European System Research Articles

Nonpharmacological intervention therapies for dementia: potential break-even intervention price and savings for selected risk factors in the European healthcare system

BackgroundNew effective treatments for dementia are lacking, and early prevention focusing on risk factors of dementia is important. Non-pharmacological intervention therapies aimed at these factors may provide a valuable tool for reducing the incidence of dementia. This study focused on the development of a mathematical model to predict the number of individuals with neurodegenerative diseases, specifically Alzheimer’s disease, Parkinson’s disease, vascular dementia, and amyotrophic lateral sclerosis. Scenarios for non-pharmacological intervention therapies based on risk factor reduction were also assessed. The estimated total costs and potential cost savings from societal were included.MethodsBased on demographic and financial data from the EU, a mathematical model was developed to predict the prevalence and resulting care costs of neurodegenerative diseases in the population. Each disease (Alzheimer’s disease, Parkinson’s disease, vascular dementia, and amyotrophic lateral sclerosis) used parameters that included prevalence, incidence, and death risk ratio, and the simulation is related to the age of the cohort and the disease stage.ResultsA replicable simulation for predicting the prevalence and resulting cost of care for neurodegenerative diseases in the population exhibited an increase in treatment costs from 267 billion EUR in 2021 to 528 billion EUR by 2050 in the EU alone. Scenarios related to the reduction of the prevalence of dementia by up to 20% per decade led to total discounted treatment cost savings of up to 558 billion EUR.ConclusionThe model indicates the magnitude of the financial burden placed on EU healthcare systems due to the growth in the population prevalence of neurodegenerative diseases in the coming decades. Lifestyle interventions based on reducing the most common risk factors could serve as a prevention strategy to reduce the incidence of dementia with substantial cost-savings potential. These findings could support the implementation of public health approaches throughout life to ultimately prevent premature mortality and promote a healthier and more active lifestyle in older individuals.

Reactivity and bioconcentration of stable cesium in a hyperturbid fluvial-estuarine continuum: A combination of field observations and geochemical modeling

Effective, post-accidental management needs an accurate understanding of the biogeochemical behavior of radionuclides in surface environments at a regional scale. Studies on stable isotopes (element homologs) can improve this knowledge. This work focuses on the biogeochemical behavior of stable cesium (Cs) along a major European fluvial-estuarine system, the Gironde Estuary (SW France). We present results obtained from (i) a long-term monitoring (2014–2017) of dissolved (Csd) and particulate (Csp) Cs concentrations at five sites along the freshwater continuum of the Garonne watershed, (ii) Csd and Csp concentrations during four oceanographic campaigns at contrasting hydrological conditions along longitudinal profiles of the estuarine system, (iii) a 24 h cycle of Csp at the estuary mouth, and (iv) a historical trend of Cs bioconcentration in wild oysters at the estuary mouth (RNO/ROCCH, 1984–2017). In addition, we model the partitioning of Cs within the estuarine environment for clay mineral interactions via PhreeqC. At fluvial sites, we observe a geogenic dependence of the Csp and a seasonal variability of Csd, with a downstream increase of the solid-liquid partitioning (log10 Kd values from 3.64 to 6.75 L kg−1) for suspended particulate matter (SPM) < 200 mg L−1. Along the estuarine salinity gradients, Cs shows a non-conservative behavior where fresh SPM (defined as Cs-depleted particles recently put in contact with Csd) act as a Cs sink during both flood and low discharge (drought) conditions. This sorption behavior was explained by the geochemical model, highlighting the relevance of ionic strength, water and SPM residence times. However, at high salinities, the overall log10 Kd value decreases from 6.02 to 5.20 for SPM ∼300–350 mg L−1 due to the Csd oceanic endmember. Despite wild oysters showing low bioconcentration factors (∼1220 L kg−1) at the estuary mouth, they are sensitive organisms to Cs fluxes.

Comparison between propofol and total inhalational anaesthesia on cardiovascular outcomes following on-pump cardiac surgery in higher-risk patients: a randomised controlled pilot and feasibility study

ObjectivesMyocardial revascularisation and cardiopulmonary bypass (CPB) can cause ischaemia-reperfusion injury, leading to myocardial and other end-organ damage. Volatile anaesthetics protect the myocardium in experimental studies. However, there is uncertainty about...

Regulation of Corporate Criminal Liability According To Law Number 1 Year 2023 On The Criminal Code

Corporation as a subject of criminal law that can be held criminally responsible is not known in the old Criminal Code. This is because the old Criminal Code is a legacy of the Dutch colonial government whose legal system adheres to the Continental European legal system (civil law). Countries that adhere to the civil law legal system are a little behind in terms of regulating corporations as subjects of criminal law, in contrast to countries that adhere to the common law legal system, which has regulated corporate liability and this has started since the industrial revolution. In Indonesia itself, the regulation on corporation as a subject of criminal law is regulated in the Law outside the Criminal Code. Meanwhile, the new Criminal Code has regulated corporations as legal subjects that can be held criminally liable. As regulated in Article 45 to Article 50, Article 56, and Articles 118 to 124 of Law No. 1 of 2023 on the Criminal Code. Although prior to the enactment of Law No. 1 of 2023 on the Criminal Code there was already Perma No. 13 of 2016 concerning Procedures for Handling Criminal Cases by Corporations and Regulation of the Attorney General of the Republic of Indonesia Number PER-28/A/JA/10/2014 concerning Guidelines for Handling Criminal Cases with Corporate Legal Subjects. Prior to the issuance of the regulation, the Attorney General's Office had first issued Circular Letter of the Attorney General of the Republic of Indonesia Number B-036/A/FT.1/06/2009 regarding Corporations as Suspects/Defendants in Corruption Crimes addressed to the Head of High Prosecutors throughout Indonesia. Thus, Corporations as a subject of criminal law can already be held criminally liable with the strength and legal certainty stipulated in the New Criminal Code.

The normative paradigm of procedure protection of possession in Brazilian Law: comparisons with possession protection models in foreign Law

“The judicial protection of possession in the Brazilian legal system reveals itself as an adoption of the absolute normative model of possession protection, in contrast to most European national legal systems, and establishes an independent possessory procedural protection in relation to the right to property” is the hypothesis that is proposed by the present article and validated with the investigation developed with the following objectives: investigate the historical development of the possessory and petitory actions in Roman Law; examine the level of independence and binding between the possessory judgment and the petitory judgment in the national legal systems; and identify particularities of the legal treatment of possession in Brazilian law, as well as the limits of its protection. The methodology used was based on a review of different doctrinal and normative sources with an analytical approach and on the exegesis of the current norms. As results, it was possible to identify and systematize the rules related to the judicial protection of possession that demonstrate that Brazil adopts a more independent and "guarantee" system of possessory protection (normative model of absolute protection of possession), as well as defining some of the singularities of the legal treatment of possession in Brazilian Law. With this, a propositional thesis is presented regarding the functioning and limits of the system of judicial protection of possession in Brazilian Law.

The Impact of Food Safety Criteria on Fruit and Vegetable Exports from Türkiye to The European Union

Food safety has become an increasingly important issue as people become more concerned about access to healthy food. Particularly in affluent societies such as the European Union, the increasing consumption of unhealthy fruits and vegetables and carcinogenic residues are constantly on the agenda. Reducing aflatoxin levels in dried foods to below health risk levels, eliminating them from food and ensuring access to healthy food are essential for food safety and human health. In this study, the impact of food safety practices in fruit and vegetable trade between the European Union and Türkiye was examined using mandarins, one of Türkiye’s main fresh fruit and vegetable exports, and the European Union Rapid Alert System for Food and Feed (RASFF) notifications for food and feed for the period between 2019 and 2022. The reasons for these notifications and the requests made in this context were examined and a TOWS analysis matrix was created based on the findings obtained. In conclusion, residue and aflatoxin inspections should be included in traceability activities in Türkiye. Producers need to be informed to ensure the effectiveness of inspections. It is crucial to provide adequate support to producers to improve storage conditions for perishable and dry products and to encourage the use of the latest production techniques. It is of great importance to raise awareness of these techniques among producers. Thus, the European Union can be an alternative market to the Russian Federation, which is Türkiye’s largest trading partner.

Participatory development of Shared Socioeconomic Pathways for Austria’s agriculture and food systems

Agriculture and food systems are central to managing biodiversity loss and climate change. Future changes in agriculture and food systems are highly uncertain and depend on underlying socio-economic developments. Scenarios allow scientists, policy and industry decision-makers to consider such uncertainties and describe a spectrum of plausible futures. The Shared Socioeconomic Pathways for European agriculture and food systems (Eur-Agri-SSPs) semi-quantitatively describe pathways along future challenges for climate change mitigation and adaptation. However, additional or adapted drivers (i.e. scenario elements), like national policies or adaptations of European policies, are relevant to frame plausible future developments at national scales. We aim to set the standard for developing country and sector-specific SSPs in a participatory process by developing and applying an eleven-step protocol and engaging a diverse group of stakeholders throughout the whole research process. By downscaling the Eu-Agri-SSPs to a national level, we contribute to improve their usability in academia, governments and industry. This is achieved by matching qualitative pathways with the needs of integrated land use models (used to simulate land use scenarios), and by quantifying selected drivers for future developments together with stakeholders. In particular, we estimate 20-year trends (2000–2019) and apply fuzzy set theory to quantify ten scenario elements, which are typically required in integrated land use models. The final scenarios describe the semi-quantitative development for 79 scenario elements along the five topics “Population and urbanization”, “Economy”, “Policy and institutions”, “Technology”, and “Environment and natural resources” for the five AT-Agri-SSPs. Exemplary results reveal that stakeholders expect payments for agri-environment-climate measures to increase to 1200 million € in AT-Agri-SSP1 or to decline to 267 million € in AT-Agri-SSP3, 4 and 5. For direct payments, a complete phase-out was specified for AT-Agri-SSP1 and an increase to 711 million € in AT-Agri-SSP3. We discuss 14 lessons learnt and recommendations for future scenario processes and participatory quantification. Recommendations include: tailoring the assignment of scenario elements for quantification to stakeholders’ expertise, keeping survey complexity low, providing historical and relevant SSP data, and encouraging stakeholders to jointly quantify interdependent elements. The AT-Agri-SSPs can inform policy-making, decision-making in industry, and research on the agriculture and food systems.

Using power system modelling outputs to identify weather-induced extreme events in highly renewable systems

In highly renewable power systems the increased weather dependence can result in new resilience challenges, such as renewable energy droughts, or a lack of sufficient renewable generation at times of high demand. The weather conditions responsible for these challenges have been well-studied in the literature. However, in reality multi-day resilience challenges are triggered by complex interactions between high demand, low renewable availability, electricity transmission constraints and storage dynamics. We show these challenges cannot be rigorously understood from an exclusively power systems, or meteorological, perspective. We propose a new method that uses electricity shadow prices—obtained by a European power system model based on 40 years of reanalysis data—to identify the most difficult periods driving system investments. Such difficult periods are driven by large-scale weather conditions such as low wind and cold temperature periods of various lengths associated with stationary high pressure over Europe. However, purely meteorological approaches fail to identify which events lead to the largest system stress over the multi-decadal study period due to the influence of subtle transmission bottlenecks and storage issues across multiple regions. These extreme events also do not relate strongly to traditional weather patterns (such as Euro-Atlantic weather regimes or the North Atlantic Oscillation index). We therefore compile a new set of weather patterns to define energy system stress events which include the impacts of electricity storage and large-scale interconnection. Without interdisciplinary studies combining state-of-the-art energy meteorology and modelling, further strive for adequate renewable power systems will be hampered.

Family without kinship – the pluralism of European regulatory research integrity systems and its implications

ABSTRACT This paper investigates the differences and similarities between European regulatory research integrity systems. The data collection process involved gathering information from public sources. A total of 27 European countries were included in the comprehensive dataset. Three determinants were examined: the legal structure of national research integrity regulation, the presence of national research integrity guidelines, and the provision of research integrity training by national research integrity offices. Qualitative content analysis was employed to identify relevant differences in national research integrity systems and the work of national research integrity offices. The findings suggest that the functions and powers of research integrity offices in Europe vary significantly, and there is extensive variation in the legal status and functions of national research integrity systems. We identify the major implications arising from these differences and explore what the challenges for harmonization of the European research integrity systems are. Our findings highlight the need for promoting dialogue between actors on an international level.

Constraint reconciliation optimization to minimize primary and reactionary delay in a research network strategic tool

AbstractWhen regulated network capacities are violated, flights may be delayed to meet time-based slot restrictions. In addition, reactionary delays occur when time buffers to subsequent flight legs are exceeded. This work aims to minimize both—primary and reactionary delays in a dynamic simulation of the European Air Transportation System. The slot allocation process is solved by minimizing network delay with a binary optimization approach instead of using the current first-planned–first-served principle. The new module presented in this study, called constraint reconciliation and optimization (CRO), is applied within EUROCONTROL’s Research Network Strategic Tool (R-NEST). The results are compared to delays generated by R-NEST’s computer-aided slot allocation (ISA–CASA). In simulations of tactical air traffic flow management (ATFM) operations, time is iterated over the day and flight plans are updated with random and propagated delays. The computational complexity of all possible delay- and slot-entry-permutations is reduced by the method of column generation for solving large linear problems. Three validation scenarios that contain flight plans, rotation margins, sector configurations, regulations, and deterministic or stochastic delays are evaluated. In the most realistic scenario, compared to ISA–CASA, CRO reduces primary and reactionary delays by up to 16% while achieving low levels of airspace sector and airport overloads and fast computation times.

SNP‐based analysis of European Thymallus spp. (Salmonidae) reveals extensive mito‐nuclear discordance relevant for biogeographic inferences, taxonomy and conservation

AbstractAimPaleohydrological dynamics are well‐documented for European river systems, promoting shifting phases of isolation and connectivity of their aquatic fauna. These conditions coupled with high rates of hybridisation found in freshwater fishes may introduce considerable complexity and potential mito‐nuclear discordance of phylogenetic patterns. We evaluate this hypothesis using the first large‐scale analysis of nuclear SNPs in European species of grayling (Thymallus) compared to mtDNA data with the aim of reassessing the evolutionary history of this group of rheophilic fishes.LocationFreshwater systems in Europe.MethodsBased on mitochondrial (mitogenomes, control region) and nuclear (ddRADseq) data, we applied population‐genetic, phylogenetic, and biogeographic tools to evaluate lineage diversity in the context of paleohydrological alterations.ResultsThe results corroborated previously recognised high levels of lineage diversity, but revealed several cases of mito‐nuclear discordance and signals of both historical (natural) and human‐mediated introgression among major inter‐ and intraspecific lineages of Thymallus in Europe. A time‐calibrated phylogeny and ancestral area estimation, based on nuclear SNP data, supported a late Pliocene diversification of the genus in Europe and suggested an early colonisation of the Black Sea basin with subsequent dispersal into Central and Western Europe.Main ConclusionsThe genetic structure of Thymallus in Europe recovered by nuclear SNPs contrasts considerably with that supported by mtDNA. Several instances of mito‐nuclear discordance underscore frequent contact of allopatric lineages in a dynamic paleohydrological landscape and reveal the weakness of basing both taxonomic and conservation decisions on inferences based on mtDNA alone. The Danube and Rhine drainages were inferred as important zones of contact between divergent phylogeographic lineages. Additionally, our data cast doubt on the genetic integrity of the endangered T. aeliani. Its divergence from T. thymallus, using nuclear SNPs, appears minimal as samples of T. aeliani group within Danubian lineages, despite carrying highly divergent reciprocally monophyletic mtDNA.

Market zone configuration under collusive bidding among the conventional generators and renewable energy sources in the day-ahead electricity market

The European cross-zonal day-ahead (DA) electricity market is transitioning to the flow-based market coupling model for market clearing. With the increasing integration of renewable energy sources (RESs), market participants have opportunities for collusive bidding, resulting in decreased social welfare (SW). Thus, this paper is the first to propose an approach to configure the market zone (MZ) considering collusive bidding among conventional generators (CGs) and RESs in the DA market. Specifically, a bi-level model is developed to analyze collusive bidding among the CGs and RESs. Then, multi-dimensional market performance indices are used to determine the critical branches (CBs), on which the configuration of MZs is based. Finally, test 6-bus and simplified European systems are used to demonstrate the validity and merit of the proposed approach. Our simulation on the 6-bus system shows that when compared with the initial zonal market (ZM), the SW of the optimized ZM increased by 18 %, while the re-dispatch surrogate cost decreased to 0. Also, the penetration of RESs improved by 12 %, which guarantees the development of RESs.

Evaluation of respiratory allergies burden and management in primary care and comparative analysis of health care data from Romania, Poland, Czech Republic and Bulgaria - preliminary study.

Respiratory allergies mostly allergic rhinitis and asthma represent an important and increasing public health problem and one of the priorities for the European health systems. There is an increasing public concern regarding the persistence and severity of allergic diseases and many difficulties of health systems in providing prompt specialized medical assistance. Our study aims to highlight the main results of the Alliance 4Life project focused on the evaluation of the burden and management of respiratory allergies in primary care from Romania and comparative health-related data from four Central and Eastern European countries. We developed a questionnaire focused on patients with allergic rhinitis and asthma directly addressed to general practitioner (GP) specialists from Romania who attended the annual national conference in Bucharest. The main results showed that patients with respiratory allergies are frequently encountered in primary care practice, only a few patients are evaluated by allergists and there is a clear need for education in this field. This preliminary study confirms that respiratory allergies represent a considerable burden in primary care and the questionnaire may be a useful tool in further studies considering the experience of other healthcare systems. More advanced studies integrating epidemiology with data on air pollution and environmental conditions should be envisaged.

Procedural Conditions for the Admissibility of an Expert's Opinion as Evidence in a Criminal Case

The proposed work examines the issues of the admissibility of such type of evidence as an expert opinion, which are traditional for any country with a continental European legal system. The appeal to this issue is not accidental due to the rather rapid development of science and technology in recent years, the course of global digitalization processes in the human environment. Objectively, it is necessary to discuss the issue of adjusting the procedural conditions for admission of expert opinions as evidence in a criminal case, especially those that are carried out in actively developing areas of application of special knowledge.

Book Review: Towards a European System of Industrial Relations? The ETUC in the Twenty-First Century, by Richard Hyman and Rebecca Gumbrell-McCormick

Book Review: <i>Towards a European System of Industrial Relations? The ETUC in the Twenty-First Century</i>, by Richard Hyman and Rebecca Gumbrell-McCormick

The freshwater discharge into the Adriatic Sea revisited

The present study reconstructs the river discharge climatology and its respective historical series for all rivers of the Adriatic Sea with averaged climatological daily river discharge above 1 m3s−1, to reach a better representation of the Adriatic rivers in hydrodynamic models and, consequently, to develop a more realistic freshwater balance in the different regions of the hydrographic basin. Based on the European Flood Awareness System (EFAS) data set, a careful method of identification and selection of the Adriatic rivers, followed by a rigorous assessment against observational data, was developed to evaluate the current state of the Adriatic river discharges and their respective trends throughout several climate indicators from 1991 to 2022. Observational data are limited to 85% of the identified rivers, totaling 98% of the overall freshwater input into the Adriatic Sea. The results confirm that the Shallow Northern Adriatic receives the largest freshwater inputs with a daily average exceeding 2,400 m3s−1, which amounts to 61% of the overall Adriatic discharges. Consequently, this region guides the freshwater seasonal cycle of the Adriatic Sea, which presents a well-defined pattern of two flood peaks in late autumn and late spring, separated by a minimum discharge period at mid-summer. From the Central to the Southern Adriatic subregions, the absence of snow-melting effects prevents the secondary flood peak during the spring, shaping the seasonal cycle of river discharges from a single flood peak in late autumn to a drought period in August. The 32 years of continuous river discharge data reveal a negligible trend in the overall Adriatic Sea but a negative trend for the last decade (2013–2022). This decadal decrease is driven by the extreme drought that drastically pounded the northern Adriatic in 2022.

Unleashing Culture and Creativity Power in European Education Processes

The European educational system stands in a unique position at the crossroads of training, research and innovation, in shaping sustainable and resilient economies, and in making its territories greener, more inclusive and more digital through culture and creativity. This paper is the result of a one-year collaboration between the Alma Mater Studiorum — Università di Bologna and the Jagiellonian University, under the umbrella of the EIT Culture &amp; Creativity (EIT C&amp;C), in the interim co-chairing of the Direction linked to the Action Program 1 Talent Scaler, to define activities and strategies for the operationalization of the Strategic Objective 1 about Education. This involvement opened up the possibility to activate a fruitful international cooperation with all the members of Una Europa, the alliance of Europe’s eleven largest leading research universities that aim to create a truly European inter-university environment, a University of the Future.

Meaningful community engagement through advanced indicator systems for sustainable destination planning

This study advances the measurement of sustainable development in communities and destinations examining socio-ecological, environmental, cultural, and economic dimensions. By integrating qualitive insights within established indicator systems such as the European Tourism Indicator System, it addresses the limitations of traditional, solely quantitative approaches. Carrying out over 400 resident surveys in Co. Clare, Ireland, the research established sustainable indicators and assessed the destination's sustainability through resident-based metrics. For instance, 87% of residents believed that tourism benefits their community, yet only 23% of residents were satisfied with their involvement in planning. Thematic analysis of the open-ended responses provided crucial themes for sustainable destination management, highlighting resident concerns on transport, planning, management, and community involvement and benefits. The study concluded that relying solely on quantitative indicators, limits Destination Management Organizations (DMOs) and planners to Likert scale results, failing to capture nuanced impacts observed by destinations. The study highlights the insufficiency of solely using quantitative indicators, which risk oversimplifying community inputs and misinterpreting resident dissatisfaction, signally a need for diverse solutions to address varied concerns. The study also identified survey fatigue as a governance challenge, potentially hindering future sustainable development efforts. Aligning with the socio-ecological indicators of the community-environment-development nexus call for papers, this interdisciplinary research demonstrates the value of advanced indicator systems in promoting meaningful community engagement and supporting policy formulation for sustainable destination development. It offers a comprehensive framework for integrating resident perspectives and thematic insights into destination management, contributing to a more inclusive and community-based approach to tourism development.

Comparative analysis of European vertical landing reusable first stage concepts

AbstractReusable launch systems have the potential to significantly impact the space launch service market if both a high reliability and low refurbishment costs can be achieved. This study delves into the Vertical Takeoff and Vertical Landing (VTVL) methodology, as currently employed by SpaceX, and forms a segment of the ENTRAIN study by DLR. This broader study encompasses an examination of both Vertical Takeoff Horizontal Landing (VTHL) and VTVL reusable first stages, exploring their performance across high-level design parameters. This manuscript’s primary objective is to assess the quantitative impact of high-level design factors on launch vehicle performance, particularly in relation to the development of a future European reusable launch system featuring a VTVL first stage. For a two-stage vehicle with a payload performance of 7.5t into GTO, the effect of varying propellant combinations, staging velocities and engine cycles are assessed. The study encompasses an iterative, multidisciplinary analysis and sizing process for ten different configurations. Each design iteration not only entails a structural design analysis but also includes optimization of the ascent and descent trajectories. Finally, the developed vehicle concepts are compared to derive quantitative insights into the trade-offs associated with key design choices.

Generational (re)alignment: emerging issues and new voters in Western Europe

Voting behaviour in Western Europe has become increasingly structured by attitudes towards socio-cultural issues, such as immigration and European unification. This study examines whether generational differences affect this form of realignment. By combining data from the ESS and the CHES, it explores party–voter alignment on specific issues across 17 West European party systems from 2002 to 2020. ‘Age-Period-Cohort’ (APC) analyses demonstrate that younger generations are more strongly aligned than older generations on immigration, LGBTQ+-rights, the environment and left–right placement, but not on the EU and income redistribution. The results also show over-time increases in issue alignment for three of the six issues, but these period effects are more country-specific than the generational differences. Consequently, generational replacement can be expected to increase party–voter alignment on the left–right dimension and (some) new issues.