Happy 2000 to all our readers, contributors, dedicated members of the Editorial Team and Editorial Advisory Board, and our expert independent referees, and to members, officers and staff of the Medical Council on Alcoholism (MCA), the European Society for Biomedical Research on Alcoholism (ESBRA), and our publisher, Oxford University Press (OUP). The new millennium is upon us and, as we promised last year (Badawy and Tipton, 1999), we consider it appropriate at this important landmark of the Christian (Western) Calendar to review the history of Alcohol and Alcoholism and its progress, and, in doing so, to pay tribute to its parent organization, the MCA, and to those individuals who have been instrumental in the development of both parent and child and their supporters. The reader of this issue will see that invited special articles have been written, among which one (Nordmann, 2000) on ESBRA by its founding President Professor Roger Nordmann and another (Evans, 2000) on the MCA and its journal by the second of the journal Editors, Dr Myrddin Evans, in which he gives his particular thoughts on key issues in alcohol research and on those he considers important for the continuing development of the journal. Our main task here will therefore be to complement these two contributions, and indeed those by Professor Karl Mann (holder of the first Chair in Addiction Research in Germany) and his colleagues, on the history of alcohol research and treatment in the twentieth century (Mann et al. , 2000) and by Dr Adriaan Potgieter on the activities of another European organization concerned with alcoholism research and treat-ment, the Plinius Maior Society (Potgieter, 2000), with our own ‘observer’ view of the MCA, specially from the journal perspective. At the national (British) level, the development of Alcohol and Alcoholism and its parent organization the MCA, …