exercise.

The Examination of the Knowledge Level of Young Papuan Female Athletes about Female Athletes Triad (FAT)

Background: Female Athletes Triad (FAT) is a syndrome characterized by impaired energy availability, menstrual dysfunction, and low bone density. FAT might interfere with the health and performance of young female athletes in training and competition, which causes a decrease in achievement. Research on FAT is still limited in Indonesia, especially on indigenous Papuans. Objectives: To obtain a description of young Papuan female athletes' knowledge of FAT, including the three main components of FAT: danger, impacts, and risk factors for FAT. Methods: The total sample was 61 young female athletes with a convenience sampling technique. The survey method used a questionnaire consisting of questions related to athlete characteristics (age, ethnicity, training duration, and sports) and eight questions about FAT knowledge; it includes the three main components of FAT (osteoporosis, menstrual disorders, eating disorders), dangers and impacts, and the risk factors (age and physical activity). Results: Young Papua female athletes (80.33%) lacked knowledge about FAT. Most athletes (80.33%) had never heard of FAT. Most of the sample failed to identify FAT's three main components and risk factors correctly. Only five athletes (8.20%) correctly answered questions about fracture occurrence. Only six athletes (9.84%) could identify FAT components entirely and correctly, and about 11 (18.30%) answered correctly regarding the risk of excessive physical activity in athletes. Finally, only 23 athletes (37.70%) correctly answered questions about age. Conclusions: Young female Papuan athletes lack knowledge about the FAT components and risk factors.