Important Events Research Articles

Insight into the post-translational modifications in pregnancy and related complications.

Successful pregnancy is dependent on a number of essential events, including embryo implantation, decidualization and placentation. Failure of the above process may lead to pregnancy-related complications, including preeclampsia (PE), gestational diabetes mellitus (GDM), preterm birth, fetal growth restriction (FGR), etc., may affect 15% of pregnancies, and lead to increased mortality and morbidity of pregnant women and perinatal infants, as well as the occurrence of short-term and long-term diseases. These complications have distinct etiology and pathogenesis, and the present comprehension is still lacking. Post-translational modifications (PTMs) are important events in epigenetics, altering the properties of proteins through protein hydrolysis or the addition of modification groups to one or more amino acids, with different modification states regulating subcellular localization, protein degradation, protein-protein interaction, signal transduction and gene transcription. In this review, we focus on the impact of various PTMs on the progress of embryo and placenta development and pregnancy-related complications, which will provide important experimental bases for exploring new insights into the physiology of pregnancy and pathogenesis associated with pregnancy complications.

Exploring Sentiment Analysis for the Indonesian Presidential Election Through Online Reviews Using Multi-Label Classification with a Deep Learning Algorithm

Presidential elections are an important political event that often trigger intense debate. With more than 139 million users, YouTube serves as a significant platform for understanding public opinion through sentiment analysis. This study aimed to implement deep learning techniques for a multi-label sentiment analysis of comments on YouTube videos related to the 2024 Indonesian presidential election. Offering a fresh perspective compared to previous research that primarily employed traditional classification methods, this study classifies comments into eight emotional labels: anger, anticipation, disgust, joy, fear, sadness, surprise, and trust. By focusing on the emotional spectrum, this study provides a more nuanced understanding of public sentiment towards presidential candidates. The CRISP-DM method is applied, encompassing stages of business understanding, data understanding, data preparation, modeling, evaluation, and deployment, ensuring a systematic and comprehensive approach. This study employs a dataset comprising 32,000 comments, obtained via YouTube Data API, from the KPU and Najwa Shihab channels. The analysis is specifically centered on comments related to presidential candidate debates. Three deep learning models—Convolutional Neural Network (CNN), Bidirectional Long Short-Term Memory (Bi-LSTM), and a hybrid model combining CNN and Bi-LSTM—are assessed using confusion matrix, Area Under the Curve (AUC), and Hamming loss metrics. The evaluation results demonstrate that the Bi-LSTM model achieved the highest accuracy with an AUC value of 0.91 and a Hamming loss of 0.08, indicating an excellent ability to classify sentiment with high precision and a low error rate. This innovative approach to multi-label sentiment analysis in the context of the 2024 Indonesian presidential election expands the insights into public sentiment towards candidates, offering valuable implications for political campaign strategies. Additionally, this research contributes to the fields of natural language processing and data mining by addressing the challenges associated with multi-label sentiment analysis.

Biomechanical research based on the recognition and detection of the strength of table tennis hitting action

The reason why China’s table tennis can continue to this day is because it is an important heritage sports event in the country. In order to ensure the high-level performance of the Chinese table tennis team in the game, the identification and detection of its sports characteristics is a very meaningful work. With the development of computer technology, the use of multimedia intelligence technology to conduct research on competitive tactics has become a general consensus in the sports world. This paper explores the recognition and detection technology of the strength of table tennis hitting movements from the perspective of biomechanics, aiming to provide scientific basis and technical support for improving the performance of athletes. Based on the principles of biomechanics and combined with multimedia intelligent algorithms, this study developed a spatiotemporal graph convolutional network (STGCN) and a motion detection method based on Kinect technology to identify and quantify the hitting strength of table tennis players. The experimental results of this paper show that in the recognition of different types of movements based on the STGCN method, the correct recognition rate of 100 groups of movement strength is 84%, and the correct recognition rate of 500 groups of movement strength is 91.6%; in the recognition of different types of movement strength based on Kinect, the correct recognition rate of 100 groups of movement strength is 97%, and the correct recognition rate of 500 groups of movement strength is 99.6%; it can be seen that no matter how many groups of hitting movements are made, the correct recognition rate of strength based on Kinect is higher than that of STGCN.

PKM Rekayasa Pembuatan Kartu Undangan Digital Sebagai Media Usaha Mandiri

The rapid advancement of information technology has significantly impacted various sectors, including theinvitation printing industry. With the increasing use of the internet in Indonesia, digital invitation businesseshave become an attractive opportunity, offering practicality and cost efficiency compared to traditional printedinvitations. This writing aims to explore the development of digital invitation cards as an independent business,focusing on appealing designs and effective marketing strategies through online platforms and social media.Through literature study methods and the implementation of community service programs, it was found thatdigital invitations have several advantages. These advantages include lower costs, easy access, and customizableinteractive features such as animations, videos, and direct links to important event information. The importanceof implementing communicative and interactive designs is key to attracting consumer attention. An attractivedesign not only serves as a visual appeal but also conveys information more clearly and effectively.Additionally, using social media as a marketing channel can enhance market reach, allowing for rapiddissemination of digital invitations to a wider audience. With the right approach, digital invitation businessescan meet the market's growing demand for digital solutions. Innovation in design and marketing will create newbusiness opportunities for individuals or groups looking to leverage information technology, making thisindustry increasingly relevant in today's digital era. Community involvement in this process can also strengthenlocal communities and enhance digital literacy among users.

Comparison of the Effects of Sanyinjiao Point (SP6) Acupressure with Combined SP6 and LI4 Acupressure on Labor Pain Intensity in Primiparous Women: A Randomized Controlled Trial

Background: Childbirth is an important event and special experience in women's lives. Labor pain is the most severe pain that women undergo in their lives. Pain management during labor is crucial for the well-being of the mother and fetus. Objective: This study aimed to compare the effect of combined LI4 and SP6 acupressure with SP6 acupressure on reducing labor pain. Methods: A total of 108 primiparous women who participated in the study were randomized into three groups, combining LI4 and SP6 acupressure, SP6 acupressure, and a control group. Pain intensity was evaluated before, immediately, 1 and 2 hours after the intervention and the second stage of labor by visual analogue scale (VAS). Results: Although the pain intensity immediately after the intervention was lower in the combined SP6 and LI4 acupressure group than in the other groups, the differences were not significant between the three groups (p = 0.147). The pain intensity 1 hour after the intervention and in the second stage of labor had a statistically significant difference between the three groups (p =0.006, p =0.001). The pain intensity 2 hours after the intervention was lower in the combined SP6 and LI4 acupressure group than the other groups, but it was not statistically significantly different (p= 0.05). The pain intensity 1 hour after the intervention was not statistically different between the SP6 group and the control group (p= 0.095). The pain intensity 2 hours after the intervention was lower in the combined SP6 and LI4 acupressure group compared to the control group, but it was not significant (p=0.06). The pain intensity in the second stage of labor was lower in the combined SP6 and LI4 acupressure group and SP6 acupressure group compared to the control group (p =0.001, p = 0.017), but there was no significant difference between the SP6 acupressure group and combined SP6 and LI4 acupressure group (p=1.000). Conclusion: The obtained results revealed that combination intervention is a safe, effective, noninvasive and economical method in alleviating labor pain intensity. Healthcare providers are expected to master the acupressure technique as an alternative, complementary therapy, which can be used as an alternative or additional therapy.

Morphology and agents of urban transformation

The study aims to propose a method of analysis that promotes a clearer perception of the spatial transformation resulting from the action of certain social groups to shape the urban space according to their interests. The territorial transformation related to the role of different agents is investigated, through urban morphology, in order to understand the correlation between the Brazilian urban form with public management and the direction of public investments. To analyze how the city is shaping over time, the work was structured from a case study, which mapped the urban transformations of the municipalities of Cuiabá and Várzea Grande, during the 2006-2021 interval. The method adopted by the research proposes as tools for investigating the territory: the conception of thematic cartographies through the comparison of aerial images from Google Earth, the establishment of analysis categories that allow the identification of the different types of building transformations preponderant of the urban blocks and the main interventions on the road system and the impact of important events that occurred in the cities in the period studied. A quantitative analysis is presented, with the approximate values of areas in hectares (ha), which represent the categories of analysis indicated. As a result, it can be seen, through the maps, that the relationship between the different forms of urban land occupation and the road infrastructure implemented ends up reinforcing the process of socio-spatial segregation. It is concluded that the proposed method, combined with historical and socioeconomic studies, manages to reconstitute urbanization processes in order to understand them in order to intervene in the reality of our cities.

Validating the Use of Continuous Glucose Monitors With Nondiabetic Recreational Runners.

Continuous glucose monitors (CGMs) are becoming increasingly popular among endurance athletes despite unconfirmed accuracy. We assessed the concurrent validity of the FreeStyle Libre 2 worn on 2 different sites at rest, during steady-state running, and postprandial. Thirteen nondiabetic, well-trained recreational runners (age = 40 [8]y, maximal aerobic oxygen consumption = 46.1 [6.4]mL·kg-1·min-1) wore a CGM on the upper arm and chest while treadmill running for 30, 60, and 90minutes at intensities corresponding to 50%, 60%, and 70% of maximal aerobic oxygen consumption, respectively. Glucose was measured by manually scanning CGMs and obtaining a finger-prick capillary blood glucose sample. Mean absolute relative difference, time in range, and continuous glucose Clarke error grid analysis were used to compare paired CGM and blood glucose readings. Across all intensities of steady-state running, we found a mean absolute relative difference of 13.8 (10.9) for the arm and 11.4 (9.0) for the chest. The coefficient of variation exceeded 70%. Approximately 47% of arm and 50% of chest paired glucose measurements had an absolute difference ≤10%. Continuous glucose Clarke error grid analysis indicated 99.8% (arm) and 99.6% (chest) CGM data fell in clinically acceptable zones A and B. Time-in-range analysis showed reduced accuracy at lower glucose levels. However, CGMs accurately detected trends in mean glucose readings over time. CGMs are not valid for point glucose monitoring but appear to be valid for monitoring glucose trends during steady-state exercise. Accuracy is similar for arm and chest. Further research is needed to determine whether CGMs can detect important events such as hypoglycemia during exercise.

Wastewater Surveillance for Poliovirus in Selected Jurisdictions, United States, 2022-2023.

Wastewater testing can inform public health action as a component of polio outbreak response. During 2022-2023, a total of 7 US jurisdictions (5 states and 2 cities) participated in prospective or retrospective testing of wastewater for poliovirus after a paralytic polio case was identified in New York state. Two distinct vaccine-derived poliovirus type 2 viruses were detected in wastewater from New York state and New York City during 2022, representing 2 separate importation events. Of those viruses, 1 resulted in persistent community transmission in multiple New York counties and 1 paralytic case. No poliovirus was detected in the other participating jurisdictions (Connecticut, New Jersey, Michigan, and Illinois and Chicago, IL). The value of routine wastewater surveillance for poliovirus apart from an outbreak is unclear. However, these results highlight the ongoing risk for poliovirus importations into the United States and the need to identify undervaccinated communities and increase vaccination coverage to prevent paralytic polio.

Comparative Study on Different Clinical Decision-Making Tools in Pediatric Head Injury Cases

Objective: To carry out a comparative study on effective clinical decision-making tools between Canadian Assessment of Tomography for Childhood Head injury, Pediatric Emergency Care Applied Research Network (PECARN) and Children's Head injury Algorithm for the prediction of Important Clinical Events in pediatrics head trauma cases. Study Design: Validation study. Place and Duration of Study: Department of Surgery, Saif Shaheed Hospital, Haveli Kahota, Azad Kashmir, Pakistan, from Oct 2021 to Nov 2022. Methodology: One hundred and fifty paediatric patients suffering from minor head injury were evaluated on clinical intervention decisions as per emergency procedures during the period of study. Sensitivity, Specificity, Positive Predictive Value and Negative Predictive Value of the selected diagnostic tests was checked. Results: Based on the head CT positivity, PECARN was found to be 81.8% sensitive and 61.9% specific. Canadian Assessment of Tomography for Childhood show sensitivity of 90.9 % and specificity of 65.5%. CHALICE had sensitivity and specificity of 63.6% and 61.5% respectively. CHALICE was unable to identify a pathological CT result with statistical significance (p=0.17) however PECARN and CATCH rule proved significant (p<0.05). CATCH rule show highest positive predictive score of 17.2% and negative predictive score of 98.8%. Conclusion: PECARN, CATCH, and CHALICE criteria are effective in deciding whether or not to perform Computerized Brain Tomography (CBT) scans on children with MHT, leading us to believe that employing these criteria could prevent unnecessary CBT scans.

Cretaceous stratigraphy in the Songliao Basin, NE China

The Songliao Basin is one of the largest non-marine oil- and gas-bearing basins that developed during the Cretaceous period, recording an almost complete Cretaceous stratigraphy. With oil and gas exploration, as well as the Continental Scientific Drilling Project of Cretaceous Songliao Basin (CCSD-SK) (2006–21), significant progress has been made on the stratigraphy of the Songliao Basin. The Songliao Basin is therefore important for understanding the non-marine Cretaceous system. Based on lithostratigraphy, sequence stratigraphy, biostratigraphy, geochronology, magnetostratigraphy and cyclostratigraphy, a comprehensive stratigraphical framework of the Songliao Basin has been established in this study. The Lower Cretaceous strata (Hauterivian–Albian) of the basin are dominated by volcanic–sedimentary deposits, while the lower-middle Upper Cretaceous (Cenomanian mid-Campanian) strata are dominated by lacustrine deposits. The upper Upper Cretaceous strata (late Campanian–Maastrichtian) are dominated by fluvial–lacustrine deposits. Fossils are very abundant in the Songliao Basin, and three biotas – the Jehol Biota sensu lato , the Songhuajiang Biota and the Mingshui Biota – are recognized in the Songliao Basin. Furthermore, several important geological events, such as lake anoxic events, seawater incursion events and the K/Pg boundary extinction events are all recorded in the Songliao Basin.

Constructing a Supplementary Benchmark Suite to Represent Android Applications with User Interactions by using Performance Counters

We find existing benchmark suites for smartphone CPU micro-architecture design such as Geekbench 5.0 fail to authentically represent the micro-architecture level performance behavior of widely used real Android applications with interactive operations such as screen sliding. It is therefore crucial to systematically construct a benchmark suite as a supplementary to Geekbench to represent the user interaction behavior of Android applications for CPU micro-architecture design. The key is to identify a small number of representative programs from a large number of real applications. To this end, a set of features used to represent a program need to be constructed, and these features should be fair for different micro-architectures and can be collected efficiently. However, this is extremely difficult for Android applications. For example, the feature collection tools for Android applications are unavailable for benchmark selection. In this paper, we propose a novel benchmark suite construction approach dubbed BEMAP to efficiently build a supplementary benchmark suite from real-world Android applications to represent their user interaction behavior. 1 BEMAP innovates four techniques. The first technique, called two-stage RFC (representative feature construction), constructs program features from performance counters (events) to represent a program for selecting benchmarks from a large number of real Android applications in two stages. The first stage identifies a set of important performance events in terms of IPC (instructions per cycle) by employing a machine learning algorithm named SGBRT (Stochastic Gradient Boosted Regression Tree). The second stage constructs representative features based on the important performance events by using ICA (independent component analysis). The second technique, named SPC-MMA (source performance counters from multiple micro-architectures), collects the performance events from multiple mobile CPUs with different micro-architectures and mixes them as the source of RFC. The goal of these two innovations is to make the program features fair to different mobile CPU micro-architectures. The third technique, called ES (Elbow-Silhouette) approach, artfully leverages the synergy between the elbow method and the silhouette method to determine an optimal K when we use K-Means to group Android applications. The fourth technique is that we design a new tool named AutoProfiler to automatically profile the micro-architecture events (e.g., IPC, L1 Icache misses) of Android applications with interactive operations. Using the proposed BEMAP methodology 2 , we constructed SPBench, a novel benchmark suite supplementary to traditional mobile benchmark suites like Geekbench, for mobile CPU micro-architecture design. It consists of fifteen benchmarks selected from one hundred real Android applications with three common user interaction operations, which is the fifth innovation of this paper. The experimental results on four significantly different micro-architectures show that SPBench can represent the micro-architecture performance behaviors of the one hundred real-world applications with three common user interactive operations on each micro-architecture with significantly higher accuracy than benchmark suites produced by the state-of-the-art approaches.

Where and when the Paleo-Asian Ocean was closed: new evidence from the Tuquan ophiolite

The Solonker suture marks the location of the final collision in southeastern Central Asian Orogenic Belt (CAOB). However, it is observed that the suture is obscured at the western margin of the Songliao Basin. Fortunately, the recently discovered Tuquan ophiolite is one of the important fragments within the Solonker suture. Testings of samples from the Tuquan ophiolite yielded LA-ICP-MS zircon U–Pb chronological data with weighted mean of 206 Pb/ 238 U ages from 265 ± 5 Ma to 279 ± 6 Ma which were interpreted to represent the formation age of the Tuquan ophiolite from the late Cisuralian to Guadalupian. The geochemical characteristics of the Tuquan ophiolite is related to supra-subduction zone features. We suggest that it represents an important bidirectional subduction event involving the oceanic crust of the Paleo-Asian Ocean beneath the Mongolia Block and the North China Craton during the early to late Permian. Integrating these findings with previous research indicates that the final subduction of the Paleo-Asian Ocean persisted until at least the late Permian. Our study provides further insights, indicating that the discovery of the Tuquan ophiolite could be regarded as the eastern extension of the Solonker suture. This finding will provide new constraints on the evolution of the southeastern CAOB.

Safety Profile of Statins for Post-Marketing Adverse Cardiovascular Events: A Real-World Pharmacovigilance Analysis.

The purpose of this study was to comprehensively evaluate the association of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) with neurological adverse events using the US Food and Drug Administration Adverse Event Reporting System (FAERS) database, with the aim of guiding the rational use of statins. The number and clinical characteristics of adverse events (AEs) to statins in the FAERS database between 2012 and March, 2023, were extracted. Neurological AEs were defined by the system organ classes (SOCs) of "Nervous System Disorders (10029205)" and the corresponding PT. Disproportionality was calculated using the reporting dominance ratio (ROR), proportional reporting ratio (PRR), and information component (IC025). Between January, 2012 and March, 2023, a total of 90,357 AEs were reported for the three statins (atorvastatin, resuvastatin, and simvastatin). The majority of reports on AEs came from the United States (n = 7284). A total of 8409 reports described neurological AEs following the use of the three statins, with atorvastatin accounting for more than half of the reports (n = 4430). The mean age of patients who developed neurological AEs was 55 years and older. The prevalence was similar in female patients (2230/4480) and male patients (1999/4480). Disproportionate analyses showed that at the SOC level, only the correlation between atorvastatin and neurological AEs suggested a positive signal (ROR: 9.77 (9.56-9.99); IC025: 3.28; PRR (χ2): 9.76 (16.07)) and in total, there were 32 PTs with a positive signal. The median time for neurological AEs was 71 days (IQR: 14-559 days), and the most common AEs were other serious effects (important medical event) (OT) (n = 2283) and hospitalization (HO) (n = 715). This study suggests that atorvastatin may be associated with an increased risk of neurological AEs. This study provides realistic evidence of the potential risk of statin-related adverse events.

Water Stress Adaptations by Rhododendron arboreum Smith in The Himalayan Treeline Environment

Drought is amongst the most important climatic events which can severely impact natural ecosystems. The under-canopy Indian Himalayan tree species are less studied on water stress in harsh climatic conditions. Rhododendron arboreum is an ecologically and economically important tree species and distributed between 1500–3500 m asl in the Himalayan ecosystems. In this study, we have tried to assess the water stress adaptations by R. arboreum near the treeline ecotone located at 30°11´02˝N and 79°39´36˝E between 3100 and 3500 m asl elevation. Water potential (Ψ) was measured using a Pressure chamber and leaf conductance with the help of AP4 porometer. Soil moisture (Sm) across the depths was highly variable (p<0.05). The pre-dawn water potential (ΨPD) of R. arboreum tree varied between -0.12 and -0.91 MPa. ANOVA showed that the ΨPD of R. arboreum seedlings varied significantly across the years, seasons, and sites (p<0.05). The decline in osmotic potential at full turgor (Ψπ100) was -1.18 to -1.20 MPa in trees and -1.42 to -1.72 MPa in seedlings. The morning leaf conductance (gwAM) of R. arboreum trees ranged from 58.00 to 271.68 m mol m-2 sec-1. Correlation showed that the maximum leaf conductance in R. arboreum trees was observed when the ΨPD was -0.5 to -0.9 MPa. Water uptake function in plants is generally affected by winter frost which can change the Ψ, osmotic potential, and leaf conductance of plants. The ΨPD in the species was relatively high across all seasons in the treeline areas to disrupt physiological activities.

NMPC‐Based Control of Underactuated Spacecraft: A Neighboring Extremal Approach Extended to SE(3)

ABSTRACTThe present work revolves around employing the benefits of neighboring extremal approach in the nonlinear model predictive control of mechanical systems evolving on SE(3). In the NMPC process, necessary conditions of optimality are extracted based on some discrete‐time version of the equations of motion referred as LGVI and the obtained TPBVP equations are solved using simplified sensitivity derivatives by means of an indirect shooting method. Taking into consideration that the repetitive optimization process of the NMPC is time consuming, making its implementation challenging, a method of neighboring extremal is proposed here for recalculating the responses of the systems in scenarios that face some unexpected changes in their parameters or are encountering some last‐minute re‐planning schemes. Based on the existing responses of the system to the first set of initial conditions, the reaction of the system to the altered set of initial conditions can be reconstructed without the need to solve the whole optimization process from scratch by utilizing the features of the NE method. A spacecraft model evolving on SE(3) with actuation constraints confirms the efficiency of the whole process in term of accuracy versus computation burden. Forasmuch as actuator failure is a probable yet important event in aerial/spatial missions, the performance of the control system in dealing with such situations is examined. The algorithm robustness and its capability to compensate the effects of the actuator loss is checked.

An mTOR-Tfeb-Fabp7a signaling axis can be harnessed to ameliorate bag3 cardiomyopathy in adult zebrafish.

Dysregulated proteostasis in cardiomyocytes is an important pathological event in BAG3 cardiomyopathy, which can be repaired by inhibiting mechanistic target of rapamycin (mTOR) for cardioprotective effects. Here, we aimed to uncover additional pathological events and therapeutic target genes via leveraging zebrafish genetics. We first assessed transcription factor EB ( tfeb ), a candidate gene that encodes a direct downstream phosphorylation target of mTOR signaling. We found that cardiomyocyte-specific transgenic overexpression of tfeb ( Tg[cmlc2:tfeb] ) is sufficient to repair defective proteostasis, attenuate accelerated cardiac senescence, a previously unrecognized phenotype in the bag3 cardiomyopathy model, and rescue cardiac dysfunction. Next, we compared cardiac transcriptomes between the Tg(cmlc2:tfeb) transgenic fish and the mtor xu015/+ mutant, and tested 4 commonly downregulated lipodystrophy genes using an F0-based genetic assay. We found that inhibition of the fatty acid binding protein a ( fabp7a ) gene, but not the other 3 genes, exerts therapeutic effects on bag3 cardiomyopathy. Conversely, fabp7a expression is elevated in bag3 cardiomyopathy model and cardiomyocyte-specific overexpression of fabp7a resulted in dysregulated proteostasis, accelerated cardiac senescence, as well as cardiac dysfunction. Together, these genetic studies in zebrafish uncovered Fabp7a activation and accelerated cardiac senescence as important pathological events in bag3 cardiomyopathy. The mTOR-Tfeb-Fabp7a signaling axis can be harnessed to repair these pathological changes and exert cardioprotective effects.

Ghaslah: Car wash application

It is known in Oman and many countries that technological devices and artificial intelligence have become a part of daily life. People use them to complete daily tasks and communicate among themselves, as well as facilitating some tasks that require time and effort. Therefore, there are many phone applications that have been developed to serve people, and they were created and developed by Omanis. These applications facilitate the promotion of the tourism, economic, and commercial sectors. Some of them support tourism by showing tourist places and introducing them to tourists, and some show important events in the Sultanate. Which tourists love to go to and supports the economy through the financial returns that result from this trade through these applications. In this project, we proposed creating a mobile application titled Ghaslah. It is an application concerned with car washes. It supports the customer and the owners of car wash companies. It enables the customer to choose the appropriate car wash company and choose the best services that the customer needs. It also supports segments of society, including women, the elderly, and people with special needs in particular. It supports car wash companies by displaying the services provided by the companies at the lowest costs in terms of advertising and other things, enabling companies to provide their services such as reservations and home services. This application will enhance the economic aspect in Oman and the owners of car wash companies and satisfy the customers with services that suit their needs.

Immune checkpoint inhibitor-associated bullous pemphigoid: Aretrospective and real-world study based on the United States Food and Drug Administration adverse event reporting system.

This study aimed to describe bullous pemphigoid (BP) associated with immune checkpoint inhibitors (ICIs) reported in the United States Food and Drug Administration adverse event reporting system (FAERS). We obtained reports of ICI-associated BP from the first quarter of 2011 to the first quarter of 2024 in the FAERS database. The reporting odds ratio (ROR) method of the disproportionality analysis was performed to assess the potential risk for ICI-associated BP. We also described the clinical characteristics of ICI-associated BP and evaluated the time to onset (TTO) of BP developed after treatment with ICIs. Eight hundred and six cases of ICI-associated BP were gathered, in which 56.58% of the patients were aged 65 years or older. The majority of patients were male, accounting for 68.49% of all cases. The prevalent potential cancer type was skin cancer (31.64%). The results of the disproportionality analysis showed that males (ROR = 2.10 [1.78-2.49]), patients aged 65 or older (ROR = 2.13 [1.79-2.55]), and patients with skin cancer (ROR = 2.08 [1.80-2.43]) were more likely to develop ICI-associated BP. In comparison to cytotoxic T-lymphocyte-associated antigen 4 inhibitor and programmed cell death ligand 1 inhibitor, programmed cell death 1 inhibitor-associated BP has a higher risk of development (ROR = 24.45 [22.52-26.56]). ICI-associated BP had a median TTO of 204 days (interquartile range 57-426 days). ICI-associated BP is a rare but important immune-related adverse event. Our study provided helpful information to help medical professionals further understand ICI-associated BP.

The concept of oral media

The oral field in the lives of societies is witnessing many important developments, because of which orality has become the subject of various studies, especially studies that have taken linguistic approaches or those related to audio and visual images or those related to spoken or written language. Orality can maintain its characteristics in light of technology and modern media, which feed on achieving the greatest possible level of communication. If oral history is the collection and study of important events and historical information about individuals and families or daily life using audio or video recordings as well as interview transcripts, then oral media is the way to successfully transfer knowledge and human communication to broader and more spacious ranges. Oral history seeks to obtain information from different points of view, more than what can be found in written sources. It also refers to information collected by the method into a written work (published or unpublished) based on this data, often preserved in archives and large libraries.

A szlovákiai magyarság történetének reprezentációja a szlovákiai alapiskolai történelemtankönyvekben

Representation of the History of the Hungarian Minority in Slovakia in Slovak Primary School History Textbooks In the past two decades, Gyula Popély, Attila Simon, László Szarka, Árpád Popély, Gergely Sallai, József Gyönyör and Katalin Vadkerty have written numerous summaries on the history of Hungarians in Slovakia, but what is less known is what children learn about this period sitting in the classroom. What can Hungarian students in Slovakia learn about their history from the textbooks, so that they can develop and shape their image of Hungarianness and form an emotional attachment to their nation, which could greatly contribute to halting the assimilation process that is affecting Hungarians in Slovakia. Of course, in addition to the school, the values conveyed by the family and home environment, society and culture are also decisive (e.g. commemorating the anniversary of the Treaty of Trianon or the day of remembrance of the Hungarians expelled from southern Slovakia). Since the school is the main source of such impact, we chose to study how our own history is reflected in history textbooks, and so we based our research on history textbooks for primary schools in Slovakia. Unfortunately, however, we do not know what other important events and additions, apart from the information in the textbooks, are mentioned in the lessons by the teachers who teach history. To explore this further, a comprehensive questionnaire survey of history teachers in primary schools in Slovakia would be needed, so in our study we have made observations and drawn conclusions only on the basis of the history textbooks analysed.