Event-related Synchronization Research Articles

Adults with cerebral palsy exhibit uncharacteristic cortical oscillations during an adaptive sensorimotor control task

Prior research has shown that the sensorimotor cortical oscillations are uncharacteristic in persons with cerebral palsy (CP); however, it is unknown if these altered cortical oscillations have an impact on adaptive sensorimotor control. This investigation evaluated the cortical dynamics when the motor action needs to be changed “on-the-fly”. Adults with CP and neurotypical controls completed a sensorimotor task that required either proactive or reactive control while undergoing magnetoencephalography (MEG). When compared with the controls, the adults with CP had a weaker beta (18–24 Hz) event-related desynchronization (ERD), post-movement beta rebound (PMBR, 16–20 Hz) and theta (4–6 Hz) event-related synchronization (ERS) in the sensorimotor cortices. In agreement with normative work, the controls exhibited differences in the strength of the sensorimotor gamma (66–84 Hz) ERS during proactive compared to reactive trials, but similar condition-wise changes were not seen in adults with CP. Lastly, the adults with CP who had a stronger theta ERS tended to have better hand dexterity, as indicated by the Box and Blocks Test and Purdue Pegboard Test. These results may suggest that alterations in the theta and gamma cortical oscillations play a role in the altered hand dexterity and uncharacteristic adaptive sensorimotor control noted in adults with CP.

Brain Networks Modulation during Simple and Complex Gait: A "Mobile Brain/Body Imaging" Study.

Walking encompasses a complex interplay of neuromuscular coordination and cognitive processes. Disruptions in gait can impact personal independence and quality of life, especially among the elderly and neurodegenerative patients. While traditional biomechanical analyses and neuroimaging techniques have contributed to understanding gait control, they often lack the temporal resolution needed for rapid neural dynamics. This study employs a mobile brain/body imaging (MoBI) platform with high-density electroencephalography (hd-EEG) to explore event-related desynchronization and synchronization (ERD/ERS) during overground walking. Simultaneous to hdEEG, we recorded gait spatiotemporal parameters. Participants were asked to walk under usual walking and dual-task walking conditions. For data analysis, we extracted ERD/ERS in α, β, and γ bands from 17 selected regions of interest encompassing not only the sensorimotor cerebral network but also the cognitive and affective networks. A correlation analysis was performed between gait parameters and ERD/ERS intensities in different networks in the different phases of gait. Results showed that ERD/ERS modulations across gait phases in the α and β bands extended beyond the sensorimotor network, over the cognitive and limbic networks, and were more prominent in all networks during dual tasks with respect to usual walking. Correlation analyses showed that a stronger α ERS in the initial double-support phases correlates with shorter step length, emphasizing the role of attention in motor control. Additionally, β ERD/ERS in affective and cognitive networks during dual-task walking correlated with dual-task gait performance, suggesting compensatory mechanisms in complex tasks. This study advances our understanding of neural dynamics during overground walking, emphasizing the multidimensional nature of gait control involving cognitive and affective networks.

Spectrotemporal cortical dynamics and semantic control during sentence completion

ObjectiveTo investigate cortical oscillations during a sentence completion task (SC) using magnetoencephalography (MEG), focusing on the semantic control network (SCN), its leftward asymmetry, and the effects of semantic control load. MethodsTwenty right-handed adults underwent MEG while performing SC, consisting of low cloze (LC: multiple responses) and high cloze (HC: single response) stimuli. Spectrotemporal power modulations as event-related synchronizations (ERS) and desynchronizations (ERD) were analyzed: first, at the whole-brain level; second, in key SCN regions, posterior middle/inferior temporal gyri (pMTG/ITG) and inferior frontal gyri (IFG), under different semantic control loads. ResultsThree cortical response patterns emerged: early (0–200 ms) theta-band occipital ERS; intermediate (200–700 ms) semantic network alpha/beta-band ERD; late (700–3000 ms) dorsal language stream alpha/beta/gamma-band ERD. Under high semantic control load (LC), pMTG/ITG showed prolonged left-sided engagement (ERD) and right-sided inhibition (ERS). Left IFG exhibited heightened late (2500–2550 ms) beta-band ERD with increased semantic control load (LC vs. HC). ConclusionsSC involves distinct cortical responses and depends on the left IFG and asymmetric engagement of the pMTG/ITG for semantic control. SignificanceFuture use of SC in neuromagnetic preoperative language mapping and for understanding the pathophysiology of language disorders in neurological conditions.

Sensorimotor Oscillations in Human Infants during an Innate Rhythmic Movement.

The relationship between cerebral rhythms and early sensorimotor development is not clear. In recent decades, evidence revealed a rhythmic modulation involving sensorimotor processing. A widely corroborated functional role of oscillatory activity is to coordinate the information flow across sensorimotor networks. Their activity is coordinated by event-related synchronisation and desynchronisation in different sensorimotor rhythms, which indicate parallel processes may be occurring in the neuronal network during movement. To date, the dynamics of these brain oscillations and early sensorimotor development are unexplored. Our study investigates the relationship between the cerebral rhythms using EEG and a typical rhythmic movement of infants, the non-nutritive sucking (NNS) behaviour. NNS is an endogenous behaviour that originates from the suck central pattern generator in the brainstem. We find, in 17 infants, that sucking frequency correlates with beta synchronisation within the sensorimotor area in two phases: one strongly anticipating (~3 s) and the other encompassing the start of the motion. These findings suggest that a beta synchronisation of the sensorimotor cortex may influence the sensorimotor dynamics of NNS activity. Our results reveal the importance of rapid brain oscillations in infants and the role of beta synchronisation and their possible role in the communication between cortical and deep generators.

Altered neural oscillations in classical galactosaemia during sentence production.

Classical galactosaemia (CG) is a hereditary disease in galactose metabolism that despite dietary treatment is characterized by a wide range of cognitive deficits, among which is language production. CG brain functioning has been studied with several neuroimaging techniques, which revealed both structural and functional atypicalities. In the present study, for the first time, we compared the oscillatory dynamics, especially the power spectrum and time-frequency representations (TFR), in the electroencephalography (EEG) of CG patients and healthy controls while they were performing a language production task. Twenty-one CG patients and 19 healthy controls described animated scenes, either in full sentences or in words, indicating two levels of complexity in syntactic planning. Based on previous work on the P300 event related potential (ERP) and its relation with theta frequency, we hypothesized that the oscillatory activity of patients and controls would differ in theta power and TFR. With regard to behavior, reaction times showed that patients are slower, reflecting the language deficit. In the power spectrum, we observed significant higher power in patients in delta (1-3 Hz), theta (4-7 Hz), beta (15-30 Hz) and gamma (30-70 Hz) frequencies, but not in alpha (8-12 Hz), suggesting an atypical oscillatory profile. The time-frequency analysis revealed significantly weaker event-related theta synchronization (ERS) and alpha desynchronization (ERD) in patients in the sentence condition. The data support the hypothesis that CG language difficulties relate to theta-alpha brain oscillations.

Classification of Motor Imagery EEG signals using high resolution time-frequency representations and convolutional neural network

A Motor Imagery (MI) based Brain Computer Interface (BCI) system aims to provide neuro-rehabilitation for the motor disabled people and patients with brain injuries (e.g., stroke patients) etc. The aim of this work is to classify the left and right hand MI tasks by utilizing the occurrence of event related desynchronization and synchronization (ERD\\ERS) in the Electroencephalogram (EEG) during these tasks. This study proposes to use a set of Complex Morlet Wavelets (CMW) having frequency dependent widths to generate high-resolution time-frequency representations (TFR) of the MI EEG signals present in the channels C3 and C4. A novel method for the selection of the value of number of cycles relative to the center frequency of the CMW is studied here for extracting the MI task features. The generated TFRs are given as input to a Convolutional neural network (CNN) for classifying them into left or right hand MI tasks. The proposed framework attains a classification accuracy of 82.2% on the BCI Competition IV dataset 2a, showing that the TFRs generated in this work give a higher classification accuracy than the baseline methods and other existing algorithms.

EEG alpha and theta time-frequency structure during a written mathematical task.

Since the first electroencephalogram (EEG) was obtained, there have been many possibilities to use it as a tool to access brain cognitive dynamics. Mathematical (Math) problem solving is one of the most important cortical processes, but it is still far from being well understood. EEG is an inexpensive and simple indirect measure of brain operation, but only recently has low-cost equipment (mobile EEG) allowed sophisticated analyses in non-clinical settings. The main purpose of this work is to study EEG activation during a Math task in a realistic environment, using mobile EEG. A matching pursuit (MP)-based signal analysis technique was employed, since MP properties render it a priori suitable to study induced EEG activity over long time sequences, when it is not tightly locked to a given stimulus. The study sample comprised sixty healthy volunteers. Unlike the majority of previous studies, subjects were studied in a sitting position with their eyes open. They completed a written Math task outside the EEG lab, wearing a mobile EEG device (EPOC+). Theta [4 Hz-7.5 Hz], alpha (7.5 Hz-13 Hz] and 0.5 Hz micro-bands in the [0.5 Hz-20 Hz] range were studied with a low-density stochastic MP dictionary. Over 1-min windows, ongoing EEG alpha and theta activity was decomposed into numerous MP atoms with median duration around 3s, similar to the duration of induced, time-locked activity obtained with event-related (des)synchronization (ERS/ERD) studies. Relative to Rest, there was lower right-side and posterior MP alpha atom/min during Math, whereas MP theta atom/min was significantly higher on anteriorly located electrodes, especially on the left side. MP alpha findings were particularly significant on a narrow range around 10 Hz-10.5 Hz, consistent with FFT alpha peak findings from ERS/ERD studies. With a streamlined protocol, these results replicate previous findings of EEG alpha and theta activation obtained during Math tasks with different signal analysis techniques and in different time frames. The efficient application to real-world, noisy EEG data with a low-resolution stochastic MP dictionary shows that this technique is very encouraging. These results provide support for studies of mathematical cognition with mobile EEG and matching pursuit.

Effects of Background Noise and Linguistic Violations on Frontal Theta Oscillations During Effortful Listening.

Background noise and linguistic violations have been shown to increase the listening effort. The present study aims to examine the effects of the interaction between background noise and linguistic violations on subjective listening effort and frontal theta oscillations during effortful listening. Thirty-two normal-hearing listeners participated in this study. The linguistic violation was operationalized as sentences versus random words (strings). Behavioral and electroencephalography data were collected while participants listened to sentences and strings in background noise at different signal to noise ratios (SNRs) (-9, -6, -3, 0 dB), maintained them in memory for about 3 sec in the presence of background noise, and then chose the correct sequence of words from a base matrix of words. Results showed the interaction effects of SNR and speech type on effort ratings. Although strings were inherently more effortful than sentences, decreasing SNR from 0 to -9 dB (in 3 dB steps), increased effort rating more for sentences than strings in each step, suggesting the more pronounced effect of noise on sentence processing that strings in low SNRs. Results also showed a significant interaction between SNR and speech type on frontal theta event-related synchronization during the retention interval. This interaction indicated that strings exhibited higher frontal theta event-related synchronization than sentences at SNR of 0 dB, suggesting increased verbal working memory demand for strings under challenging listening conditions. The study demonstrated that the interplay between linguistic violation and background noise shapes perceived effort and cognitive load during speech comprehension under challenging listening conditions. The differential impact of noise on processing sentences versus strings highlights the influential role of context and cognitive resource allocation in the processing of speech.

Neural correlates tracking different aspects of the emerging representation of novel visual categories.

Current studies investigating electroencephalogram correlates associated with categorization of sensory stimuli (P300 event-related potential, alpha event-related desynchronization, theta event-related synchronization) typically use an oddball paradigm with few, familiar, highly distinct stimuli providing limited insight about the aspects of categorization (e.g. difficulty, membership, uncertainty) that the correlates are linked to. Using a more complex task, we investigated whether such more specific links could be established between correlates and learning and how these links change during the emergence of new categories. In our study, participants learned to categorize novel stimuli varying continuously on multiple integral feature dimensions, while electroencephalogram was recorded from the beginning of the learning process. While there was no significant P300 event-related potential modulation, both alpha event-related desynchronization and theta event-related synchronization followed a characteristic trajectory in proportion with the gradual acquisition of the two categories. Moreover, the two correlates were modulated by different aspects of categorization, alpha event-related desynchronization by the difficulty of the task, whereas the magnitude of theta -related synchronization by the identity and possibly the strength of category membership. Thus, neural signals commonly related to categorization are appropriate for tracking both the dynamic emergence of internal representation of categories, and different meaningful aspects of the categorization process.

Electroencephalography-based biological and functional characteristics of spinal cord injury patients with neuropathic pain and numbness.

To identify potential treatment targets for spinal cord injury (SCI)-related neuropathic pain (NP) by analysing the differences in electroencephalogram (EEG) and brain network connections among SCI patients with NP or numbness. The EEG signals during rest, as well as left- and right-hand and feet motor imagination (MI), were recorded. The power spectral density (PSD) of the θ (4-8 Hz), α (8-12 Hz), and β (13-30 Hz) bands was calculated by applying Continuous Wavelet Transform (CWT) and Modified S-transform (MST) to the data. We used 21 electrodes as network nodes and performed statistical measurements of the phase synchronisation between two brain regions using a phase-locking value, which captures nonlinear phase synchronisation. The specificity of the MST algorithm was higher than that of the CWT. Widespread non-lateralised event-related synchronization was observed in both groups during the left- and right-hand MI. The PWP (patients with pain) group had lower θ and α bands PSD values in multiple channels of regions including the frontal, premotor, motor, and temporal regions compared with the PWN (patients with numbness) group (all p < 0.05), but higher β band PSD values in multiple channels of regions including the frontal, premotor, motor, and parietal region compared with the PWN group (all p < 0.05). During left-hand and feet MI, in the lower frequency bands (θ and α bands), the brain network connections of the PWP group were significantly weaker than the PWN group except for the frontal region. Conversely, in the higher frequency bands (β band), the brain network connections of the PWP group were significantly stronger in all regions than the PWN group. The differences in the power of EEG and network connectivity in the frontal, premotor, motor, and temporal regions are potential biological and functional characteristics that can be used to distinguish NP from numbness. The differences in brain network connections between the two groups suggest that the distinct mechanisms for pain and numbness.

Acute Bouts of Aerobic Exercise Do Not Modulate Task-Evoked Midfrontal Theta Oscillations in School-Age Children

While acute aerobic exercise has been found to have a facilitative effect on task components with varied cognitive control demands in school-age children, its effects on specific neural processes evoked by a cognitive control task remain underexplored. The objective of the current study was to examine the effects of acute aerobic exercise on task-evoked midfrontal theta event-related synchronization (ERS)—which plays a crucial role in supporting cognitive control. Thirty-three preadolescent children were recruited into this within-subjects, crossover study. Participants engaged in an aerobic exercise condition and a seated rest condition in a counterbalanced order. After both conditions, participants completed a flanker task, with concurrent EEG data collection. The results revealed no differences in midfrontal theta ERS following acute aerobic exercise as compared with following the control condition. However, midfrontal theta ERS was higher during congruent trials relative to incongruent trials following control condition but not following aerobic exercise. Collectively, acute bouts of aerobic exercise do not appear to modulate the control and behavioral monitoring processes indexed by midfrontal theta ERS during cognitive control in children.

The temporal effect of uncertain context on the perceptual processing of painful and non-painful stimulation

Uncertainty has been demonstrated to influence the perception of noxious stimuli, but little is known about the effects of prolonged uncertain contexts on the perception of painful and non-painful stimuli. To address this knowledge gap, the present study utilized a cue-based NPU-threat task, where uncertain and certain trials were separated into distinct blocks. The objective was to investigate the impact of uncertain contexts on the temporal dynamics of electroencephalogram (EEG) activity during the processing of painful and non-painful stimuli. The results revealed that the influence of uncertain contexts on neural responses extends beyond painful trials and is also evident in non-painful trials. In uncertain contexts, it has been observed that painful stimuli elicit larger P2 amplitudes and late beta band (13–30 Hz) event-related desynchronization (ERD) around 500–700 ms. However, in certain contexts, painful stimuli evoke stronger late gamma band (50–70 Hz) event-related synchronization (ERS) around 600–700 ms. For non-painful trials, in uncertain contexts, significantly higher amplitudes of the late positive potential (LPP) component and delta-theta band (2–7 Hz) ERS were observed compared to certain non-painful stimuli. These findings demonstrate that uncertain contexts exert a significant impact on the processing of both painful and non-painful stimuli, and this influence is mediated by distinct neural mechanisms.

Induced synchronization by endogenous noise modulation in finite-size random neural networks: A stochastic mean-field study.

Event-related synchronization and desynchronization (ERS/ERD) are well-known features found experimentally in brain signals during cognitive tasks. Their understanding promises to have much better insights into neural information processes in cognition. Under the hypothesis that neural information affects the endogenous neural noise level in populations, we propose to employ a stochastic mean-field model to explain ERS/ERD in the γ-frequency range. The work extends previous mean-field studies by deriving novel effects from finite network size. Moreover, numerical simulations of ERS/ERD and their analytical explanation by the mean-field model suggest several endogenous noise modulation schemes, which may modulate the system's synchronization.

Effect of white matter tract microstructural integrity on gamma entrainment using flickering light stimulation

AbstractBackgroundAlthough gamma entrainment using flickering light stimulation (FLS), which was found to reduce Alzheimer’s disease pathologies in mice model, it failed to reduce cerebral amyloid burden in patients with AD or mild cognitive impairment. We investigated the optimal parameters of the FLS for entraining gamma waves in older adults in their brain may be influenced by white‐matter tract microstructural integrity (WMMSI) in humans.MethodWe enrolled 31 cognitively normal volunteers aged ≥ 65 years and measured resting‐state electroencephalography and the steady‐state visually evoked potential (SSVEP) of gamma rhythms induced by optimal FLS. We analyzed the spectral power change of the electroencephalogram induced by FLS using event‐related synchronization (ERS) and the propagation of gamma rhythms from the visual cortex to other brain regions using spectral Granger causality (sGC). Diffusion tensor images were acquired, and the microstructural integrity of white‐matter tracts of interest was measured. We investigated the relationship between white matter integrity and entrainment and propagation using fractional anisotropy (FA).ResultAfter excluding five participants with SSVEP deficit, 26 participants were included in the final analysis. The lowest quartile group of the FA of the left posterior thalamic radiation exhibited a significantly lower ERS of gamma rhythms in the visual cortex than the second‐to‐highest quartile group (p = 0.045). In the multiple linear regression analyses, the effects of the FA of the middle longitudinal fasciculus and superior longitudinal fasciculus 3 on the sGC of the gamma rhythm connectivity from the occipital to the temporal, central, and frontal regions were statistically significant in both hemispheres (p &lt; 0.05).ConclusionThese findings suggest intact WMMSI may be required for proper gamma entrainment using FLS. Therefore, future clinical trials on gamma entrainment using FLS needs to consider WMMSI for participant selection.

Long-term exposure to high altitude reduces alpha and beta bands event-related desynchronization in a Go/NoGo task.

More than 80 million people worldwide permanently live at high altitudes, and living in such a hypoxic environment can impair cognitive functions. However, it is largely unknown how long-term exposure to high altitude affects neural oscillations underlying these cognitive functions. The present study employed a Go/NoGo task to investigate the effects of long-term exposure to high altitude on neural oscillations during cognitive control. We compared event-related spectral perturbations between the low-altitude and high-altitude groups, and the results revealed increased theta event-related synchronization (ERS) and decreased alpha and beta event-related desynchronizations (ERDs) during the NoGo condition compared to the Go condition. Importantly, the high-altitude group showed reduced alpha and beta ERDs compared to the low-altitude group, while the theta ERS was not affected by altitude. We suggest that long-term exposure to high altitude has an impact on top-down inhibitory control and movement preparation and execution in the Go/NoGo task.

Movement-related ERS and connectivity in the gamma frequency decrease with practice

Previous work showed that movements are accompanied by modulation of electroencephalographic (EEG) activity in both beta (13–30 Hz) and gamma (>30 Hz) ranges. The amplitude of beta event-related synchronization (ERS) is not linked to movement characteristics, but progressively increases with motor practice, returning to baseline after a period of rest. Conversely, movement-related gamma ERS amplitude is proportional to movement distance and velocity. Here, high-density EEG was recorded in 51 healthy subjects to investigate whether i) three-hour practice in two learning tasks, one with a motor component and one without, affects gamma ERS amplitude and connectivity during a motor reaching test, and ii) 90-minutes of either sleep or quiet rest have an effect on gamma oscillatory activity. We found that, while gamma ERS was appropriately scaled to the target extent at all testing points, its amplitude decreased after practice, independently of the type of interposed learning, and after both quiet wake and nap, with partial correlations with subjective fatigue scores. During movement execution, connectivity patterns within fronto-parieto-occipital electrodes, over areas associated with attentional networks, decreased after both practice and after 90-minute rest. While confirming the prokinetic nature of movement-related gamma ERS, these findings demonstrated the preservation of gamma ERS scaling to movement velocity with practice, despite constant amplitude reduction. We thus speculate that such decreases, differently from the practice-related increases of beta ERS, are related to reduced attention or working memory mechanisms due to fatigue or a switch of strategy toward automatization of movement execution and do not specifically reflect plasticity phenomena.

Reaction time and brain oscillations in Go/No-go tasks with different meanings of stimulus color

Color has meaning in particular contexts, and the meaning of color can impact behavioral performance. For example, the meaning of color about traffic rules (blue/green and red mean “go” and “stop” respectively) influences reaction times (RTs) to signals. Specifically, in a Go/No-go task, RTs have been reported to be longer when responding to a red signal and withholding the response to a blue signal (Red Go/Blue No-go task) than when responding to a blue signal and withholding the response to a red signal (Blue Go/Red No-go task). However, the neurophysiological background of this phenomenon has not been fully understood. The purpose of this study was to investigate the brain oscillatory activity associated with the effect of meaning of color on RTs in the Go/No-go task.Twenty participants performed a Blue simple reaction task, a Red simple reaction task, a Blue Go/Red No-go task, and a Red Go/Blue No-go task. We recorded responses to signals and electroencephalogram (EEG) during the tasks and evaluated RTs and changes in spectral power over time, referred to as event-related synchronization (ERS) and event-related desynchronization (ERD).The behavioral results were similar to previous studies. The EEG results showed that frontal beta ERD and theta ERS were greater when signals were presented in blue than red color in both simple reaction and Go/No-go tasks. In addition, the onset of theta ERS was delayed in the Red Go than Blue Go trial in the Go/No-go task.The enhanced beta ERD may indicate that blue signals facilitate motor response, and the delayed onset of theta ERS may indicate the delayed onset of cognitive process when responding to red signals as compared to blue signals in the Go/No-go task. Thus, this delay in cognitive process can be involved in the slow response in the Red Go/Blue No-go task.

Immature event-related alpha dynamics in children compared with the young adults during inhibition shown by day-night stroop task.

Inhibitory control develops gradually from infancy to childhood and improves further during adolescence as the brain matures. Related previous studies showed the indispensable role of task-related alpha power during inhibition both in children and young adults. Nonetheless, none of the studies have been able to investigate the direct differences in brain responses between children and young adults when confronted with a stimulus that should be inhibited. Because, unlike event-related designs, task-related designs involve continuous tasks over a certain period, which precludes the possibility of making such a comparison. Accordingly, by employing event-related design, the present study first time in the literature, aimed to analyze the event-related alpha phase locking and event-related alpha synchronization/ desynchronization to differentiate the inhibitory processes in children compared to young adults. Twenty children between the ages of 6 to 7 years and 20 healthy young adult subjects between the ages of 18 to 30 years were included in the study. Day-night Stroop task was applied to all subjects during 18-channel EEG recordings. Event-related time-frequency analysis was performed with the complex Morlet Wavelet Transform for the alpha frequency band (8-13 Hz). Event related spectral perturbation (ERSP) in three different time windows (0-200 ms, 200-400 ms, 400-600 ms) and Event-related phase locking in the early time window (0-400 ms) was calculated. The children had increased alpha power in early and late time windows but decreased alpha phase locking in the early time windows compared to young adults. There were also topological differences between groups; while young adults had increased alpha phase-locking in frontal and parietal electrode sites, children had increased occipital alpha power and phase locking. The shift in event-related alpha power observed from posterior to anterior regions with age may suggest a progressive maturation of the frontal areas involved in inhibitory processes from childhood to adulthood. The results of the present study showed that children and young adults had different EEG oscillatory dynamics during inhibitory processes at alpha frequency range.

Quantification of event related brain patterns for the motor imagery tasks using inter-trial variance technique

Quantification of event-related (de) synchronization (ERD/ERS) patterns is a challenging task in the field of motor imagery (MI)-based brain–computer interface (BCI). Accurately determining the optimal time and frequency band for localizing the ERD/ERS brain patterns is crucial in designing a robust MI-based BCI. To address above issue, this study proposes an inter-trial variance (IV) technique that focuses on localizing the ERD/ERS brain patterns and classifying the left and right hand imaginations of the subjects. The effectiveness of the proposed technique is validated using the BCI Competition-IV, Dataset-2b, which includes raw EEG signals from nine healthy subjects performing both left and right hand MI movements. In this technique, the sensorimotor frequency band (8–30 Hz) and its ERD/ERS brain patterns related to the left and right hand MI movements are derived from the signals. The obtained brain patterns are fed into various ML models, and the efficiency of the models is assessed using the classification accuracy (%CA) and Cohen’s kappa coefficient (K). The outcomes show that the proposed technique enhances the performance of the BCI system, classifying both left and right hand imaginations of the subjects with higher %CA (86.11%) and K (0.72), and outperforming the state-of-the-art techniques. This concludes that the ERD and ERS brain patterns extracted from the proposed technique are significant features in designing the MI-based BCI system.

Neural oscillations modulation during working memory in pre-manifest and early Huntington’s disease

IntroductionWe recently demonstrated specific spectral signatures associated with updating of memory information, working memory (WM) maintenance and readout, with relatively high spatial resolution by means of high-density electroencephalography (hdEEG). WM is impaired already in early symptomatic HD (early-HD) and in pre-manifest HD (pre-HD). The aim of this study was to test whether hdEEG coupled to source localization allows for the identification of neuronal oscillations in specific frequency bands in 16 pre-HD and early-HD during different phases of a WM task. MethodsWe examined modulation of neural oscillations by event-related synchronization and desynchronization (ERS/ERD) of θ, β, gamma low, γLOW and γHIGH EEG bands in a-priori selected large fronto-parietal network, including the insula and the cerebellum. ResultsWe found: (i) Reduced θ oscillations in HD with respect to controls in almost all the areas of the WM network during the update and readout phases; (ii) Modulation of β oscillations, which increased during the maintenance phase of the WM task in both groups; (iii) correlation of γHIGH oscillations during WM task with disease burden score in HD patients. ConclusionsOur data show reduced phase-specific modulation of oscillations in pre-HD and early-HD, even in the presence of preserved dynamic of modulation. Particularly, reduced synchronization in the θ band in the areas of the WM network, consistent with abnormal long-range coordination of neuronal activity within this network, was found in update and readout phases in HD groups.