We study the importance of several processes that influence the evolution of dust and its grain size distribution on spatially resolved scales in nearby galaxies. Here, we compiled several multi-wavelength observations for the nearby galaxies NGC\,628 (M74), NGC\,5457 (M101), NGC\,598 (M33), and NGC 300. We applied spatially resolved spectral energy distribution (SED) fitting to the latest iteration of infrared data to get constraints on the galaxy dust masses and the small-to-large grain abundance ratio (SLR). We separated each galaxy into radial rings and obtained the radial profiles of the properties mentioned above. For comparison, we took the radial profiles of the stellar mass and gas mass surface density for NGC\,628 combined with its metallicity gradient in the literature to calibrate a single-galaxy simulation using the GADGET4-OSAKA code. The simulations include a parametrization to separate the dense and diffuse phases of the ISM where different dust-evolution mechanisms are in action. We find that our simulation can reproduce the radial profile of dust mass surface density but overestimates the SLR in NGC\,628. Changing the dust-accretion timescale has little impact on the dust mass or SLR, as most of the available metals are accreted onto dust grains at early times ($<3$\,Gyr), except in the outer regions of the galaxy where the metallicity is below $2 $. This suggests we can only constrain the accretion timescale of galaxies at extremely low metallicities where accretion still competes with other mechanisms controlling the dust budget. The overestimation of the SLR likely results from (i) overly efficient shattering processes in the diffuse interstellar medium (ISM), which were calibrated to reproduce Milky Way-type galaxies and/or (ii) our use of a diffuse and dense gas density subgrid model that does not entirely capture the intricacies of the small-scale structure present in NGC\,628. We conclude that future modeling efforts will need to focus on improving the subgrid recipes to mimic the multi-phase gas distribution in galaxies before the efficiency of dust evolution processes can be calibrated for galaxies other than the Milky Way.