This article examines the origins and evolution of the field of science policy and innovation studies (SPIS). Like other studies in this Special Issue, it seeks to systematically identify the key intellectual developments in the field over the last 50 years by analysing the publications that have been highly cited by other researchers. The analysis reveals how the emerging field of SPIS drew upon a growing range of disciplines in the late 1950s and 1960s, and how the relationship with these disciplines evolved over time. Around the mid-1980s, substantial parts of SPIS started to coalesce into a more coherent field centred on the adoption of an evolutionary (or neo-Schumpeterian) economics framework, an interactive model of the innovation process, and (a little later) the concept of ‘systems of innovation’ and the resource-based view of the firm. The article concludes with a discussion of whether SPIS is perhaps in the early stages of becoming a discipline.