Evaluation Of D-dimer Levels Research Articles

Evaluation of D-dimer levels as a marker of chronic refractory urticaria and its correlation with disease severity

Evaluation of D-dimer levels as a marker of chronic refractory urticaria and its correlation with disease severity

Evaluation of D-Dimer Level in Patients with Pulmonary Thromboembolism Accompanied by SARS-Cov-2 Infection

We read with interest your articles in the first issue of 2022 of the dear editor's journal, in which the experiences of patients with pulmonary embolism in the emergency department were shared. We would like to thank Bilir et al and Örün et al for these interesting articles. On the other hand, we would like to point out a few points about the evaluation of D-dimer level in patients with pulmonary thromboembolism accompanied by SARS-CoV-2 infection, which may be useful in the post-pandemic period.

A Case of Adverse Reaction to Booster Dose of COVID-19 Vaccination: Could D-Dimer Elevation Suggest Increased Clotting Risk?

We report the clinical case of a 40-year-old Italian woman, who soon after her booster vaccination with mRNA-1273 after the two previous vaccinations with BNT162b2, developed severe headache, high fever, and Musculo-skeletal pain. She went to the emergency department, where computerized tomography (CT) scans of chest and brain were performed, resulting in both negative for pathologic findings. On the contrary, white blood count was strongly lowered and D-dimer severely elevated. She improved after treatment with enoxaparin and the blood analyses returned in the normal range after ten days. This case supports the hypothesis that COVID-19 vaccines could increase blood clotting in some predisposed subjects. Therefore, we believe that robust and well-designed clinical trials, considering the evaluation of D-dimer levels, should be performed to eliminate any doubts on this issue.

D-dimer as a Predictor of Altered Coagulation in HIV Patients in Nigeria.

Recent medical advances have improved the quality of life and correspondingly reduced the morbidity and mortality associated with HIV infection. However increased life expectancy has led to a relative rise in comorbidities and complications such as alterations in coagulation systems. This study is aimed at the evaluation of D-dimer level as a predictor of thromboembolic risk in HIV patients. A total of 152 HIV positive and negative subjects and control respectively attending the PEPFAR clinic UCH in Ibadan were recruited both for a questionnaire-based survey and a coagulation profile screening. Activated Partial Thromboplastin Time (APTT), Prothrombin Time (PT), D-dimer level the viral load indices of the HIV patients and their CD4 counts were also evaluated. In the subjects, the D-dimer level was significantly higher (193.6 ± 177.00ng/ml) than the controls (118.10 ± 140.58ng/ml) while a significantly lower APTT was also reported (36.22 ± 4.05 seconds) compared to the controls (41.14 ± 8.87 seconds). An evaluation of the coagulation profile in the Highly Active Antiretroviral Therapy (HAART) naïve and experienced group revealed only a significant increase (417.4) in the CD4 count whilst no difference was observed in the coagulation profile. In our study, a higher predisposition to a hypercoagulable state presenting as a short APTT was observed. This finding along with the higher D-dimer level underscores the relevance of the evaluation of this biomarker as an important predictor of thromboembolic event risk.

Evaluation of D-dimer levels in patients with prosthetic valve thrombosis: relationship with thrombus burden and cerebrovascular events.

: Plasma D-dimer level is an indicator of thrombosis and endogenous fibrinolytic activity. We investigated the association between the D-dimer levels and thrombus burden and cerebrovascular events in patients with obstructive prosthetic valve thrombosis (PVT). This retrospective study included 47 patients with obstructive left-sided PVT and 32 controls in whom PVT was excluded with comprehensive transthoracic and transesophageal echocardiography (TEE). The patient group included 11 aortic, 27 mitral, and 9 aortic and mitral valve PVT patients and the control group included 2 aortic, 25 mitral, and 5 aortic and mitral valve patients. Laboratory analysis including plasma D-dimer levels was performed at the time of admission in all patients. The baseline characteristics were similar between the two groups. The plasma D-dimer levels were significantly higher in patients with obstructive PVT compared with controls [680 (110-3590) vs. 310 (80-380) μg/l; P < 0.001]. By multivariate logistic regression analysis high D-dimer level, low-INR value on admission, high NYHA functional class and recent history of cerebrovascular accident (CVA), and transient ischemic attack (TIA) were the independent predictors of obstructive PVT. A plasma D-dimer level of greater than 365 μg/l predicted the presence of PVT with a sensitivity of 81% and a specificity of 69% (AUC= 0.781, P < 0.001). Plasma D-dimer levels were significantly higher in patients with a recent history of CVA/TIA [2140 (470-2980) vs. 590 (380-830) μg/l; P = 0.021]. In addition to the so-called indicators of PVT including subtherapeutic anticoagulation, increased D-Dimer levels may strengthen the suspicion of PVT. Moreover, higher plasma D-dimer levels were associated with higher thrombus burden and higher prevalence of recent CVA/TIA.

Evaluation of D-Dimer Level in Sudanese Patients with Chronic Liver Disease in IbnSina Hospital

Background: Chronic liver disease is a disease process of the liver that involves a process of progressive destruction and regeneration of the liver parenchyma leading to fibrosis and cirrhosis chronic liver disease refers to disease of the liver which had lasted over a period of 6 months. This study was conducted to evaluate the D-dimer levels among Sudanese patients with Chronic Liver Diseases. Materials and Method: In IbnSina hospital, Khartoum state, Sudan, a case control study was conducted. For this study, 100 participants were selected, 70 of them were patients known diagnosed by chronic liver diseases as a test group. Other 30 participants were normal healthy individual as control group. The plasma D-dimer level was measured by using MINDRAY auto analyzer BS 380). Results: In this study, the plasma D-dimer level has statistically significantly higher in chronic liver diseases patients (mean ± SD 0.634 ± 0.215 ug/l) compared to normal healthy control group (mean ± SD 0.223 ± 0.077 ug/l) with P value 0.000. Conclusion: The present study revealed that the D-dimer levels were statistically significant higher in chronic liver diseases patients.

Evaluation of D-dimer level among adult patients in Al-Quwayyah Government Hospital, Saudi Arabia

Our Objective was to Evaluate the D-dimer level among adult patients in Al-Quwayyah Government Hospital, Saudi Arabia. A prospective study was conducted during four months period in 2012. The inclusion criteria were patients eighteen years of age and above who have surgical procedure. Information was obtained by the Laboratory Department of Al-Quwayyah Government Hospital. A Total of 46 patients were done a D-dimer test in a hospital. The patient's constituted 32 males and 14 females and the average age was 60 years. D-dimer test, findings indicated that 69.5% was found abnormal level of D-dimer (elevated) and 30.5% was normal D-dimer level. The average age of abnormal D-dimer group is 59 years old (Male and female). No difference in the result of abnormality of D-dimer. Levels were found between male and female, but there were found a significantly relationship that associated with increasing of the age of patients. In this study, the proportion of the high level of D-dimer in this group was 69.5%. The increase in the client age plays a vital role in the increase of D-dimer level. Advices and recommendations are should be pay attention to help those patients suffering of elevated D-dimer level.