The Maastrichtian deposits (late Campanian? to early Danian?) of the central Andes comprise three transgressive-regressive sequences. In Bolivia (El Molino Formation) they have yielded diverse terrestrial, brackish-water or marine fossils, which make it possible to define the depositional environments at their exact stratigraphic position. Marine-influenced transgressive facies are by far the best developed in the first sequence. Among the vertebrates, five groups of fishes are restricted, with some rare exceptions, to marine environmentsl. Some other fish families, genera or species, are known to occur both in freshwater, brackish and marine environments and therefore provide no precise environmental indications. Among the invertebrates, echinoids, serpulids, foraminifera and some pelecypods and gastropods attest to a marine-influenced environment, which may however have experienced periodic salinity variations. The other pelecypods and gastropods generally indicate freshwater environments. The ostracods, often ubiquitous, only provide paleoecologic indications when they constitute oligospecific shell beds, suggesting abnormally low salinity values. Calcispheres and dinoflagellates indicate a stronger marine influence. Charophytes, especially when abundant, suggest a lacustrine environment. Because of their stratigraphic and paleogeographic positions, stromatolites may indicate intertidal to supratidal environments. The fossils most likely of marine generally occur in the transgressive lower parts of the three sequences, where marine oolites and glauconite are also observed. The often endemic nature of the marine assemblages, the common occurrence of dwarfism and the lack of true nektonic forms suggest that most part of the basin was permanently rather shallow and subjected to important, frequent and/or local, salinity variations. The freshwater fishes appear to be reworked and dissociated in the marine levels, but are better preserved in the mainly continental upper parts of the sequences. Marine fossils are rare in the upper sequence. These data contradict with interpretations which suggest that the central Andean Senonian deposits are exclusively terrestrial. Given other paleogeographic constraints, we propose that Maastrichtian sedimentation took place in a wide, elongated, subsident basin, forming the eastern foreland of the paleo-Andes and showing a “cul-de-sac” shape in the south. This restricted basin was periodically connected with the open sea through present-day Venezuela. The salinity of its southern part, situated far from the basin mouth, was shallow and affected by fresh water from inflowing rivers.