The long-term evolution of slopes affected by Mass Rock Creep deformations is controlled by both time-invariant predisposing factors, such as the geo-structural inheritance, and time-dependent preparatory conditions, including regional uplift and landscape evolution rates. However, the relationship among Deep-seated Gravitational Slope Deformations, drainage network evolution, and tectonics remains poorly defined. Here, we focused on an undocumented Deep-seated Gravitational Slope Deformation affecting an area of about 8 km2 in the SE tip termination of the Siah Kuh anticline in the Lorestan arc (Zagros Mts., Iran), upstream to the Mountain Front Fault. To assess the evolution processes which involved the slope up to the present, we integrated quantitative geomorphic analysis, optically stimulated luminescence dating of geomorphic markers, and SAR interferometry techniques. In detail, we semi-automatically extracted the river terrace treads to which we associated an elevation above the thalweg based on the Relative Elevation Model allowing the order definition. The plano-altimetric distribution of the treads and the OSL ages of two levels of strath terraces sampled in the field have been correlated along the river longitudinal profile, allowing the estimation of an uplift rate of 2.8 ± 0.2 mm year−1 and 0.42 ± 0.03 mm year−1, respectively upstream and downstream of the Mountain Front Fault. SAR interferometry was used to spot present-day shallow ground displacements associated with the ongoing slope deformation, by processing 279 satellite Sentinel-1 (A and B) radar images of the ascending and descending orbit spanning from 06 October 2014 to 31 March 2019. Different landslide mechanisms were distinguished across the fold axis, rototranslative to lateral spreading interpreted as two different evolutionary stages of the same process transposed spatially through the fold axis. Indeed, the rototranslative mechanism represents an advanced stage of the strain evolution while the lateral spreading is an earlier one. Finally, we infer that the variability in the spatial distribution of the slope deformation styles and patterns in the Lorestan arc is strictly related to the coupled evolution of the drainage system and tectonics. Involved volumes (from 0.6 up to 44 km3), local relief (from 400 up to 2000 m), incision rates (from 0.8 to 2.8 ± 0.2 mm year−1), and persistence time (from 104 to 105 years) represent the most important preparatory conditions and are predisposed by a moderately dipping downslope (from 8 to 25°) sedimentary sequence characterised by units with significantly different rheological behaviour.