Eventual Stability Research Articles

7533 Mifepristone For Primary Hypercortisolism Contributing To Profound Hypokalemia

Abstract Disclosure: J. Watkins: None. J.G. Melendez-Rivera: None. E. Florin: None. K.B. Rivera: None. Background: Primary hypercortisolism is typically treated surgically, but when adrenalectomy is not pursued, medical therapy can be effective. Adrenal enzyme inhibitors or glucocorticoid antagonists can be used. Mifepristone is the only available glucocorticoid antagonist at this time. Mifepristone is approved specifically for glucose control in Cushing’s syndrome. Because mifepristone blocks cortisol action rather than production, hormone levels may increase and are unhelpful in titrating the mifepristone dose. Rather, titration is based on clinical manifestations of Cushing’s syndrome. Further, the increased hormone levels can lead to increased activation of mineralocorticoid receptor, in addition to the increased activation caused by hypercortisolism, which can cause hypokalemia. Clinical Case: An 82-year-old woman had been following with endocrinology for hypercortisolism found to be secondary to bilateral adrenal adenomas. She preferred medical therapy rather than surgery given her age, and she was started on mifepristone 300 mg/day. Within a few weeks, she developed leg swelling and was started on a low dose of chlorthalidone by her primary care doctor. She then presented to the emergency department after five days of nausea, abdominal pain, palpitations, and reduced oral intake. She was found to have severe hypokalemia (potassium 1.8 mEq/L, normal 3.5 - 5.0 mEq/L), and her creatinine was 0.97 µmol/L (baseline 0.6-0.75 µmol/L). Physical exam was unremarkable. CT abdomen/pelvis revealed three adrenal lesions, similar to a study from one year prior. Her mifepristone was stopped, and she was given potassium supplementation and started on spironolactone with eventual stabilization of her potassium level. She was also started on ketoconazole for management of her hypercortisolism. It was discussed that she might now consider adrenal vein sampling to pursue adrenalectomy. Severe hypokalemia and borderline metabolic alkalosis were most likely multifactorial in etiology. Hypercortisolism predisposed the patient to hypokalemia. She was then started on mifepristone, which inhibits the glucocorticoid receptor thereby increasing activation of the mineralocorticoid receptor, which likely further contributed to hypokalemia. The leg swelling that she developed and saw her primary doctor for may have been a sign of over-activation of the mineralocorticoid receptor due to the mifepristone, and prescription of chlorthalidone at that time would have worsened the hypokalemia that was likely present at that time. Conclusion: It is important to be aware of the possible severity of side effects of medical therapy for hypercortisolism, such as severe hypokalemia. There is a role for increased awareness of routine monitoring of potassium levels, as well as considering spironolactone in many patients even prior to onset of hypokalemia. Presentation: 6/3/2024

Research on the evolution law and control technology of deviatoric stress in the surrounding rock of gob-side entry retaining

Gob-side entry retaining (GER) play a crucial role in enhancing coal recovery, improving roadway stress conditions, and ensuring safe and efficient mining operations. This study focuses on investigating the stability characteristics of surrounding rock using flexible formwork concrete (FFC) along the headgate of 3405 panel. According to the fracture pattern of roof, a mechanical model of GER was developed. This study derived expressions for the support resistance of the filling body and determined its optimal bearing capacity. A FLAC3D numerical model was employed to simulate the GER process, segmented into early, middle, and late stages. Simulation results demonstrate a progression in peak deviatoric stress and extent of plastic zones in the surrounding rock. This evolution includes an initial minor increase (early stage), followed by rapid escalation (middle stage), and eventual stabilization (late stage). The middle stage emerges as critical, characterized by pronounced mining-induced stress effects on the roof. During this phase, significant changes are observed in deviatoric stress curves, with plastic zones rapidly migrating deeper into the rock mass. Practical implementation of the findings revealed a maximum deformation of the filling body of only 198 mm, affirming the feasibility of employing FFC in GER. This research provides valuable insights into managing stability concerns in GER thereby enhancing safety and operational efficiency in coal mining under similar conditions.

The Structural and Orbital Effects of Active Galactic Nuclei Feedback on SMBH Binaries Embedded in Gaseous Circumbinary Disks

Using subparsec-scale-resolution radiation+hydrodynamical adaptive mesh refinement simulations deployed with the RAMSES code, we study the dynamics of supermassive black hole (SMBH) binaries embedded in gaseous nuclear circumbinary disks, where we investigate the effects of active galactic nucleus feedback on the SMBH binaries' migration behavior and disk structure. The radiative feedback effects are modeled by injecting photons that interact with the gas, through the adoption of a grid of BH emission spectra. We run simulations with initial conditions that lead by pure gravity plus hydrodynamics both to the formation of a low-density tidal cavity and to systems where gas–viscous diffusion is efficient enough to maintain a sizable gas reservoir surrounding the binary. For gap-forming binaries we find that orbital evolution is unchanged with the inclusion of feedback, but ionizing radiation photoevaporates gas that is at the outer edge of the low-density region. For non-gap-forming systems we find that when feedback is included a strong initial disruption of the circumbinary disk is followed by an eventual stabilization of the medium that can usher a return to a fast binary migration regime. All of this is possible as a result of how our simulations capture the ionization states of the nuclear disk region and how this affects the coupling efficiency decrease with respect to the radiative feedback.

A Secondary Analysis of the Complex Interplay between Psychopathology, Cognitive Functions, Brain Derived Neurotrophic Factor Levels, and Suicide in Psychotic Disorders: Data from a 2-Year Longitudinal Study.

Identifying phenotypes at high risk of suicidal behaviour is a relevant objective of clinical and translational research and can facilitate the identification of possible candidate biomarkers. We probed the potential association and eventual stability of neuropsychological profiles and serum BDNF concentrations with lifetime suicide ideation and attempts (LSI and LSA, respectively) in individuals with schizophrenia (SCZ) and schizoaffective disorder (SCA) in a 2-year follow-up study. A secondary analysis was conducted on a convenience sample of previously recruited subjects from a single outpatient clinic. Retrospectively assessed LSI and LSA were recorded by analysing the available longitudinal clinical health records. LSI + LSA subjects consistently exhibited lower PANSS-defined negative symptoms and better performance in the BACS-letter fluency subtask. There was no significant association between BDNF levels and either LSI or LSA. We found a relatively stable pattern of lower negative symptoms over two years among patients with LSI and LSA. No significant difference in serum BDNF concentrations was detected. The translational viability of using neuropsychological profiles as a possible avenue for the identification of populations at risk for suicide behaviours rather than the categorical diagnosis represents a promising option but requires further confirmation.

Study on the active regeneration characteristics of DPF in diesel-methanol dual-fuel engine under different exhaust oxygen concentrations

This study proposes a method to control exhaust oxygen (O2) concentration by adjusting the intake throttle valve, achieving intake throttling, and reducing intake airflow. The impact of exhaust O2 concentration at the inlet of the diesel oxidation catalyst (DOC) the diesel particulate filter (DPF) performance during active regeneration in diesel engines is investigated. Experiments are conducted under methanol substitution rates (MSR) of 0% and 20% to investigate how different exhaust O2 concentrations affect the performance of the DOC and DPF during active regeneration. A comparative analysis of fuel consumption and cumulative CO2 emissions during DPF active regeneration under different exhaust O2 concentrations is performed. Research results indicate that decreasing exhaust O2 concentration reduces exhaust flow, raising DOC inlet temperature. This enhancement improves catalytic conversion efficiency, accelerating the rise in DPF inlet temperature. The average conversion efficiency of DOC to unburned methanol exceeds 98.07%. After initiating DPF active regeneration, O2 concentration sharply drops, leading to elevated CO2 emissions. As soot combustion advances, the required O2 diminishes, resulting in a gradual rise and eventual stabilization of O2 emissions. Economically and environmentally, irrespective of MSR (20% or 0%), there exists an optimal exhaust O2 concentration that minimizes effective regeneration time during DPF active regeneration, achieving minimal fuel consumption and the lowest CO2 mass emissions. This study offers theoretical support for optimizing energy-saving and emission-reduction processes during DPF active regeneration.

Revealing Dynamic Evolution of the Anode‐Electrolyte Interphase in All‐Solid‐State Batteries with Excellent Cyclability

AbstractAll‐solid‐state‐batteries (ASSBs) based on a halide solid electrolyte (SE) and a lithium‐metal based anode typically have poor cyclability without a buffer layer (such as Li3PS4 or Li6PS5Cl) to prevent the degradation reactions. Here excellent cycling stability of ASSB consisting of an uncoated single‐crystal LiNi0.8Co0.1Mn0.1O2 cathode and a Li3YCl6 (LYC) SE separator in direct contact with a Li‐In anode are demonstrated. Through a combination of electrochemical measurements, synchrotron micro‐X‐ray absorption and diffraction analyses, and density functional theory calculations, reveal for the first time that along with the standard Li+ transport during charge/discharge, indium in the Li‐In anode also participates in the redox reactions. The in‐situ generated In3+ preferentially occupies the vacant Li sites in the trigonal LYC lattice, leading to the formation, growth, and eventual stabilization of an anode‐electrolyte interphase (AEI) layer consisting of an In‐doped Li3‐xInxYCl6 (x = ≈0.2) phase. It is discussed how the presence of such an AEI layer prevents LYC decomposition and suppresses dendrite formation and propagation, enabling stable cycling of ASSB with ≈90% capacity retention over 1000 cycles. This work sheds light on the dynamic evolution of the halide SE and alloy anode interphase, and opens new avenues in the future design of long‐lasting high‐energy all‐solid‐state‐batteries.

Analysis of the Drag Reduction Performance and Rheological Properties of Drag-Reducing Additives.

In the practical application of hydraulic rotating machinery, it is essential to thoroughly explore drag reduction and rheological characteristics of drag-reducing additives to optimize machinery efficiency and reduce equipment consumption. This paper combines simulation and experimental approaches to investigate the drag-reduction performance and rheological properties of drag-reducing additives. Numerical simulations are initially conducted to investigate the shear-thinning properties of drag-reducing fluid and explore variations in drag-reduction rate. Turbulent phenomena characteristics are described by analyzing turbulent statistical quantities. Subsequently, the rheological behaviors of polyethylene oxide (PEO), cetyltrimethyl ammonium chloride (CTAC), and their mixed solutions under different conditions are scrutinized using a rotational rheometer. The findings indicate that the drag reduction effect amplifies as the rheological index n and characteristic time λ decrease. The numerical simulations show a maximum drag reduction rate of 20.18%. In rheological experiments, a three-stage viscosity variation is observed in single drag-reducing additives: shear thickening, shear thinning, and eventual stabilization. Composite drag-reducing additives significantly reduce the apparent viscosity at low shear rates, thereby strengthening the shear resistance of the system.

Microscopic deformation and fragmentation energy consumption characteristics of soils with various moisture contents using discrete element method

Increased soil moisture content commonly leads to higher resistance and energy consumption during agricultural operations. However, the impact of moisture content on soil microscopic deformation and fragmentation energy consumption characteristics remains unclear. In this study, discrete element models of sandy clay loam with different gravimetric water contents (15.0%, 18.8%, 21.6%, 24.1%, and 27.3%) were constructed for simulation experiments using coupled contact method (Hertz-Mindlin with bonding and Hertz-Mindlin with JKR). The degree of soil fragmentation and the rate of crack propagation were investigated. The results indicated that at fixed gravimetric water content, fissure rate exhibited a pattern of slow increase, rapid increase, and eventual stabilization with increasing compression displacement, while the fissure transfer coefficient showed a pattern of first increase and then decrease. At a fixed compression displacement, the increase in moisture content led to a decrease in both fissure rate and fissure transfer coefficient. The analysis of soil stress-strain characteristics and energy dissipation patterns found that soil with a gravimetric water content of 27.3% (close to soil liquid limit) exhibited no compression yield point; at a soil gravimetric water content of 15.0%, the minimum crushing energy (Udmin) was achieved (1.32 J), with a maximum elastic strain energy (Uemax) of 1.83 J. Similarly, at a soil gravimetric water content of 24.1%, the minimum crushing energy (Udmin) was reached (2.17 J), with a maximum elastic strain energy (Uemax) of 2.25 J. The comparison between actual and simulated results revealed low relative errors (<6%) in Udmin for all the above soil gravimetric water contents, suggesting the feasibility of our coupled discrete element model for assessing soil crushing energy consumption. This study revealed microscopic deformation and instability fragmentation mechanisms of soils with various moisture contents under vertical axial loads. Our findings provide novel method and strategy for developing the high-efficiency low-consumption soil fragmentation model.

Eventual smoothness and stabilization of global weak solutions to a chemotaxis system with sublinear consumption of chemoattractant

Eventual smoothness and stabilization of global weak solutions to a chemotaxis system with sublinear consumption of chemoattractant

On a Class of Piecewise Continuous Lyapunov Functions and Uniform Eventual Stability of Nonlinear Impulsive Caputo Fractional Differential Equations via New Generalized Dini Derivative

On a Class of Piecewise Continuous Lyapunov Functions and Uniform Eventual Stability of Nonlinear Impulsive Caputo Fractional Differential Equations via New Generalized Dini Derivative

Study on the impact of debris flow from tailings dam failure on shale gas well station

The shale gas well station plays a critical role in the extraction of shale gas, and its safety status exerts significant influence not only on shale gas production but also on the ecological balance of the surrounding environment. To investigate the response characteristics of the shale gas well station under the impact of tailings dam failure debris flow, a comprehensive analysis was conducted using a combination of physical modeling and numerical simulation. The analysis focused on the dynamic inundation process and the impact siltation law caused by the downstream flow of tailings dam failure debris at the shale gas well station. The depth of inundation and the extent of siltation damage were employed as key parameters for characterization. Experimental findings revealed that the downstream mudflow inundation process could be divided into three distinct stages: rapid increase (0–60 s), steady increase (60–106 s), and slow advance (106–250 s). The pattern of mudflow siltation height variation at the well station exhibited an initial rise, followed by a subsequent decline and eventual stabilization. The highest siltation volumes recorded at measurement points A to D were 4.4, 4, 5.2, and 6 m, respectively. Additionally, by employing computational fluid dynamics, numerical calculations were performed under unprotected conditions, with the error between the calculated conclusions and the test results not exceeding 15%. Furthermore, the blocking effect of 8 and 16 m debris flow blocking dam on the debris flow was thoroughly investigated. The study demonstrated that the check dam with a height of 16 m yielded the most effective blockage, resulting in the highest sediment siltation height of 0.4 m. The research results provide some reference for the prevention and control of debris flow disasters.

Improving the Stability of Halide Perovskites for Photo‐, Electro‐, Photoelectro‐Chemical Applications

AbstractOwing to their remarkable and adjustable optoelectronic properties, halide perovskites (HPs) have been regarded as a class of promising materials for various optoelectronic applications based on different energy conversion reactions, including photovoltaic cell, photocatalysis, electrocatalysis, and photoelectrochemical (PEC) systems. However, the low stability of HPs upon exposure to ambient conditions (e.g., water, heat, light, electricity) greatly hinders the practical applications of HPs. In the past few years, significant efforts have been devoted to enhancing the eventual stability of the perovskite‐based optoelectronic systems, mainly focusing on delivering improvements in the stabilities of halide perovskite materials and the relevant operation conditions of optoelectronic systems, which deserve in‐depth and systematic summaries. In this comprehensive review, the in‐depth environment‐induced decomposition mechanisms of typical HPs are elucidated. Simultaneously, the strategies for addressing the instability issues of halide perovskite materials are critically reviewed, including dimension control, compositional engineering, ligand passivation, and encapsulation engineering. Furthermore, the photoelectric applications based on the modified HPs and operation conditions are discussed systematically. In the last part of this review, future perspectives and outlooks toward the stability of HPs and their photoelectric applications are envisaged respectively.

Evolution of Water-Conducting Fracture in Weakly Cemented Strata in Response to Mining Activity: Insights from Experimental Investigation and Numerical Simulation

The accurate prediction of the vertical extent of water-conducting fracture (WCF) zones in weakly cemented strata is particularly significant in preventing and controlling water hazards in western coal mines. The evolution of fractures in weakly cemented strata affected by mining disturbances was comprehensively analyzed by physical similarity models, numerical simulations, and field investigations. Results indicated that the development progress of water-conducting fractures can be divided into three phases: initial slow generation, subsequent rapid development, and eventual stabilization. The numerical simulation results revealed that in the initial stage of working face mining, the development of the plastic zone is limited, and there is minimal failure in the overlying strata; therefore, fractures are slowly produced without penetrating through the strata. When the plastic zone fully encompasses the entire main roof, it triggers severe shear failure in the overlying strata, resulting in rapid fracture propagation and penetration. Once the fracture height reaches a stable state, there is no further increase in the maximum vertical displacement of key strata, indicating the extensive collapse and compaction of the overburden as well as the stabilization of the fracture heights. A modified prediction equation for WCF in weakly cemented strata was obtained by correcting the traditional empirical formula based on field investigations. This modified prediction equation enhances the accuracy in predicting fracture heights and provides a theoretical reference to address the issue of the inaccurate prediction of the water-conducting fracture height in western mine rock strata.

Data Analysis of the Wordle Game: Insights and Predictive Models Based on Twitter Data

In 2022, the game "Wordle" gained immense popularity worldwide as players faced the challenge of guessing a five-letter word within six attempts, accompanied by feedback. This paper presents an extensive analysis of "Wordle" based on data mined from Twitter during the period from January 7 to December 31, 2022. The primary objective is to explore the game's dynamics and player engagement comprehensively.To achieve this, a sophisticated time-series model was developed to effectively track the fluctuation in the number of players. The model highlights an initial upward trend, reaching its peak on February 3, followed by a gradual decline and eventual stabilization, reflecting the sustained allure of the game. Additionally, this paper leveraged an XGBoost model to predict the distribution of player attempts, exhibiting remarkable accuracy, particularly for attempts ranging from three to six. This research demonstrates the powerful impact of data science in decoding intricate game dynamics and player behavior. Moreover, it emphasizes the fusion of gaming, data analytics, and social media as an exciting frontier for future research. The study's findings provide valuable insights into the gaming community's preferences and the underlying mechanisms that drive user engagement in digital gaming platforms.

A Mathematical Model of Financial Bubbles: A Behavioral Approach

In this work, we propose a mathematical model to describe the price trends of unsustainable growth, abrupt collapse, and eventual stabilization characteristic of financial bubbles. The proposed model uses a set of ordinary differential equations to depict the role played by social contagion and herd behavior in the formation of financial bubbles from a behavioral standpoint, in which the market population is divided into neutral, bull (optimistic), bear (pessimistic), and quitter subgroups. The market demand is taken to be a function of both price and bull population, and the market supply is taken to be a function of both price and bear population. In such a manner, the spread of optimism and pessimism controls the supply and demand dynamics of the market and offers a dynamical characterization of the asset price behavior of a financial bubble.

Damped Oscillatory Dynamics of a Drop Impacting over Oil-Infused Slippery Interfaces─Does the Oil Viscosity Slow it Down?

A liquid drop impacting on a soft surface is known to exhibit fascinating dynamics that is distinctive from its bounce-back atop a rigid surface. However, while the early spreading of the drop subsequent to its immediate impact with a lubricating liquid layer appears to be reasonably well understood, the later events of retraction and eventual stabilization appear to be poorly addressed. Here, we bring out the nontrivial confluence of the solid substrate wettability and the liquid layer viscosity toward modulating the post-collision dynamics of an impinging liquid drop on a viscous oil-infused surface during its later phase of settlement before arriving at an equilibrium state. Our results reveal that despite an intuitive analogy with the classical phenomenon of damped oscillation, the drop, during its later stages of motion, undergoes dynamical events that may be nontrivially dictated by not only the relative viscosity of the impacting drop and the liquid layer but also the intrinsic wettability of the solid substrate, governing its post-impact settlement via a sequel of spreading-retraction cycles. As a consequence, the viscous liquid layer, instead of providing additional damping, may nonintuitively reduce the effective viscous dissipation so as to hasten the drop's final settlement. These results may turn out to be critical in designing engineered surfaces for tuning the movement of drops in a preferential pathway, bearing decisive implications in the functionalities of liquid lenses, inkjet printing, spray coating and cooling, and several other emerging applications in the realm of lubricated fluidic interfaces.

Electro-wetting induced dynamic manipulation of symmetrically coalescing viscoelastic liquid bridges

Merging of isolated liquid drops is a common phenomenon that may greatly be influenced by adding polymeric contents to the liquid. Here, we bring out an exclusive control on the dynamics of the intermediate liquid bridge, thus, formed via exploiting the interactions of an exciting electric field with a trace amount of polymeric inclusions present in the intermingling drops. Our results unveil a unique competition of the elastic recovery and time-oscillatory forcing during the drop-unification at early times. However, damped oscillations as a specific signature of the polymer concentration feature eventual stabilization of the bridge at later instants of time. We rationalize these experimental findings in light of a simple unified theory that holds its critical implications in droplet manipulation in a wide variety of applications encompassing digital microfluidics, chemical processing, and biomedical analytics.

A direct numerical simulation analysis of localised forced ignition in turbulent slot jets of CH4/CO2 blends

The early stages of flame evolution following successful localised forced ignition of different CH[Formula: see text]/CO[Formula: see text] blends in a slot jet configuration have been analysed using three-dimensional direct numerical simulations. The simulations have been conducted for three different concentration levels of CO[Formula: see text] in the fuel blend composed of CH[Formula: see text] and CO[Formula: see text] (ranging from 0% to 20% by volume). The effects of CO[Formula: see text] concentration have been analysed based on five different energy deposition scenarios which include situations where the mean mixture composition at the ignitor varies, but not its location in space, whereas other cases represent the scenarios where the mean mixture composition within the energy deposition region remains constant, but its spatial location changes with CO[Formula: see text] concentration. The most favourable region for successful flame development following thermal runaway, from the mixture composition standpoint (i.e. the highest flammability factor), has been found to be displaced close to the nozzle with an increase in CO[Formula: see text] concentration. The flame development following thermal runaway exhibits initial growth of hot gas kernel followed by downstream advection and eventual flame propagation along with radial expansion with a possibility of flame stabilisation irrespective of the level of CO[Formula: see text] concentration. The triple flame propagation has been found to play a key role in the upstream flame propagation and eventual stabilisation. The orientation of the local flame normal plays a key role in the flame stabilisation. The lift off height has been found to increase with increasing CO[Formula: see text] concentration which also adversely affect flame stabilisation for high levels of CO[Formula: see text] concentration.

Symptom Assessment Following Surgery for Lung Cancer: A Canadian Population-based Retrospective Cohort Study.

To conduct a population-level analysis of temporal trends and risk factors for high symptom burden in patients receiving surgery for non-small cell lung cancer (NSCLC). A population-level overview of symptoms after curative intent surgery is necessary to inform decision making and supportive care for patients with lung cancer. Retrospective cohort study of patients receiving surgery for stages I to III NSCLC between January 2007 and September 2018. Prospectively collection Edmonton Symptom Assessment System (ESAS) scores, linked to provincial administrative data, were used to describe the prevalence, trajectory, and predictors of moderate-to-severe symptoms in the year following surgery. A total of 5350 patients, with 28,490 unique ESAS assessments, were included in the analysis. Moderate-to-severe tiredness (68%), poor wellbeing (63%), and shortness of breath (60%) were the most common symptoms reported. The rise and fall in the proportion of patients experiencing moderate-to-severe symptoms after surgery coincided with the median time to first (58 days, interquartile range: 47-72) and last cycle of chemotherapy (140 days, interquartile range: 118-168), respectively. There was eventual stabilization, albeit above the preoperative baseline, within 6 to 7 months after surgery. Female sex (relative risk [RR] 1.09- 1.26), lower income (RR 1.08-1.23), stage III disease (RR 1.15-1.43), adjuvant therapy (RR 1.09-1.42), chemotherapy within 2 weeks of an ESAS assessment (RR 1.14-1.73), and pneumonectomy (RR 1.05-1.15) were associated with moderate-to-severe symptoms following surgery. Knowledge of population-level prevalence, trajectory, and predictors of moderate-to-severe symptoms after surgery for NSCLC can be used to facilitate shared decision making and improve symptom management throughout the course of illness.

Bevacizumab-Laden Nanofibers Simulating an Antiangiogenic Niche to Improve the Submuscular Stability of Stem Cell Engineered Cartilage.

Bone marrow stem cells (BMSCs) engineered cartilage (BEC) is prone to endochondral ossification in a submuscular environment due to the process of vascular infiltration, which limits its application in repairing tracheal cartilage defects. Bevacizumab, an antitumor drug with pronounced antiangiogenic activity, is successfully laden into a poly(L-lactide-co-caprolactone) system to prepare bevacizumab-laden nanofiber (BevNF) characterized by 5% and 10% bevacizumab concentrations. The in vitro results reveal that a sustained release of bevacizumab can be realized from BevNF, exhibiting inhibitive cytotoxicity toward human umbilical vein endothelial cells whereas non-cytotoxicity toward BMSCs-induced chondrocytes. A model is also established by encapsulating BEC within BevNF, aiming to realize an antiangiogenic niche under conditions of sustained and localized release of bevacizumab to inhibit the process of vascular invasion, resulting in the eventual stabilization of the cartilaginous phenotype and promotion of the process of cartilage maturation in the submuscular environment. These results also confirm that the chondrogenesis stability of BEC increases with an increase in the bevacizumab concentration, and 10% BevNF is sufficient to protect BEC from vascularization. This demonstrates that the use of BevNF can potentially help develop an effective strategy for regulating the submuscular stability of BEC to repair the defects formed in tracheal cartilage.