Based on the hybrid event-triggered mechanism (HETM), the boundary stabilization issue for fractional-order nonlinear reaction–diffusion systems (FNRDSs) with time-varying delay is studied by using two kinds of measurements. First, when the system state is measurable, a event-triggered feedback controller (ETFC) is designed directly based on the average measured output. Secondly, for the case that the state is unmeasurable, an event-triggered feedback controller based on observer framework is constructed through the boundary point measurement information. Utilizing the Lyapunov method and Wirtinger’s inequality, sufficient conditions for the asymptotic stability of the system are given in the form of linear matrix inequalities (LMIs), respectively, in which the Razumikhin theorem is used to deal with time-varying delay. Meanwhile, it is proved that Zeno behavior can be excluded by the designed HETM. Finally, numerical simulations demonstrate the validity and feasibility of the proposed control scheme.