Evaluation Of Topical Gel Research Articles

Formulation and Evaluation of Topical Gel Containing Nepalese Medicinal Plants

Background: The formulation of herbal gel offers a great advantage in non-sticky products as compared to ointments and creams. Herbs are beneficial for human health containing several phytochemicals. Traditionally herbal preparations are used to enhance and facilitate the quality of the skin. Therefore, the aim of the present study was to prepare the herbal gel for the use of skin nourishing and help to cure skin related disease. Methods: Different crude drugs like Aloe (Aloe vera), Neem (Azadiracta indica), Turmeric (Curcuma longa),Onion (Allium cepa), and Basil (Ocimum tenuiflorum) are used to formulate the gel. Selection of these herbs are based on literature review on their individual uses in skin related problems. Formulation was developed from polymer base by experimental design based on previous works. Different compositions of herbs were designed for the formulation study. The water extract of the herb was prepared individually and later on mixed with the gel base ingredients containing carbopol 934, methylparaben and propyl paraben. The gel is subjected to evaluation of organoleptic properties and consistency, pH, and spreadability. Disk diffusion method was used to evaluate the antimicrobial property of the extract. DPPH method was used to determine the antioxidant property of extracts. Results: The average pH values of the formulations were 6.12 and 5.91, similarly, the spreadability of the two formulations F and S were 9.223 and 9.336 respectively. All the parameters were within the range. The antimicrobial study showed that both of the formulations have strong antimicrobial properties to E.coli. Conclusion: The study concludes that the developed formulation of different concentrations are safe and within the range of standard. Therefore, we can say that our formulation product is one of the good natural gels which can be considered for the antioxidant benefit.

Formulation and evaluation of topical gel containing combination of dapsone and acetazolamide

The idea of innovation is to formulate a gel containing the combination of Dapsone and Acetazolamide for the treatment of Angioedema. Dapsone being a sulfone has antibacterial and antibiotic properties whereas Acetazolamide has a Diuretic property. So, a combination of these drugs helps to obtain a formulation with antibacterial, antibiotic and diuretic effect for the treatment of Angioedema. Various excipients such as a gelling agent, preservative, solubilizing agent etc. are used to form a stable and flawless gel formulation. The gel formulation prepared is used in the treatment of Angioedema that is a rapid oedema or swelling at specific areas such as face, genitals, hands, feet’s etc. The formulation has a comparatively greater effect for treatment of angioedema. Marketed formulations in treatment of angioedema have a specific action on the body such as antibiotic or diuretic whereas this new formulated gel has a combination of drugs that have a dual effect for the treatment of Angioedema. The swelling caused by the disease and the spread of infection is more effectively treated by this combination used in the gel formulation.

Optimization and evaluation of topical gel containing solid lipid nanoparticles loaded with luliconazole and its anti-fungal activity

Optimization and evaluation of topical gel containing solid lipid nanoparticles loaded with luliconazole and its anti-fungal activity

Formulation and Evaluation of Topical Gel Using Avocado Extract

Formulation and Evaluation of Topical Gel Using Avocado Extract

FORMULATION AND EVALUATION OF TOPICAL GEL OF ACYCLOVIR FOR TREATMENT OF VIRAL DISEASE

Aim: Formulation & Evaluation of Topical Gel of Acyclovir for Treatment of Viral Disease. 
 Material & Methods: Acyclovir gels were formulated using different polymers like Carbopol 934, Carbopol 940, hydroxy propyl methyl cellulose and Sodium Carboxy methyl cellulose. Different concentrations of polymer were used in the formulation of gels. All the formulations were evaluated for the various parameters.
 Results & Discussion: Different formulations with use of different polymers were prepared. The amount and percentage of drug present in gel formulation using different polymers were estimated as per the procedure. The prepared gel using 1% carbopol- 934(A2) showed maximum drug content (101.72%) compared to other formulations. The spreadability of gels was determined as per the procedure. From spreadability data is observed that the formulation with 1.0% carbopol-934 showed maximum (8cm), where as the formulations with 1% carbopol-940, 3%, HPMC and Sodium CMC 3% were showed significant spreadability. 1.0 % carbopol-934 shows maximum release (74.59%). The addition of DMSO as permeation enhancer improves the drug release from gel formulation. 1.0% carbopol-940 also showed a similar release pattern, but the release was lesser. In case of HPMC and Sodium CMC gels the release was much lesser than carbopol gels. The addition of DMSO as permeation enhancer drug release was improved. Stability study for the best formulation was done as per the procedure. The gel was both physically and chemically stable at 4-50C, Room temperature and 37±50C.
 Conclusion: From this investigation, it was concluded that formulation A2 with 1% Carbopol-934 may be the best formulation having good in vitro release profile, stability and bioavailability. Based on the results from the study further utility of the dosage form may depend on pharmacokinetic data. Forthcoming research work of antiviral activity may contribute in the challenging area.
 Keywords: Acyclovir, Topical gel, Viral Disease, Skin Disease, Formulation & Development

Formulation and evaluation of topical gel containing nanostructured lipid carriers dispersion of an antifungal drug

Formulation and evaluation of topical gel containing nanostructured lipid carriers dispersion of an antifungal drug

Development and Evaluation of Topical Gel with Aloe vera: Novel Treatment of Psoriasis

Development and Evaluation of Topical Gel with Aloe vera: Novel Treatment of Psoriasis