Excessive Eosinophilia Research Articles

Chromophobe renal cell carcinoma associated with eosinophilia: A report of three cases.

Eosinophilia is typically associated with allergic reactions, parasitic infestations, certain forms of vasculitis, the use of certain medications and hematologic malignancies. In addition to eosinophilia associated with gastrointestinal tumors, lung cancer and thyroid carcinoma in solid malignancies, there are a limited number of cases describing peripheral hypereosinophilia in urologic tumors. The present study reports three cases of eosinophilia in patients with chromophobe renal cell carcinoma (CRCC) and investigates the association between excessive eosinophilia and the recurrence and prognosis of renal carcinoma. This is the first report of CRCC associated with excessive eosinophilia. Eosinophilia following tumor resectioning may indicate a poor prognosis, tumor recurrence and rapid disease progression.

Lung Carcinoma Associated With Excessive Eosinophilia

Lung Carcinoma Associated With Excessive Eosinophilia

Non‐small‐cell lung cancer associated with excessive eosinophilia and secretion of interleukin‐5 as a paraneoplastic syndrome

Eosinophilia associated with solid tumors is an infrequent occurrence. The pathogenesis of tumor-associated eosinophilia is not well understood. Interleukin-5 (IL-5) is a cytokine that has been implicated in the development of eosinophilia in mice and humans. However, there is little data associating IL-5 production with eosinophilia in the presence of tumor. We report, in a patient with locally advanced NSCLC, the presence of excessive eosinophilia and elevated serum IL-5 levels at diagnosis. Immunohistochemical staining of the primary tumor showed large amounts of intracellular IL-5. Both eosinophil count and IL-5 levels normalized after surgical removal of the tumor. Tumor-associated eosinophilia observed in this case is mediated by IL-5. The production of IL-5 is related to the presence of the tumor.

Eosinophilic leukemia: report of a case with autopsy.

Excerpt The existence of eosinophilic leukemia as a distinct entity is the subject of much controversy. When confronted with the problem of excessive eosinophilia, most clinicians are reluctant to ...

DISSEMINATED VISCERAL LESIONS ASSOCIATED WITH EXTREME EOSINOPHILIA

AMONG the conditions associated with pronounced and persistent - eosinophilia of the blood there is an obscure group of disorders reported under various names, such as chronic eosinophilia,1eosinophilia leukemoides,2extreme eosinophilia and leukocytosis,3eosinophilia and splenomegaly,4Loeffler's syndrome5and others. Many cases of so-called eosinophilic leukemia and some instances of familial eosinophilia6evidently belong in the same ill defined category. Clearcut criteria for a clinical syndrome embracing the entire group have not been established, and few pathologic studies of pertinent cases are available. The diagnosis is, therefore, often difficult. Prompted by a chance observation made in the course of an autopsy, we studied biopsy specimens of liver obtained from 3 patients with excessive eosinophilia and observed a characteristic widespread lesion which seems to us to represent the anatomic substrate of a clinical entity. We present the pathologic findings, together with clinical observations and with